MOUSE:NLGN3

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Nlgn3
Protein Name(s)	Neuroligin-3 Gliotactin homolog
External Links
UniProt	Q8BYM5
EMBL	AK039018 AK044438 AL683892
CCDS	CCDS30313.1
RefSeq	NP_766520.2
UniGene	Mm.121508
ProteinModelPortal	Q8BYM5
SMR	Q8BYM5
IntAct	Q8BYM5
MINT	MINT-4103912
MEROPS	S09.987
PhosphoSite	Q8BYM5
MaxQB	Q8BYM5
PaxDb	Q8BYM5
PRIDE	Q8BYM5
Ensembl	ENSMUST00000065858
GeneID	245537
KEGG	mmu:245537
UCSC	uc009txj.3
CTD	54413
MGI	MGI:2444609
eggNOG	COG2272
GeneTree	ENSGT00760000118946
HOGENOM	HOG000231424
HOVERGEN	HBG008839
InParanoid	Q8BYM5
KO	K07378
TreeFam	TF326187
NextBio	386794
PRO	PR:Q8BYM5
Proteomes	UP000000589
Bgee	Q8BYM5
CleanEx	MM_NLGN3
ExpressionAtlas	Q8BYM5
Genevestigator	Q8BYM5
GO	GO:0030054 GO:0009986 GO:0030139 GO:0060076 GO:0005887 GO:0045202 GO:0050839 GO:0042043 GO:0004872 GO:0030534 GO:0048675 GO:0007158 GO:0048709 GO:2000969 GO:2000463 GO:0051965 GO:0051968 GO:0097104 GO:0097105 GO:0006898 GO:2000311 GO:0061001 GO:0060079 GO:0060080 GO:1900271 GO:2000310 GO:0002087 GO:0050804 GO:0051966 GO:2000331 GO:0060024 GO:0035176 GO:0007416 GO:0050808 GO:0008542 GO:0071625
Gene3D	3.40.50.1820
InterPro	IPR029058 IPR002018 IPR019819 IPR000460 IPR030024
PANTHER	PTHR11559:SF145
Pfam	PF00135
PRINTS	PR01090
SUPFAM	SSF53474
PROSITE	PS00941

