MOUSE:NOTC3

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Notch3
Protein Name(s)	Neurogenic locus notch homolog protein 3 Notch 3 Notch 3 extracellular truncation Notch 3 intracellular domain
External Links
UniProt	Q61982
EMBL	X74760
CCDS	CCDS28614.1
PIR	S45306
RefSeq	NP_032742.1
UniGene	Mm.439741
ProteinModelPortal	Q61982
SMR	Q61982
BioGrid	201811
IntAct	Q61982
MINT	MINT-1955915
PhosphoSite	Q61982
MaxQB	Q61982
PaxDb	Q61982
PRIDE	Q61982
Ensembl	ENSMUST00000087723
GeneID	18131
KEGG	mmu:18131
UCSC	uc008bvx.1
CTD	4854
MGI	MGI:99460
eggNOG	COG0666
GeneTree	ENSGT00760000118786
HOGENOM	HOG000234369
HOVERGEN	HBG052650
InParanoid	Q61982
KO	K02599
OMA	ADHFADG
OrthoDB	EOG7992RD
PhylomeDB	Q61982
TreeFam	TF351641
Reactome	REACT_196492 REACT_196517 REACT_199413 REACT_223683
NextBio	293368
PRO	PR:Q61982
Proteomes	UP000000589
Bgee	Q61982
CleanEx	MM_NOTCH3
Genevestigator	Q61982
GO	GO:0015629 GO:0005737 GO:0005887 GO:0005634 GO:0005886 GO:0043235 GO:0005509 GO:0019899 GO:0030900 GO:0072104 GO:0045596 GO:0045665 GO:0048663 GO:0007219 GO:0048661 GO:0006355 GO:0006351
Gene3D	1.25.40.20
InterPro	IPR002110 IPR020683 IPR024600 IPR000742 IPR001881 IPR013032 IPR000152 IPR018097 IPR009030 IPR008297 IPR022331 IPR000800 IPR010660 IPR011656
PANTHER	PTHR24033:SF47
Pfam	PF00023 PF11936 PF00008 PF07645 PF12661 PF06816 PF07684 PF00066
PIRSF	PIRSF002279
PRINTS	PR01452 PR01986
SMART	SM00248 SM00181 SM00179 SM00004
SUPFAM	SSF48403 SSF57184 SSF90193
PROSITE	PS50297 PS50088 PS00010 PS00022 PS01186 PS50026 PS01187 PS50258

