MOUSE:NFL

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Nefl (synonyms: Nf68, Nfl)
Protein Name(s)	Neurofilament light polypeptide NF-L 68 kDa neurofilament protein Neurofilament triplet L protein
External Links
UniProt	P08551
EMBL	M20480 M13016 DQ201635 BC029203 AH002053 X02165
CCDS	CCDS27232.1
PIR	A25227
RefSeq	NP_035040.1
UniGene	Mm.1956
ProteinModelPortal	P08551
SMR	P08551
BioGrid	201757
DIP	DIP-31944N
IntAct	P08551
MINT	MINT-4116847
STRING	10090.ENSMUSP00000022639
PhosphoSite	P08551
UCD-2DPAGE	P08551
MaxQB	P08551
PaxDb	P08551
PRIDE	P08551
Ensembl	ENSMUST00000022639
GeneID	18039
KEGG	mmu:18039
UCSC	uc007uln.1
CTD	4747
MGI	MGI:97313
eggNOG	NOG145720
GeneTree	ENSGT00760000118905
HOGENOM	HOG000230977
HOVERGEN	HBG013015
InParanoid	P08551
KO	K04572
OMA	MDVSTKP
OrthoDB	EOG7FV3Q8
PhylomeDB	P08551
TreeFam	TF330122
ChiTaRS	Nefl
NextBio	293145
PRO	PR:P08551
Proteomes	UP000000589
Bgee	P08551
CleanEx	MM_NEFL
Genevestigator	P08551
GO	GO:0030424 GO:0005737 GO:0030426 GO:0005882 GO:0005883 GO:0043005 GO:0033596 GO:0030674 GO:0005200 GO:0008089 GO:0019896 GO:0045110 GO:0045109 GO:0040011 GO:0000226 GO:0043524 GO:0033693 GO:0060052 GO:0050885 GO:0048812 GO:0014012 GO:0050772 GO:0051258 GO:0031133 GO:0051412 GO:0043434 GO:0009636 GO:0008090
InterPro	IPR001664 IPR006821 IPR018039 IPR027692
PANTHER	PTHR23239 PTHR23239:SF22
Pfam	PF00038 PF04732
PROSITE	PS00226

