MOUSE:NIPBL

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Nipbl
Protein Name(s)	Nipped-B-like protein Delangin homolog SCC2 homolog
External Links
UniProt	Q6KCD5
EMBL	AJ627033 AJ640138 AK014915 AK016861 AK049588 BC055787
CCDS	CCDS37035.1
RefSeq	NP_081983.2 NP_957684.1 XP_006520057.1 XP_006520058.1
UniGene	Mm.240329 Mm.440537
ProteinModelPortal	Q6KCD5
SMR	Q6KCD5
BioGrid	214531
DIP	DIP-56622N
IntAct	Q6KCD5
MINT	MINT-4104022
PhosphoSite	Q6KCD5
MaxQB	Q6KCD5
PaxDb	Q6KCD5
PRIDE	Q6KCD5
DNASU	71175
Ensembl	ENSMUST00000052965
GeneID	71175
KEGG	mmu:71175
UCSC	uc007veq.1 uc007ver.1 uc007vev.1
CTD	25836
MGI	MGI:1913976
eggNOG	NOG128278
GeneTree	ENSGT00390000010427
HOGENOM	HOG000113787
HOVERGEN	HBG052626
InParanoid	Q6KCD5
KO	K06672
OMA	KQKGESR
OrthoDB	EOG7CZK4Q
PhylomeDB	Q6KCD5
TreeFam	TF313121
Reactome	REACT_196634
NextBio	333221
PRO	PR:Q6KCD5
Proteomes	UP000000589
Bgee	Q6KCD5
CleanEx	MM_NIPBL
Genevestigator	Q6KCD5
GO	GO:0000785 GO:0070062 GO:0032116 GO:0003682 GO:0036033 GO:0007420 GO:0034613 GO:0006974 GO:0071481 GO:0050890 GO:0048589 GO:0042471 GO:0048701 GO:0048557 GO:0035115 GO:0048703 GO:0035261 GO:0048592 GO:0060325 GO:0045444 GO:0061010 GO:0007507 GO:0034088 GO:0000122 GO:0003151 GO:0031065 GO:0040018 GO:0045778 GO:0045944 GO:0048638 GO:0045995 GO:0042634 GO:0007605 GO:0019827 GO:0061038
Gene3D	1.25.10.10
InterPro	IPR011989 IPR016024 IPR026003 IPR024986
Pfam	PF12765 PF12830
SUPFAM	SSF48371

