GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:15611229
| Citation |
Liu, QH, Liu, X, Wen, Z, Hondowicz, B, King, L, Monroe, J and Freedman, BD (2005) Distinct calcium channels regulate responses of primary B lymphocytes to B cell receptor engagement and mechanical stimuli. J. Immunol. 174:68-79 |
|---|---|
| Abstract |
Intracellular Ca(2+) plays a central role in controlling lymphocyte function. Nonetheless, critical gaps remain in our understanding of the mechanisms that regulate its concentration. Although Ca(2+)-release-activated calcium (CRAC) channels are the primary Ca(2+) entry pathways in T cells, additional pathways appear to be operative in B cells. Our efforts to delineate these pathways in primary murine B cells reveal that Ca(2+)-permeant nonselective cation channels (NSCCs) operate in a cooperative fashion with CRAC. Interestingly, these non-CRAC channels are selectively activated by mechanical stress, although the mechanism overlaps with BCR-activated pathways, suggesting that they may operate in concert to produce functionally diverse Ca(2+) signals. NSCCs also regulate the membrane potential, which activates integrin-dependent binding of B cells to extracellular matrix elements involved in their trafficking and localization within secondary lymphoid organs. Thus, CRAC and distinct Ca(2+) permeant NSCCs are differentially activated by the BCR and mechanical stimuli and regulate distinct aspects of B cell physiology. |
| Links | |
| Keywords |
Animals; B-Lymphocytes/drug effects; B-Lymphocytes/immunology; B-Lymphocytes/metabolism; Blotting, Western; Calcium Channels/drug effects; Calcium Channels/metabolism; Cell Adhesion/immunology; Cell Movement/immunology; Cells, Cultured; Enzyme Inhibitors/pharmacology; Integrins/immunology; Integrins/metabolism; Membrane Potentials/drug effects; Membrane Potentials/immunology; Mice; Patch-Clamp Techniques; Phospholipase C gamma; Physical Stimulation; Polymerase Chain Reaction; Receptors, Antigen, B-Cell/immunology; Receptors, Antigen, B-Cell/metabolism; Signal Transduction/immunology; Type C Phospholipases/immunology; Type C Phospholipases/metabolism |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| edit table |
See also
References
See Help:References for how to manage references in GONUTS.
