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MOUSE:MAVS
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Mavs (synonyms: Ips1, Visa) | |
| Protein Name(s) | Mitochondrial antiviral-signaling protein
MAVS CARD adapter inducing interferon beta Cardif Interferon beta promoter stimulator protein 1 IPS-1 Virus-induced-signaling adapter VISA | |
| External Links | ||
| UniProt | Q8VCF0 | |
| EMBL | DQ174271 DQ167127 AK028421 BC020006 BC025825 BC031352 BC037391 | |
| CCDS | CCDS16760.1 | |
| RefSeq | NP_001193314.1 NP_659137.1 | |
| UniGene | Mm.287226 | |
| PDB | 4GHU | |
| PDBsum | 4GHU | |
| ProteinModelPortal | Q8VCF0 | |
| SMR | Q8VCF0 | |
| BioGrid | 230748 | |
| IntAct | Q8VCF0 | |
| MINT | MINT-2839937 | |
| STRING | 10090.ENSMUSP00000038339 | |
| PhosphoSite | Q8VCF0 | |
| MaxQB | Q8VCF0 | |
| PaxDb | Q8VCF0 | |
| PRIDE | Q8VCF0 | |
| Ensembl | ENSMUST00000041362 ENSMUST00000110199 | |
| GeneID | 228607 | |
| UCSC | uc008mld.2 | |
| CTD | 57506 | |
| MGI | MGI:2444773 | |
| eggNOG | NOG79681 | |
| GeneTree | ENSGT00510000049120 | |
| HOGENOM | HOG000231697 | |
| HOVERGEN | HBG079638 | |
| InParanoid | Q8VCF0 | |
| OMA | EQDTELG | |
| OrthoDB | EOG71ZP2Z | |
| PhylomeDB | Q8VCF0 | |
| TreeFam | TF333444 | |
| Reactome | R-MMU-168928 R-MMU-918233 R-MMU-933541 R-MMU-933542 R-MMU-933543 R-MMU-936440 | |
| ChiTaRS | Mavs | |
| NextBio | 379056 | |
| PRO | PR:Q8VCF0 | |
| Proteomes | UP000000589 | |
| Bgee | Q8VCF0 | |
| CleanEx | MM_D430028G21RIK | |
| ExpressionAtlas | Q8VCF0 | |
| Genevisible | Q8VCF0 | |
| GO | GO:0016021 GO:0031966 GO:0005741 GO:0005739 GO:0005778 GO:0005777 GO:0050700 GO:0019901 GO:0004871 GO:0002218 GO:0071360 GO:0042742 GO:0051607 GO:0045087 GO:0045071 GO:0071651 GO:0002230 GO:0043123 GO:0032727 GO:0032728 GO:0032757 GO:0071660 GO:0033160 GO:0001934 GO:0051091 GO:0042993 GO:0045944 GO:0032760 GO:0032481 GO:0060340 GO:1900063 GO:0039529 GO:0007165 | |
| InterPro | IPR026148 | |
| PANTHER | PTHR21446 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0002735 |
positive regulation of myeloid dendritic cell cytokine production |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:2000778 |
positive regulation of interleukin-6 secretion |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1904469 |
positive regulation of tumor necrosis factor secretion |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071360 |
cellular response to exogenous dsRNA |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0060760 |
positive regulation of response to cytokine stimulus |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1902741 |
positive regulation of interferon-alpha secretion |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0035549 |
positive regulation of interferon-beta secretion |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1900063 |
regulation of peroxisome organization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045087 |
innate immune response |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045071 |
negative regulation of viral genome replication |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042742 |
defense response to bacterium |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032728 |
positive regulation of interferon-beta production |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032727 |
positive regulation of interferon-alpha production |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007165 |
signal transduction |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
occurs_in:(CL:0000057) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005777 |
peroxisome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(CL:0000235)|part_of:(CL:0000057) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(CL:0000235)|part_of:(CL:0000057) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0035591 |
signaling adaptor activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
occurs_in:(CL:0000057) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0002230 |
positive regulation of defense response to virus by host |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0060340 |
positive regulation of type I interferon-mediated signaling pathway |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002725602 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051607 |
defense response to virus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2444773 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045087 |
innate immune response |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002725602 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0035591 |
signaling adaptor activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2444773 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007165 |
signal transduction |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2444773 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002725602 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2444773 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0002218 |
activation of innate immune response |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2444773 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:2000778 |
positive regulation of interleukin-6 secretion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:1904469 |
positive regulation of tumor necrosis factor secretion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:1902741 |
positive regulation of interferon-alpha secretion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:1900063 |
regulation of peroxisome organization |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0071660 |
positive regulation of IP-10 production |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0071651 |
positive regulation of chemokine (C-C motif) ligand 5 production |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0071360 |
cellular response to exogenous dsRNA |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0060760 |
positive regulation of response to cytokine stimulus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0060340 |
positive regulation of type I interferon-mediated signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0051607 |
defense response to virus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0051091 |
positive regulation of DNA-binding transcription factor activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0050700 |
CARD domain binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0045087 |
innate immune response |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0045071 |
negative regulation of viral genome replication |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0042742 |
defense response to bacterium |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0042307 |
positive regulation of protein import into nucleus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0039529 |
RIG-I signaling pathway |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1914320 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0035591 |
signaling adaptor activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0035549 |
positive regulation of interferon-beta secretion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0032760 |
positive regulation of tumor necrosis factor production |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0032757 |
positive regulation of interleukin-8 production |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0032728 |
positive regulation of interferon-beta production |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0032727 |
positive regulation of interferon-alpha production |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0032481 |
positive regulation of type I interferon production |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3654145 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0031966 |
mitochondrial membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0019901 |
protein kinase binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0007165 |
signal transduction |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005778 |
peroxisomal membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005777 |
peroxisome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005741 |
mitochondrial outer membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0002230 |
positive regulation of defense response to virus by host |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3654145 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0002230 |
positive regulation of defense response to virus by host |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0002218 |
activation of innate immune response |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0001934 |
positive regulation of protein phosphorylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051607 |
defense response to virus |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005741 |
mitochondrial outer membrane |
Reactome:R-MMU-936387 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045087 |
innate immune response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005741 |
mitochondrial outer membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051607 |
defense response to virus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005777 |
peroxisome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0002376 |
immune system process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Zhang, Z et al. (2011) DDX1, DDX21, and DHX36 helicases form a complex with the adaptor molecule TRIF to sense dsRNA in dendritic cells. Immunity 34 866-78 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Dixit, E et al. (2010) Peroxisomes are signaling platforms for antiviral innate immunity. Cell 141 668-81 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 4.0 4.1 Li, Y et al. (2012) LSm14A is a processing body-associated sensor of viral nucleic acids that initiates cellular antiviral response in the early phase of viral infection. Proc. Natl. Acad. Sci. U.S.A. 109 11770-5 PubMed GONUTS page
- ↑ 5.0 5.1 Bhoj, VG et al. (2008) MAVS and MyD88 are essential for innate immunity but not cytotoxic T lymphocyte response against respiratory syncytial virus. Proc. Natl. Acad. Sci. U.S.A. 105 14046-51 PubMed GONUTS page
- ↑ Pagliarini, DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134 112-23 PubMed GONUTS page
c
g
i
m
p
- GO:0005778 ! peroxisomal membrane
- GO:0005777 ! peroxisome
- GO:0001934 ! positive regulation of protein phosphorylation
- GO:0002735 ! positive regulation of myeloid dendritic cell cytokine production
- GO:0032481 ! positive regulation of type I interferon production
- GO:0035549 ! positive regulation of interferon-beta secretion
- GO:0032728 ! positive regulation of interferon-beta production
- GO:0032727 ! positive regulation of interferon-alpha production
- GO:0060760 ! positive regulation of response to cytokine stimulus
- GO:1904469 ! positive regulation of tumor necrosis factor secretion
- GO:0032757 ! positive regulation of interleukin-8 production
- GO:0002230 ! positive regulation of defense response to virus by host
- GO:0060340 ! positive regulation of type I interferon-mediated signaling pathway
- GO:1902741 ! positive regulation of interferon-alpha secretion
- GO:0071660 ! positive regulation of IP-10 production
- GO:0071651 ! positive regulation of chemokine (C-C motif) ligand 5 production
- GO:0051091 ! positive regulation of DNA-binding transcription factor activity
- GO:0045944 ! positive regulation of transcription by RNA polymerase II
- GO:0042307 ! positive regulation of protein import into nucleus
- GO:2000778 ! positive regulation of interleukin-6 secretion
- GO:0032760 ! positive regulation of tumor necrosis factor production
- GO:0019901 ! protein kinase binding
r