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0051965	positive regulation of synapse assembly	PMID:21642956^[1]	ECO:0000315			P		Figure 1F shows over expressed Nlgn3 in wild type mice increase synapse density compared to mutant R704C mutant Nlgn3 in transfected Cos cells in artificial synapse formation assays (figure 1C and D) and transfected neurons (Figure1E and F). In both assays wild type showed more number of synapse than mutant Nlgn3.	complete CACAO 2142
	GO:0010629	negative regulation of gene expression	PMID:21642956^[1]	ECO:0000315			P		Figure 2B and 2C: Nlgn3 mutation mice showed increase on AMPA types glutamate receptor subunits. To further examine changes in glutamate receptor levels immunoblotting was used to study major glutamate receptor subtypes (figure 2D to E) showed increase in GluR1 and GluR3 therefore there was increase in AMPA-type glutamate receptors levels compared to wild type mice.	complete CACAO 2143
	GO:2000463	positive regulation of excitatory postsynaptic membrane potential	PMID:21642956^[1]	ECO:0000315			P		Whole cell voltage-clamp recording in hippocampal CA1 pyramidal neurons mutated Nlgn3 showed decreased frequency of mEPSCs but had no effect on mIPSC (seen in figure 4A-F). Figure 5A, B showed frequency EPSC was measured and showed decrease in excitatory synaptic strength in input-output experiments of mutated Nlgn3 compared to wild type. This was also conformed by measuring the slope of the input-output experiment figure 5C.	complete CACAO 2144
	GO:0035176	social behavior	PMID:21808020^[2]	ECO:0000315			P		Figure 1A, wild type mice significantly spent more time with novel stranger than familiar social object compared to mutant Nlgn3 mice. Similar result seen is figure 1B and C	complete CACAO 3077
	GO:0035640	exploration behavior	PMID:21808020^[2]	ECO:0000315			P		Figure 1B showed the mutant Nlgn3 mice explored unfamiliar caged mouse less then wild type.	complete CACAO 3078
	GO:0051967	negative regulation of synaptic transmission, glutamatergic	PMID:21808020^[2]	ECO:0000315			P		Figure 2A-C showed that mutant Nlgn3 mice had large increase in excitatory mediated by AMPA receptor synaptic transmission compared to wild typed. Similar result seen in figure 3B there was an increase NMDA/AMPA ratio in mutant mice.	complete CACAO 3079
	GO:0090394	negative regulation of excitatory postsynaptic membrane potential	PMID:21808020^[2]	ECO:0000315			P		Figure 2A-C showed that mutant had large increase in excitatory mediated by AMPA receptor synaptic transmission compared to wild typed. Figure S2 showing increase in mEPSC in mutant Nlgn3 mice in the hippocampus cortex compared to wild type. This is just a suggestion: Might be helpful to add type of tissue (hippocampal neurons) column 16 in the protein 2GO database.	complete CACAO 3080
	GO:2000311	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	PMID:21808020^[2]	ECO:0000315			P		Figure 2A-C showed that mutant had large increase in excitatory mediated by AMPA receptor synaptic transmission compared to wild typed.	complete CACAO 3081
	GO:2000310	regulation of N-methyl-D-aspartate selective glutamate receptor activity	PMID:21808020^[2]	ECO:0000315			P		Figure 3B shows increase in NMDA/AMPA ratio indicating that there was a greater increase in NMDA than AMPA in mutant Nlgn3 mice compared to wild type. Mutant mice showed increase NMDA receptor response compared to control figure 4B.	complete CACAO 3082
	GO:0060080	regulation of inhibitory postsynaptic membrane potential	PMID:21808020^[2]	ECO:0000315			P		Figure S2 showing increase in mIPSC in mutant nlgn3 mice in the somatosensory cortex compared to wild type. This is just a suggestion: Might be helpful to add type of tissue (somatosensory neurons) column 16 in the protein 2GO database.	complete CACAO 3083
	GO:0060291	long-term synaptic potentiation	PMID:21808020^[2]	ECO:0000315			P		Figure 3C, investigated LTP using extracellular field recording. Mutant Nlgn3 showed enhanced LTP (figure 3D) compared to control. There was a 70% increase in Nlgn3 mutant mice compared to control, figure 3E.	complete CACAO 3084
	GO:0061002	negative regulation of dendritic spine morphogenesis	PMID:21808020^[2]	ECO:0000315			P		Figure 5A, B showed that mutant Nlgn3 has greater number of dendritic branch points of pyramidal neurons in stratum radiatum.	complete CACAO 3085
	GO:2000331	regulation of terminal button organization	PMID:21808020^[2]	ECO:0000315			P		Figure 5G shows decrease in bouton area in mutant Nlgn3 mice compared to wild type.	complete CACAO 3086
	GO:2000809	positive regulation of synaptic vesicle clustering	PMID:21808020^[2]	ECO:0000315			P		Figure 5H showed decrease in number of synaptic vesicles per bouton in mutant Nlgn3 mice compared to wild type.	complete CACAO 3087
	GO:0051968	positive regulation of synaptic transmission, glutamatergic	PMID:21642956^[1]	ECO:0000315			P		Figure 7A and 7B shows that mutant Nlgn3 increase ratio NMDA/AMPA receptors mediated response due to decrease in AMPA receptor mediated synaptic transmission. Similar result seen in figure 9A-C.	complete CACAO 3108
	GO:2000969	positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	PMID:21642956^[1]	ECO:0000315			P		Whole cell voltage-clamp recording in hippocampal CA1 pyramidal neurons mutated Nlgn3 showed decreased frequency of mEPSCs but had no effect on mIPSC (seen in figure 4A-F). Figure 5A, B showed frequency EPSC was measured and showed decrease in excitatory synaptic strength in input-output experiments of mutated Nlgn3 compared to wild type. This was also conformed by measuring the slope of the input-output experiment figure 5C. Mouse Brain slices, Figure 7A: looked at relative ratio of NMDA and AMPA synaptic response using whole cell recording. There was a reduction in AMPA but not NMDA receptor meditated synaptic transmission. Also NMDA/AMPA ratio increased in Nlgn3 mutant mice compared to control, figure 7B. Figure 9 A-C culture hippocampal neurons showed decrease AMPA receptor mediated response in Nlgn3 mutant mice but having no effect on NMDA receptor mediated response. Therefore mutation reduced postsynaptic AMPA receptor function in cultured neurons.	complete CACAO 3109
involved_in	GO:2000809	positive regulation of synaptic vesicle clustering	PMID:21808020^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000331	regulation of terminal button organization	PMID:21808020^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061002	negative regulation of dendritic spine morphogenesis	PMID:21808020^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060291	long-term synaptic potentiation	PMID:21808020^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060080	inhibitory postsynaptic potential	PMID:21808020^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000969	positive regulation of AMPA receptor activity	PMID:21642956^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051968	positive regulation of synaptic transmission, glutamatergic	PMID:21642956^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000310	regulation of NMDA receptor activity	PMID:21808020^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000311	regulation of AMPA receptor activity	PMID:21808020^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090394	negative regulation of excitatory postsynaptic potential	PMID:21808020^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035176	social behavior	PMID:21808020^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000463	positive regulation of excitatory postsynaptic potential	PMID:21642956^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051965	positive regulation of synapse assembly	PMID:21642956^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000969	positive regulation of AMPA receptor activity	PMID:21642956^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000463	positive regulation of excitatory postsynaptic potential	PMID:21642956^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000331	regulation of terminal button organization	PMID:21808020^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0003881)\|occurs_in:(CL:0002608)	Seeded From UniProt	complete
