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MOUSE:NDRG1

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Ndrg1 (synonyms: Ndr1, Ndrl, Tdd5)
Protein Name(s) Protein NDRG1

N-myc downstream-regulated gene 1 protein Protein Ndr1

External Links
UniProt Q62433
EMBL U60593
U52073
BC015282
BC071235
CCDS CCDS37092.1
RefSeq NP_032707.2
XP_006520631.1
UniGene Mm.30837
ProteinModelPortal Q62433
SMR Q62433
IntAct Q62433
MINT MINT-1849784
MEROPS S33.987
PhosphoSite Q62433
MaxQB Q62433
PaxDb Q62433
PRIDE Q62433
DNASU 17988
Ensembl ENSMUST00000005256
GeneID 17988
KEGG mmu:17988
UCSC uc007wax.1
CTD 10397
MGI MGI:1341799
eggNOG NOG310435
GeneTree ENSGT00390000001874
HOGENOM HOG000230891
HOVERGEN HBG052591
InParanoid Q62433
KO K18266
OMA KTCFNPL
OrthoDB EOG7KH9JS
PhylomeDB Q62433
TreeFam TF313168
ChiTaRS Ndrg1
NextBio 292963
PRO PR:Q62433
Proteomes UP000000589
Bgee Q62433
CleanEx MM_NDRG1
ExpressionAtlas Q62433
Genevestigator Q62433
GO GO:0005913
GO:0005813
GO:0005737
GO:0005829
GO:0070062
GO:0005874
GO:0005634
GO:0048471
GO:0005886
GO:0055038
GO:0071456
GO:0030330
GO:0045576
GO:0032287
GO:0090232
Gene3D 3.40.50.1820
InterPro IPR029058
IPR004142
PANTHER PTHR11034
Pfam PF03096
SUPFAM SSF53474

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0008285

negative regulation of cell proliferation

PMID:23555679[1]

ECO:0000315

P

figure 10

complete
CACAO 7676

involved_in

GO:0008285

negative regulation of cell population proliferation

PMID:23555679[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0043209

myelin sheath

PMID:17634366[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(CL:0000128)

Seeded From UniProt

complete

involved_in

GO:0032287

peripheral nervous system myelin maintenance

PMID:15082788[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:15082788[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000867215
RGD:621874

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1341799
MGI:MGI:1352498
MGI:MGI:2384590
PANTHER:PTN000867215
UniProtKB:Q92597
UniProtKB:Q9UGV2
UniProtKB:Q9ULP0

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0099173

postsynapse organization

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1307303

P

Seeded From UniProt

complete

part_of

GO:0098978

glutamatergic synapse

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1307303

C

Seeded From UniProt

complete

part_of

GO:0055038

recycling endosome membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q92597

C

Seeded From UniProt

complete

part_of

GO:0048471

perinuclear region of cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q92597

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045576

mast cell activation

PMID:12804568[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0045296

cadherin binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q92597

F

Seeded From UniProt

complete

enables

GO:0043015

gamma-tubulin binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q92597

F

Seeded From UniProt

complete

enables

GO:0017137

Rab GTPase binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q92597

F

Seeded From UniProt

complete

part_of

GO:0015630

microtubule cytoskeleton

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q92597

C

Seeded From UniProt

complete

enables

GO:0008017

microtubule binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q92597

F

Seeded From UniProt

complete

part_of

GO:0005913

cell-cell adherens junction

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q92597

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q92597

C

Seeded From UniProt

complete

part_of

GO:0005874

microtubule

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q92597

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q92597

C

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q92597

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q92597

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q92597

C

Seeded From UniProt

complete

involved_in

GO:0099173

postsynapse organization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6JE36
ensembl:ENSRNOP00000010811

P

Seeded From UniProt

complete

part_of

GO:0098978

glutamatergic synapse

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6JE36
ensembl:ENSRNOP00000010811

C

Seeded From UniProt

complete

involved_in

GO:0071456

cellular response to hypoxia

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q92597
ensembl:ENSP00000404854

P

Seeded From UniProt

complete

part_of

GO:0055038

recycling endosome membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q92597
ensembl:ENSP00000404854

C

Seeded From UniProt

complete

part_of

GO:0048471

perinuclear region of cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q92597
ensembl:ENSP00000404854

C

Seeded From UniProt

complete

enables

GO:0045296

cadherin binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q92597
ensembl:ENSP00000404854

F

Seeded From UniProt

complete

enables

GO:0043015

gamma-tubulin binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q92597
ensembl:ENSP00000404854

F

Seeded From UniProt

complete

involved_in

GO:0030330

DNA damage response, signal transduction by p53 class mediator

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q92597
ensembl:ENSP00000404854

P

Seeded From UniProt

complete

enables

GO:0017137

Rab GTPase binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q92597
ensembl:ENSP00000404854

F

Seeded From UniProt

complete

part_of

GO:0015630

microtubule cytoskeleton

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q92597
ensembl:ENSP00000404854

C

Seeded From UniProt

complete

enables

GO:0008017

microtubule binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q92597
ensembl:ENSP00000404854

F

Seeded From UniProt

complete

part_of

GO:0005913

cell-cell adherens junction

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q92597
ensembl:ENSP00000404854

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q92597
ensembl:ENSP00000404854

C

Seeded From UniProt

complete

part_of

GO:0005874

microtubule

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q92597
ensembl:ENSP00000404854

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q92597
ensembl:ENSP00000404854

C

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q92597
ensembl:ENSP00000404854

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q92597
ensembl:ENSP00000404854

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q92597
ensembl:ENSP00000404854

C

Seeded From UniProt

complete

involved_in

GO:0032287

peripheral nervous system myelin maintenance

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR030693

P

Seeded From UniProt

complete

involved_in

GO:0042127

regulation of cell population proliferation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR030693

P

Seeded From UniProt

complete

involved_in

GO:0045576

mast cell activation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR030693

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0206

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

part_of

GO:0005874

microtubule

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0493

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0091

C

Seeded From UniProt

complete

part_of

GO:0005815

microtubule organizing center

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0048

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Tang, MK et al. (2013) Promyelocytic leukemia (PML) protein plays important roles in regulating cell adhesion, morphology, proliferation and migration. PLoS ONE 8 e59477 PubMed GONUTS page
  2. Werner, HB et al. (2007) Proteolipid protein is required for transport of sirtuin 2 into CNS myelin. J. Neurosci. 27 7717-30 PubMed GONUTS page
  3. 3.0 3.1 Okuda, T et al. (2004) Ndrg1-deficient mice exhibit a progressive demyelinating disorder of peripheral nerves. Mol. Cell. Biol. 24 3949-56 PubMed GONUTS page
  4. 4.0 4.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  5. Taketomi, Y et al. (2003) Identification of NDRG1 as an early inducible gene during in vitro maturation of cultured mast cells. Biochem. Biophys. Res. Commun. 306 339-46 PubMed GONUTS page