MOUSE:NLGN1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Nlgn1 (synonyms: Kiaa1070)
Protein Name(s)	Neuroligin-1
External Links
UniProt	Q99K10
EMBL	AK122433 BC005523
CCDS	CCDS17268.1
RefSeq	NP_619607.2
UniGene	Mm.316080
PDB	3B3Q
PDBsum	3B3Q
ProteinModelPortal	Q99K10
SMR	Q99K10
DIP	DIP-32027N
IntAct	Q99K10
MINT	MINT-5104301
STRING	10090.ENSMUSP00000074565
MEROPS	S09.994
PhosphoSite	Q99K10
MaxQB	Q99K10
PaxDb	Q99K10
PRIDE	Q99K10
Ensembl	ENSMUST00000075054
GeneID	192167
KEGG	mmu:192167
UCSC	uc008otc.1 uc008otd.1
CTD	22871
MGI	MGI:2179435
eggNOG	COG2272
GeneTree	ENSGT00760000118946
HOGENOM	HOG000231424
HOVERGEN	HBG008839
InParanoid	Q99K10
KO	K07378
OMA	KFVELIV
PhylomeDB	Q99K10
TreeFam	TF326187
EvolutionaryTrace	Q99K10
NextBio	371168
PRO	PR:Q99K10
Proteomes	UP000000589
Bgee	Q99K10
CleanEx	MM_NLGN1
ExpressionAtlas	Q99K10
Genevestigator	Q99K10
GO	GO:0030054 GO:0009986 GO:0030425 GO:0060076 GO:0009897 GO:0032433 GO:0005887 GO:0017146 GO:0014069 GO:0045211 GO:0045202 GO:0042043 GO:0046983 GO:0004872 GO:0097113 GO:0016339 GO:0048789 GO:0045184 GO:0007157 GO:0097114 GO:0007399 GO:0097115 GO:0007158 GO:0060999 GO:2000463 GO:0051491 GO:1902533 GO:1900029 GO:0051965 GO:0032230 GO:0051968 GO:1900244 GO:2000302 GO:0097119 GO:0097104 GO:0097105 GO:0051290 GO:0051260 GO:0035418 GO:0006605 GO:0097120 GO:2000311 GO:2000310 GO:0045664 GO:0002087 GO:0050804 GO:0007416 GO:0050808 GO:0097091 GO:0016080 GO:0072553
Gene3D	3.40.50.1820
InterPro	IPR029058 IPR002018 IPR019819 IPR000460 IPR030022
PANTHER	PTHR11559:SF52
Pfam	PF00135
PRINTS	PR01090
SUPFAM	SSF53474
PROSITE	PS00941

