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MOUSE:NRAP

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Nrap (ECO:0000312 with MGI:MGI:1098765)
Protein Name(s) Nebulin-related-anchoring protein

N-RAP

External Links
UniProt Q80XB4
EMBL U76618
AY177622
AY177623
AC115771
AK138925
AK138975
CCDS CCDS29913.1
CCDS29914.1
PIR T37192
RefSeq NP_001273481.1
NP_032759.3
NP_932307.2
XP_006526811.1
UniGene Mm.386769
ProteinModelPortal Q80XB4
SMR Q80XB4
BioGrid 201842
IntAct Q80XB4
MINT MINT-4104875
STRING 10090.ENSMUSP00000073228
PhosphoSite Q80XB4
MaxQB Q80XB4
PaxDb Q80XB4
PRIDE Q80XB4
Ensembl ENSMUST00000040711
ENSMUST00000073536
ENSMUST00000095947
GeneID 18175
KEGG mmu:18175
UCSC uc008hyu.2
uc008hyv.2
uc012bnr.2
CTD 4892
MGI MGI:1098765
eggNOG NOG262357
GeneTree ENSGT00530000062924
HOGENOM HOG000049095
HOVERGEN HBG052905
InParanoid Q80XB4
OMA WMKGVGW
TreeFam TF313758
NextBio 293482
PRO PR:Q80XB4
Proteomes UP000000589
Bgee Q80XB4
CleanEx MM_NRAP
ExpressionAtlas Q80XB4
Genevestigator Q80XB4
GO GO:0005916
GO:0005927
GO:0030016
GO:0003779
GO:0051371
GO:0017166
GO:0008270
GO:0030036
Gene3D 2.10.110.10
InterPro IPR013998
IPR000900
IPR001781
Pfam PF00412
PF00880
PRINTS PR00510
SMART SM00132
SM00227
PROSITE PS00478
PS50023
PS51216

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0051371

muscle alpha-actinin binding

PMID:11732910[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0051371

muscle alpha-actinin binding

PMID:12692149[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0051371

muscle alpha-actinin binding

PMID:10320340[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0017166

vinculin binding

PMID:10320340[3]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P12003

F

Seeded From UniProt

complete

part_of

GO:0005927

muscle tendon junction

PMID:9295142[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005916

fascia adherens

PMID:9295142[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005916

fascia adherens

PMID:15765519[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005916

fascia adherens

PMID:11732910[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003779

actin binding

PMID:9295142[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003779

actin binding

PMID:10320340[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0071691

cardiac muscle thin filament assembly

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001665296
UniProtKB:O76041

P

Seeded From UniProt

complete

enables

GO:0051015

actin filament binding

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000113268
UniProtKB:O76041

F

Seeded From UniProt

complete

involved_in

GO:0048747

muscle fiber development

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001665296
ZFIN:ZDB-GENE-041111-216

P

Seeded From UniProt

complete

part_of

GO:0030018

Z disc

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97292
PANTHER:PTN001665296
UniProtKB:O76041
UniProtKB:P20929

C

Seeded From UniProt

complete

part_of

GO:0030016

myofibril

PMID:11732910[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003779

actin binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR013998

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030036

actin cytoskeleton organization

PMID:9295142[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

enables

GO:0003779

actin binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0009

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 Zhang, JQ et al. (2001) Ultrastructural and biochemical localization of N-RAP at the interface between myofibrils and intercalated disks in the mouse heart. Biochemistry 40 14898-906 PubMed GONUTS page
  2. Lu, S et al. (2003) New N-RAP-binding partners alpha-actinin, filamin and Krp1 detected by yeast two-hybrid screening: implications for myofibril assembly. J. Cell. Sci. 116 2169-78 PubMed GONUTS page
  3. 3.0 3.1 3.2 Luo, G et al. (1999) Molecular interactions of N-RAP, a nebulin-related protein of striated muscle myotendon junctions and intercalated disks. Biochemistry 38 6135-43 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 Luo, G et al. (1997) Complete cDNA sequence and tissue localization of N-RAP, a novel nebulin-related protein of striated muscle. Cell Motil. Cytoskeleton 38 75-90 PubMed GONUTS page
  5. Lu, S et al. (2005) N-RAP expression during mouse heart development. Dev. Dyn. 233 201-12 PubMed GONUTS page
  6. 6.0 6.1 6.2 6.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page