MOUSE:NLGN2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Nlgn2 (synonyms: Kiaa1366)
Protein Name(s)	Neuroligin-2
External Links
UniProt	Q69ZK9
EMBL	AK173159 AL603707
CCDS	CCDS24914.1
RefSeq	NP_942562.2 XP_006532964.1
UniGene	Mm.151293
PDB	3BL8
PDBsum	3BL8
ProteinModelPortal	Q69ZK9
SMR	Q69ZK9
DIP	DIP-29702N
IntAct	Q69ZK9
STRING	10090.ENSMUSP00000104274
PhosphoSite	Q69ZK9
MaxQB	Q69ZK9
PaxDb	Q69ZK9
PRIDE	Q69ZK9
Ensembl	ENSMUST00000056484 ENSMUST00000108634
GeneID	216856
KEGG	mmu:216856
UCSC	uc007jrw.1
CTD	57555
MGI	MGI:2681835
eggNOG	COG2272
GeneTree	ENSGT00760000118946
HOGENOM	HOG000231424
HOVERGEN	HBG008839
InParanoid	Q69ZK9
KO	K07378
OMA	DIRDPGK
OrthoDB	EOG7RBZ7R
PhylomeDB	Q69ZK9
TreeFam	TF326187
ChiTaRS	Nlgn2
EvolutionaryTrace	Q69ZK9
NextBio	375400
PRO	PR:Q69ZK9
Proteomes	UP000000589
Bgee	Q69ZK9
CleanEx	MM_NLGN2
ExpressionAtlas	Q69ZK9
Genevestigator	Q69ZK9
GO	GO:0030054 GO:0009986 GO:0060076 GO:0060077 GO:0005887 GO:0045211 GO:0042734 GO:0045202 GO:0050839 GO:0042043 GO:0004872 GO:0097116 GO:0007630 GO:0035641 GO:0050885 GO:0007158 GO:2000463 GO:0097151 GO:0051965 GO:0032230 GO:0051968 GO:0097119 GO:0097104 GO:0097105 GO:0035418 GO:2000311 GO:0002087 GO:0050804 GO:0019233 GO:0035176 GO:0007416 GO:0050808 GO:0072553 GO:0001966
Gene3D	3.40.50.1820
InterPro	IPR029058 IPR002018 IPR019819 IPR000460 IPR030023
PANTHER	PTHR11559:SF53
Pfam	PF00135
PRINTS	PR01090
SUPFAM	SSF53474
PROSITE	PS00941

