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MOUSE:OXYR
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Oxtr | |
| Protein Name(s) | Oxytocin receptor
OT-R | |
| External Links | ||
| UniProt | P97926 | |
| EMBL | D86599 D86631 AC153594 | |
| CCDS | CCDS39588.1 | |
| RefSeq | NP_001074616.1 XP_006505786.1 XP_006505787.1 | |
| UniGene | Mm.333310 | |
| ProteinModelPortal | P97926 | |
| SMR | P97926 | |
| STRING | 10090.ENSMUSP00000051132 | |
| GuidetoPHARMACOLOGY | 369 | |
| PhosphoSite | P97926 | |
| PRIDE | P97926 | |
| Ensembl | ENSMUST00000053306 | |
| GeneID | 18430 | |
| KEGG | mmu:18430 | |
| CTD | 5021 | |
| MGI | MGI:109147 | |
| eggNOG | NOG299951 | |
| GeneTree | ENSGT00760000119156 | |
| HOGENOM | HOG000237331 | |
| HOVERGEN | HBG105710 | |
| InParanoid | P97926 | |
| KO | K04229 | |
| OMA | GPPRRNE | |
| OrthoDB | EOG7Z69CP | |
| TreeFam | TF106499 | |
| Reactome | REACT_207651 REACT_259014 | |
| NextBio | 294094 | |
| PRO | PR:P97926 | |
| Proteomes | UP000000589 | |
| CleanEx | MM_OXTR | |
| Genevestigator | P97926 | |
| GO | GO:0016324 GO:0005913 GO:0016021 GO:0005902 GO:0004990 GO:0017046 GO:0005000 GO:0048565 GO:0042755 GO:0070371 GO:0007565 GO:0007507 GO:0042711 GO:0060137 GO:0007613 GO:0060455 GO:0045777 GO:0007204 GO:0010701 GO:0060406 GO:0051965 GO:0032230 GO:0051968 GO:0070474 GO:0001975 GO:0034059 GO:0042220 GO:0034097 GO:0042493 GO:0032355 GO:0043434 GO:0032570 GO:0030431 GO:0035176 GO:0042713 GO:0001967 GO:0021537 | |
| InterPro | IPR000276 IPR017452 IPR002062 IPR001817 | |
| Pfam | PF00001 | |
| PRINTS | PR00237 PR00665 PR00896 | |
| PROSITE | PS00237 PS50262 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0120162 |
positive regulation of cold-induced thermogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045907 |
positive regulation of vasoconstriction |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000662574 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042711 |
maternal behavior |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000662660 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0035176 |
social behavior |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000662660 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032870 |
cellular response to hormone stimulus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001202348 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007565 |
female pregnancy |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000662660 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007186 |
G protein-coupled receptor signaling pathway |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0025595 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0038880 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005000 |
vasopressin receptor activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001202415 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004990 |
oxytocin receptor activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000662657 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001992 |
regulation of systemic arterial blood pressure by vasopressin |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1347010 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0070474 |
positive regulation of uterine smooth muscle contraction |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3239 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0070371 |
ERK1 and ERK2 cascade |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3239 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0060455 |
negative regulation of gastric acid secretion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3239 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0060406 |
positive regulation of penile erection |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3239 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0051968 |
positive regulation of synaptic transmission, glutamatergic |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3239 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0051965 |
positive regulation of synapse assembly |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3239 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0048545 |
response to steroid hormone |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3239 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0045777 |
positive regulation of blood pressure |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:94927 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0044058 |
regulation of digestive system process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3239 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0042755 |
eating behavior |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3239 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0042713 |
sperm ejaculation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3239 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0042711 |
maternal behavior |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3239 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0035176 |
social behavior |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3239 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0034059 |
response to anoxia |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3239 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0032230 |
positive regulation of synaptic transmission, GABAergic |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3239 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0030431 |
sleep |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3239 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0017046 |
peptide hormone binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3239 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0016324 |
apical plasma membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3239 |
C |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0010701 |
positive regulation of norepinephrine secretion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3239 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0007613 |
memory |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3239 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0007204 |
positive regulation of cytosolic calcium ion concentration |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3239 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0007186 |
G protein-coupled receptor signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3239 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005913 |
cell-cell adherens junction |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3239 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005902 |
microvillus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3239 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004990 |
oxytocin receptor activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3239 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0001975 |
response to amphetamine |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3239 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0001967 |
suckling behavior |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3239 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0070474 |
positive regulation of uterine smooth muscle contraction |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P70536 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0070371 |
ERK1 and ERK2 cascade |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P70536 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060455 |
negative regulation of gastric acid secretion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P70536 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060406 |