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0043209	myelin sheath	PMID:17634366^[1]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000128)	Seeded From UniProt	complete
involved_in	GO:0045110	intermediate filament bundle assembly	PMID:11034913^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P16884	P		Seeded From UniProt	complete
enables	GO:0030674	protein binding, bridging	PMID:11034913^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005882	intermediate filament	PMID:11034913^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:11034913^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005200	structural constituent of cytoskeleton	PMID:11034913^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0099184	structural constituent of postsynaptic intermediate filament cytoskeleton	PMID:25869803^[3]	ECO:0001225	knockout evidence used in manual assertion		F	occurs_in:(GO:0098685) occurs_in:(UBERON:0000061)	Seeded From UniProt	complete
part_of	GO:0099182	presynaptic intermediate filament cytoskeleton	PMID:25232125^[4]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(GO:0031594) part_of:(UBERON:0000061)	Seeded From UniProt	complete
part_of	GO:0099160	postsynaptic intermediate filament cytoskeleton	PMID:25869803^[3]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0099160	postsynaptic intermediate filament cytoskeleton	PMID:25869803^[3]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(UBERON:0000061) part_of:(UBERON:0002435)	Seeded From UniProt	complete
part_of	GO:0098981	cholinergic synapse	PMID:25232125^[4]	ECO:0005589	confocal microscopy evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0098981	cholinergic synapse	PMID:25232125^[4]	ECO:0001225	knockout evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0098685	Schaffer collateral - CA1 synapse	PMID:25869803^[3]	ECO:0001225	knockout evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0060074	synapse maturation	PMID:25232125^[4]	ECO:0005589	confocal microscopy evidence used in manual assertion		P	occurs_in:(GO:0098981) occurs_in:(UBERON:0000061)	Seeded From UniProt	complete
involved_in	GO:0060074	synapse maturation	PMID:25232125^[4]	ECO:0005589	confocal microscopy evidence used in manual assertion		P	occurs_in:(GO:0031594) occurs_in:(UBERON:0000061)	Seeded From UniProt	complete
involved_in	GO:0060074	synapse maturation	PMID:25232125^[4]	ECO:0001225	knockout evidence used in manual assertion		P	occurs_in:(GO:0098981) occurs_in:(UBERON:0000061)	Seeded From UniProt	complete
involved_in	GO:0060074	synapse maturation	PMID:25232125^[4]	ECO:0001225	knockout evidence used in manual assertion		P	occurs_in:(GO:0031594) occurs_in:(UBERON:0000061)	Seeded From UniProt	complete
part_of	GO:0031594	neuromuscular junction	PMID:25232125^[4]	ECO:0005589	confocal microscopy evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0031594	neuromuscular junction	PMID:25232125^[4]	ECO:0001225	knockout evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903935	response to sodium arsenite	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621458	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060052	neurofilament cytoskeleton organization	PMID:11343650^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98351	P	occurs_in:(EMAPA:35794) occurs_in:(CL:0000100)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060052	neurofilament cytoskeleton organization	PMID:10461886^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97309 MGI:MGI:97314	P	occurs_in:(EMAPA:17577) occurs_in:(CL:0000540)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060052	neurofilament cytoskeleton organization	PMID:10350642^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:96568	P	occurs_in:(EMAPA:17575) occurs_in:(CL:0000540)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060052	neurofilament cytoskeleton organization	PMID:9398473^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2180095	P	occurs_in:(EMAPA:18577) occurs_in:(CL:0000111)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060052	neurofilament cytoskeleton organization	PMID:16920084^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2180095	P	occurs_in:(EMAPA:35794) occurs_in:(CL:0000540)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060052	neurofilament cytoskeleton organization	PMID:15132161^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2180095	P	occurs_in:(EMAPA:17577) occurs_in:(CL:0000540)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060052	neurofilament cytoskeleton organization	PMID:14561875^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2180095	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060052	neurofilament cytoskeleton organization	PMID:11487626^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2180095	P	occurs_in:(EMAPA:17577) occurs_in:(CL:0000540)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051258	protein polymerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621458	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050885	neuromuscular process controlling balance	PMID:15884021^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2180095	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050772	positive regulation of axonogenesis	PMID:7946341^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_occurs_in:(EMAPA:17577) regulates_o_occurs_in:(CL:0000100)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048812	neuron projection morphogenesis	PMID:10884316^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2180095	P	occurs_in:(EMAPA:17577) occurs_in:(CL:0000540)	Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621458	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045110	intermediate filament bundle assembly	PMID:10461886^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97309 MGI:MGI:97314	P	occurs_in:(EMAPA:17577) occurs_in:(CL:0000540)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045109	intermediate filament organization	PMID:7946341^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(EMAPA:17577) occurs_in:(CL:0000100)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045109	intermediate filament organization	PMID:2121744^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045109	intermediate filament organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P07196	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045105	intermediate filament polymerization or depolymerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621458	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043524	negative regulation of neuron apoptotic process	PMID:7946341^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(EMAPA:17577) regulates_o_occurs_in:(CL:0000100)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043524	negative regulation of neuron apoptotic process	PMID:10884316^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2180095	P	occurs_in:(EMAPA:17577) regulates_o_occurs_in:(CL:0000100)	Seeded From UniProt	complete
enables	GO:0043274	phospholipase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621458	F		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:19646951^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:11834298^[18]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000540)	Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621458	C		Seeded From UniProt	complete
colocalizes_with	GO:0043005	neuron projection	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621458	C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P07196	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0040011	locomotion	PMID:15132161^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2180095	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033693	neurofilament bundle assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P07196	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033693	neurofilament bundle assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621458	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031133	regulation of axon diameter	PMID:9398473^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2180095	P	regulates_o_has_participant:(EMAPA:18577) regulates_o_has_participant:(CL:0000111)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031133	regulation of axon diameter	PMID:11343650^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2180095	P	regulates_o_has_participant:(EMAPA:35794) regulates_o_has_participant:(CL:0000100)	Seeded From UniProt	complete
part_of	GO:0030426	growth cone	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621458	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:8821035^[19]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17185) part_of:(CL:0000111)	Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:8110465^[20]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17575) part_of:(CL:0000540)	Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P07196	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621458	C		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621458	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019896	axonal transport of mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P07196	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014012	peripheral nervous system axon regeneration	PMID:9398473^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2180095	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008090	retrograde axonal transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P07196	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008089	anterograde axonal transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P07196	P		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P07196	F		Seeded From UniProt	complete
part_of	GO:0005883	neurofilament	PMID:8821035^[19]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17185) part_of:(CL:0000111)	Seeded From UniProt	complete
part_of	GO:0005883	neurofilament	PMID:15242779^[21]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005883	neurofilament	PMID:10221457^[22]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16247) part_of:(CL:0000029)\|part_of:(EMAPA:16247) part_of:(CL:0000029)\|part_of:(EMAPA:16247) part_of:(CL:0000029)	Seeded From UniProt	complete
part_of	GO:0005883	neurofilament	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P07196	C		Seeded From UniProt	complete
part_of	GO:0005883	neurofilament	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621458	C		Seeded From UniProt	complete
part_of	GO:0005882	intermediate filament	PMID:2493000^[23]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005200	structural constituent of cytoskeleton	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P07196	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000226	microtubule cytoskeleton organization	PMID:11487626^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2180095	P	occurs_in:(EMAPA:17577) occurs_in:(CL:0000540)	Seeded From UniProt	complete
involved_in	GO:0099185	postsynaptic intermediate filament cytoskeleton organization	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0099184	P		Seeded From UniProt	complete
part_of	GO:1904115	axon cytoplasm	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0019896	C		Seeded From UniProt	complete
part_of	GO:1904115	axon cytoplasm	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0019896	C		Seeded From UniProt	complete
part_of	GO:1904115	axon cytoplasm	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008089	C		Seeded From UniProt	complete
involved_in	GO:0045109	intermediate filament organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07196 ensembl:ENSP00000482169	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07196 ensembl:ENSP00000482169	F		Seeded From UniProt	complete
involved_in	GO:0033693	neurofilament bundle assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07196 ensembl:ENSP00000482169	P		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07196 ensembl:ENSP00000482169	C		Seeded From UniProt	complete
involved_in	GO:0019896	axonal transport of mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07196 ensembl:ENSP00000482169	P		Seeded From UniProt	complete
involved_in	GO:0008090	retrograde axonal transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07196 ensembl:ENSP00000482169	P		Seeded From UniProt	complete
involved_in	GO:0008089	anterograde axonal transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07196 ensembl:ENSP00000482169	P		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07196 ensembl:ENSP00000482169	F		Seeded From UniProt	complete
part_of	GO:0005883	neurofilament	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07196 ensembl:ENSP00000482169	C		Seeded From UniProt	complete
enables	GO:0005200	structural constituent of cytoskeleton	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07196 ensembl:ENSP00000482169	F		Seeded From UniProt	complete
involved_in	GO:1903937	response to acrylamide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19527 ensembl:ENSRNOP00000018599	P		Seeded From UniProt	complete
involved_in	GO:1903935	response to sodium arsenite	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19527 ensembl:ENSRNOP00000018599	P		Seeded From UniProt	complete
involved_in	GO:0051412	response to corticosterone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19527 ensembl:ENSRNOP00000018599	P		Seeded From UniProt	complete
involved_in	GO:0051258	protein polymerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19527 ensembl:ENSRNOP00000018599	P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19527 ensembl:ENSRNOP00000018599	F		Seeded From UniProt	complete
involved_in	GO:0045105	intermediate filament polymerization or depolymerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19527 ensembl:ENSRNOP00000018599	P		Seeded From UniProt	complete
involved_in	GO:0043434	response to peptide hormone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19527 ensembl:ENSRNOP00000018599	P		Seeded From UniProt	complete
enables	GO:0043274	phospholipase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19527 ensembl:ENSRNOP00000018599	F		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19527 ensembl:ENSRNOP00000018599	C		Seeded From UniProt	complete
involved_in	GO:0033693	neurofilament bundle assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19527 ensembl:ENSRNOP00000018599	P		Seeded From UniProt	complete
part_of	GO:0030426	growth cone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19527 ensembl:ENSRNOP00000018599	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19527 ensembl:ENSRNOP00000018599	C		Seeded From UniProt	complete
involved_in	GO:0021987	cerebral cortex development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19527 ensembl:ENSRNOP00000018599	P		Seeded From UniProt	complete
involved_in	GO:0021766	hippocampus development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19527 ensembl:ENSRNOP00000018599	P		Seeded From UniProt	complete
involved_in	GO:0021510	spinal cord development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19527 ensembl:ENSRNOP00000018599	P		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19527 ensembl:ENSRNOP00000018599	F		Seeded From UniProt	complete
involved_in	GO:0010033	response to organic substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19527 ensembl:ENSRNOP00000018599	P		Seeded From UniProt	complete
involved_in	GO:0009636	response to toxic substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19527 ensembl:ENSRNOP00000018599	P		Seeded From UniProt	complete
part_of	GO:0005883	neurofilament	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19527 ensembl:ENSRNOP00000018599	C		Seeded From UniProt	complete
enables	GO:0005198	structural molecule activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001664	F		Seeded From UniProt	complete
part_of	GO:0005882	intermediate filament	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001664 InterPro:IPR006821	C		Seeded From UniProt	complete
part_of	GO:0005883	neurofilament	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027692	C		Seeded From UniProt	complete
involved_in	GO:0061564	axon development	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027692	P		Seeded From UniProt	complete
part_of	GO:0005882	intermediate filament	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0403	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Werner, HB et al. (2007) Proteolipid protein is required for transport of sirtuin 2 into CNS myelin. J. Neurosci. 27 7717-30 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Chen, J et al. (2000) The C-terminal tail domain of neurofilament protein-H (NF-H) forms the crossbridges and regulates neurofilament bundle formation. J. Cell. Sci. 113 Pt 21 3861-9 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Yuan, A et al. (2015) Neurofilament subunits are integral components of synapses and modulate neurotransmission and behavior in vivo. Mol. Psychiatry 20 986-94 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 ^4.8 Roche, SL et al. (2014) Loss of glial neurofascin155 delays developmental synapse elimination at the neuromuscular junction. J. Neurosci. 34 12904-18 PubMed GONUTS page
↑ ^5.0 ^5.1 Nguyen, MD et al. (2001) Deregulation of Cdk5 in a mouse model of ALS: toxicity alleviated by perikaryal neurofilament inclusions. Neuron 30 135-47 PubMed GONUTS page
↑ ^6.0 ^6.1 Jacomy, H et al. (1999) Disruption of type IV intermediate filament network in mice lacking the neurofilament medium and heavy subunits. J. Neurochem. 73 972-84 PubMed GONUTS page
↑ Levavasseur, F et al. (1999) No requirement of alpha-internexin for nervous system development and for radial growth of axons. Brain Res. Mol. Brain Res. 69 104-12 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Zhu, Q et al. (1997) Delayed maturation of regenerating myelinated axons in mice lacking neurofilaments. Exp. Neurol. 148 299-316 PubMed GONUTS page
↑ Li, ZH et al. (2006) Mice with targeted disruption of neurofilament light subunit display formation of protein aggregation in motoneurons and downregulation of complement receptor type 3 alpha subunit in microglia in the spinal cord at their earlier age: a possible feature in pre-clinical development of neurodegenerative diseases. Brain Res. 1113 200-9 PubMed GONUTS page
↑ ^10.0 ^10.1 Beaulieu, JM et al. (1999) Late onset of motor neurons in mice overexpressing wild-type peripherin. J. Cell Biol. 147 531-44 PubMed GONUTS page
↑ Yuan, A et al. (2003) Neurofilament transport in vivo minimally requires hetero-oligomer formation. J. Neurosci. 23 9452-8 PubMed GONUTS page
↑ ^12.0 ^12.1 Ishihara, T et al. (2001) Attenuated neurodegenerative disease phenotype in tau transgenic mouse lacking neurofilaments. J. Neurosci. 21 6026-35 PubMed GONUTS page
↑ Dubois, M et al. (2005) Mice with the deleted neurofilament of low molecular weight (Nefl) gene: 2. Effects on motor functions and spatial orientation. J. Neurosci. Res. 80 751-8 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 Lee, MK et al. (1994) A mutant neurofilament subunit causes massive, selective motor neuron death: implications for the pathogenesis of human motor neuron disease. Neuron 13 975-88 PubMed GONUTS page
↑ ^15.0 ^15.1 Beaulieu, JM et al. (2000) Formation of intermediate filament protein aggregates with disparate effects in two transgenic mouse models lacking the neurofilament light subunit. J. Neurosci. 20 5321-8 PubMed GONUTS page
↑ Gill, SR et al. (1990) Assembly properties of dominant and recessive mutations in the small mouse neurofilament (NF-L) subunit. J. Cell Biol. 111 2005-19 PubMed GONUTS page
↑ Smorodchenko, A et al. (2009) Comparative analysis of uncoupling protein 4 distribution in various tissues under physiological conditions and during development. Biochim. Biophys. Acta 1788 2309-19 PubMed GONUTS page
↑ Kuramochi, Y et al. (2002) Characterization of mouse homolog of brain acyl-CoA hydrolase: molecular cloning and neuronal localization. Brain Res. Mol. Brain Res. 98 81-92 PubMed GONUTS page
↑ ^19.0 ^19.1 Butz, S & Larue, L (1995) Expression of catenins during mouse embryonic development and in adult tissues. Cell Adhes. Commun. 3 337-52 PubMed GONUTS page
↑ Eyer, J & Peterson, A (1994) Neurofilament-deficient axons and perikaryal aggregates in viable transgenic mice expressing a neurofilament-beta-galactosidase fusion protein. Neuron 12 389-405 PubMed GONUTS page
↑ Gu, L et al. (2004) In vitro assembly properties of mutant and chimeric intermediate filament proteins: insight into the function of sequences in the rod and end domains of IF. Exp. Cell Res. 298 249-61 PubMed GONUTS page
↑ Faussone-Pellegrini, MS et al. (1999) The cytoskeleton of the myenteric neurons during murine embryonic life. Anat. Embryol. 199 459-69 PubMed GONUTS page
↑ Monteiro, MJ & Cleveland, DW (1989) Expression of NF-L and NF-M in fibroblasts reveals coassembly of neurofilament and vimentin subunits. J. Cell Biol. 108 579-93 PubMed GONUTS page

[PMID:17634366-1] Werner, HB et al. (2007) Proteolipid protein is required for transport of sirtuin 2 into CNS myelin. J. Neurosci. 27 7717-30 PubMed GONUTS page

[PMID:11034913-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Chen, J et al. (2000) The C-terminal tail domain of neurofilament protein-H (NF-H) forms the crossbridges and regulates neurofilament bundle formation. J. Cell. Sci. 113 Pt 21 3861-9 PubMed GONUTS page

[PMID:25869803-3] 3.0 ^3.1 ^3.2 ^3.3 Yuan, A et al. (2015) Neurofilament subunits are integral components of synapses and modulate neurotransmission and behavior in vivo. Mol. Psychiatry 20 986-94 PubMed GONUTS page

[PMID:25232125-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 ^4.8 Roche, SL et al. (2014) Loss of glial neurofascin155 delays developmental synapse elimination at the neuromuscular junction. J. Neurosci. 34 12904-18 PubMed GONUTS page

[PMID:11343650-5] 5.0 ^5.1 Nguyen, MD et al. (2001) Deregulation of Cdk5 in a mouse model of ALS: toxicity alleviated by perikaryal neurofilament inclusions. Neuron 30 135-47 PubMed GONUTS page

[PMID:10461886-6] 6.0 ^6.1 Jacomy, H et al. (1999) Disruption of type IV intermediate filament network in mice lacking the neurofilament medium and heavy subunits. J. Neurochem. 73 972-84 PubMed GONUTS page

[PMID:10350642-7] Levavasseur, F et al. (1999) No requirement of alpha-internexin for nervous system development and for radial growth of axons. Brain Res. Mol. Brain Res. 69 104-12 PubMed GONUTS page

[PMID:9398473-8] 8.0 ^8.1 ^8.2 Zhu, Q et al. (1997) Delayed maturation of regenerating myelinated axons in mice lacking neurofilaments. Exp. Neurol. 148 299-316 PubMed GONUTS page

[PMID:16920084-9] Li, ZH et al. (2006) Mice with targeted disruption of neurofilament light subunit display formation of protein aggregation in motoneurons and downregulation of complement receptor type 3 alpha subunit in microglia in the spinal cord at their earlier age: a possible feature in pre-clinical development of neurodegenerative diseases. Brain Res. 1113 200-9 PubMed GONUTS page

[PMID:15132161-10] 10.0 ^10.1 Beaulieu, JM et al. (1999) Late onset of motor neurons in mice overexpressing wild-type peripherin. J. Cell Biol. 147 531-44 PubMed GONUTS page

[PMID:14561875-11] Yuan, A et al. (2003) Neurofilament transport in vivo minimally requires hetero-oligomer formation. J. Neurosci. 23 9452-8 PubMed GONUTS page

[PMID:11487626-12] 12.0 ^12.1 Ishihara, T et al. (2001) Attenuated neurodegenerative disease phenotype in tau transgenic mouse lacking neurofilaments. J. Neurosci. 21 6026-35 PubMed GONUTS page

[PMID:15884021-13] Dubois, M et al. (2005) Mice with the deleted neurofilament of low molecular weight (Nefl) gene: 2. Effects on motor functions and spatial orientation. J. Neurosci. Res. 80 751-8 PubMed GONUTS page

[PMID:7946341-14] 14.0 ^14.1 ^14.2 Lee, MK et al. (1994) A mutant neurofilament subunit causes massive, selective motor neuron death: implications for the pathogenesis of human motor neuron disease. Neuron 13 975-88 PubMed GONUTS page

[PMID:10884316-15] 15.0 ^15.1 Beaulieu, JM et al. (2000) Formation of intermediate filament protein aggregates with disparate effects in two transgenic mouse models lacking the neurofilament light subunit. J. Neurosci. 20 5321-8 PubMed GONUTS page

[PMID:2121744-16] Gill, SR et al. (1990) Assembly properties of dominant and recessive mutations in the small mouse neurofilament (NF-L) subunit. J. Cell Biol. 111 2005-19 PubMed GONUTS page

[PMID:19646951-17] Smorodchenko, A et al. (2009) Comparative analysis of uncoupling protein 4 distribution in various tissues under physiological conditions and during development. Biochim. Biophys. Acta 1788 2309-19 PubMed GONUTS page

[PMID:11834298-18] Kuramochi, Y et al. (2002) Characterization of mouse homolog of brain acyl-CoA hydrolase: molecular cloning and neuronal localization. Brain Res. Mol. Brain Res. 98 81-92 PubMed GONUTS page

[PMID:8821035-19] 19.0 ^19.1 Butz, S & Larue, L (1995) Expression of catenins during mouse embryonic development and in adult tissues. Cell Adhes. Commun. 3 337-52 PubMed GONUTS page

[PMID:8110465-20] Eyer, J & Peterson, A (1994) Neurofilament-deficient axons and perikaryal aggregates in viable transgenic mice expressing a neurofilament-beta-galactosidase fusion protein. Neuron 12 389-405 PubMed GONUTS page

[PMID:15242779-21] Gu, L et al. (2004) In vitro assembly properties of mutant and chimeric intermediate filament proteins: insight into the function of sequences in the rod and end domains of IF. Exp. Cell Res. 298 249-61 PubMed GONUTS page

[PMID:10221457-22] Faussone-Pellegrini, MS et al. (1999) The cytoskeleton of the myenteric neurons during murine embryonic life. Anat. Embryol. 199 459-69 PubMed GONUTS page

[PMID:2493000-23] Monteiro, MJ & Cleveland, DW (1989) Expression of NF-L and NF-M in fibroblasts reveals coassembly of neurofilament and vimentin subunits. J. Cell Biol. 108 579-93 PubMed GONUTS page

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