GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
MOUSE:PARD3
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Pard3 (synonyms: Par3) | |
| Protein Name(s) | Partitioning defective 3 homolog
PAR-3 PARD-3 Atypical PKC isotype-specific-interacting protein ASIP Ephrin-interacting protein PHIP | |
| External Links | ||
| UniProt | Q99NH2 | |
| EMBL | AY026057 AY856081 AY856082 AK037015 | |
| CCDS | CCDS22788.1 CCDS40523.1 | |
| RefSeq | NP_001013598.1 NP_001013599.1 | |
| UniGene | Mm.299254 | |
| PDB | 2KOH 2KOJ | |
| PDBsum | 2KOH 2KOJ | |
| ProteinModelPortal | Q99NH2 | |
| SMR | Q99NH2 | |
| BioGrid | 220283 | |
| DIP | DIP-41727N | |
| IntAct | Q99NH2 | |
| MINT | MINT-254636 | |
| STRING | 10090.ENSMUSP00000026921 | |
| PhosphoSite | Q99NH2 | |
| MaxQB | Q99NH2 | |
| PaxDb | Q99NH2 | |
| PRIDE | Q99NH2 | |
| Ensembl | ENSMUST00000079777 ENSMUST00000108752 ENSMUST00000160717 ENSMUST00000162456 | |
| GeneID | 93742 | |
| KEGG | mmu:93742 | |
| UCSC | uc009nzk.2 | |
| CTD | 56288 | |
| MGI | MGI:2135608 | |
| eggNOG | NOG268288 | |
| GeneTree | ENSGT00760000119017 | |
| HOGENOM | HOG000232109 | |
| HOVERGEN | HBG053508 | |
| InParanoid | Q99NH2 | |
| KO | K04237 | |
| Reactome | REACT_196549 REACT_236746 | |
| ChiTaRS | Pard3 | |
| EvolutionaryTrace | Q99NH2 | |
| NextBio | 351599 | |
| PRO | PR:Q99NH2 | |
| Proteomes | UP000000589 | |
| Bgee | Q99NH2 | |
| ExpressionAtlas | Q99NH2 | |
| Genevestigator | Q99NH2 | |
| GO | GO:0005912 GO:0045177 GO:0005938 GO:0030054 GO:0005913 GO:0005911 GO:0005737 GO:0012505 GO:0033269 GO:0043219 GO:0005886 GO:0043234 GO:0043220 GO:0005819 GO:0005923 GO:0005547 GO:0032266 GO:0005546 GO:0005080 GO:0003383 GO:0007049 GO:0051301 GO:0051642 GO:0090162 GO:0007163 GO:0000226 GO:0022011 GO:0010801 GO:0031643 GO:0006612 GO:0032970 GO:0016337 GO:0070830 GO:0044319 | |
| Gene3D | 2.30.42.10 | |
| InterPro | IPR021922 IPR001478 | |
| Pfam | PF12053 PF00595 | |
| SMART | SM00228 | |
| SUPFAM | SSF50156 | |
| PROSITE | PS50106 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0002092 |
positive regulation of receptor internalization |
ECO:0000315 |
P |
Figure 4: While Alexa dye-coupled VEGF-A and VEGF-C were readily taken up by cultured mouse control endothelial cells, knockdown of Pard3 or Dab2 significantly decreased the perinuclear accumulation of VEGF-A and VEGF-C (Fig. 4a–c). Surface biotinylation experiments further confirmed that VEGF-C-induced internalization of VEGFR3 and VEGFR2 was impaired in Dab2 knockdown or Pard3 knockdown cells (Fig. 4d,e). |
complete | |||||
|
involved_in |
GO:0002092 |
positive regulation of receptor internalization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0043220 |
Schmidt-Lanterman incisure |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0043219 |
lateral loop |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0090162 |
establishment of epithelial cell polarity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0070830 |
bicellular tight junction assembly |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0033269 |
internode region of axon |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0032266 |
phosphatidylinositol-3-phosphate binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0031643 |
positive regulation of myelination |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0022011 |
myelination in peripheral nervous system |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010801 |
negative regulation of peptidyl-threonine phosphorylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006612 |
protein targeting to membrane |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005923 |
bicellular tight junction |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005923 |
bicellular tight junction |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005911 |
cell-cell junction |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005547 |
phosphatidylinositol-3,4,5-trisphosphate binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005546 |
phosphatidylinositol-4,5-bisphosphate binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051660 |
establishment of centrosome localization |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001046835 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045197 |
establishment or maintenance of epithelial cell apical/basal polarity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0000163 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0043296 |
apical junction complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0000163 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0035091 |
phosphatidylinositol binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0000163 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030010 |
establishment of cell polarity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001046835 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0016324 |
apical plasma membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0000163 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0008104 |
protein localization |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001046835 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007155 |
cell adhesion |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001046835 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005938 |
cell cortex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2135608 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005913 |
cell-cell adherens junction |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2135608 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005912 |
adherens junction |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0000163 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2135608 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0000226 |
microtubule cytoskeleton organization |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2135608 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0098609 |
cell-cell adhesion |
ECO:0000305 |
curator inference used in manual assertion |
GO:0005913 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0090162 |
establishment of epithelial cell polarity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620374 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0070830 |
bicellular tight junction assembly |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620374 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0060341 |
regulation of cellular localization |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620374 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0051642 |
centrosome localization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0044319 |
wound healing, spreading of cells |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0044295 |
axonal growth cone |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620374 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0043296 |
apical junction complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0043025 |
