MOUSE:NSUN2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Nsun2 (synonyms: D13Wsu123e, Misu)
Protein Name(s)	tRNA (cytosine(34)-C(5))-methyltransferase Myc-induced SUN domain-containing protein Misu NOL1/NOP2/Sun domain family member 2
External Links
UniProt	Q1HFZ0
EMBL	DQ490066 AK030124 AK075999 AK150631 AK151917 BC013625 BC025549
CCDS	CCDS36722.2
RefSeq	NP_663329.3
UniGene	Mm.260009
ProteinModelPortal	Q1HFZ0
SMR	Q1HFZ0
BioGrid	205771
PhosphoSite	Q1HFZ0
MaxQB	Q1HFZ0
PaxDb	Q1HFZ0
PRIDE	Q1HFZ0
Ensembl	ENSMUST00000022087 ENSMUST00000109699
GeneID	28114
KEGG	mmu:28114
UCSC	uc007rcm.2
CTD	54888
MGI	MGI:107252
eggNOG	COG0144
GeneTree	ENSGT00660000095589
HOGENOM	HOG000205147
HOVERGEN	HBG106711
InParanoid	Q1HFZ0
KO	K15335
OMA	EQAWHTN
OrthoDB	EOG72VH5D
PhylomeDB	Q1HFZ0
TreeFam	TF300702
ChiTaRS	Nsun2
NextBio	306674
PRO	PR:Q1HFZ0
Proteomes	UP000000589
Bgee	Q1HFZ0
CleanEx	MM_NSUN2
ExpressionAtlas	Q1HFZ0
Genevestigator	Q1HFZ0
GO	GO:0005737 GO:0005730 GO:0005819 GO:0044822 GO:0016428 GO:0000049 GO:0007067
Gene3D	3.40.50.150
InterPro	IPR001678 IPR023267 IPR023270 IPR029063
Pfam	PF01189
PRINTS	PR02008 PR02011
SUPFAM	SSF53335
PROSITE	PS51686

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0007286	spermatid development	PMID:23401851^[1]	ECO:0000315			P	Figures 1 C and D illustrate the lack of spermatids but the presence of spermatogonia and primary spermatocytes.	complete CACAO 7047
	GO:0033313	meiotic cell cycle checkpoint	PMID:23401851^[1]	ECO:0000315			P	Figure 2 shows the arrest of germ cells in the leptotene and zygotene stages in the mutant mice. This indicates that NSun2 is required for entry into the pachytene stage.	complete CACAO 7048
	GO:0033391	chromatoid body	PMID:23401851^[1]	ECO:0000314			C	Figure 5 A, B, D, and E.	complete CACAO 7049
involved_in	GO:0033313	meiotic cell cycle checkpoint	PMID:23401851^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0033391	chromatoid body	PMID:23401851^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0007286	spermatid development	PMID:23401851^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030488	tRNA methylation	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000516077 SGD:S000000120 UniProtKB:Q08J23	P	Seeded From UniProt	complete
enables	GO:0016428	tRNA (cytosine-5-)-methyltransferase activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000516077 SGD:S000000120 UniProtKB:Q08J23	F	Seeded From UniProt	complete
enables	GO:0008168	methyltransferase activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000516075 UniProtKB:Q96CB9	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000516077 UniProtKB:Q08J23	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0026079 PANTHER:PTN000516077 SGD:S000000120	C	Seeded From UniProt	complete
enables	GO:0000049	tRNA binding	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000516077 SGD:S000000120	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048820	hair follicle maturation	PMID:25340873^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4432654	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030488	tRNA methylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q08J23	P	Seeded From UniProt	complete
enables	GO:0016428	tRNA (cytosine-5-)-methyltransferase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q08J23	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q08J23	C	Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q08J23	C	Seeded From UniProt	complete
involved_in	GO:0030488	tRNA methylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q08J23 ensembl:ENSP00000264670	P	Seeded From UniProt	complete
enables	GO:0016428	tRNA (cytosine-5-)-methyltransferase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q08J23 ensembl:ENSP00000264670	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q08J23 ensembl:ENSP00000264670	C	Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q08J23 ensembl:ENSP00000264670	C	Seeded From UniProt	complete
enables	GO:0008168	methyltransferase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001678	F	Seeded From UniProt	complete
enables	GO:0016428	tRNA (cytosine-5-)-methyltransferase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR023270	F	Seeded From UniProt	complete
enables	GO:0000049	tRNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0820	F	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539	C	Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C	Seeded From UniProt	complete
enables	GO:0008168	methyltransferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0489	F	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0694	F	Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206	C	Seeded From UniProt	complete
involved_in	GO:0008033	tRNA processing	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0819	P	Seeded From UniProt	complete
involved_in	GO:0051301	cell division	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0132	P	Seeded From UniProt	complete
involved_in	GO:0032259	methylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0489	P	Seeded From UniProt	complete
part_of	GO:0005819	spindle	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0251	C	Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0188	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Hussain, S et al. (2013) The mouse cytosine-5 RNA methyltransferase NSun2 is a component of the chromatoid body and required for testis differentiation. Mol. Cell. Biol. 33 1561-70 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ DiTommaso, T et al. (2014) Identification of genes important for cutaneous function revealed by a large scale reverse genetic screen in the mouse. PLoS Genet. 10 e1004705 PubMed GONUTS page

[PMID:23401851-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Hussain, S et al. (2013) The mouse cytosine-5 RNA methyltransferase NSun2 is a component of the chromatoid body and required for testis differentiation. Mol. Cell. Biol. 33 1561-70 PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:25340873-3] DiTommaso, T et al. (2014) Identification of genes important for cutaneous function revealed by a large scale reverse genetic screen in the mouse. PLoS Genet. 10 e1004705 PubMed GONUTS page

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MOUSE:NSUN2

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