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MOUSE:MT2

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Mt2
Protein Name(s) Metallothionein-2

MT-2 Metallothionein-II MT-II

External Links
UniProt P02798
EMBL K02236
AK002567
BC031758
CCDS CCDS40437.1
PIR A03275
I57572
RefSeq NP_032656.1
UniGene Mm.147226
ProteinModelPortal P02798
SMR P02798
STRING 10090.ENSMUSP00000034214
PhosphoSite P02798
MaxQB P02798
PaxDb P02798
PRIDE P02798
Ensembl ENSMUST00000034214
GeneID 17750
KEGG mmu:17750
UCSC uc009mvv.1
CTD 17750
MGI MGI:97172
eggNOG NOG138665
GeneTree ENSGT00730000110883
HOGENOM HOG000236262
InParanoid P02798
KO K14739
OMA CKKSCCT
TreeFam TF336054
Reactome REACT_198660
NextBio 292411
PRO PR:P02798
Proteomes UP000000589
Bgee P02798
CleanEx MM_MT2
Genevestigator P02798
GO GO:0005737
GO:0005634
GO:0048471
GO:0008270
GO:0071276
GO:0036018
GO:0071294
GO:0006882
GO:0010273
GO:0045926
GO:0007263
Gene3D 4.10.10.10
InterPro IPR017854
IPR023587
IPR003019
IPR000006
IPR018064
PANTHER PTHR23299
Pfam PF00131
PRINTS PR00860
SUPFAM SSF57868
PROSITE PS00203

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0071294

cellular response to zinc ion

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P13640

P

Seeded From UniProt

complete

part_of

GO:0048471

perinuclear region of cytoplasm

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P13640

C

Seeded From UniProt

complete

involved_in

GO:0045926

negative regulation of growth

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P13640

P

Seeded From UniProt

complete

enables

GO:0008270

zinc ion binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P13640

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P13640

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P13640

C

Seeded From UniProt

complete

involved_in

GO:0071294

cellular response to zinc ion

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97171
PANTHER:PTN001151654
UniProtKB:P02795
UniProtKB:P04731
UniProtKB:P04732
UniProtKB:P07438
UniProtKB:P13640
UniProtKB:P80294
UniProtKB:P80297
UniProtKB:Q93083

P

Seeded From UniProt

complete

involved_in

GO:0071280

cellular response to copper ion

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001151654
UniProtKB:P13640

P

Seeded From UniProt

complete

involved_in

GO:0071276

cellular response to cadmium ion

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001151654
UniProtKB:P04731
UniProtKB:P04732
UniProtKB:P04733
UniProtKB:P13640
UniProtKB:P25713
UniProtKB:P80294
UniProtKB:P80297

P

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97171
MGI:MGI:97173
MGI:MGI:99692
PANTHER:PTN001151654

F

Seeded From UniProt

complete

involved_in

GO:0010273

detoxification of copper ion

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97171
MGI:MGI:97172
PANTHER:PTN001151654

P

Seeded From UniProt

complete

involved_in

GO:0006882

cellular zinc ion homeostasis

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97171
MGI:MGI:97172
MGI:MGI:97173
PANTHER:PTN001151654

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001151654
UniProtKB:P04732
UniProtKB:P04733
UniProtKB:P13640
UniProtKB:P25713
UniProtKB:P80297

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001151654
UniProtKB:P04732
UniProtKB:P04733
UniProtKB:P13640
UniProtKB:P80297

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010273

detoxification of copper ion

PMID:8640230[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:97171
MGI:MGI:99400

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0009617

response to bacterium

PMID:23012479[3]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007263

nitric oxide mediated signal transduction

PMID:11792622[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2668455

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006882

cellular zinc ion homeostasis

PMID:11792622[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2668455

P

Seeded From UniProt

complete

involved_in

GO:0071294

cellular response to zinc ion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P02795
ensembl:ENSP00000245185

P

Seeded From UniProt

complete

involved_in

GO:0036018

cellular response to erythropoietin

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P02795
ensembl:ENSP00000245185

P

Seeded From UniProt

complete

involved_in

GO:0036016

cellular response to interleukin-3

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P02795
ensembl:ENSP00000245185

P

Seeded From UniProt

complete

involved_in

GO:0035690

cellular response to drug

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P02795
ensembl:ENSP00000245185

P

Seeded From UniProt

complete

enables

GO:0008270

zinc ion binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P02795
ensembl:ENSP00000245185

F

Seeded From UniProt

complete

enables

GO:0008144

drug binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P02795
ensembl:ENSP00000245185

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000006
InterPro:IPR003019
InterPro:IPR017854

F

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-MMU-6798563

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0008270

zinc ion binding

PMID:11792622[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037
GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479
UniProtKB-KW:KW-0480

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  2. ↑ Kelly, EJ & Palmiter, RD (1996) A murine model of Menkes disease reveals a physiological function of metallothionein. Nat. Genet. 13 219-22 PubMed GONUTS page
  3. ↑ Archambaud, C et al. (2012) Impact of lactobacilli on orally acquired listeriosis. Proc. Natl. Acad. Sci. U.S.A. 109 16684-9 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 St Croix, CM et al. (2002) Nitric oxide-induced changes in intracellular zinc homeostasis are mediated by metallothionein/thionein. Am. J. Physiol. Lung Cell Mol. Physiol. 282 L185-92 PubMed GONUTS page
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