neuronal cell body |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620374 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620374 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0032991 |
protein-containing complex |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620374 |
C |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0032970 |
regulation of actin filament-based process |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:107927 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0032266 |
phosphatidylinositol-3-phosphate binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620374 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0030054 |
cell junction |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030054 |
cell junction |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0019903 |
protein phosphatase binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620374 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0006612 |
protein targeting to membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620374 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005923 |
bicellular tight junction |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005913 |
cell-cell adherens junction |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005912 |
adherens junction |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005912 |
adherens junction |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005911 |
cell-cell junction |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(EMAPA:17525) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005911 |
cell-cell junction |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005911 |
cell-cell junction |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620374 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005819 |
spindle |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(CL:0000654) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(CL:0000654) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005547 |
phosphatidylinositol-3,4,5-trisphosphate binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620374 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005546 |
phosphatidylinositol-4,5-bisphosphate binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620374 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0003383 |
apical constriction |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:107927 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0000226 |
microtubule cytoskeleton organization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005938 |
cell cortex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(CL:0000655) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007163 |
establishment or maintenance of cell polarity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007049 |
cell cycle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005923 |
bicellular tight junction |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030054 |
cell junction |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030154 |
cell differentiation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008289 |
lipid binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005856 |
cytoskeleton |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051301 |
cell division |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0012505 |
endomembrane system |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005938 |
cell cortex |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005912 |
adherens junction |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Nakayama, M et al. (2013) Spatial regulation of VEGF receptor endocytosis in angiogenesis. Nat. Cell Biol. 15 249-60 PubMed GONUTS page
- ↑ 2.0 2.1 Ozçelik, M et al. (2010) Pals1 is a major regulator of the epithelial-like polarization and the extension of the myelin sheath in peripheral nerves. J. Neurosci. 30 4120-31 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Beirowski, B et al. (2011) Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling. Proc. Natl. Acad. Sci. U.S.A. 108 E952-61 PubMed GONUTS page
- ↑ 4.0 4.1 Johansson, A et al. (2000) The mammalian homologue of the Caenorhabditis elegans polarity protein PAR-6 is a binding partner for the Rho GTPases Cdc42 and Rac1. J. Cell. Sci. 113 ( Pt 18) 3267-75 PubMed GONUTS page
- ↑ 5.00 5.01 5.02 5.03 5.04 5.05 5.06 5.07 5.08 5.09 5.10 5.11 5.12 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 6.0 6.1 Takekuni, K et al. (2003) Direct binding of cell polarity protein PAR-3 to cell-cell adhesion molecule nectin at neuroepithelial cells of developing mouse. J. Biol. Chem. 278 5497-500 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 7.3 Schmoranzer, J et al. (2009) Par3 and dynein associate to regulate local microtubule dynamics and centrosome orientation during migration. Curr. Biol. 19 1065-74 PubMed GONUTS page
- ↑ Ishiuchi, T & Takeichi, M (2012) Nectins localize Willin to cell-cell junctions. Genes Cells 17 387-97 PubMed GONUTS page
- ↑ 9.0 9.1 Ishiuchi, T & Takeichi, M (2011) Willin and Par3 cooperatively regulate epithelial apical constriction through aPKC-mediated ROCK phosphorylation. Nat. Cell Biol. 13 860-6 PubMed GONUTS page
- ↑ Ikenouchi, J & Umeda, M (2010) FRMD4A regulates epithelial polarity by connecting Arf6 activation with the PAR complex. Proc. Natl. Acad. Sci. U.S.A. 107 748-53 PubMed GONUTS page
- ↑ Manabe, N et al. (2002) Association of ASIP/mPAR-3 with adherens junctions of mouse neuroepithelial cells. Dev. Dyn. 225 61-9 PubMed GONUTS page
- ↑ Tunggal, JA et al. (2005) E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions. EMBO J. 24 1146-56 PubMed GONUTS page
- ↑ 13.0 13.1 13.2 Duncan, FE et al. (2005) PAR-3 defines a central subdomain of the cortical actin cap in mouse eggs. Dev. Biol. 280 38-47 PubMed GONUTS page
a
c
- GO:0098609 ! cell-cell adhesion
- GO:0005913 ! cell-cell adherens junction
- GO:0005911 ! cell-cell junction
- GO:0007155 ! cell adhesion
- GO:0005938 ! cell cortex
- GO:0007049 ! cell cycle
- GO:0030154 ! cell differentiation
- GO:0051301 ! cell division
- GO:0030054 ! cell junction
- GO:0051642 ! centrosome localization
- Chordata
- Craniata
- GO:0005737 ! cytoplasm
- GO:0005856 ! cytoskeleton
e
- GO:0012505 ! endomembrane system
- GO:0090162 ! establishment of epithelial cell polarity
- GO:0007163 ! establishment or maintenance of cell polarity
- GO:0030010 ! establishment of cell polarity
- GO:0045197 ! establishment or maintenance of epithelial cell apical/basal polarity
- GO:0051660 ! establishment of centrosome localization
- Euarchontoglires
- Eukaryota
- Euteleostomi
- Eutheria
g
m
n
p
- GO:0035091 ! phosphatidylinositol binding
- GO:0032266 ! phosphatidylinositol-3-phosphate binding
- GO:0005547 ! phosphatidylinositol-3,4,5-trisphosphate binding
- GO:0005546 ! phosphatidylinositol-4,5-bisphosphate binding
- GO:0005886 ! plasma membrane
- GO:0031643 ! positive regulation of myelination
- GO:0002092 ! positive regulation of receptor internalization
- GO:0032991 ! protein-containing complex
- GO:0008104 ! protein localization
- GO:0019903 ! protein phosphatase binding
- GO:0006612 ! protein targeting to membrane
r
