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MOUSE:NLRC3
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Nlrc3 | |
| Protein Name(s) | Protein NLRC3 | |
| External Links | ||
| UniProt | Q5DU56 | |
| EMBL | AK220314 AK079766 AK084199 AK171971 BC130223 | |
| CCDS | CCDS70677.1 | |
| RefSeq | NP_780756.1 | |
| UniGene | Mm.215994 | |
| ProteinModelPortal | Q5DU56 | |
| SMR | Q5DU56 | |
| PhosphoSite | Q5DU56 | |
| MaxQB | Q5DU56 | |
| PRIDE | Q5DU56 | |
| Ensembl | ENSMUST00000180200 | |
| GeneID | 268857 | |
| KEGG | mmu:268857 | |
| UCSC | uc007xzd.1 uc007xze.1 | |
| CTD | 197358 | |
| MGI | MGI:2444070 | |
| eggNOG | NOG69209 | |
| GeneTree | ENSGT00770000120460 | |
| HOGENOM | HOG000108875 | |
| HOVERGEN | HBG055285 | |
| InParanoid | Q5DU56 | |
| PhylomeDB | Q5DU56 | |
| PRO | PR:Q5DU56 | |
| Proteomes | UP000000589 | |
| CleanEx | MM_NLRC3 | |
| ExpressionAtlas | Q5DU56 | |
| Genevestigator | Q5DU56 | |
| GO | GO:0005737 GO:0005524 GO:0007249 GO:0043124 GO:0032088 GO:0031396 GO:0032496 GO:0042110 | |
| InterPro | IPR007111 IPR027417 | |
| SUPFAM | SSF52540 | |
| PROSITE | PS50837 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0032720 |
negative regulation of tumor necrosis factor production |
ECO:0000315 |
P |
With knockout mice, Figure 4c graph 1 shows that with stimulation of the TLR on the cell that there is an increased production of the TNF when compared to the WT. |
complete | |||||
| GO:0032715 |
negative regulation of interleukin-6 production |
ECO:0000315 |
P |
Figure 4c graph 2. In knockout mice of the NLCR3 protein then in response to stimulation of TLR then there is an increased amount of IL-6 made when compared to the WT cell. |
complete | |||||
| GO:0032695 |
negative regulation of interleukin-12 production |
ECO:0000315 |
P |
Figure 4c graph 4. With knockout mice of NLRC3 protein when TLR was stimulated there was an increased production of IL-12 when compared to the WT thus indicating that NLRC3 negatively regulates the IL-12 production. |
complete | |||||
| GO:0032691 |
negative regulation of interleukin-1 beta production |
ECO:0000315 |
P |
With knockdown of protein NLRC3 in mice, figure 4c graph 3 indicates that these mice upon TLR stimulation resulted in increased production of IL-1 beta when compared to the WT mice TLR response. This indicates that NLRC3 negatively regulates the production if IL-1 beta. |
complete | |||||
|
part_of |
GO:0048471 |
perinuclear region of cytoplasm |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045824 |
negative regulation of innate immune response |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050728 |
negative regulation of inflammatory response |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1900016 |
negative regulation of cytokine production involved in inflammatory response |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032687 |
negative regulation of interferon-alpha production |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032688 |
negative regulation of interferon-beta production |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032715 |
negative regulation of interleukin-6 production |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0036312 |
phosphatidylinositol 3-kinase regulatory subunit binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0014067 |
negative regulation of phosphatidylinositol 3-kinase signaling |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0048147 |
negative regulation of fibroblast proliferation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050680 |
negative regulation of epithelial cell proliferation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1901223 |
negative regulation of NIK/NF-kappaB signaling |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1900226 |
negative regulation of NLRP3 inflammasome complex assembly |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050728 |
negative regulation of inflammatory response |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032691 |
negative regulation of interleukin-1 beta production |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032695 |
negative regulation of interleukin-12 production |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032715 |
negative regulation of interleukin-6 production |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032720 |
negative regulation of tumor necrosis factor production |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042110 |
T cell activation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032088 |
negative regulation of NF-kappaB transcription factor activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007249 |
I-kappaB kinase/NF-kappaB signaling |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003674 |
molecular_function |
ECO:0000307 |
no biological data found used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043124 |
negative regulation of I-kappaB kinase/NF-kappaB signaling |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2444070 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0035556 |
intracellular signal transduction |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000716087 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001946600 |
C |
Seeded From UniProt |
complete | ||
|
colocalizes_with |
GO:0005737 |
cytoplasm |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000716087 |
C |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:1901223 |
negative regulation of NIK/NF-kappaB signaling |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:1900226 |
negative regulation of NLRP3 inflammasome complex assembly |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0050728 |
negative regulation of inflammatory response |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0048471 |
perinuclear region of cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0043124 |
negative regulation of I-kappaB kinase/NF-kappaB signaling |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:108072 |
P |
regulates_o_occurs_in:(CL:0000235) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0043124 |
negative regulation of I-kappaB kinase/NF-kappaB signaling |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
regulates_o_occurs_in:(CL:0000576) |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0043124 |
negative regulation of I-kappaB kinase/NF-kappaB signaling |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0032720 |
negative regulation of tumor necrosis factor production |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0032715 |
negative regulation of interleukin-6 production |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0032496 |
response to lipopolysaccharide |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:5439971 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0032088 |
negative regulation of NF-kappaB transcription factor activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0031396 |
regulation of protein ubiquitination |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:5439971 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0031396 |
regulation of protein ubiquitination |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0007249 |
I-kappaB kinase/NF-kappaB signaling |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005815 |
microtubule organizing center |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 Schneider, M et al. (2012) The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κB. Nat. Immunol. 13 823-31 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Zhang, L et al. (2014) NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STING. Immunity 40 329-41 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Karki, R et al. (2016) NLRC3 is an inhibitory sensor of PI3K-mTOR pathways in cancer. Nature PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Conti, BJ et al. (2005) CATERPILLER 16.2 (CLR16.2), a novel NBD/LRR family member that negatively regulates T cell function. J. Biol. Chem. 280 18375-85 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
c
g
m
n
- GO:0043124 ! negative regulation of canonical NF-kappaB signal transduction
- GO:0032088 ! negative regulation of NF-kappaB transcription factor activity
- GO:0032695 ! negative regulation of interleukin-12 production
- GO:0032691 ! negative regulation of interleukin-1 beta production
- GO:0045824 ! negative regulation of innate immune response
- GO:0050728 ! negative regulation of inflammatory response
- GO:1900016 ! negative regulation of cytokine production involved in inflammatory response
- GO:0032687 ! negative regulation of interferon-alpha production
- GO:0032688 ! negative regulation of interferon-beta production
- GO:0032720 ! negative regulation of tumor necrosis factor production
- GO:0048147 ! negative regulation of fibroblast proliferation
- GO:0050680 ! negative regulation of epithelial cell proliferation
- GO:1901223 ! negative regulation of non-canonical NF-kappaB signal transduction
- GO:1900226 ! negative regulation of NLRP3 inflammasome complex assembly
- GO:0032715 ! negative regulation of interleukin-6 production
- GO:0000166 ! nucleotide binding
p
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