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0005886	plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UM47	C		Seeded From UniProt	complete
enables	GO:0038023	signaling receptor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UM47	F		Seeded From UniProt	complete
involved_in	GO:0072104	glomerular capillary formation	PMID:15821257^[1]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048661	positive regulation of smooth muscle cell proliferation	PMID:19855400^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:17573339^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9NWT6	F		Seeded From UniProt	complete
involved_in	GO:0007219	Notch signaling pathway	PMID:19855400^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007219	Notch signaling pathway	PMID:10551863^[4]	ECO:0000305	curator inference used in manual assertion	GO:0005515	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:10551863^[4]	ECO:0000305	curator inference used in manual assertion	GO:0005515	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048844	artery morphogenesis	PMID:23117660^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2687010	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048663	neuron fate commitment	PMID:16120638^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97363	P	has_participant:(EMAPA:17547) results_in_commitment_to:(CL:0000117)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:23117660^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2687010	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045665	negative regulation of neuron differentiation	PMID:15064243^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(EMAPA:16728) regulates_o_results_in_acquisition_of_features_of:(CL:0000540)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045596	negative regulation of cell differentiation	PMID:15064243^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(EMAPA:16728) regulates_o_results_in_acquisition_of_features_of:(CL:0000031)	Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	PMID:23382219^[8]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UM47	C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UM47	F		Seeded From UniProt	complete
enables	GO:0038023	signaling receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UM47	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030900	forebrain development	PMID:16120638^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97363	P	results_in_development_of:(EMAPA:17549)	Seeded From UniProt	complete
part_of	GO:0015629	actin cytoskeleton	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UM47	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007219	Notch signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620761	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620761	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:17079689^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:35315)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UM47	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UM47	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UM47	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:23117660^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2687010	P		Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UM47 ensembl:ENSP00000263388	C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UM47 ensembl:ENSP00000263388	F		Seeded From UniProt	complete
enables	GO:0038023	signaling receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UM47 ensembl:ENSP00000263388	F		Seeded From UniProt	complete
part_of	GO:0015629	actin cytoskeleton	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UM47 ensembl:ENSP00000263388	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UM47 ensembl:ENSP00000263388	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UM47 ensembl:ENSP00000263388	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UM47 ensembl:ENSP00000263388	C		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001881 InterPro:IPR018097	F		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR022331	P		Seeded From UniProt	complete
involved_in	GO:0007219	Notch signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008297 InterPro:IPR011656 InterPro:IPR022331	P		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011656	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008297 InterPro:IPR010660 InterPro:IPR011656	C		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008297 InterPro:IPR010660 InterPro:IPR011656	P		Seeded From UniProt	complete
enables	GO:0038023	signaling receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR022331	F		Seeded From UniProt	complete
involved_in	GO:0050793	regulation of developmental process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008297	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21191019^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-MMU-9013059 Reactome:R-MMU-9012893 Reactome:R-MMU-9012873	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-MMU-9017868	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-NUL-9013660 Reactome:R-NUL-9013647 Reactome:R-MMU-9017420 Reactome:R-MMU-9016915	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0007219	Notch signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0914	P		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Chen, L & Al-Awqati, Q (2005) Segmental expression of Notch and Hairy genes in nephrogenesis. Am. J. Physiol. Renal Physiol. 288 F939-52 PubMed GONUTS page
↑ ^2.0 ^2.1 Li, X et al. (2009) Notch3 signaling promotes the development of pulmonary arterial hypertension. Nat. Med. 15 1289-97 PubMed GONUTS page
↑ Coleman, ML et al. (2007) Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor. J. Biol. Chem. 282 24027-38 PubMed GONUTS page
↑ ^4.0 ^4.1 Shimizu, K et al. (1999) Mouse jagged1 physically interacts with notch2 and other notch receptors. Assessment by quantitative methods. J. Biol. Chem. 274 32961-9 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Fouillade, C et al. (2013) Transcriptome analysis for Notch3 target genes identifies Grip2 as a novel regulator of myogenic response in the cerebrovasculature. Arterioscler. Thromb. Vasc. Biol. 33 76-86 PubMed GONUTS page
↑ ^6.0 ^6.1 Mason, HA et al. (2005) Notch signaling coordinates the patterning of striatal compartments. Development 132 4247-58 PubMed GONUTS page
↑ ^7.0 ^7.1 Kong, Y et al. (2004) Functional diversity of notch family genes in fetal lung development. Am. J. Physiol. Lung Cell Mol. Physiol. 286 L1075-83 PubMed GONUTS page
↑ Ghai, R et al. (2013) Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Proc. Natl. Acad. Sci. U.S.A. 110 E643-52 PubMed GONUTS page
↑ Blanpain, C et al. (2006) Canonical notch signaling functions as a commitment switch in the epidermal lineage. Genes Dev. 20 3022-35 PubMed GONUTS page
↑ Workman, A et al. (2011) A protein (ORF2) encoded by the latency-related gene of bovine herpesvirus 1 interacts with Notch1 and Notch3. J. Virol. 85 2536-46 PubMed GONUTS page

[PMID:15821257-1] Chen, L & Al-Awqati, Q (2005) Segmental expression of Notch and Hairy genes in nephrogenesis. Am. J. Physiol. Renal Physiol. 288 F939-52 PubMed GONUTS page

[PMID:19855400-2] 2.0 ^2.1 Li, X et al. (2009) Notch3 signaling promotes the development of pulmonary arterial hypertension. Nat. Med. 15 1289-97 PubMed GONUTS page

[PMID:17573339-3] Coleman, ML et al. (2007) Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor. J. Biol. Chem. 282 24027-38 PubMed GONUTS page

[PMID:10551863-4] 4.0 ^4.1 Shimizu, K et al. (1999) Mouse jagged1 physically interacts with notch2 and other notch receptors. Assessment by quantitative methods. J. Biol. Chem. 274 32961-9 PubMed GONUTS page

[PMID:23117660-5] 5.0 ^5.1 ^5.2 Fouillade, C et al. (2013) Transcriptome analysis for Notch3 target genes identifies Grip2 as a novel regulator of myogenic response in the cerebrovasculature. Arterioscler. Thromb. Vasc. Biol. 33 76-86 PubMed GONUTS page

[PMID:16120638-6] 6.0 ^6.1 Mason, HA et al. (2005) Notch signaling coordinates the patterning of striatal compartments. Development 132 4247-58 PubMed GONUTS page

[PMID:15064243-7] 7.0 ^7.1 Kong, Y et al. (2004) Functional diversity of notch family genes in fetal lung development. Am. J. Physiol. Lung Cell Mol. Physiol. 286 L1075-83 PubMed GONUTS page

[PMID:23382219-8] Ghai, R et al. (2013) Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Proc. Natl. Acad. Sci. U.S.A. 110 E643-52 PubMed GONUTS page

[PMID:17079689-9] Blanpain, C et al. (2006) Canonical notch signaling functions as a commitment switch in the epidermal lineage. Genes Dev. 20 3022-35 PubMed GONUTS page

[PMID:21191019-10] Workman, A et al. (2011) A protein (ORF2) encoded by the latency-related gene of bovine herpesvirus 1 interacts with Notch1 and Notch3. J. Virol. 85 2536-46 PubMed GONUTS page

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MOUSE:NOTC3

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