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0097113	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering	PMID:21940442^[1]	ECO:0000315			P		Nlgn1 overexpression reduces the surface diffusion of GluA2-containing AMPA receptor. Figure 1B. Figure 2C and D, Knockout Nlgn1 mice increase AMPA receptor membrane diffusion.	complete CACAO 3063
	GO:0097119	postsynaptic density protein 95 clustering	PMID:20869594^[2]	ECO:0000247		UniProtKB:D2X2K4	P		Figure 1A shows sequence similarity to xenopus Nlgn1	complete
	GO:0097119	postsynaptic density protein 95 clustering	PMID:20869594^[2]	ECO:0000314			P		Figure 2K showed decrease in PSD-95 density when neurons treated with soluble Nrx1B-Fc. Therefore interaction between Nlgn1 and Nrxn1B is needed for location of PSD-95 at the postsynaptic membrane figure 2P and Q. Similar results seen when Nlgn1 is mutated there is a decrease of PSD-95 figure 3G and H. Only 20% of PSD-95 was present on dendritic filopodia figure 3I suggesting that the recruitment and clustering of PSD-95 is impaired. When Nlgn1 is over expressed these is increase in PSD-95 density, figure 4G, H. (Figure 1A shows sequence similarities to xenopus Nlgn1)	complete CACAO 3225
part_of	GO:0009986	cell surface	PMID:26440732^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1904861	excitatory synapse assembly	PMID:26440732^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	results_in_development_of:(GO:0098978)	Seeded From UniProt	complete
involved_in	GO:0035418	protein localization to synapse	PMID:22960622^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	transports_or_maintains_localization_of:(UniProtKB:Q9R0N3)	Seeded From UniProt	complete
involved_in	GO:1904861	excitatory synapse assembly	PMID:22960622^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0099560	synaptic membrane adhesion	PMID:26771491^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62765	C	part_of:(CL:0002608)	Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62765	C	part_of:(CL:0002608)	Seeded From UniProt	complete
colocalizes_with	GO:0014069	postsynaptic density	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62765	C	part_of:(CL:0002608)	Seeded From UniProt	complete
involved_in	GO:0097119	postsynaptic density protein 95 clustering	PMID:20869594^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097113	AMPA glutamate receptor clustering	PMID:21940442^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62765	C	part_of:(CL:0000540)	Seeded From UniProt	complete
involved_in	GO:2000809	positive regulation of synaptic vesicle clustering	PMID:15620359^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000463	positive regulation of excitatory postsynaptic potential	PMID:23143522^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:1001571)	Seeded From UniProt	complete
involved_in	GO:0060999	positive regulation of dendritic spine development	PMID:23143522^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:1001571)	Seeded From UniProt	complete
involved_in	GO:2000310	regulation of NMDA receptor activity	PMID:23143522^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:1001571)	Seeded From UniProt	complete
involved_in	GO:0061002	negative regulation of dendritic spine morphogenesis	PMID:23143522^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:1001571)	Seeded From UniProt	complete
involved_in	GO:0010841	positive regulation of circadian sleep/wake cycle, wakefulness	PMID:23716671^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000463	positive regulation of excitatory postsynaptic potential	PMID:17582332^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000311	regulation of AMPA receptor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62765	P		Seeded From UniProt	complete
involved_in	GO:2000310	regulation of NMDA receptor activity	PMID:17582332^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000302	positive regulation of synaptic vesicle exocytosis	PMID:19628693^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1900244	positive regulation of synaptic vesicle endocytosis	PMID:19628693^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097120	receptor localization to synapse	PMID:12796785^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097119	postsynaptic density protein 95 clustering	PMID:12796785^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097119	postsynaptic density protein 95 clustering	PMID:15620359^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097115	neurexin clustering involved in presynaptic membrane assembly	PMID:12796785^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097114	NMDA glutamate receptor clustering	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62765	P		Seeded From UniProt	complete
involved_in	GO:0097113	AMPA glutamate receptor clustering	PMID:21940442^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097113	AMPA glutamate receptor clustering	PMID:12796785^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097105	presynaptic membrane assembly	PMID:10892652^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097105	presynaptic membrane assembly	PMID:12796785^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097105	presynaptic membrane assembly	PMID:15620359^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097104	postsynaptic membrane assembly	PMID:12796785^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097104	postsynaptic membrane assembly	PMID:15620359^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097091	synaptic vesicle clustering	PMID:10892652^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097091	synaptic vesicle clustering	PMID:12796785^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072553	terminal button organization	PMID:19628693^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060999	positive regulation of dendritic spine development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62765	P		Seeded From UniProt	complete
NOT\|involved_in	GO:0060080	inhibitory postsynaptic potential	PMID:17582332^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0060076	excitatory synapse	PMID:10892652^[12]	ECO:0000305	curator inference used in manual assertion	GO:0007416	C		Seeded From UniProt	complete
part_of	GO:0060076	excitatory synapse	PMID:17582332^[9]	ECO:0000305	curator inference used in manual assertion	GO:2000463	C		Seeded From UniProt	complete
involved_in	GO:0051968	positive regulation of synaptic transmission, glutamatergic	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62765	P		Seeded From UniProt	complete
involved_in	GO:0051965	positive regulation of synapse assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62765	P		Seeded From UniProt	complete
involved_in	GO:0051491	positive regulation of filopodium assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62765	P		Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	PMID:12796785^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048789	cytoskeletal matrix organization at active zone	PMID:19628693^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0046983	protein dimerization activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62765	F		Seeded From UniProt	complete
involved_in	GO:0045184	establishment of protein localization	PMID:12796785^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042043	neurexin family protein binding	PMID:12796785^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P0DI97	F		Seeded From UniProt	complete
enables	GO:0042043	neurexin family protein binding	PMID:19098102^[13]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P0DI97	F		Seeded From UniProt	complete
involved_in	GO:0035418	protein localization to synapse	PMID:15620359^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0032433	filopodium tip	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62765	C		Seeded From UniProt	complete
involved_in	GO:0032230	positive regulation of synaptic transmission, GABAergic	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62765	P		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62765	C		Seeded From UniProt	complete
involved_in	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	PMID:12796785^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62765	C		Seeded From UniProt	complete
involved_in	GO:0007158	neuron cell-cell adhesion	PMID:12796785^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	PMID:12796785^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045664	regulation of neuron differentiation	PMID:10892652^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62765	C		Seeded From UniProt	complete
enables	GO:0042043	neurexin family protein binding	PMID:10892652^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62765	P		Seeded From UniProt	complete
involved_in	GO:0016080	synaptic vesicle targeting	PMID:10892652^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007416	synapse assembly	PMID:10892652^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	PMID:10892652^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:10892652^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0099560	synaptic membrane adhesion	PMID:12796785^[11]	ECO:0006063	over expression analysis evidence used in manual assertion		P	occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0099560	synaptic membrane adhesion	PMID:12796785^[11]	ECO:0005589	confocal microscopy evidence used in manual assertion		P	occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:15620359^[6]	ECO:0006063	over expression analysis evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:15620359^[6]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0098698	postsynaptic specialization assembly	PMID:15620359^[6]	ECO:0006063	over expression analysis evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0098698	postsynaptic specialization assembly	PMID:15620359^[6]	ECO:0005589	confocal microscopy evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0097105	presynaptic membrane assembly	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2179435 MGI:MGI:2681835 PANTHER:PTN000168538 RGD:621117 RGD:621118 RGD:621119 UniProtKB:Q8N0W4	P		Seeded From UniProt	complete
involved_in	GO:0097104	postsynaptic membrane assembly	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2179435 MGI:MGI:2444609 MGI:MGI:2681835 PANTHER:PTN000168538	P		Seeded From UniProt	complete
involved_in	GO:0050804	modulation of chemical synaptic transmission	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2179435 MGI:MGI:2444609 MGI:MGI:2681835 PANTHER:PTN000168538 RGD:621117	P		Seeded From UniProt	complete
involved_in	GO:0048488	synaptic vesicle endocytosis	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0083963 PANTHER:PTN000168538	P		Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2179435 MGI:MGI:2681835 MGI:MGI:3775191 PANTHER:PTN000168538 RGD:621117 RGD:621119 WB:WBGene00006412	C		Seeded From UniProt	complete
enables	GO:0042043	neurexin family protein binding	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0031866 MGI:MGI:2179435 MGI:MGI:2681835 PANTHER:PTN000168538 RGD:621117 RGD:621119 UniProtKB:Q8N0W4	F		Seeded From UniProt	complete
enables	GO:0038023	signaling receptor activity	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000168538 RGD:621117 RGD:621119	F		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2179435 PANTHER:PTN000168538 RGD:621117 RGD:621118 RGD:621119 UniProtKB:Q8N0W4 UniProtKB:Q9NZ94	C		Seeded From UniProt	complete
involved_in	GO:0007158	neuron cell-cell adhesion	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2179435 PANTHER:PTN000168538 RGD:621117 RGD:621118 RGD:621119	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2179435 PANTHER:PTN000168538 UniProtKB:Q8N0W4	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000463	positive regulation of excitatory postsynaptic potential	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8N2Q7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000463	positive regulation of excitatory postsynaptic potential	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621117	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000311	regulation of AMPA receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621117	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000310	regulation of NMDA receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8N2Q7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000310	regulation of NMDA receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621117	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000302	positive regulation of synaptic vesicle exocytosis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621117	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1905520	positive regulation of presynaptic active zone assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621117	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902533	positive regulation of intracellular signal transduction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621117	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902474	positive regulation of protein localization to synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621117	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900244	positive regulation of synaptic vesicle endocytosis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621117	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900029	positive regulation of ruffle assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621117	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0140058	neuron projection arborization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621117	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0099174	regulation of presynapse organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621117	P		Seeded From UniProt	complete
part_of	GO:0099060	integral component of postsynaptic specialization membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621117	C		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621117	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0098942	retrograde trans-synaptic signaling by trans-synaptic protein complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621117	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097119	postsynaptic density protein 95 clustering	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621117	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097114	NMDA glutamate receptor clustering	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621117	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097113	AMPA glutamate receptor clustering	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621117	P		Seeded From UniProt	complete
enables	GO:0097110	scaffold protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8N2Q7	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097105	presynaptic membrane assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621117	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097091	synaptic vesicle clustering	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621117	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072553	terminal button organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621117	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071277	cellular response to calcium ion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621117	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061002	negative regulation of dendritic spine morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8N2Q7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060999	positive regulation of dendritic spine development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8N2Q7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060999	positive regulation of dendritic spine development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621117	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060291	long-term synaptic potentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621117	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051968	positive regulation of synaptic transmission, glutamatergic	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621117	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051965	positive regulation of synapse assembly	PMID:21356198^[15]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(EMAPA:17544) regulates_o_occurs_in:(CL:0000117)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051965	positive regulation of synapse assembly	PMID:24613359^[16]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8N2Q7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051965	positive regulation of synapse assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621117	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051491	positive regulation of filopodium assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621117	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051290	protein heterotetramerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621117	P		Seeded From UniProt	complete
enables	GO:0050839	cell adhesion molecule binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621117	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050808	synapse organization	PMID:21788371^[17]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2389173 MGI:MGI:2389174 MGI:MGI:2444609	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050808	synapse organization	PMID:15681343^[18]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q62765	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050804	modulation of chemical synaptic transmission	PMID:16982420^[19]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2681835	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050804	modulation of chemical synaptic transmission	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621117	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048789	cytoskeletal matrix organization at active zone	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621117	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048489	synaptic vesicle transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621117	P		Seeded From UniProt	complete
enables	GO:0046983	protein dimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621117	F		Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:15681343^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:12202822^[20]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621117	C		Seeded From UniProt	complete
part_of	GO:0043198	dendritic shaft	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621117	C		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621117	C		Seeded From UniProt	complete
enables	GO:0042043	neurexin family protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621117	F		Seeded From UniProt	complete
enables	GO:0038023	signaling receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621117	F		Seeded From UniProt	complete
part_of	GO:0032433	filopodium tip	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621117	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032230	positive regulation of synaptic transmission, GABAergic	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621117	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031175	neuron projection development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8N2Q7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031175	neuron projection development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621117	P		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621117	C		Seeded From UniProt	complete
enables	GO:0030165	PDZ domain binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8N2Q7	F		Seeded From UniProt	complete
colocalizes_with	GO:0017146	NMDA selective glutamate receptor complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621117	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621117	P		Seeded From UniProt	complete
colocalizes_with	GO:0014069	postsynaptic density	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621117	C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:23791195^[21]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621117	C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:20573900^[22]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007416	synapse assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621117	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007158	neuron cell-cell adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621117	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006605	protein targeting	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621117	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621117	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621117	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002087	regulation of respiratory gaseous exchange by neurological system process	PMID:16982420^[19]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2444609	P		Seeded From UniProt	complete
part_of	GO:0098793	presynapse	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0097091	C		Seeded From UniProt	complete
part_of	GO:0098793	presynapse	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0097091	C		Seeded From UniProt	complete
part_of	GO:0098793	presynapse	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0097091	C		Seeded From UniProt	complete
part_of	GO:0098793	presynapse	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0097091	C		Seeded From UniProt	complete
part_of	GO:0098793	presynapse	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0016080	C		Seeded From UniProt	complete
part_of	GO:0098793	presynapse	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0048488	C		Seeded From UniProt	complete
involved_in	GO:2000463	positive regulation of excitatory postsynaptic potential	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	P		Seeded From UniProt	complete
involved_in	GO:2000311	regulation of AMPA receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	P		Seeded From UniProt	complete
involved_in	GO:2000310	regulation of NMDA receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	P		Seeded From UniProt	complete
involved_in	GO:2000302	positive regulation of synaptic vesicle exocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	P		Seeded From UniProt	complete
involved_in	GO:1905520	positive regulation of presynaptic active zone assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	P		Seeded From UniProt	complete
involved_in	GO:1902533	positive regulation of intracellular signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	P		Seeded From UniProt	complete
involved_in	GO:1902474	positive regulation of protein localization to synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	P		Seeded From UniProt	complete
involved_in	GO:1900244	positive regulation of synaptic vesicle endocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	P		Seeded From UniProt	complete
involved_in	GO:1900029	positive regulation of ruffle assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	P		Seeded From UniProt	complete
involved_in	GO:0140058	neuron projection arborization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	P		Seeded From UniProt	complete
involved_in	GO:0099174	regulation of presynapse organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	P		Seeded From UniProt	complete
part_of	GO:0099060	integral component of postsynaptic specialization membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	C		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	C		Seeded From UniProt	complete
involved_in	GO:0098942	retrograde trans-synaptic signaling by trans-synaptic protein complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	P		Seeded From UniProt	complete
involved_in	GO:0097119	postsynaptic density protein 95 clustering	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	P		Seeded From UniProt	complete
involved_in	GO:0097114	NMDA glutamate receptor clustering	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	P		Seeded From UniProt	complete
involved_in	GO:0097113	AMPA glutamate receptor clustering	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	P		Seeded From UniProt	complete
involved_in	GO:0097105	presynaptic membrane assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	P		Seeded From UniProt	complete
involved_in	GO:0097091	synaptic vesicle clustering	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	P		Seeded From UniProt	complete
involved_in	GO:0072553	terminal button organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	P		Seeded From UniProt	complete
involved_in	GO:0071277	cellular response to calcium ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	P		Seeded From UniProt	complete
involved_in	GO:0060999	positive regulation of dendritic spine development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	P		Seeded From UniProt	complete
involved_in	GO:0060291	long-term synaptic potentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	P		Seeded From UniProt	complete
involved_in	GO:0051968	positive regulation of synaptic transmission, glutamatergic	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	P		Seeded From UniProt	complete
involved_in	GO:0051965	positive regulation of synapse assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	P		Seeded From UniProt	complete
involved_in	GO:0051491	positive regulation of filopodium assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	P		Seeded From UniProt	complete
involved_in	GO:0051290	protein heterotetramerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	P		Seeded From UniProt	complete
enables	GO:0050839	cell adhesion molecule binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	F		Seeded From UniProt	complete
involved_in	GO:0050808	synapse organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	P		Seeded From UniProt	complete
involved_in	GO:0050804	modulation of chemical synaptic transmission	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	P		Seeded From UniProt	complete
involved_in	GO:0048789	cytoskeletal matrix organization at active zone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	P		Seeded From UniProt	complete
involved_in	GO:0048489	synaptic vesicle transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	P		Seeded From UniProt	complete
enables	GO:0046983	protein dimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	F		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	C		Seeded From UniProt	complete
part_of	GO:0043198	dendritic shaft	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	C		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	C		Seeded From UniProt	complete
enables	GO:0042043	neurexin family protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	F		Seeded From UniProt	complete
enables	GO:0038023	signaling receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	F		Seeded From UniProt	complete
part_of	GO:0032433	filopodium tip	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	C		Seeded From UniProt	complete
involved_in	GO:0032230	positive regulation of synaptic transmission, GABAergic	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	P		Seeded From UniProt	complete
involved_in	GO:0031175	neuron projection development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	P		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	C		Seeded From UniProt	complete
part_of	GO:0017146	NMDA selective glutamate receptor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	C		Seeded From UniProt	complete
involved_in	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	P		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	C		Seeded From UniProt	complete
involved_in	GO:0007416	synapse assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	P		Seeded From UniProt	complete
involved_in	GO:0007158	neuron cell-cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	P		Seeded From UniProt	complete
involved_in	GO:0006605	protein targeting	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	C		Seeded From UniProt	complete
involved_in	GO:2000463	positive regulation of excitatory postsynaptic potential	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8N2Q7 ensembl:ENSP00000392500	P		Seeded From UniProt	complete
involved_in	GO:2000310	regulation of NMDA receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8N2Q7 ensembl:ENSP00000392500	P		Seeded From UniProt	complete
enables	GO:0097110	scaffold protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8N2Q7 ensembl:ENSP00000392500	F		Seeded From UniProt	complete
involved_in	GO:0061002	negative regulation of dendritic spine morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8N2Q7 ensembl:ENSP00000392500	P		Seeded From UniProt	complete
involved_in	GO:0060999	positive regulation of dendritic spine development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8N2Q7 ensembl:ENSP00000392500	P		Seeded From UniProt	complete
involved_in	GO:0051965	positive regulation of synapse assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8N2Q7 ensembl:ENSP00000392500	P		Seeded From UniProt	complete
involved_in	GO:0031175	neuron projection development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8N2Q7 ensembl:ENSP00000392500	P		Seeded From UniProt	complete
enables	GO:0030165	PDZ domain binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8N2Q7 ensembl:ENSP00000392500	F		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030022	C		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030022	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000460	C		Seeded From UniProt	complete
enables	GO:0042043	neurexin family protein binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000460 InterPro:IPR030022	F		Seeded From UniProt	complete
involved_in	GO:0050804	modulation of chemical synaptic transmission	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030022	P		Seeded From UniProt	complete
involved_in	GO:0050808	synapse organization	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030022	P		Seeded From UniProt	complete
part_of	GO:0060076	excitatory synapse	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030022	C		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0628	C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0130	P		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770 UniProtKB-SubCell:SL-0258	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0048511	rhythmic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0090	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0297	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Mondin, M et al. (2011) Neurexin-neuroligin adhesions capture surface-diffusing AMPA receptors through PSD-95 scaffolds. J. Neurosci. 31 13500-15 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Chen, SX et al. (2010) Neurexin-neuroligin cell adhesion complexes contribute to synaptotropic dendritogenesis via growth stabilization mechanisms in vivo. Neuron 67 967-83 PubMed GONUTS page
↑ ^3.0 ^3.1 Tristán-Clavijo, E et al. (2015) A truncating mutation in Alzheimer's disease inactivates neuroligin-1 synaptic function. Neurobiol. Aging 36 3171-3175 PubMed GONUTS page
↑ ^4.0 ^4.1 Yeo, H et al. (2012) Developmental expression and subcellular distribution of synaptotagmin 11 in rat hippocampus. Neuroscience 225 35-43 PubMed GONUTS page
↑ Singh, SK et al. (2016) Astrocytes Assemble Thalamocortical Synapses by Bridging NRX1α and NL1 via Hevin. Cell 164 183-196 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 ^6.8 Graf, ER et al. (2004) Neurexins induce differentiation of GABA and glutamate postsynaptic specializations via neuroligins. Cell 119 1013-26 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Kwon, HB et al. (2012) Neuroligin-1-dependent competition regulates cortical synaptogenesis and synapse number. Nat. Neurosci. 15 1667-74 PubMed GONUTS page
↑ El Helou, J et al. (2013) Neuroligin-1 links neuronal activity to sleep-wake regulation. Proc. Natl. Acad. Sci. U.S.A. 110 9974-9 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Chubykin, AA et al. (2007) Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2. Neuron 54 919-31 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Wittenmayer, N et al. (2009) Postsynaptic Neuroligin1 regulates presynaptic maturation. Proc. Natl. Acad. Sci. U.S.A. 106 13564-9 PubMed GONUTS page
↑ ^11.00 ^11.01 ^11.02 ^11.03 ^11.04 ^11.05 ^11.06 ^11.07 ^11.08 ^11.09 ^11.10 ^11.11 ^11.12 ^11.13 ^11.14 Dean, C et al. (2003) Neurexin mediates the assembly of presynaptic terminals. Nat. Neurosci. 6 708-16 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 ^12.6 ^12.7 ^12.8 Scheiffele, P et al. (2000) Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons. Cell 101 657-69 PubMed GONUTS page
↑ Heine, M et al. (2008) Activity-independent and subunit-specific recruitment of functional AMPA receptors at neurexin/neuroligin contacts. Proc. Natl. Acad. Sci. U.S.A. 105 20947-52 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 ^14.6 ^14.7 ^14.8 ^14.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Joo, JY et al. (2011) Differential interactions of cerebellin precursor protein (Cbln) subtypes and neurexin variants for synapse formation of cortical neurons. Biochem. Biophys. Res. Commun. 406 627-32 PubMed GONUTS page
↑ Um, JW et al. (2014) Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins. Cell Rep 6 1096-109 PubMed GONUTS page
↑ Ko, J et al. (2011) Neuroligins/LRRTMs prevent activity- and Ca2+/calmodulin-dependent synapse elimination in cultured neurons. J. Cell Biol. 194 323-34 PubMed GONUTS page
↑ ^18.0 ^18.1 Chih, B et al. (2005) Control of excitatory and inhibitory synapse formation by neuroligins. Science 307 1324-8 PubMed GONUTS page
↑ ^19.0 ^19.1 Varoqueaux, F et al. (2006) Neuroligins determine synapse maturation and function. Neuron 51 741-54 PubMed GONUTS page
↑ Biederer, T et al. (2002) SynCAM, a synaptic adhesion molecule that drives synapse assembly. Science 297 1525-31 PubMed GONUTS page
↑ Wentzel, C et al. (2013) mSYD1A, a mammalian synapse-defective-1 protein, regulates synaptogenic signaling and vesicle docking. Neuron 78 1012-23 PubMed GONUTS page
↑ Wilson, PM et al. (2010) Astn2, a novel member of the astrotactin gene family, regulates the trafficking of ASTN1 during glial-guided neuronal migration. J. Neurosci. 30 8529-40 PubMed GONUTS page

[PMID:21940442-1] 1.0 ^1.1 ^1.2 Mondin, M et al. (2011) Neurexin-neuroligin adhesions capture surface-diffusing AMPA receptors through PSD-95 scaffolds. J. Neurosci. 31 13500-15 PubMed GONUTS page

[PMID:20869594-2] 2.0 ^2.1 ^2.2 Chen, SX et al. (2010) Neurexin-neuroligin cell adhesion complexes contribute to synaptotropic dendritogenesis via growth stabilization mechanisms in vivo. Neuron 67 967-83 PubMed GONUTS page

[PMID:26440732-3] 3.0 ^3.1 Tristán-Clavijo, E et al. (2015) A truncating mutation in Alzheimer's disease inactivates neuroligin-1 synaptic function. Neurobiol. Aging 36 3171-3175 PubMed GONUTS page

[PMID:22960622-4] 4.0 ^4.1 Yeo, H et al. (2012) Developmental expression and subcellular distribution of synaptotagmin 11 in rat hippocampus. Neuroscience 225 35-43 PubMed GONUTS page

[PMID:26771491-5] Singh, SK et al. (2016) Astrocytes Assemble Thalamocortical Synapses by Bridging NRX1α and NL1 via Hevin. Cell 164 183-196 PubMed GONUTS page

[PMID:15620359-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 ^6.8 Graf, ER et al. (2004) Neurexins induce differentiation of GABA and glutamate postsynaptic specializations via neuroligins. Cell 119 1013-26 PubMed GONUTS page

[PMID:23143522-7] 7.0 ^7.1 ^7.2 ^7.3 Kwon, HB et al. (2012) Neuroligin-1-dependent competition regulates cortical synaptogenesis and synapse number. Nat. Neurosci. 15 1667-74 PubMed GONUTS page

[PMID:23716671-8] El Helou, J et al. (2013) Neuroligin-1 links neuronal activity to sleep-wake regulation. Proc. Natl. Acad. Sci. U.S.A. 110 9974-9 PubMed GONUTS page

[PMID:17582332-9] 9.0 ^9.1 ^9.2 ^9.3 Chubykin, AA et al. (2007) Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2. Neuron 54 919-31 PubMed GONUTS page

[PMID:19628693-10] 10.0 ^10.1 ^10.2 ^10.3 Wittenmayer, N et al. (2009) Postsynaptic Neuroligin1 regulates presynaptic maturation. Proc. Natl. Acad. Sci. U.S.A. 106 13564-9 PubMed GONUTS page

[PMID:12796785-11] 11.00 ^11.01 ^11.02 ^11.03 ^11.04 ^11.05 ^11.06 ^11.07 ^11.08 ^11.09 ^11.10 ^11.11 ^11.12 ^11.13 ^11.14 Dean, C et al. (2003) Neurexin mediates the assembly of presynaptic terminals. Nat. Neurosci. 6 708-16 PubMed GONUTS page

[PMID:10892652-12] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 ^12.6 ^12.7 ^12.8 Scheiffele, P et al. (2000) Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons. Cell 101 657-69 PubMed GONUTS page

[PMID:19098102-13] Heine, M et al. (2008) Activity-independent and subunit-specific recruitment of functional AMPA receptors at neurexin/neuroligin contacts. Proc. Natl. Acad. Sci. U.S.A. 105 20947-52 PubMed GONUTS page

[PMID:21873635-14] 14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 ^14.6 ^14.7 ^14.8 ^14.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21356198-15] Joo, JY et al. (2011) Differential interactions of cerebellin precursor protein (Cbln) subtypes and neurexin variants for synapse formation of cortical neurons. Biochem. Biophys. Res. Commun. 406 627-32 PubMed GONUTS page

[PMID:24613359-16] Um, JW et al. (2014) Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins. Cell Rep 6 1096-109 PubMed GONUTS page

[PMID:21788371-17] Ko, J et al. (2011) Neuroligins/LRRTMs prevent activity- and Ca2+/calmodulin-dependent synapse elimination in cultured neurons. J. Cell Biol. 194 323-34 PubMed GONUTS page

[PMID:15681343-18] 18.0 ^18.1 Chih, B et al. (2005) Control of excitatory and inhibitory synapse formation by neuroligins. Science 307 1324-8 PubMed GONUTS page

[PMID:16982420-19] 19.0 ^19.1 Varoqueaux, F et al. (2006) Neuroligins determine synapse maturation and function. Neuron 51 741-54 PubMed GONUTS page

[PMID:12202822-20] Biederer, T et al. (2002) SynCAM, a synaptic adhesion molecule that drives synapse assembly. Science 297 1525-31 PubMed GONUTS page

[PMID:23791195-21] Wentzel, C et al. (2013) mSYD1A, a mammalian synapse-defective-1 protein, regulates synaptogenic signaling and vesicle docking. Neuron 78 1012-23 PubMed GONUTS page

[PMID:20573900-22] Wilson, PM et al. (2010) Astn2, a novel member of the astrotactin gene family, regulates the trafficking of ASTN1 during glial-guided neuronal migration. J. Neurosci. 30 8529-40 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

[18]

[19]

[20]

[21]

[22]

MOUSE:NLGN1

Contents

Annotations

Notes

References

a

c

d

e

f

g

h

i

l

m

n

o

p

r

s

t

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools