MOUSE:NK2R

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Tacr2 (synonyms: Tac2r)
Protein Name(s)	Substance-K receptor SKR NK-2 receptor NK-2R Neurokinin A receptor Tachykinin receptor 2
External Links
UniProt	P30549
EMBL	X62933
CCDS	CCDS35919.1
PIR	S20303
RefSeq	NP_033340.3
UniGene	Mm.8054
ProteinModelPortal	P30549
SMR	P30549
BindingDB	P30549
ChEMBL	CHEMBL2813
GuidetoPHARMACOLOGY	361
PhosphoSite	P30549
PRIDE	P30549
Ensembl	ENSMUST00000020278
GeneID	21337
KEGG	mmu:21337
UCSC	uc007fgx.2
CTD	6865
MGI	MGI:98477
eggNOG	NOG331485
HOGENOM	HOG000013018
HOVERGEN	HBG103412
InParanoid	P30549
KO	K04223
OMA	LCMAAFN
OrthoDB	EOG7N37FW
PhylomeDB	P30549
TreeFam	TF315303
Reactome	REACT_207651 REACT_252339
NextBio	300504
PRO	PR:P30549
Proteomes	UP000000589
Bgee	P30549
CleanEx	MM_TACR2
ExpressionAtlas	P30549
Genevestigator	P30549
GO	GO:0016021 GO:0005886 GO:0016497 GO:0014827 GO:0033685 GO:0035106 GO:0014057 GO:0070474 GO:0043117 GO:0070459 GO:0051602
InterPro	IPR000276 IPR017452 IPR001681 IPR000913
Pfam	PF00001
PRINTS	PR00237 PR01025 PR00244
PROSITE	PS00237 PS50262

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0070472	positive regulation of uterine smooth muscle contraction	PMID:15647454^[1]	ECO:0000314			P	from figure 1 increasing amounts of NK2 were added to the uterine preparation prior to testing. Contractile force produced by the longitudinally oriented smooth muscle fibers was recorded by a Grass FT03 force transducer connected to a MacLab data acquisition system. Uterine preparations treated with larger amounts of NK2 displayed increased levels of contraction.	complete CACAO 1969
involved_in	GO:0070472	regulation of uterine smooth muscle contraction	PMID:15647454^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1902093	positive regulation of flagellated sperm motility	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002538240 UniProtKB:P21452 UniProtKB:P25103 UniProtKB:P29371	P	Seeded From UniProt	complete
part_of	GO:0097225	sperm midpiece	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002538240 UniProtKB:P21452 UniProtKB:P25103 UniProtKB:P29371	C	Seeded From UniProt	complete
enables	GO:0016497	substance K receptor activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002930710 RGD:3812	F	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001544873 RGD:3810 RGD:3811 UniProtKB:P21452 UniProtKB:P25103	C	Seeded From UniProt	complete
enables	GO:0004995	tachykinin receptor activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001544873 RGD:3810 RGD:3811 RGD:3812 UniProtKB:P25103 ZFIN:ZDB-GENE-061207-19 ZFIN:ZDB-GENE-090312-106	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902093	positive regulation of flagellated sperm motility	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21452	P	Seeded From UniProt	complete
part_of	GO:0097225	sperm midpiece	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21452	C	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070474	positive regulation of uterine smooth muscle contraction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3812	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070459	prolactin secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3812	P	Seeded From UniProt	complete
part_of	GO:0061827	sperm head	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21452	C	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043270	positive regulation of ion transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3812	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043117	positive regulation of vascular permeability	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3812	P	Seeded From UniProt	complete
part_of	GO:0036126	sperm flagellum	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21452	C	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035106	operant conditioning	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3812	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033685	negative regulation of luteinizing hormone secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3812	P	Seeded From UniProt	complete
enables	GO:0016497	substance K receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3812	F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3812	C	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014827	intestine smooth muscle contraction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3812	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014057	positive regulation of acetylcholine secretion, neurotransmission	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3812	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21452	C	Seeded From UniProt	complete
involved_in	GO:0007217	tachykinin receptor signaling pathway	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004995	P	Seeded From UniProt	complete
involved_in	GO:0007217	tachykinin receptor signaling pathway	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0016497	P	Seeded From UniProt	complete
involved_in	GO:0007217	tachykinin receptor signaling pathway	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0016497	P	Seeded From UniProt	complete
involved_in	GO:0007217	tachykinin receptor signaling pathway	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004995	P	Seeded From UniProt	complete
involved_in	GO:0007217	tachykinin receptor signaling pathway	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0016497	P	Seeded From UniProt	complete
involved_in	GO:0070474	positive regulation of uterine smooth muscle contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16610 ensembl:ENSRNOP00000067266	P	Seeded From UniProt	complete
involved_in	GO:0070459	prolactin secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16610 ensembl:ENSRNOP00000067266	P	Seeded From UniProt	complete
involved_in	GO:0051602	response to electrical stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16610 ensembl:ENSRNOP00000067266	P	Seeded From UniProt	complete
involved_in	GO:0043270	positive regulation of ion transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16610 ensembl:ENSRNOP00000067266	P	Seeded From UniProt	complete
involved_in	GO:0043117	positive regulation of vascular permeability	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16610 ensembl:ENSRNOP00000067266	P	Seeded From UniProt	complete
involved_in	GO:0035106	operant conditioning	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16610 ensembl:ENSRNOP00000067266	P	Seeded From UniProt	complete
involved_in	GO:0033685	negative regulation of luteinizing hormone secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16610 ensembl:ENSRNOP00000067266	P	Seeded From UniProt	complete
enables	GO:0016497	substance K receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16610 ensembl:ENSRNOP00000067266	F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16610 ensembl:ENSRNOP00000067266	C	Seeded From UniProt	complete
involved_in	GO:0014827	intestine smooth muscle contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16610 ensembl:ENSRNOP00000067266	P	Seeded From UniProt	complete
involved_in	GO:0014057	positive regulation of acetylcholine secretion, neurotransmission	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16610 ensembl:ENSRNOP00000067266	P	Seeded From UniProt	complete
involved_in	GO:1902093	positive regulation of flagellated sperm motility	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21452 ensembl:ENSP00000362403	P	Seeded From UniProt	complete
part_of	GO:0097225	sperm midpiece	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21452 ensembl:ENSP00000362403	C	Seeded From UniProt	complete
part_of	GO:0061827	sperm head	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21452 ensembl:ENSP00000362403	C	Seeded From UniProt	complete
part_of	GO:0036126	sperm flagellum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21452 ensembl:ENSP00000362403	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21452 ensembl:ENSP00000362403	C	Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276	F	Seeded From UniProt	complete
enables	GO:0004995	tachykinin receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000913 InterPro:IPR001681	F	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000913 InterPro:IPR001681	C	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276 InterPro:IPR000913 InterPro:IPR001681	P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276 InterPro:IPR000913 InterPro:IPR001681 InterPro:IPR017452	C	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	P	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0807	P	Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	F	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Patak, E et al. (2005) Functional and molecular characterization of tachykinins and tachykinin receptors in the mouse uterus. Biol. Reprod. 72 1125-33 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:15647454-1] 1.0 ^1.1 Patak, E et al. (2005) Functional and molecular characterization of tachykinins and tachykinin receptors in the mouse uterus. Biol. Reprod. 72 1125-33 PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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MOUSE:NK2R

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