positive regulation of penile erection |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P70536 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060137 |
maternal process involved in parturition |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P70536 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051968 |
positive regulation of synaptic transmission, glutamatergic |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P70536 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051965 |
positive regulation of synapse assembly |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P70536 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0048565 |
digestive tract development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P70536 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0048545 |
response to steroid hormone |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P70536 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0044849 |
estrous cycle |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P70536 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0044058 |
regulation of digestive system process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P70536 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043434 |
response to peptide hormone |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P70536 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042755 |
eating behavior |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P70536 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042713 |
sperm ejaculation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P70536 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042711 |
maternal behavior |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P70536 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042493 |
response to drug |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P70536 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042220 |
response to cocaine |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P70536 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0035176 |
social behavior |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P70536 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0034097 |
response to cytokine |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P70536 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0034059 |
response to anoxia |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P70536 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032570 |
response to progesterone |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P70536 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032355 |
response to estradiol |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P70536 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032230 |
positive regulation of synaptic transmission, GABAergic |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P70536 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030431 |
sleep |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P70536 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0021537 |
telencephalon development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P70536 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0017046 |
peptide hormone binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P70536 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0016324 |
apical plasma membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P70536 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0014070 |
response to organic cyclic compound |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P70536 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010701 |
positive regulation of norepinephrine secretion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P70536 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007613 |
memory |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P70536 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007565 |
female pregnancy |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P70536 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007507 |
heart development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P70536 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007204 |
positive regulation of cytosolic calcium ion concentration |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P70536 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007186 |
G protein-coupled receptor signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P70536 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005913 |
cell-cell adherens junction |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P70536 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005902 |
microvillus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P70536 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004990 |
oxytocin receptor activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P70536 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001975 |
response to amphetamine |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P70536 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001967 |
suckling behavior |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P70536 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004930 |
G protein-coupled receptor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004990 |
oxytocin receptor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005000 |
vasopressin receptor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007186 |
G protein-coupled receptor signaling pathway |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR000276 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004930 |
G protein-coupled receptor activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007165 |
signal transduction |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007186 |
G protein-coupled receptor signaling pathway |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Kasahara, Y et al. (2013) Oxytocin receptor in the hypothalamus is sufficient to rescue normal thermoregulatory function in male oxytocin receptor knockout mice. Endocrinology 154 4305-15 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 2.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Hollon, TR et al. (2002) Mice lacking D5 dopamine receptors have increased sympathetic tone and are hypertensive. J. Neurosci. 22 10801-10 PubMed GONUTS page
c
e
g
m
p
- GO:0017046 ! peptide hormone binding
- GO:0005886 ! plasma membrane
- GO:0120162 ! positive regulation of cold-induced thermogenesis
- GO:0051968 ! positive regulation of synaptic transmission, glutamatergic
- GO:0032230 ! positive regulation of synaptic transmission, GABAergic
- GO:0051965 ! positive regulation of synapse assembly
- GO:0060406 ! positive regulation of penile erection
- GO:0070474 ! positive regulation of uterine smooth muscle contraction
- GO:0010701 ! positive regulation of norepinephrine secretion
- GO:0007204 ! positive regulation of cytosolic calcium ion concentration
- GO:0045907 ! positive regulation of vasoconstriction
- GO:0045777 ! positive regulation of blood pressure
r
- GO:0044058 ! regulation of digestive system process
- GO:0001992 ! regulation of systemic arterial blood pressure by vasopressin
- GO:0048545 ! response to steroid hormone
- GO:0001975 ! response to amphetamine
- GO:0034097 ! response to cytokine
- GO:0042220 ! response to cocaine
- GO:0034059 ! response to anoxia
- GO:0043434 ! response to peptide hormone
- GO:0042493 ! response to drug
- GO:0032355 ! response to estradiol
- GO:0032570 ! response to progesterone
- Rodentia
s