involved_in	GO:2000311	regulation of AMPA receptor activity	PMID:21808020^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0003881)	Seeded From UniProt	complete
involved_in	GO:2000310	regulation of NMDA receptor activity	PMID:21808020^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0003881)	Seeded From UniProt	complete
involved_in	GO:1900271	regulation of long-term synaptic potentiation	PMID:21808020^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0003881)	Seeded From UniProt	complete
involved_in	GO:0097105	presynaptic membrane assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62889	P		Seeded From UniProt	complete
involved_in	GO:0097104	postsynaptic membrane assembly	PMID:21642956^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061001	regulation of dendritic spine morphogenesis	PMID:21808020^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002608)\|occurs_in:(UBERON:0003881)	Seeded From UniProt	complete
involved_in	GO:0060080	inhibitory postsynaptic potential	PMID:21808020^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0008930)	Seeded From UniProt	complete
involved_in	GO:0060079	excitatory postsynaptic potential	PMID:21808020^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0003881)	Seeded From UniProt	complete
part_of	GO:0060076	excitatory synapse	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62889	C		Seeded From UniProt	complete
part_of	GO:0060076	excitatory synapse	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9NZ94	C		Seeded From UniProt	complete
involved_in	GO:0060024	rhythmic synaptic transmission	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62889	P		Seeded From UniProt	complete
involved_in	GO:0051968	positive regulation of synaptic transmission, glutamatergic	PMID:21642956^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051966	regulation of synaptic transmission, glutamatergic	PMID:21808020^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0003881)	Seeded From UniProt	complete
involved_in	GO:0051965	positive regulation of synapse assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62889	P		Seeded From UniProt	complete
enables	GO:0050839	cell adhesion molecule binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62889	F		Seeded From UniProt	complete
involved_in	GO:0048675	axon extension	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62889	P		Seeded From UniProt	complete
enables	GO:0042043	neurexin family protein binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62889	F		Seeded From UniProt	complete
involved_in	GO:0035176	social behavior	PMID:21808020^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030139	endocytic vesicle	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62889	C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62889	C		Seeded From UniProt	complete
involved_in	GO:0007158	neuron cell-cell adhesion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62889	P		Seeded From UniProt	complete
involved_in	GO:0006898	receptor-mediated endocytosis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62889	P		Seeded From UniProt	complete
part_of	GO:0099055	integral component of postsynaptic membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62889	C		Seeded From UniProt	complete
involved_in	GO:0097105	presynaptic membrane assembly	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2179435 MGI:MGI:2681835 PANTHER:PTN000168538 RGD:621117 RGD:621118 RGD:621119 UniProtKB:Q8N0W4	P		Seeded From UniProt	complete
involved_in	GO:0097104	postsynaptic membrane assembly	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2179435 MGI:MGI:2444609 MGI:MGI:2681835 PANTHER:PTN000168538	P		Seeded From UniProt	complete
involved_in	GO:0050804	modulation of chemical synaptic transmission	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2179435 MGI:MGI:2444609 MGI:MGI:2681835 PANTHER:PTN000168538 RGD:621117	P		Seeded From UniProt	complete
involved_in	GO:0048488	synaptic vesicle endocytosis	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0083963 PANTHER:PTN000168538	P		Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2179435 MGI:MGI:2681835 MGI:MGI:3775191 PANTHER:PTN000168538 RGD:621117 RGD:621119 WB:WBGene00006412	C		Seeded From UniProt	complete
enables	GO:0042043	neurexin family protein binding	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0031866 MGI:MGI:2179435 MGI:MGI:2681835 PANTHER:PTN000168538 RGD:621117 RGD:621119 UniProtKB:Q8N0W4	F		Seeded From UniProt	complete
enables	GO:0038023	signaling receptor activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000168538 RGD:621117 RGD:621119	F		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2179435 PANTHER:PTN000168538 RGD:621117 RGD:621118 RGD:621119 UniProtKB:Q8N0W4 UniProtKB:Q9NZ94	C		Seeded From UniProt	complete
involved_in	GO:0007158	neuron cell-cell adhesion	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2179435 PANTHER:PTN000168538 RGD:621117 RGD:621118 RGD:621119	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2179435 PANTHER:PTN000168538 UniProtKB:Q8N0W4	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902474	positive regulation of protein localization to synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621119	P		Seeded From UniProt	complete
part_of	GO:0099060	integral component of postsynaptic specialization membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621119	C		Seeded From UniProt	complete
part_of	GO:0099055	integral component of postsynaptic membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621119	C		Seeded From UniProt	complete
part_of	GO:0098982	GABA-ergic synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621119	C		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621119	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0098698	postsynaptic specialization assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621119	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097151	positive regulation of inhibitory postsynaptic potential	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621119	P		Seeded From UniProt	complete
enables	GO:0097110	scaffold protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NZ94	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097105	presynaptic membrane assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621119	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071625	vocalization behavior	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NZ94	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060999	positive regulation of dendritic spine development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621119	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060080	inhibitory postsynaptic potential	PMID:17823315^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3758949	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060080	inhibitory postsynaptic potential	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621119	P		Seeded From UniProt	complete
part_of	GO:0060077	inhibitory synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621119	C		Seeded From UniProt	complete
colocalizes_with	GO:0060077	inhibitory synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621119	C		Seeded From UniProt	complete
part_of	GO:0060076	excitatory synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NZ94	C		Seeded From UniProt	complete
part_of	GO:0060076	excitatory synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621119	C		Seeded From UniProt	complete
colocalizes_with	GO:0060076	excitatory synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621119	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060024	rhythmic synaptic transmission	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621119	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051965	positive regulation of synapse assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621119	P		Seeded From UniProt	complete
enables	GO:0050839	cell adhesion molecule binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621119	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050808	synapse organization	PMID:21788371^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2179435 MGI:MGI:2389173 MGI:MGI:2389174	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050808	synapse organization	PMID:15681343^[6]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q62889	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050808	synapse organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NZ94	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050804	modulation of chemical synaptic transmission	PMID:16982420^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2179435 MGI:MGI:2681835	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048709	oligodendrocyte differentiation	PMID:19139271^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048675	axon extension	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621119	P		Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:15681343^[6]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q62889	C		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621119	C		Seeded From UniProt	complete
enables	GO:0042043	neurexin family protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621119	F		Seeded From UniProt	complete
enables	GO:0038023	signaling receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621119	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035176	social behavior	PMID:17823315^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3758949	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035176	social behavior	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NZ94	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030534	adult behavior	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NZ94	P		Seeded From UniProt	complete
colocalizes_with	GO:0030425	dendrite	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621119	C		Seeded From UniProt	complete
part_of	GO:0030139	endocytic vesicle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621119	C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NZ94	C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621119	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008542	visual learning	PMID:17823315^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3758949	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007612	learning	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NZ94	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007416	synapse assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621119	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007158	neuron cell-cell adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621119	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006898	receptor-mediated endocytosis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621119	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002087	regulation of respiratory gaseous exchange by neurological system process	PMID:16982420^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2179435 MGI:MGI:2681835	P		Seeded From UniProt	complete
part_of	GO:0098793	presynapse	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0048488	C		Seeded From UniProt	complete
enables	GO:0097110	scaffold protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NZ94 ensembl:ENSP00000351591	F		Seeded From UniProt	complete
involved_in	GO:0071625	vocalization behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NZ94 ensembl:ENSP00000351591	P		Seeded From UniProt	complete
part_of	GO:0060076	excitatory synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NZ94 ensembl:ENSP00000351591	C		Seeded From UniProt	complete
involved_in	GO:0050808	synapse organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NZ94 ensembl:ENSP00000351591	P		Seeded From UniProt	complete
involved_in	GO:0035176	social behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NZ94 ensembl:ENSP00000351591	P		Seeded From UniProt	complete
involved_in	GO:0030534	adult behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NZ94 ensembl:ENSP00000351591	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NZ94 ensembl:ENSP00000351591	C		Seeded From UniProt	complete
involved_in	GO:0007612	learning	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NZ94 ensembl:ENSP00000351591	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030024	C		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030024	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000460	C		Seeded From UniProt	complete
enables	GO:0042043	neurexin family protein binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000460 InterPro:IPR030024	F		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030024	C		Seeded From UniProt	complete
involved_in	GO:0050804	modulation of chemical synaptic transmission	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030024	P		Seeded From UniProt	complete
involved_in	GO:0050808	synapse organization	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030024	P		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770 UniProtKB-SubCell:SL-0258	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0130	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 Etherton, MR et al. (2011) An autism-associated point mutation in the neuroligin cytoplasmic tail selectively impairs AMPA receptor-mediated synaptic transmission in hippocampus. EMBO J. 30 2908-19 PubMed GONUTS page
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 ^2.13 ^2.14 ^2.15 ^2.16 ^2.17 ^2.18 ^2.19 ^2.20 ^2.21 ^2.22 ^2.23 ^2.24 ^2.25 ^2.26 ^2.27 ^2.28 Etherton, M et al. (2011) Autism-linked neuroligin-3 R451C mutation differentially alters hippocampal and cortical synaptic function. Proc. Natl. Acad. Sci. U.S.A. 108 13764-9 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 ^3.8 ^3.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Tabuchi, K et al. (2007) A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice. Science 318 71-6 PubMed GONUTS page
↑ Ko, J et al. (2011) Neuroligins/LRRTMs prevent activity- and Ca2+/calmodulin-dependent synapse elimination in cultured neurons. J. Cell Biol. 194 323-34 PubMed GONUTS page
↑ ^6.0 ^6.1 Chih, B et al. (2005) Control of excitatory and inhibitory synapse formation by neuroligins. Science 307 1324-8 PubMed GONUTS page
↑ ^7.0 ^7.1 Varoqueaux, F et al. (2006) Neuroligins determine synapse maturation and function. Neuron 51 741-54 PubMed GONUTS page
↑ Gobert, RP et al. (2009) Convergent functional genomics of oligodendrocyte differentiation identifies multiple autoinhibitory signaling circuits. Mol. Cell. Biol. 29 1538-53 PubMed GONUTS page

[PMID:21642956-1] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 Etherton, MR et al. (2011) An autism-associated point mutation in the neuroligin cytoplasmic tail selectively impairs AMPA receptor-mediated synaptic transmission in hippocampus. EMBO J. 30 2908-19 PubMed GONUTS page

[PMID:21808020-2] 2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 ^2.13 ^2.14 ^2.15 ^2.16 ^2.17 ^2.18 ^2.19 ^2.20 ^2.21 ^2.22 ^2.23 ^2.24 ^2.25 ^2.26 ^2.27 ^2.28 Etherton, M et al. (2011) Autism-linked neuroligin-3 R451C mutation differentially alters hippocampal and cortical synaptic function. Proc. Natl. Acad. Sci. U.S.A. 108 13764-9 PubMed GONUTS page

[PMID:21873635-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 ^3.8 ^3.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:17823315-4] 4.0 ^4.1 ^4.2 Tabuchi, K et al. (2007) A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice. Science 318 71-6 PubMed GONUTS page

[PMID:21788371-5] Ko, J et al. (2011) Neuroligins/LRRTMs prevent activity- and Ca2+/calmodulin-dependent synapse elimination in cultured neurons. J. Cell Biol. 194 323-34 PubMed GONUTS page

[PMID:15681343-6] 6.0 ^6.1 Chih, B et al. (2005) Control of excitatory and inhibitory synapse formation by neuroligins. Science 307 1324-8 PubMed GONUTS page

[PMID:16982420-7] 7.0 ^7.1 Varoqueaux, F et al. (2006) Neuroligins determine synapse maturation and function. Neuron 51 741-54 PubMed GONUTS page

[PMID:19139271-8] Gobert, RP et al. (2009) Convergent functional genomics of oligodendrocyte differentiation identifies multiple autoinhibitory signaling circuits. Mol. Cell. Biol. 29 1538-53 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

MOUSE:NLGN3

Contents

Annotations

Notes

References

a

c

d

e

g

i

l

m

n

o

p

r

s

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools