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MOUSE:MCHR1

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Mchr1 (synonyms: Gpr24, Slc1)
Protein Name(s) Melanin-concentrating hormone receptor 1

MCH receptor 1 MCH-R1 MCHR-1 G-protein coupled receptor 24 MCH-1R MCH1R MCHR SLC-1 Somatostatin receptor-like protein

External Links
UniProt Q8JZL2
EMBL CAAA01177985
AY049011
AF498247
AF498248
BY276741
RefSeq NP_660114.1
UniGene Mm.323523
ProteinModelPortal Q8JZL2
SMR Q8JZL2
BindingDB Q8JZL2
ChEMBL CHEMBL4730
GuidetoPHARMACOLOGY 280
PhosphoSite Q8JZL2
PRIDE Q8JZL2
GeneID 207911
KEGG mmu:207911
UCSC uc007wwh.2
CTD 2847
MGI MGI:2180756
eggNOG NOG282817
HOGENOM HOG000000704
HOVERGEN HBG105726
InParanoid Q8JZL2
KO K04320
PhylomeDB Q8JZL2
Reactome REACT_207651
REACT_235286
REACT_250376
NextBio 372081
PRO PR:Q8JZL2
Proteomes UP000000589
Bgee Q8JZL2
CleanEx MM_MCHR1
ExpressionAtlas Q8JZL2
Genevestigator Q8JZL2
GO GO:0060170
GO:0016021
GO:0031513
GO:0005886
GO:0042562
GO:0030273
GO:0007218
GO:0051928
GO:0007204
GO:0060259
InterPro IPR000276
IPR017452
IPR004047
IPR008361
Pfam PF00001
PRINTS PR00237
PR01507
PR01783
PROSITE PS50262

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0097730

non-motile cilium

PMID:18334641[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0042277

peptide binding

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001200938
ZFIN:ZDB-GENE-030729-1

F

Seeded From UniProt

complete

enables

GO:0030273

melanin-concentrating hormone receptor activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001955515
RGD:619841

F

Seeded From UniProt

complete

involved_in

GO:0007218

neuropeptide signaling pathway

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0036789
FB:FBgn0036790
FB:FBgn0266429
MGI:MGI:97438
MGI:MGI:98327
MGI:MGI:98328
PANTHER:PTN000659780

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0266429
MGI:MGI:97439
PANTHER:PTN001200938
UniProtKB:P41145
UniProtKB:P41146
ZFIN:ZDB-GENE-990415-199

C

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1330275
PANTHER:PTN001200938
RGD:3234
UniProtKB:P41146
UniProtKB:Q9Y5Y4

F

Seeded From UniProt

complete

part_of

GO:0097730

non-motile cilium

PMID:23351594[3]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(CL:0000540)
  • part_of:(EMAPA:32768)|part_of:(CL:0000540)
  • part_of:(EMAPA:35421)

Seeded From UniProt

complete

part_of

GO:0097730

non-motile cilium

PMID:23029470[4]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:32768)
  • part_of:(CL:0000540)|part_of:(EMAPA:32767)
  • part_of:(CL:0000540)|part_of:(EMAPA:17536)
  • part_of:(CL:0000540)

Seeded From UniProt

complete

part_of

GO:0060170

ciliary membrane

PMID:22139371[5]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:2000029)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051928

positive regulation of calcium ion transport

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:619841

P

Seeded From UniProt

complete

enables

GO:0042562

hormone binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:619841

F

Seeded From UniProt

complete

enables

GO:0030273

melanin-concentrating hormone receptor activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:619841

F

Seeded From UniProt

complete

enables

GO:0008022

protein C-terminus binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:619841

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007204

positive regulation of cytosolic calcium ion concentration

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:619841

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007166

cell surface receptor signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:619841

P

Seeded From UniProt

complete

part_of

GO:0005929

cilium

PMID:28154160[6]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99705

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:23029470[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:15950311[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:619841

C

Seeded From UniProt

complete

enables

GO:0005102

signaling receptor binding

PMID:23029470[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P30935

F

  • occurs_in:(CL:0000540)
  • occurs_in:(EMAPA:32768)

Seeded From UniProt

complete

involved_in

GO:0051928

positive regulation of calcium ion transport

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97639
ensembl:ENSRNOP00000025564

P

Seeded From UniProt

complete

enables

GO:0042562

hormone binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97639
ensembl:ENSRNOP00000025564

F

Seeded From UniProt

complete

enables

GO:0030273

melanin-concentrating hormone receptor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97639
ensembl:ENSRNOP00000025564

F

Seeded From UniProt

complete

enables

GO:0008022

protein C-terminus binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97639
ensembl:ENSRNOP00000025564

F

Seeded From UniProt

complete

involved_in

GO:0007204

positive regulation of cytosolic calcium ion concentration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97639
ensembl:ENSRNOP00000025564

P

Seeded From UniProt

complete

involved_in

GO:0007166

cell surface receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97639
ensembl:ENSRNOP00000025564

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97639
ensembl:ENSRNOP00000025564

C

Seeded From UniProt

complete

part_of

GO:0005929

cilium

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99705
ensembl:ENSP00000249016

C

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000276

F

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000276
InterPro:IPR008361

P

Seeded From UniProt

complete

involved_in

GO:0007218

neuropeptide signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004047

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000276
InterPro:IPR004047
InterPro:IPR008361
InterPro:IPR017452

C

Seeded From UniProt

complete

enables

GO:0030273

melanin-concentrating hormone receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004047

F

Seeded From UniProt

complete

involved_in

GO:0060259

regulation of feeding behavior

PMID:18334641[1]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0807

P

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0297

F

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0297

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Berbari, NF et al. (2008) Bardet-Biedl syndrome proteins are required for the localization of G protein-coupled receptors to primary cilia. Proc. Natl. Acad. Sci. U.S.A. 105 4242-6 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  3. ↑ Sun, X et al. (2012) Tubby is required for trafficking G protein-coupled receptors to neuronal cilia. Cilia 1 21 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 Green, JA et al. (2012) Heteromerization of ciliary G protein-coupled receptors in the mouse brain. PLoS ONE 7 e46304 PubMed GONUTS page
  5. ↑ Zhang, Q et al. (2011) Bardet-Biedl syndrome 3 (Bbs3) knockout mouse model reveals common BBS-associated phenotypes and Bbs3 unique phenotypes. Proc. Natl. Acad. Sci. U.S.A. 108 20678-83 PubMed GONUTS page
  6. ↑ Badgandi, HB et al. (2017) Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins. J. Cell Biol. 216 743-760 PubMed GONUTS page
  7. ↑ Francke, F et al. (2005) Immunohistochemical distribution of MIZIP and its co-expression with the Melanin-concentrating hormone receptor 1 in the adult rodent brain. Brain Res. Mol. Brain Res. 139 31-41 PubMed GONUTS page
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