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MOUSE:MBD5

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Mbd5
Protein Name(s) Methyl-CpG-binding domain protein 5

Methyl-CpG-binding protein MBD5

External Links
UniProt B1AYB6
EMBL BX546465
AL845298
AL845298
BX546465
BC138375
BC138378
CCDS CCDS71051.1
RefSeq NP_001277585.1
UniGene Mm.440436
ProteinModelPortal B1AYB6
SMR B1AYB6
PRIDE B1AYB6
Ensembl ENSMUST00000112754
GeneID 109241
KEGG mmu:109241
UCSC uc012bve.1
CTD 55777
MGI MGI:2138934
eggNOG NOG27778
GeneTree ENSGT00530000064137
HOGENOM HOG000049255
HOVERGEN HBG052419
InParanoid B1AYB6
ChiTaRS Mbd5
PRO PR:B1AYB6
Proteomes UP000000589
Bgee B1AYB6
ExpressionAtlas B1AYB6
Genevestigator B1AYB6
GO GO:0005694
GO:0005634
GO:0003682
GO:0042593
GO:0060399
GO:0040014
InterPro IPR001739
PROSITE PS50982

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0045899

positive regulation of RNA polymerase II transcriptional preinitiation complex assembly

PMID:23077600[1]

ECO:0000314

P

Figure 2 shows that 'The Mbd5-knockout mice had significantly smaller body size than their littermates, and the reduction in body weight was accompanied by a reduction in body length.'

complete
CACAO 5404

enables

GO:0003682

chromatin binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9P267

F

Seeded From UniProt

complete

NOT|enables

GO:0003677

DNA binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9P267

F

Seeded From UniProt

complete

part_of

GO:0010369

chromocenter

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001441501
UniProtKB:Q96DN6
UniProtKB:Q9P267

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001441501
UniProtKB:Q96DN6
UniProtKB:Q9P267

C

Seeded From UniProt

complete

enables

GO:0003682

chromatin binding

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001441501
UniProtKB:Q96DN6
UniProtKB:Q9P267

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060399

positive regulation of growth hormone receptor signaling pathway

PMID:23077600[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:5466580

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050795

regulation of behavior

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9P267

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042593

glucose homeostasis

PMID:23077600[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:5466580

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0040014

regulation of multicellular organism growth

PMID:23077600[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:5466580

P

Seeded From UniProt

complete

part_of

GO:0030496

midbody

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9P267

C

Seeded From UniProt

complete

part_of

GO:0010369

chromocenter

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9P267

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007399

nervous system development

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9P267

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9P267

C

Seeded From UniProt

complete

enables

GO:0003682

chromatin binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9P267

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001739

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

part_of

GO:0005694

chromosome

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0158
UniProtKB-SubCell:SL-0468

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 Du, Y et al. (2012) The essential role of Mbd5 in the regulation of somatic growth and glucose homeostasis in mice. PLoS ONE 7 e47358 PubMed GONUTS page
  2. 2.0 2.1 2.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page