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0035418	protein localization to synapse	PMID:22960622^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	transports_or_maintains_localization_of:(UniProtKB:Q9R0N3)	Seeded From UniProt	complete
involved_in	GO:1904862	inhibitory synapse assembly	PMID:22960622^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000809	positive regulation of synaptic vesicle clustering	PMID:15620359^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000463	positive regulation of excitatory postsynaptic potential	PMID:15620359^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000311	regulation of AMPA receptor activity	PMID:15620359^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097151	positive regulation of inhibitory postsynaptic potential	PMID:15620359^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097151	positive regulation of inhibitory postsynaptic potential	PMID:17582332^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097119	postsynaptic density protein 95 clustering	PMID:15620359^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097116	gephyrin clustering involved in postsynaptic density assembly	PMID:15620359^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097105	presynaptic membrane assembly	PMID:19016888^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097105	presynaptic membrane assembly	PMID:15620359^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097104	postsynaptic membrane assembly	PMID:15620359^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072553	terminal button organization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62888	P		Seeded From UniProt	complete
part_of	GO:0060077	inhibitory synapse	PMID:15620359^[2]	ECO:0000305	curator inference used in manual assertion	GO:0097151	C		Seeded From UniProt	complete
part_of	GO:0060077	inhibitory synapse	PMID:17582332^[3]	ECO:0000305	curator inference used in manual assertion	GO:0097151	C		Seeded From UniProt	complete
part_of	GO:0060076	excitatory synapse	PMID:15620359^[2]	ECO:0000305	curator inference used in manual assertion	GO:2000463	C		Seeded From UniProt	complete
involved_in	GO:0051968	positive regulation of synaptic transmission, glutamatergic	PMID:15620359^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051965	positive regulation of synapse assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62888	P		Seeded From UniProt	complete
involved_in	GO:0050885	neuromuscular process controlling balance	PMID:19016888^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0050839	cell adhesion molecule binding	PMID:21424692^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9CS84	F		Seeded From UniProt	complete
involved_in	GO:0050808	synapse organization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62888	P		Seeded From UniProt	complete
enables	GO:0042043	neurexin family protein binding	PMID:21424692^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9CS84	F		Seeded From UniProt	complete
enables	GO:0042043	neurexin family protein binding	PMID:21424692^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:E9Q7X7	F		Seeded From UniProt	complete
involved_in	GO:0035641	locomotory exploration behavior	PMID:19016888^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035418	protein localization to synapse	PMID:15620359^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035176	social behavior	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62888	P		Seeded From UniProt	complete
involved_in	GO:0032230	positive regulation of synaptic transmission, GABAergic	PMID:15620359^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019233	sensory perception of pain	PMID:19016888^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62888	C		Seeded From UniProt	complete
involved_in	GO:0007630	jump response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62888	P		Seeded From UniProt	complete
involved_in	GO:0007416	synapse assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62888	P		Seeded From UniProt	complete
involved_in	GO:0007158	neuron cell-cell adhesion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62888	P		Seeded From UniProt	complete
part_of	GO:0099055	integral component of postsynaptic membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62888	C		Seeded From UniProt	complete
involved_in	GO:0001966	thigmotaxis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62888	P		Seeded From UniProt	complete
part_of	GO:0099060	integral component of postsynaptic specialization membrane	PMID:27035941^[6]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(GO:0098691) part_of:(UBERON:0000061) part_of:(UBERON:0002435)	Seeded From UniProt	complete
part_of	GO:0098982	GABA-ergic synapse	PMID:19755106^[7]	ECO:0006063	over expression analysis evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098982	GABA-ergic synapse	PMID:19755106^[7]	ECO:0006063	over expression analysis evidence used in manual assertion		C	part_of:(UBERON:0002298)	Seeded From UniProt	complete
part_of	GO:0098982	GABA-ergic synapse	PMID:15620359^[2]	ECO:0006063	over expression analysis evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098982	GABA-ergic synapse	PMID:19755106^[7]	ECO:0006013	patch-clamp recording evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098982	GABA-ergic synapse	PMID:19755106^[7]	ECO:0006013	patch-clamp recording evidence used in manual assertion		C	part_of:(UBERON:0002298)	Seeded From UniProt	complete
part_of	GO:0098982	GABA-ergic synapse	PMID:15620359^[2]	ECO:0006013	patch-clamp recording evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098982	GABA-ergic synapse	PMID:19755106^[7]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098982	GABA-ergic synapse	PMID:19755106^[7]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(UBERON:0002298)	Seeded From UniProt	complete
part_of	GO:0098982	GABA-ergic synapse	PMID:15620359^[2]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098982	GABA-ergic synapse	PMID:19755106^[7]	ECO:0001225	knockout evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098982	GABA-ergic synapse	PMID:19755106^[7]	ECO:0001225	knockout evidence used in manual assertion		C	part_of:(UBERON:0002298)	Seeded From UniProt	complete
involved_in	GO:0098698	postsynaptic specialization assembly	PMID:19755106^[7]	ECO:0006063	over expression analysis evidence used in manual assertion		P	occurs_in:(GO:0098982) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0098698	postsynaptic specialization assembly	PMID:19755106^[7]	ECO:0006063	over expression analysis evidence used in manual assertion		P	occurs_in:(GO:0098982) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002298)	Seeded From UniProt	complete
involved_in	GO:0098698	postsynaptic specialization assembly	PMID:19755106^[7]	ECO:0006063	over expression analysis evidence used in manual assertion		P	occurs_in:(GO:0098690) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002298)	Seeded From UniProt	complete
