MOUSE:NDRG1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Ndrg1 (synonyms: Ndr1, Ndrl, Tdd5)
Protein Name(s)	Protein NDRG1 N-myc downstream-regulated gene 1 protein Protein Ndr1
External Links
UniProt	Q62433
EMBL	U60593 U52073 BC015282 BC071235
CCDS	CCDS37092.1
RefSeq	NP_032707.2 XP_006520631.1
UniGene	Mm.30837
ProteinModelPortal	Q62433
SMR	Q62433
IntAct	Q62433
MINT	MINT-1849784
MEROPS	S33.987
PhosphoSite	Q62433
MaxQB	Q62433
PaxDb	Q62433
PRIDE	Q62433
DNASU	17988
Ensembl	ENSMUST00000005256
GeneID	17988
KEGG	mmu:17988
UCSC	uc007wax.1
CTD	10397
MGI	MGI:1341799
eggNOG	NOG310435
GeneTree	ENSGT00390000001874
HOGENOM	HOG000230891
HOVERGEN	HBG052591
InParanoid	Q62433
KO	K18266
OMA	KTCFNPL
OrthoDB	EOG7KH9JS
PhylomeDB	Q62433
TreeFam	TF313168
ChiTaRS	Ndrg1
NextBio	292963
PRO	PR:Q62433
Proteomes	UP000000589
Bgee	Q62433
CleanEx	MM_NDRG1
ExpressionAtlas	Q62433
Genevestigator	Q62433
GO	GO:0005913 GO:0005813 GO:0005737 GO:0005829 GO:0070062 GO:0005874 GO:0005634 GO:0048471 GO:0005886 GO:0055038 GO:0071456 GO:0030330 GO:0045576 GO:0032287 GO:0090232
Gene3D	3.40.50.1820
InterPro	IPR029058 IPR004142
PANTHER	PTHR11034
Pfam	PF03096
SUPFAM	SSF53474

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0008285	negative regulation of cell proliferation	PMID:23555679^[1]	ECO:0000315			P		figure 10	complete CACAO 7676
involved_in	GO:0008285	negative regulation of cell population proliferation	PMID:23555679^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0043209	myelin sheath	PMID:17634366^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000128)	Seeded From UniProt	complete
involved_in	GO:0032287	peripheral nervous system myelin maintenance	PMID:15082788^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:15082788^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000867215 RGD:621874	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1341799 MGI:MGI:1352498 MGI:MGI:2384590 PANTHER:PTN000867215 UniProtKB:Q92597 UniProtKB:Q9UGV2 UniProtKB:Q9ULP0	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0099173	postsynapse organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1307303	P		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1307303	C		Seeded From UniProt	complete
part_of	GO:0055038	recycling endosome membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92597	C		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92597	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045576	mast cell activation	PMID:12804568^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0045296	cadherin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92597	F		Seeded From UniProt	complete
enables	GO:0043015	gamma-tubulin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92597	F		Seeded From UniProt	complete
enables	GO:0017137	Rab GTPase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92597	F		Seeded From UniProt	complete
part_of	GO:0015630	microtubule cytoskeleton	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92597	C		Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92597	F		Seeded From UniProt	complete
part_of	GO:0005913	cell-cell adherens junction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92597	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92597	C		Seeded From UniProt	complete
part_of	GO:0005874	microtubule	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92597	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92597	C		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92597	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92597	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92597	C		Seeded From UniProt	complete
involved_in	GO:0099173	postsynapse organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6JE36 ensembl:ENSRNOP00000010811	P		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6JE36 ensembl:ENSRNOP00000010811	C		Seeded From UniProt	complete
involved_in	GO:0071456	cellular response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92597 ensembl:ENSP00000404854	P		Seeded From UniProt	complete
part_of	GO:0055038	recycling endosome membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92597 ensembl:ENSP00000404854	C		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92597 ensembl:ENSP00000404854	C		Seeded From UniProt	complete
enables	GO:0045296	cadherin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92597 ensembl:ENSP00000404854	F		Seeded From UniProt	complete
enables	GO:0043015	gamma-tubulin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92597 ensembl:ENSP00000404854	F		Seeded From UniProt	complete
involved_in	GO:0030330	DNA damage response, signal transduction by p53 class mediator	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92597 ensembl:ENSP00000404854	P		Seeded From UniProt	complete
enables	GO:0017137	Rab GTPase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92597 ensembl:ENSP00000404854	F		Seeded From UniProt	complete
part_of	GO:0015630	microtubule cytoskeleton	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92597 ensembl:ENSP00000404854	C		Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92597 ensembl:ENSP00000404854	F		Seeded From UniProt	complete
part_of	GO:0005913	cell-cell adherens junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92597 ensembl:ENSP00000404854	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92597 ensembl:ENSP00000404854	C		Seeded From UniProt	complete
part_of	GO:0005874	microtubule	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92597 ensembl:ENSP00000404854	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92597 ensembl:ENSP00000404854	C		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92597 ensembl:ENSP00000404854	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92597 ensembl:ENSP00000404854	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92597 ensembl:ENSP00000404854	C		Seeded From UniProt	complete
involved_in	GO:0032287	peripheral nervous system myelin maintenance	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030693	P		Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030693	P		Seeded From UniProt	complete
involved_in	GO:0045576	mast cell activation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030693	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0005874	microtubule	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0493	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0091	C		Seeded From UniProt	complete
part_of	GO:0005815	microtubule organizing center	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0048	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Tang, MK et al. (2013) Promyelocytic leukemia (PML) protein plays important roles in regulating cell adhesion, morphology, proliferation and migration. PLoS ONE 8 e59477 PubMed GONUTS page
↑ Werner, HB et al. (2007) Proteolipid protein is required for transport of sirtuin 2 into CNS myelin. J. Neurosci. 27 7717-30 PubMed GONUTS page
↑ ^3.0 ^3.1 Okuda, T et al. (2004) Ndrg1-deficient mice exhibit a progressive demyelinating disorder of peripheral nerves. Mol. Cell. Biol. 24 3949-56 PubMed GONUTS page
↑ ^4.0 ^4.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Taketomi, Y et al. (2003) Identification of NDRG1 as an early inducible gene during in vitro maturation of cultured mast cells. Biochem. Biophys. Res. Commun. 306 339-46 PubMed GONUTS page

[PMID:23555679-1] 1.0 ^1.1 Tang, MK et al. (2013) Promyelocytic leukemia (PML) protein plays important roles in regulating cell adhesion, morphology, proliferation and migration. PLoS ONE 8 e59477 PubMed GONUTS page

[PMID:17634366-2] Werner, HB et al. (2007) Proteolipid protein is required for transport of sirtuin 2 into CNS myelin. J. Neurosci. 27 7717-30 PubMed GONUTS page

[PMID:15082788-3] 3.0 ^3.1 Okuda, T et al. (2004) Ndrg1-deficient mice exhibit a progressive demyelinating disorder of peripheral nerves. Mol. Cell. Biol. 24 3949-56 PubMed GONUTS page

[PMID:21873635-4] 4.0 ^4.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:12804568-5] Taketomi, Y et al. (2003) Identification of NDRG1 as an early inducible gene during in vitro maturation of cultured mast cells. Biochem. Biophys. Res. Commun. 306 339-46 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

MOUSE:NDRG1

Contents

Annotations

Notes

References

c

d

e

g

m

n

p

r

s

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools