MOUSE:PIN1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Pin1
Protein Name(s)	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Peptidyl-prolyl cis-trans isomerase Pin1 PPIase Pin1
External Links
UniProt	Q9QUR7
EMBL	AB009691 AB009692 AK002665 AK003369 AK054045 AK150652 AK160228 BC038254
CCDS	CCDS22882.1
PIR	JC7136
RefSeq	NP_075860.1
UniGene	Mm.7906
ProteinModelPortal	Q9QUR7
SMR	Q9QUR7
BioGrid	204839
DIP	DIP-44280N
IntAct	Q9QUR7
MINT	MINT-4107624
PhosphoSite	Q9QUR7
MaxQB	Q9QUR7
PaxDb	Q9QUR7
PRIDE	Q9QUR7
Ensembl	ENSMUST00000034689
GeneID	23988
KEGG	mmu:23988
UCSC	uc009ojd.1
CTD	5300
MGI	MGI:1346036
eggNOG	COG0760
GeneTree	ENSGT00640000091578
HOGENOM	HOG000275331
HOVERGEN	HBG002101
InParanoid	Q9QUR7
KO	K09578
OMA	FALKVGD
OrthoDB	EOG7S4X82
PhylomeDB	Q9QUR7
TreeFam	TF101101
BRENDA	5.2.1.8
Reactome	REACT_198532
NextBio	303885
PRO	PR:Q9QUR7
Proteomes	UP000000589
Bgee	Q9QUR7
Genevestigator	Q9QUR7
GO	GO:0005737 GO:0016607 GO:0003755 GO:0007049 GO:0042127 GO:0032465
InterPro	IPR000297 IPR023058 IPR001202
Pfam	PF00639 PF00397
SMART	SM00456
SUPFAM	SSF51045
PROSITE	PS01096 PS50198 PS01159 PS50020