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0090694	Scc2-Scc4 cohesin loading complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q6KC79	C		Seeded From UniProt	complete
involved_in	GO:0071921	cohesin loading	PMID:29094699^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:29094699^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0032039	integrator complex	PMID:28041881^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	PMID:28041881^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2001224	positive regulation of neuron migration	PMID:28041881^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034088	maintenance of mitotic sister chromatid cohesion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q6KC79	P		Seeded From UniProt	complete
part_of	GO:0032116	SMC loading complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q6KC79	C		Seeded From UniProt	complete
involved_in	GO:1990414	replication-born double-strand break repair via sister chromatid exchange	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000496017 SGD:S000002588	P		Seeded From UniProt	complete
involved_in	GO:1905406	positive regulation of mitotic cohesin loading	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000496017 PomBase:SPAC31A2.05c	P		Seeded From UniProt	complete
part_of	GO:0090694	Scc2-Scc4 cohesin loading complex	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000496017 PomBase:SPAC31A2.05c UniProtKB:Q6KC79	C		Seeded From UniProt	complete
involved_in	GO:0071733	transcriptional activation by promoter-enhancer looping	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0026401 PANTHER:PTN000496017 ZFIN:ZDB-GENE-030131-6070 ZFIN:ZDB-GENE-060526-121	P		Seeded From UniProt	complete
involved_in	GO:0071169	establishment of protein localization to chromatin	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000496017 SGD:S000002588	P		Seeded From UniProt	complete
involved_in	GO:0070550	rDNA condensation	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000496017 SGD:S000002588	P		Seeded From UniProt	complete
involved_in	GO:0048703	embryonic viscerocranium morphogenesis	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1913976 PANTHER:PTN000496024	P		Seeded From UniProt	complete
involved_in	GO:0034087	establishment of mitotic sister chromatid cohesion	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000496017 SGD:S000002588	P		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1913976 PANTHER:PTN000496024	P		Seeded From UniProt	complete
involved_in	GO:0007420	brain development	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000496024 UniProtKB:Q6KC79	P		Seeded From UniProt	complete
involved_in	GO:0007076	mitotic chromosome condensation	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000496017 SGD:S000002588	P		Seeded From UniProt	complete
involved_in	GO:0007064	mitotic sister chromatid cohesion	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0026401 PANTHER:PTN000496017 UniProtKB:Q6KC79	P		Seeded From UniProt	complete
involved_in	GO:0006302	double-strand break repair	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000496017 SGD:S000002588	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0026401 MGI:MGI:1913976 PANTHER:PTN000496017 SGD:S000002588 UniProtKB:Q6KC79	C		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0026401 MGI:MGI:1913976 PANTHER:PTN000496017	F		Seeded From UniProt	complete
involved_in	GO:0003007	heart morphogenesis	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000496024 UniProtKB:Q6KC79	P		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000496017 SGD:S000002588	C		Seeded From UniProt	complete
part_of	GO:0000785	chromatin	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1913976 PANTHER:PTN000496017	C		Seeded From UniProt	complete
part_of	GO:0000228	nuclear chromosome	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000496017 PomBase:SPAC31A2.05c	C		Seeded From UniProt	complete
part_of	GO:0090694	Scc2-Scc4 cohesin loading complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6KC79	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071921	cohesin loading	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6KC79	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071481	cellular response to X-ray	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6KC79	P		Seeded From UniProt	complete
enables	GO:0070087	chromo shadow domain binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6KC79	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061038	uterus morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6KC79	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061010	gall bladder development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6KC79	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060325	face morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6KC79	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050890	cognition	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6KC79	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048703	embryonic viscerocranium morphogenesis	PMID:19763162^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4332250	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048701	embryonic cranial skeleton morphogenesis	PMID:19763162^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4332250	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048638	regulation of developmental growth	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6KC79	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048592	eye morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6KC79	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048589	developmental growth	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6KC79	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048557	embryonic digestive tract morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6KC79	P		Seeded From UniProt	complete
enables	GO:0047485	protein N-terminus binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6KC79	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045995	regulation of embryonic development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6KC79	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:23920377^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4332250	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6KC79	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045778	positive regulation of ossification	PMID:19763162^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4332250	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045444	fat cell differentiation	PMID:19763162^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4332250	P		Seeded From UniProt	complete
enables	GO:0042826	histone deacetylase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6KC79	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042634	regulation of hair cycle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6KC79	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042471	ear morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6KC79	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0040018	positive regulation of multicellular organism growth	PMID:19763162^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4332250	P		Seeded From UniProt	complete
enables	GO:0036033	mediator complex binding	PMID:20720539^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0002322)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035261	external genitalia morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6KC79	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035136	forelimb morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6KC79	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035115	embryonic forelimb morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6KC79	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034613	cellular protein localization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6KC79	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034088	maintenance of mitotic sister chromatid cohesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6KC79	P		Seeded From UniProt	complete
part_of	GO:0032116	SMC loading complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6KC79	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031065	positive regulation of histone deacetylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6KC79	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019827	stem cell population maintenance	PMID:20720539^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6KC79	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007605	sensory perception of sound	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6KC79	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007507	heart development	PMID:19763162^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4332250	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007420	brain development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6KC79	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007064	mitotic sister chromatid cohesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6KC79	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6KC79	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6KC79	C		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:20720539^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0002322) has_participant:(MGI:MGI:101893)\|occurs_in(CL:0002322) has_participant:(MGI:MGI:101893)\|occurs_in(CL:0002322) has_participant:(MGI:MGI:1919200)\|occurs_in(CL:0002322) has_participant:(MGI:MGI:1919200)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003151	outflow tract morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6KC79	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003007	heart morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6KC79	P		Seeded From UniProt	complete
part_of	GO:0000785	chromatin	PMID:23920377^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6KC79	P		Seeded From UniProt	complete
part_of	GO:0090694	Scc2-Scc4 cohesin loading complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6KC79 ensembl:ENSP00000282516	C		Seeded From UniProt	complete
involved_in	GO:0071921	cohesin loading	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6KC79 ensembl:ENSP00000282516	P		Seeded From UniProt	complete
involved_in	GO:0071481	cellular response to X-ray	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6KC79 ensembl:ENSP00000282516	P		Seeded From UniProt	complete
enables	GO:0070087	chromo shadow domain binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6KC79 ensembl:ENSP00000282516	F		Seeded From UniProt	complete
involved_in	GO:0061038	uterus morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6KC79 ensembl:ENSP00000282516	P		Seeded From UniProt	complete
involved_in	GO:0061010	gall bladder development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6KC79 ensembl:ENSP00000282516	P		Seeded From UniProt	complete
involved_in	GO:0060325	face morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6KC79 ensembl:ENSP00000282516	P		Seeded From UniProt	complete
involved_in	GO:0050890	cognition	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6KC79 ensembl:ENSP00000282516	P		Seeded From UniProt	complete
involved_in	GO:0048638	regulation of developmental growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6KC79 ensembl:ENSP00000282516	P		Seeded From UniProt	complete
involved_in	GO:0048592	eye morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6KC79 ensembl:ENSP00000282516	P		Seeded From UniProt	complete
involved_in	GO:0048589	developmental growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6KC79 ensembl:ENSP00000282516	P		Seeded From UniProt	complete
involved_in	GO:0048557	embryonic digestive tract morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6KC79 ensembl:ENSP00000282516	P		Seeded From UniProt	complete
enables	GO:0047485	protein N-terminus binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6KC79 ensembl:ENSP00000282516	F		Seeded From UniProt	complete
involved_in	GO:0045995	regulation of embryonic development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6KC79 ensembl:ENSP00000282516	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6KC79 ensembl:ENSP00000282516	P		Seeded From UniProt	complete
enables	GO:0042826	histone deacetylase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6KC79 ensembl:ENSP00000282516	F		Seeded From UniProt	complete
involved_in	GO:0042634	regulation of hair cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6KC79 ensembl:ENSP00000282516	P		Seeded From UniProt	complete
involved_in	GO:0042471	ear morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6KC79 ensembl:ENSP00000282516	P		Seeded From UniProt	complete
involved_in	GO:0035261	external genitalia morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6KC79 ensembl:ENSP00000282516	P		Seeded From UniProt	complete
involved_in	GO:0035136	forelimb morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6KC79 ensembl:ENSP00000282516	P		Seeded From UniProt	complete
involved_in	GO:0035115	embryonic forelimb morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6KC79 ensembl:ENSP00000282516	P		Seeded From UniProt	complete
involved_in	GO:0034613	cellular protein localization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6KC79 ensembl:ENSP00000282516	P		Seeded From UniProt	complete
involved_in	GO:0034088	maintenance of mitotic sister chromatid cohesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6KC79 ensembl:ENSP00000282516	P		Seeded From UniProt	complete
part_of	GO:0032116	SMC loading complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6KC79 ensembl:ENSP00000282516	C		Seeded From UniProt	complete
involved_in	GO:0031065	positive regulation of histone deacetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6KC79 ensembl:ENSP00000282516	P		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6KC79 ensembl:ENSP00000282516	F		Seeded From UniProt	complete
involved_in	GO:0007605	sensory perception of sound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6KC79 ensembl:ENSP00000282516	P		Seeded From UniProt	complete
involved_in	GO:0007420	brain development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6KC79 ensembl:ENSP00000282516	P		Seeded From UniProt	complete
involved_in	GO:0007064	mitotic sister chromatid cohesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6KC79 ensembl:ENSP00000282516	P		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6KC79 ensembl:ENSP00000282516	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6KC79 ensembl:ENSP00000282516	C		Seeded From UniProt	complete
involved_in	GO:0003151	outflow tract morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6KC79 ensembl:ENSP00000282516	P		Seeded From UniProt	complete
involved_in	GO:0003007	heart morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6KC79 ensembl:ENSP00000282516	P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6KC79 ensembl:ENSP00000282516	P		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR033031	F		Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR033031	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
part_of	GO:0005694	chromosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0158 UniProtKB-SubCell:SL-0468	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Schwarzer, W et al. (2017) Two independent modes of chromatin organization revealed by cohesin removal. Nature 551 51-56 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 van den Berg, DLC et al. (2017) Nipbl Interacts with Zfp609 and the Integrator Complex to Regulate Cortical Neuron Migration. Neuron 93 348-361 PubMed GONUTS page
↑ ^3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 ^3.11 ^3.12 ^3.13 ^3.14 ^3.15 ^3.16 ^3.17 ^3.18 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Kawauchi, S et al. (2009) Multiple organ system defects and transcriptional dysregulation in the Nipbl(+/-) mouse, a model of Cornelia de Lange Syndrome. PLoS Genet. 5 e1000650 PubMed GONUTS page
↑ ^5.0 ^5.1 Remeseiro, S et al. (2013) Reduction of Nipbl impairs cohesin loading locally and affects transcription but not cohesion-dependent functions in a mouse model of Cornelia de Lange Syndrome. Biochim. Biophys. Acta 1832 2097-102 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Kagey, MH et al. (2010) Mediator and cohesin connect gene expression and chromatin architecture. Nature 467 430-5 PubMed GONUTS page

[PMID:29094699-1] 1.0 ^1.1 Schwarzer, W et al. (2017) Two independent modes of chromatin organization revealed by cohesin removal. Nature 551 51-56 PubMed GONUTS page

[PMID:28041881-2] 2.0 ^2.1 ^2.2 van den Berg, DLC et al. (2017) Nipbl Interacts with Zfp609 and the Integrator Complex to Regulate Cortical Neuron Migration. Neuron 93 348-361 PubMed GONUTS page

[PMID:21873635-3] 3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 ^3.11 ^3.12 ^3.13 ^3.14 ^3.15 ^3.16 ^3.17 ^3.18 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:19763162-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Kawauchi, S et al. (2009) Multiple organ system defects and transcriptional dysregulation in the Nipbl(+/-) mouse, a model of Cornelia de Lange Syndrome. PLoS Genet. 5 e1000650 PubMed GONUTS page

[PMID:23920377-5] 5.0 ^5.1 Remeseiro, S et al. (2013) Reduction of Nipbl impairs cohesin loading locally and affects transcription but not cohesion-dependent functions in a mouse model of Cornelia de Lange Syndrome. Biochim. Biophys. Acta 1832 2097-102 PubMed GONUTS page

[PMID:20720539-6] 6.0 ^6.1 ^6.2 Kagey, MH et al. (2010) Mediator and cohesin connect gene expression and chromatin architecture. Nature 467 430-5 PubMed GONUTS page

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