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MOUSE:NENF

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Nenf (synonyms: Spuf)
Protein Name(s) Neudesin

Neuron-derived neurotrophic factor Secreted protein of unknown function SPUF protein

External Links
UniProt Q9CQ45
EMBL AB126218
AK002413
AK004329
AK009304
AK020403
AK155319
BC048464
CCDS CCDS15618.1
RefSeq NP_079700.1
UniGene Mm.46444
ProteinModelPortal Q9CQ45
SMR Q9CQ45
PhosphoSite Q9CQ45
MaxQB Q9CQ45
PaxDb Q9CQ45
PRIDE Q9CQ45
Ensembl ENSMUST00000046770
GeneID 66208
KEGG mmu:66208
UCSC uc007ecg.1
CTD 29937
MGI MGI:1913458
eggNOG NOG317011
GeneTree ENSGT00730000110948
HOGENOM HOG000187840
HOVERGEN HBG059971
InParanoid Q9CQ45
OMA GKGAPYN
OrthoDB EOG7K3TNZ
PhylomeDB Q9CQ45
TreeFam TF332131
NextBio 320967
PRO PR:Q9CQ45
Proteomes UP000000589
Bgee Q9CQ45
CleanEx MM_NENF
Genevestigator Q9CQ45
GO GO:0005615
GO:0008083
GO:0020037
GO:0046872
GO:0043410
Gene3D 3.10.120.10
InterPro IPR001199
Pfam PF00173
SUPFAM SSF55856

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0020037

heme binding

PMID:23805070[1]

ECO:0000314

F

Figure 1C: as emphasized in yellow, neudesin is a part of the domain for heme-binding.

complete

involved_in

GO:0032099

negative regulation of appetite

PMID:23576617[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043410

positive regulation of MAPK cascade

PMID:15605373[3]

ECO:0000314

direct assay evidence used in manual assertion

P

  • regulates_o_occurs_in:(EMAPA:17544)
  • regulates_o_occurs_in:(CL:0000117)

Seeded From UniProt

complete

enables

GO:0008083

growth factor activity

PMID:15605373[3]

ECO:0000314

direct assay evidence used in manual assertion

F

  • occurs_in:(EMAPA:17544)
  • occurs_in:(CL:0000117)

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9UMX5

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9UMX5

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:15605373[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0008083

P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9UMX5
ensembl:ENSP00000355955

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9UMX5
ensembl:ENSP00000355955

C

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0112

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Kimura, I et al. (2013) Neurotrophic effects of neudesin in the central nervous system. Front Neurosci 7 111 PubMed GONUTS page
  2. Byerly, MS et al. (2013) Identification of hypothalamic neuron-derived neurotrophic factor as a novel factor modulating appetite. Am. J. Physiol. Regul. Integr. Comp. Physiol. 304 R1085-95 PubMed GONUTS page
  3. 3.0 3.1 3.2 Kimura, I et al. (2005) Neudesin, a novel secreted protein with a unique primary structure and neurotrophic activity. J. Neurosci. Res. 79 287-94 PubMed GONUTS page