MOUSE:NET1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Ntn1
Protein Name(s)	Netrin-1
External Links
UniProt	O09118
EMBL	U65418 AF128865 AL669842 AL606831 AL662894 AL606831 AL662894 AL669842 AL662894 AL606831 AL669842 CH466601 BC141294 U23505
CCDS	CCDS24864.1
RefSeq	NP_032770.2
UniGene	Mm.39095
ProteinModelPortal	O09118
SMR	O09118
IntAct	O09118
STRING	10090.ENSMUSP00000021284
PhosphoSite	O09118
MaxQB	O09118
PRIDE	O09118
Ensembl	ENSMUST00000021284 ENSMUST00000108674
GeneID	18208
KEGG	mmu:18208
UCSC	uc007jnm.1
CTD	9423
MGI	MGI:105088
eggNOG	NOG244580
GeneTree	ENSGT00760000118860
HOGENOM	HOG000286017
HOVERGEN	HBG006464
InParanoid	O09118
KO	K06843
OMA	WQSENFV
OrthoDB	EOG7SR4KJ
TreeFam	TF352481
Reactome	REACT_229826 REACT_230631 REACT_243212 REACT_248291 REACT_253341
NextBio	293590
PRO	PR:O09118
Proteomes	UP000000589
Bgee	O09118
CleanEx	MM_NTN1
ExpressionAtlas	O09118
Genevestigator	O09118
GO	GO:0005604 GO:0071944 GO:0005737 GO:0005576 GO:0033564 GO:0006915 GO:0007411 GO:0007409 GO:0040023 GO:0042472 GO:0030879 GO:0060603 GO:0030517 GO:0001764 GO:0045773 GO:0008284 GO:0030334 GO:0016337
Gene3D	2.60.120.260
InterPro	IPR013032 IPR002049 IPR008979 IPR008211 IPR001134 IPR018933 IPR008993
Pfam	PF00053 PF00055 PF01759
SMART	SM00643 SM00180 SM00136
SUPFAM	SSF49785 SSF50242
PROSITE	PS00022 PS01248 PS50027 PS51117 PS50189

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:22159717^[1]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0002048)	Seeded From UniProt	complete
enables	GO:0005201	extracellular matrix structural constituent	PMID:22159717^[1]	ECO:0007666	automatically integrated combinatorial computational and experimental evidence used in manual assertion		F	occurs_in:(UBERON:0002048)	Seeded From UniProt	complete
involved_in	GO:0061643	chemorepulsion of axon	PMID:28483977^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000147	positive regulation of cell motility	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q924Z9	P		Seeded From UniProt	complete
involved_in	GO:0032488	Cdc42 protein signal transduction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q924Z9	P		Seeded From UniProt	complete
involved_in	GO:0007265	Ras protein signal transduction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q924Z9	P		Seeded From UniProt	complete
involved_in	GO:0006930	substrate-dependent cell migration, cell extension	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q924Z9	P		Seeded From UniProt	complete
involved_in	GO:0051963	regulation of synapse assembly	PMID:24174661^[3]	ECO:0006063	over expression analysis evidence used in manual assertion		P	occurs_in:(UBERON:0000061) occurs_in:(UBERON:0000956)	Seeded From UniProt	complete
involved_in	GO:0051963	regulation of synapse assembly	PMID:24174661^[3]	ECO:0006062	wide-field fluorescence microscopy evidence used in manual assertion		P	occurs_in:(UBERON:0000061) occurs_in:(UBERON:0000956)	Seeded From UniProt	complete
involved_in	GO:0051963	regulation of synapse assembly	PMID:24174661^[3]	ECO:0006054	pharmacological assay evidence used in manual assertion		P	occurs_in:(UBERON:0000061) occurs_in:(UBERON:0000956)	Seeded From UniProt	complete
involved_in	GO:0051963	regulation of synapse assembly	PMID:24174661^[3]	ECO:0006013	patch-clamp recording evidence used in manual assertion		P	occurs_in:(UBERON:0000061) occurs_in:(UBERON:0000956)	Seeded From UniProt	complete
involved_in	GO:0051963	regulation of synapse assembly	PMID:24174661^[3]	ECO:0001225	knockout evidence used in manual assertion		P	occurs_in:(UBERON:0000061) occurs_in:(UBERON:0000956)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000147	positive regulation of cell motility	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619809	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0098609	cell-cell adhesion	PMID:16439476^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1315205	P		Seeded From UniProt	complete
part_of	GO:0071944	cell periphery	PMID:16455951^[5]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q90922	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060603	mammary gland duct morphogenesis	PMID:16439476^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1315205	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045773	positive regulation of axon extension	PMID:10704383^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045773	positive regulation of axon extension	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619809	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042472	inner ear morphogenesis	PMID:17616930^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2137018	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033564	anterior/posterior axon guidance	PMID:18479186^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032488	Cdc42 protein signal transduction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619809	P		Seeded From UniProt	complete
part_of	GO:0031012	extracellular matrix	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619809	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030879	mammary gland development	PMID:18425773^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97762	P	results_in_development_of:(EMAPA:17759)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030517	negative regulation of axon extension	PMID:10704383^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030334	regulation of cell migration	PMID:16481423^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1927548	P	regulates_o_occurs_in:(EMAPA:17577) regulates_o_results_in_movement_of:(CL:0000128)\|regulates_o_occurs_in(EMAPA:17787) regulates_o_results_in_movement_of:(CL:0000128)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030334	regulation of cell migration	PMID:10704383^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	PMID:16481423^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1927548	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007411	axon guidance	PMID:17898206^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1927548	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007411	axon guidance	PMID:16481423^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1927548	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007411	axon guidance	PMID:10908620^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1927548	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007411	axon guidance	PMID:17086203^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007411	axon guidance	PMID:12679031^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007411	axon guidance	PMID:12051827^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007409	axonogenesis	PMID:10908620^[12]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(EMAPA:17540) occurs_in:(CL:0000117)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007265	Ras protein signal transduction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619809	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007097	nuclear migration	PMID:12051827^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006930	substrate-dependent cell migration, cell extension	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619809	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:18425773^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17760)	Seeded From UniProt	complete
part_of	GO:0005604	basement membrane	PMID:18757743^[16]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:18547)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001764	neuron migration	PMID:16267219^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1927548	P	occurs_in:(EMAPA:16525) results_in_movement_of:(CL:0000741)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001764	neuron migration	PMID:14750959^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1927548	P	occurs_in:(EMAPA:16895) results_in_movement_of:(CL:0000110)\|occurs_in(EMAPA:16895) results_in_movement_of:(CL:0000117)\|occurs_in(EMAPA:17612) results_in_movement_of:(CL:0000110)\|occurs_in(EMAPA:17612) results_in_movement_of:(CL:0000117)	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-MMU-9011252 Reactome:R-MMU-9011231 Reactome:R-MMU-593695 Reactome:R-MMU-451348 Reactome:R-MMU-421694 Reactome:R-MMU-421693 Reactome:R-MMU-421688 Reactome:R-MMU-418870 Reactome:R-MMU-418862	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964	C		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Naba, A et al. (2012) The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices. Mol. Cell Proteomics 11 M111.014647 PubMed GONUTS page
↑ Shao, Q et al. (2017) Uncoupling of UNC5C with Polymerized TUBB3 in Microtubules Mediates Netrin-1 Repulsion. J. Neurosci. 37 5620-5633 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Goldman, JS et al. (2013) Netrin-1 promotes excitatory synaptogenesis between cortical neurons by initiating synapse assembly. J. Neurosci. 33 17278-89 PubMed GONUTS page
↑ ^4.0 ^4.1 Strickland, P et al. (2006) Slit2 and netrin 1 act synergistically as adhesive cues to generate tubular bi-layers during ductal morphogenesis. Development 133 823-32 PubMed GONUTS page
↑ Takayanagi, S et al. (2006) Genetic marking of hematopoietic stem and endothelial cells: identification of the Tmtsp gene encoding a novel cell surface protein with the thrombospondin-1 domain. Blood 107 4317-25 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Alcántara, S et al. (2000) Netrin 1 acts as an attractive or as a repulsive cue for distinct migrating neurons during the development of the cerebellar system. Development 127 1359-72 PubMed GONUTS page
↑ Matilainen, T et al. (2007) Analysis of Netrin 1 receptors during inner ear development. Int. J. Dev. Biol. 51 409-13 PubMed GONUTS page
↑ Powell, AW et al. (2008) Topography of thalamic projections requires attractive and repulsive functions of Netrin-1 in the ventral telencephalon. PLoS Biol. 6 e116 PubMed GONUTS page
↑ ^9.0 ^9.1 Strizzi, L et al. (2008) Netrin-1 can affect morphogenesis and differentiation of the mouse mammary gland. J. Cell. Physiol. 216 824-34 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Tsai, HH et al. (2006) Netrin-1 is required for the normal development of spinal cord oligodendrocytes. J. Neurosci. 26 1913-22 PubMed GONUTS page
↑ Ren, T et al. (2007) Diffusion tensor magnetic resonance imaging and tract-tracing analysis of Probst bundle structure in Netrin1- and DCC-deficient mice. J. Neurosci. 27 10345-9 PubMed GONUTS page
↑ ^12.0 ^12.1 Braisted, JE et al. (2000) Netrin-1 promotes thalamic axon growth and is required for proper development of the thalamocortical projection. J. Neurosci. 20 5792-801 PubMed GONUTS page
↑ Okada, A et al. (2006) Boc is a receptor for sonic hedgehog in the guidance of commissural axons. Nature 444 369-73 PubMed GONUTS page
↑ Charron, F et al. (2003) The morphogen sonic hedgehog is an axonal chemoattractant that collaborates with netrin-1 in midline axon guidance. Cell 113 11-23 PubMed GONUTS page
↑ ^15.0 ^15.1 Causeret, F et al. (2002) Slit antagonizes netrin-1 attractive effects during the migration of inferior olivary neurons. Dev. Biol. 246 429-40 PubMed GONUTS page
↑ Manabe, R et al. (2008) Transcriptome-based systematic identification of extracellular matrix proteins. Proc. Natl. Acad. Sci. U.S.A. 105 12849-54 PubMed GONUTS page
↑ Dillon, AK et al. (2005) Molecular control of spinal accessory motor neuron/axon development in the mouse spinal cord. J. Neurosci. 25 10119-30 PubMed GONUTS page
↑ Schwarting, GA et al. (2004) Netrin 1-mediated chemoattraction regulates the migratory pathway of LHRH neurons. Eur. J. Neurosci. 19 11-20 PubMed GONUTS page

[PMID:22159717-1] 1.0 ^1.1 Naba, A et al. (2012) The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices. Mol. Cell Proteomics 11 M111.014647 PubMed GONUTS page

[PMID:28483977-2] Shao, Q et al. (2017) Uncoupling of UNC5C with Polymerized TUBB3 in Microtubules Mediates Netrin-1 Repulsion. J. Neurosci. 37 5620-5633 PubMed GONUTS page

[PMID:24174661-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Goldman, JS et al. (2013) Netrin-1 promotes excitatory synaptogenesis between cortical neurons by initiating synapse assembly. J. Neurosci. 33 17278-89 PubMed GONUTS page

[PMID:16439476-4] 4.0 ^4.1 Strickland, P et al. (2006) Slit2 and netrin 1 act synergistically as adhesive cues to generate tubular bi-layers during ductal morphogenesis. Development 133 823-32 PubMed GONUTS page

[PMID:16455951-5] Takayanagi, S et al. (2006) Genetic marking of hematopoietic stem and endothelial cells: identification of the Tmtsp gene encoding a novel cell surface protein with the thrombospondin-1 domain. Blood 107 4317-25 PubMed GONUTS page

[PMID:10704383-6] 6.0 ^6.1 ^6.2 Alcántara, S et al. (2000) Netrin 1 acts as an attractive or as a repulsive cue for distinct migrating neurons during the development of the cerebellar system. Development 127 1359-72 PubMed GONUTS page

[PMID:17616930-7] Matilainen, T et al. (2007) Analysis of Netrin 1 receptors during inner ear development. Int. J. Dev. Biol. 51 409-13 PubMed GONUTS page

[PMID:18479186-8] Powell, AW et al. (2008) Topography of thalamic projections requires attractive and repulsive functions of Netrin-1 in the ventral telencephalon. PLoS Biol. 6 e116 PubMed GONUTS page

[PMID:18425773-9] 9.0 ^9.1 Strizzi, L et al. (2008) Netrin-1 can affect morphogenesis and differentiation of the mouse mammary gland. J. Cell. Physiol. 216 824-34 PubMed GONUTS page

[PMID:16481423-10] 10.0 ^10.1 ^10.2 Tsai, HH et al. (2006) Netrin-1 is required for the normal development of spinal cord oligodendrocytes. J. Neurosci. 26 1913-22 PubMed GONUTS page

[PMID:17898206-11] Ren, T et al. (2007) Diffusion tensor magnetic resonance imaging and tract-tracing analysis of Probst bundle structure in Netrin1- and DCC-deficient mice. J. Neurosci. 27 10345-9 PubMed GONUTS page

[PMID:10908620-12] 12.0 ^12.1 Braisted, JE et al. (2000) Netrin-1 promotes thalamic axon growth and is required for proper development of the thalamocortical projection. J. Neurosci. 20 5792-801 PubMed GONUTS page

[PMID:17086203-13] Okada, A et al. (2006) Boc is a receptor for sonic hedgehog in the guidance of commissural axons. Nature 444 369-73 PubMed GONUTS page

[PMID:12679031-14] Charron, F et al. (2003) The morphogen sonic hedgehog is an axonal chemoattractant that collaborates with netrin-1 in midline axon guidance. Cell 113 11-23 PubMed GONUTS page

[PMID:12051827-15] 15.0 ^15.1 Causeret, F et al. (2002) Slit antagonizes netrin-1 attractive effects during the migration of inferior olivary neurons. Dev. Biol. 246 429-40 PubMed GONUTS page

[PMID:18757743-16] Manabe, R et al. (2008) Transcriptome-based systematic identification of extracellular matrix proteins. Proc. Natl. Acad. Sci. U.S.A. 105 12849-54 PubMed GONUTS page

[PMID:16267219-17] Dillon, AK et al. (2005) Molecular control of spinal accessory motor neuron/axon development in the mouse spinal cord. J. Neurosci. 25 10119-30 PubMed GONUTS page

[PMID:14750959-18] Schwarting, GA et al. (2004) Netrin 1-mediated chemoattraction regulates the migratory pathway of LHRH neurons. Eur. J. Neurosci. 19 11-20 PubMed GONUTS page

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MOUSE:NET1

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