involved_in	GO:0098698	postsynaptic specialization assembly	PMID:15620359^[2]	ECO:0006063	over expression analysis evidence used in manual assertion		P	occurs_in:(GO:0098982) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0098698	postsynaptic specialization assembly	PMID:19755106^[7]	ECO:0006013	patch-clamp recording evidence used in manual assertion		P	occurs_in:(GO:0098982) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0098698	postsynaptic specialization assembly	PMID:19755106^[7]	ECO:0006013	patch-clamp recording evidence used in manual assertion		P	occurs_in:(GO:0098982) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002298)	Seeded From UniProt	complete
involved_in	GO:0098698	postsynaptic specialization assembly	PMID:19755106^[7]	ECO:0006013	patch-clamp recording evidence used in manual assertion		P	occurs_in:(GO:0098690) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002298)	Seeded From UniProt	complete
involved_in	GO:0098698	postsynaptic specialization assembly	PMID:15620359^[2]	ECO:0006013	patch-clamp recording evidence used in manual assertion		P	occurs_in:(GO:0098982) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0098698	postsynaptic specialization assembly	PMID:19755106^[7]	ECO:0005589	confocal microscopy evidence used in manual assertion		P	occurs_in:(GO:0098982) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0098698	postsynaptic specialization assembly	PMID:19755106^[7]	ECO:0005589	confocal microscopy evidence used in manual assertion		P	occurs_in:(GO:0098982) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002298)	Seeded From UniProt	complete
involved_in	GO:0098698	postsynaptic specialization assembly	PMID:19755106^[7]	ECO:0005589	confocal microscopy evidence used in manual assertion		P	occurs_in:(GO:0098690) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002298)	Seeded From UniProt	complete
involved_in	GO:0098698	postsynaptic specialization assembly	PMID:15620359^[2]	ECO:0005589	confocal microscopy evidence used in manual assertion		P	occurs_in:(GO:0098982) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0098698	postsynaptic specialization assembly	PMID:19755106^[7]	ECO:0001225	knockout evidence used in manual assertion		P	occurs_in:(GO:0098982) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0098698	postsynaptic specialization assembly	PMID:19755106^[7]	ECO:0001225	knockout evidence used in manual assertion		P	occurs_in:(GO:0098982) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002298)	Seeded From UniProt	complete
involved_in	GO:0098698	postsynaptic specialization assembly	PMID:19755106^[7]	ECO:0001225	knockout evidence used in manual assertion		P	occurs_in:(GO:0098690) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002298)	Seeded From UniProt	complete
part_of	GO:0098691	dopaminergic synapse	PMID:27035941^[6]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(UBERON:0000061) part_of:(UBERON:0002435)	Seeded From UniProt	complete
part_of	GO:0098690	glycinergic synapse	PMID:19755106^[7]	ECO:0006063	over expression analysis evidence used in manual assertion		C	part_of:(UBERON:0002298)	Seeded From UniProt	complete
part_of	GO:0098690	glycinergic synapse	PMID:19755106^[7]	ECO:0006013	patch-clamp recording evidence used in manual assertion		C	part_of:(UBERON:0002298)	Seeded From UniProt	complete
part_of	GO:0098690	glycinergic synapse	PMID:19755106^[7]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(UBERON:0002298)	Seeded From UniProt	complete
part_of	GO:0098690	glycinergic synapse	PMID:19755106^[7]	ECO:0001225	knockout evidence used in manual assertion		C	part_of:(UBERON:0002298)	Seeded From UniProt	complete
involved_in	GO:0097105	presynaptic membrane assembly	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2179435 MGI:MGI:2681835 PANTHER:PTN000168538 RGD:621117 RGD:621118 RGD:621119 UniProtKB:Q8N0W4	P		Seeded From UniProt	complete
involved_in	GO:0097104	postsynaptic membrane assembly	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2179435 MGI:MGI:2444609 MGI:MGI:2681835 PANTHER:PTN000168538	P		Seeded From UniProt	complete
involved_in	GO:0050804	modulation of chemical synaptic transmission	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2179435 MGI:MGI:2444609 MGI:MGI:2681835 PANTHER:PTN000168538 RGD:621117	P		Seeded From UniProt	complete
involved_in	GO:0048488	synaptic vesicle endocytosis	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0083963 PANTHER:PTN000168538	P		Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2179435 MGI:MGI:2681835 MGI:MGI:3775191 PANTHER:PTN000168538 RGD:621117 RGD:621119 WB:WBGene00006412	C		Seeded From UniProt	complete
enables	GO:0042043	neurexin family protein binding	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0031866 MGI:MGI:2179435 MGI:MGI:2681835 PANTHER:PTN000168538 RGD:621117 RGD:621119 UniProtKB:Q8N0W4	F		Seeded From UniProt	complete
enables	GO:0038023	signaling receptor activity	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000168538 RGD:621117 RGD:621119	F		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2179435 PANTHER:PTN000168538 RGD:621117 RGD:621118 RGD:621119 UniProtKB:Q8N0W4 UniProtKB:Q9NZ94	C		Seeded From UniProt	complete
involved_in	GO:0007158	neuron cell-cell adhesion	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2179435 PANTHER:PTN000168538 RGD:621117 RGD:621118 RGD:621119	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2179435 PANTHER:PTN000168538 UniProtKB:Q8N0W4	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1905606	regulation of presynapse assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621118	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904034	positive regulation of t-SNARE clustering	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621118	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902474	positive regulation of protein localization to synapse	PMID:24613359^[9]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8NFZ4	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902474	positive regulation of protein localization to synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621118	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901142	insulin metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621118	P		Seeded From UniProt	complete
part_of	GO:0099060	integral component of postsynaptic specialization membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621118	C		Seeded From UniProt	complete
part_of	GO:0099055	integral component of postsynaptic membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621118	C		Seeded From UniProt	complete
part_of	GO:0098982	GABA-ergic synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621118	C		Seeded From UniProt	complete
part_of	GO:0097470	ribbon synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621118	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097151	positive regulation of inhibitory postsynaptic potential	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621118	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097105	presynaptic membrane assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621118	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072553	terminal button organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621118	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060999	positive regulation of dendritic spine development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621118	P		Seeded From UniProt	complete
part_of	GO:0060077	inhibitory synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621118	C		Seeded From UniProt	complete
part_of	GO:0060076	excitatory synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621118	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051965	positive regulation of synapse assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621118	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050808	synapse organization	PMID:15681343^[10]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q62888	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050808	synapse organization	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q62888	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050804	modulation of chemical synaptic transmission	PMID:16982420^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2179435	P		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621118	C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:15681343^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043198	dendritic shaft	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621118	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035176	social behavior	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621118	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032024	positive regulation of insulin secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8NFZ4	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032024	positive regulation of insulin secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621118	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621118	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621118	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007630	jump response	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621118	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007416	synapse assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621118	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007158	neuron cell-cell adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621118	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621118	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621118	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002087	regulation of respiratory gaseous exchange by neurological system process	PMID:16982420^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2444609	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001966	thigmotaxis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621118	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:18250328^[12]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q69ZK9	F		Seeded From UniProt	complete
involved_in	GO:1902474	positive regulation of protein localization to synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8NFZ4 ensembl:ENSP00000305288	P		Seeded From UniProt	complete
involved_in	GO:0032024	positive regulation of insulin secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8NFZ4 ensembl:ENSP00000305288	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030023	C		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030023	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000460	C		Seeded From UniProt	complete
enables	GO:0042043	neurexin family protein binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000460 InterPro:IPR030023	F		Seeded From UniProt	complete
involved_in	GO:0050804	modulation of chemical synaptic transmission	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030023	P		Seeded From UniProt	complete
involved_in	GO:0050808	synapse organization	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030023	P		Seeded From UniProt	complete
part_of	GO:0060077	inhibitory synapse	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030023	C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770	C		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0130	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0628 UniProtKB-SubCell:SL-0219	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0042734	presynaptic membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0222	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Yeo, H et al. (2012) Developmental expression and subcellular distribution of synaptotagmin 11 in rat hippocampus. Neuroscience 225 35-43 PubMed GONUTS page
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 ^2.13 ^2.14 ^2.15 ^2.16 ^2.17 ^2.18 Graf, ER et al. (2004) Neurexins induce differentiation of GABA and glutamate postsynaptic specializations via neuroligins. Cell 119 1013-26 PubMed GONUTS page
↑ ^3.0 ^3.1 Chubykin, AA et al. (2007) Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2. Neuron 54 919-31 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Blundell, J et al. (2009) Increased anxiety-like behavior in mice lacking the inhibitory synapse cell adhesion molecule neuroligin 2. Genes Brain Behav. 8 114-26 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Gauthier, J et al. (2011) Truncating mutations in NRXN2 and NRXN1 in autism spectrum disorders and schizophrenia. Hum. Genet. 130 563-73 PubMed GONUTS page
↑ ^6.0 ^6.1 Uchigashima, M et al. (2016) Dopamine synapse is a neuroligin-2-mediated contact between dopaminergic presynaptic and GABAergic postsynaptic structures. Proc. Natl. Acad. Sci. U.S.A. 113 4206-11 PubMed GONUTS page
↑ ^7.00 ^7.01 ^7.02 ^7.03 ^7.04 ^7.05 ^7.06 ^7.07 ^7.08 ^7.09 ^7.10 ^7.11 ^7.12 ^7.13 ^7.14 ^7.15 ^7.16 ^7.17 ^7.18 ^7.19 ^7.20 ^7.21 ^7.22 ^7.23 Poulopoulos, A et al. (2009) Neuroligin 2 drives postsynaptic assembly at perisomatic inhibitory synapses through gephyrin and collybistin. Neuron 63 628-42 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 ^8.7 ^8.8 ^8.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Um, JW et al. (2014) Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins. Cell Rep 6 1096-109 PubMed GONUTS page
↑ ^10.0 ^10.1 Chih, B et al. (2005) Control of excitatory and inhibitory synapse formation by neuroligins. Science 307 1324-8 PubMed GONUTS page
↑ ^11.0 ^11.1 Varoqueaux, F et al. (2006) Neuroligins determine synapse maturation and function. Neuron 51 741-54 PubMed GONUTS page
↑ Koehnke, J et al. (2008) Crystal structure of the extracellular cholinesterase-like domain from neuroligin-2. Proc. Natl. Acad. Sci. U.S.A. 105 1873-8 PubMed GONUTS page

[PMID:22960622-1] 1.0 ^1.1 Yeo, H et al. (2012) Developmental expression and subcellular distribution of synaptotagmin 11 in rat hippocampus. Neuroscience 225 35-43 PubMed GONUTS page

[PMID:15620359-2] 2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 ^2.13 ^2.14 ^2.15 ^2.16 ^2.17 ^2.18 Graf, ER et al. (2004) Neurexins induce differentiation of GABA and glutamate postsynaptic specializations via neuroligins. Cell 119 1013-26 PubMed GONUTS page

[PMID:17582332-3] 3.0 ^3.1 Chubykin, AA et al. (2007) Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2. Neuron 54 919-31 PubMed GONUTS page

[PMID:19016888-4] 4.0 ^4.1 ^4.2 ^4.3 Blundell, J et al. (2009) Increased anxiety-like behavior in mice lacking the inhibitory synapse cell adhesion molecule neuroligin 2. Genes Brain Behav. 8 114-26 PubMed GONUTS page

[PMID:21424692-5] 5.0 ^5.1 ^5.2 Gauthier, J et al. (2011) Truncating mutations in NRXN2 and NRXN1 in autism spectrum disorders and schizophrenia. Hum. Genet. 130 563-73 PubMed GONUTS page

[PMID:27035941-6] 6.0 ^6.1 Uchigashima, M et al. (2016) Dopamine synapse is a neuroligin-2-mediated contact between dopaminergic presynaptic and GABAergic postsynaptic structures. Proc. Natl. Acad. Sci. U.S.A. 113 4206-11 PubMed GONUTS page

[PMID:19755106-7] 7.00 ^7.01 ^7.02 ^7.03 ^7.04 ^7.05 ^7.06 ^7.07 ^7.08 ^7.09 ^7.10 ^7.11 ^7.12 ^7.13 ^7.14 ^7.15 ^7.16 ^7.17 ^7.18 ^7.19 ^7.20 ^7.21 ^7.22 ^7.23 Poulopoulos, A et al. (2009) Neuroligin 2 drives postsynaptic assembly at perisomatic inhibitory synapses through gephyrin and collybistin. Neuron 63 628-42 PubMed GONUTS page

[PMID:21873635-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 ^8.7 ^8.8 ^8.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:24613359-9] Um, JW et al. (2014) Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins. Cell Rep 6 1096-109 PubMed GONUTS page

[PMID:15681343-10] 10.0 ^10.1 Chih, B et al. (2005) Control of excitatory and inhibitory synapse formation by neuroligins. Science 307 1324-8 PubMed GONUTS page

[PMID:16982420-11] 11.0 ^11.1 Varoqueaux, F et al. (2006) Neuroligins determine synapse maturation and function. Neuron 51 741-54 PubMed GONUTS page

[PMID:18250328-12] Koehnke, J et al. (2008) Crystal structure of the extracellular cholinesterase-like domain from neuroligin-2. Proc. Natl. Acad. Sci. U.S.A. 105 1873-8 PubMed GONUTS page

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