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MOUSE:OTOF
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Otof (synonyms: Fer1l2) | |
| Protein Name(s) | Otoferlin
Fer-1-like protein 2 | |
| External Links | ||
| UniProt | Q9ESF1 | |
| EMBL | AF183183 AF183184 AY586513 BC150702 AK033317 | |
| CCDS | CCDS19157.1 CCDS51452.1 | |
| RefSeq | NP_001093865.1 NP_001273350.1 NP_114081.2 | |
| UniGene | Mm.244502 | |
| ProteinModelPortal | Q9ESF1 | |
| SMR | Q9ESF1 | |
| IntAct | Q9ESF1 | |
| STRING | 10090.ENSMUSP00000073803 | |
| PhosphoSite | Q9ESF1 | |
| PaxDb | Q9ESF1 | |
| PRIDE | Q9ESF1 | |
| Ensembl | ENSMUST00000114747 | |
| GeneID | 83762 | |
| KEGG | mmu:83762 | |
| UCSC | uc008wvl.1 uc012dud.1 | |
| CTD | 9381 | |
| MGI | MGI:1891247 | |
| eggNOG | COG5038 | |
| GeneTree | ENSGT00550000074414 | |
| HOGENOM | HOG000006770 | |
| HOVERGEN | HBG108221 | |
| InParanoid | Q9ESF1 | |
| OrthoDB | EOG7J9VNQ | |
| PhylomeDB | Q9ESF1 | |
| NextBio | 350750 | |
| PRO | PR:Q9ESF1 | |
| Proteomes | UP000000589 | |
| Bgee | Q9ESF1 | |
| CleanEx | MM_OTOF | |
| ExpressionAtlas | Q9ESF1 | |
| Genevestigator | Q9ESF1 | |
| GO | GO:0016323 GO:0030054 GO:0005789 GO:0016021 GO:0030672 GO:0035612 GO:0005509 GO:0007605 GO:0016079 | |
| Gene3D | 2.60.40.150 | |
| InterPro | IPR000008 IPR012968 IPR012561 IPR029996 | |
| PANTHER | PTHR12546:SF32 | |
| Pfam | PF00168 PF08150 PF08151 | |
| PRINTS | PR00360 | |
| SMART | SM00239 | |
| SUPFAM | SSF49562 | |
| PROSITE | PS50004 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0016082 |
synaptic vesicle priming |
ECO:0000315 |
P |
Figs 4&5. |
complete | |||||
|
involved_in |
GO:0016082 |
synaptic vesicle priming |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030672 |
synaptic vesicle membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016079 |
synaptic vesicle exocytosis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016079 |
synaptic vesicle exocytosis |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005509 |
calcium ion binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0048787 |
presynaptic active zone membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(CL:0000589) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0045178 |
basal part of cell |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620646 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0045177 |
apical part of cell |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620646 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0044877 |
protein-containing complex binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620646 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0035612 |
AP-2 adaptor complex binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0016079 |
synaptic vesicle exocytosis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:4950055 |
P |
occurs_in:(CL:0000589) |
Seeded From UniProt |
complete | |
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620646 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620646 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620646 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005509 |
calcium ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016079 |
synaptic vesicle exocytosis |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030054 |
cell junction |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007605 |
sensory perception of sound |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031410 |
cytoplasmic vesicle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0045202 |
synapse |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005789 |
endoplasmic reticulum membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030672 |
synaptic vesicle membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016323 |
basolateral plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Pangrsic, T et al. (2010) Hearing requires otoferlin-dependent efficient replenishment of synaptic vesicles in hair cells. Nat. Neurosci. 13 869-76 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Roux, I et al. (2006) Otoferlin, defective in a human deafness form, is essential for exocytosis at the auditory ribbon synapse. Cell 127 277-89 PubMed GONUTS page
- ↑ Beurg, M et al. (2008) Calcium- and otoferlin-dependent exocytosis by immature outer hair cells. J. Neurosci. 28 1798-803 PubMed GONUTS page
- ↑ 4.0 4.1 Vogl, C et al. (2015) Unconventional molecular regulation of synaptic vesicle replenishment in cochlear inner hair cells. J. Cell. Sci. 128 638-44 PubMed GONUTS page
- ↑ Duncker, SV et al. (2013) Otoferlin couples to clathrin-mediated endocytosis in mature cochlear inner hair cells. J. Neurosci. 33 9508-19 PubMed GONUTS page
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