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0051219	phosphoprotein binding	PMID:23362255^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P10637	F	occurs_in:(UBERON:0000955) activated_by:(CHEBI:15422) happens_during:(GO:0006468)	Seeded From UniProt	complete
involved_in	GO:0050821	protein stabilization	PMID:11533658^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	stabilizes:(UniProtKB:Q02248)	Seeded From UniProt	complete
involved_in	GO:0030182	neuron differentiation	PMID:22645310^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0000956) happens_during:(GO:0009790)	Seeded From UniProt	complete
involved_in	GO:0090263	positive regulation of canonical Wnt signaling pathway	PMID:22645310^[3]	ECO:0000305	curator inference used in manual assertion	GO:0008013,GO:0050821	P		Seeded From UniProt	complete
involved_in	GO:0050821	protein stabilization	PMID:22645310^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	stabilizes:(UniProtKB:Q02248) part_of:(GO:0030182)	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:22645310^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:22645310^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	PMID:22645310^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q02248	F	part_of:(GO:0030182)	Seeded From UniProt	complete
involved_in	GO:0050808	synapse organization	PMID:22645310^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003774	motor activity	PMID:22645310^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1346036 PANTHER:PTN002579701 RGD:1310299 TAIR:locus:2060922	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015379 MGI:MGI:1346036 PANTHER:PTN000069608 PomBase:SPCC16C4.03 RGD:1310299 UniProtKB:Q13526 dictyBase:DDB_G0268618	C		Seeded From UniProt	complete
enables	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1346036 MGI:MGI:3649546 PANTHER:PTN002579701 SGD:S000003778 TAIR:locus:2060922 UniProtKB:Q13526 dictyBase:DDB_G0268618	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060393	regulation of pathway-restricted SMAD protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13526	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051443	positive regulation of ubiquitin-protein transferase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13526	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050821	protein stabilization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13526	P		Seeded From UniProt	complete
enables	GO:0050816	phosphothreonine residue binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13526	F		Seeded From UniProt	complete
enables	GO:0050815	phosphoserine residue binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13526	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13526	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043547	positive regulation of GTPase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13526	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043525	positive regulation of neuron apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1310299	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043524	negative regulation of neuron apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1310299	P		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1310299	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042177	negative regulation of protein catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13526	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042127	regulation of cell population proliferation	PMID:12810604^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2177943	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035307	positive regulation of protein dephosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1310299	P		Seeded From UniProt	complete
enables	GO:0032794	GTPase activating protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13526	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032465	regulation of cytokinesis	PMID:19638580^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032465	regulation of cytokinesis	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13526	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032092	positive regulation of protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13526	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032091	negative regulation of protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13526	P		Seeded From UniProt	complete
enables	GO:0031434	mitogen-activated protein kinase kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13526	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13526	P		Seeded From UniProt	complete
part_of	GO:0030496	midbody	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13526	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010468	regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13526	P		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13526	F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1310299	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1310299	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13526	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1310299	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13526	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13526	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1310299	C		Seeded From UniProt	complete
enables	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	PMID:17548053^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13526	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1310299	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13526	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001932	regulation of protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13526	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000146	negative regulation of cell motility	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13526	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900180	regulation of protein localization to nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13526	P		Seeded From UniProt	complete
part_of	GO:0099524	postsynaptic cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13526	C		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13526	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090263	positive regulation of canonical Wnt signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13526	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070373	negative regulation of ERK1 and ERK2 cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13526	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061051	positive regulation of cell growth involved in cardiac muscle cell development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1310299	P		Seeded From UniProt	complete
involved_in	GO:0000413	protein peptidyl-prolyl isomerization	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0003755	P		Seeded From UniProt	complete
involved_in	GO:0000413	protein peptidyl-prolyl isomerization	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0003755	P		Seeded From UniProt	complete
involved_in	GO:0000413	protein peptidyl-prolyl isomerization	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0003755	P		Seeded From UniProt	complete
involved_in	GO:0000413	protein peptidyl-prolyl isomerization	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0003755	P		Seeded From UniProt	complete
involved_in	GO:0000413	protein peptidyl-prolyl isomerization	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0003755	P		Seeded From UniProt	complete
involved_in	GO:0000413	protein peptidyl-prolyl isomerization	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0003755	P		Seeded From UniProt	complete
enables	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000297	F		Seeded From UniProt	complete
enables	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:5.2.1.8	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0697	F		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
enables	GO:0016853	isomerase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0413	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0186	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Kimura, T et al. (2013) Isomerase Pin1 stimulates dephosphorylation of tau protein at cyclin-dependent kinase (Cdk5)-dependent Alzheimer phosphorylation sites. J. Biol. Chem. 288 7968-77 PubMed GONUTS page
↑ Ryo, A et al. (2001) Pin1 regulates turnover and subcellular localization of beta-catenin by inhibiting its interaction with APC. Nat. Cell Biol. 3 793-801 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 Nakamura, K et al. (2012) Prolyl isomerase Pin1 regulates neuronal differentiation via β-catenin. Mol. Cell. Biol. 32 2966-78 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Atchison, FW et al. (2003) Pin1 regulates the timing of mammalian primordial germ cell proliferation. Development 130 3579-86 PubMed GONUTS page
↑ van der Horst, A & Khanna, KK (2009) The peptidyl-prolyl isomerase Pin1 regulates cytokinesis through Cep55. Cancer Res. 69 6651-9 PubMed GONUTS page
↑ Zhu, JX et al. (2007) Identification and characterization of a novel and functional murine Pin1 isoform. Biochem. Biophys. Res. Commun. 359 529-35 PubMed GONUTS page

[PMID:23362255-1] Kimura, T et al. (2013) Isomerase Pin1 stimulates dephosphorylation of tau protein at cyclin-dependent kinase (Cdk5)-dependent Alzheimer phosphorylation sites. J. Biol. Chem. 288 7968-77 PubMed GONUTS page

[PMID:11533658-2] Ryo, A et al. (2001) Pin1 regulates turnover and subcellular localization of beta-catenin by inhibiting its interaction with APC. Nat. Cell Biol. 3 793-801 PubMed GONUTS page

[PMID:22645310-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 Nakamura, K et al. (2012) Prolyl isomerase Pin1 regulates neuronal differentiation via β-catenin. Mol. Cell. Biol. 32 2966-78 PubMed GONUTS page

[PMID:21873635-4] 4.0 ^4.1 ^4.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:12810604-5] Atchison, FW et al. (2003) Pin1 regulates the timing of mammalian primordial germ cell proliferation. Development 130 3579-86 PubMed GONUTS page

[PMID:19638580-6] van der Horst, A & Khanna, KK (2009) The peptidyl-prolyl isomerase Pin1 regulates cytokinesis through Cep55. Cancer Res. 69 6651-9 PubMed GONUTS page

[PMID:17548053-7] Zhu, JX et al. (2007) Identification and characterization of a novel and functional murine Pin1 isoform. Biochem. Biophys. Res. Commun. 359 529-35 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

MOUSE:PIN1

Contents

Annotations

Notes

References

b

c

e

g

i

m

n

o

p

r

s

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools