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MOUSE:LAX1

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Lax1 (synonyms: Lax)
Protein Name(s) Lymphocyte transmembrane adapter 1

Linker for activation of X cells Membrane-associated adapter protein LAX

External Links
UniProt Q8BHB3
EMBL AY090785
AK040834
AK088503
BC042765
CCDS CCDS35711.1
RefSeq NP_001153121.1
NP_766430.3
XP_006529620.1
UniGene Mm.36534
ProteinModelPortal Q8BHB3
PhosphoSite Q8BHB3
PaxDb Q8BHB3
PRIDE Q8BHB3
Ensembl ENSMUST00000169295
GeneID 240754
KEGG mmu:240754
UCSC uc007cqs.2
CTD 54900
MGI MGI:2443362
eggNOG NOG43404
GeneTree ENSGT00390000014063
HOGENOM HOG000113286
HOVERGEN HBG081892
InParanoid Q8BHB3
OMA TSNDYVN
OrthoDB EOG76QFHV
PhylomeDB Q8BHB3
TreeFam TF337411
NextBio 384719
PRO PR:Q8BHB3
Proteomes UP000000589
Bgee Q8BHB3
CleanEx MM_LAX1
Genevestigator Q8BHB3
GO GO:0005794
GO:0016021
GO:0005886
GO:0050851
GO:0042113
GO:0006955
GO:0048305
GO:0000188
GO:0035556
GO:0046649
GO:0050868

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

acts_upstream_of_or_within

GO:0050868

negative regulation of T cell activation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q8IWV1

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050851

antigen receptor-mediated signaling pathway

PMID:15843560[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3579135

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048305

immunoglobulin secretion

PMID:15843560[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3579135

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0046649

lymphocyte activation

PMID:15843560[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3579135

P

Seeded From UniProt

complete

enables

GO:0042169

SH2 domain binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q8IWV1

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042113

B cell activation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q8IWV1

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0035556

intracellular signal transduction

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q8IWV1

P

Seeded From UniProt

complete

enables

GO:0019901

protein kinase binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q8IWV1

F

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q8IWV1

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006955

immune response

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q8IWV1

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q8IWV1

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q8IWV1

C

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q8IWV1

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0000188

inactivation of MAPK activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q8IWV1

P

Seeded From UniProt

complete

involved_in

GO:0050868

negative regulation of T cell activation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8IWV1
ensembl:ENSP00000406970

P

Seeded From UniProt

complete

enables

GO:0042169

SH2 domain binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8IWV1
ensembl:ENSP00000406970

F

Seeded From UniProt

complete

involved_in

GO:0042113

B cell activation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8IWV1
ensembl:ENSP00000406970

P

Seeded From UniProt

complete

involved_in

GO:0035556

intracellular signal transduction

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8IWV1
ensembl:ENSP00000406970

P

Seeded From UniProt

complete

enables

GO:0019901

protein kinase binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8IWV1
ensembl:ENSP00000406970

F

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8IWV1
ensembl:ENSP00000406970

C

Seeded From UniProt

complete

involved_in

GO:0006955

immune response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8IWV1
ensembl:ENSP00000406970

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8IWV1
ensembl:ENSP00000406970

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8IWV1
ensembl:ENSP00000406970

C

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8IWV1
ensembl:ENSP00000406970

C

Seeded From UniProt

complete

involved_in

GO:0000188

inactivation of MAPK activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8IWV1
ensembl:ENSP00000406970

P

Seeded From UniProt

complete

involved_in

GO:0006955

immune response

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR031393

P

Seeded From UniProt

complete

involved_in

GO:0051249

regulation of lymphocyte activation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR031393

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

involved_in

GO:0002376

immune system process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0391

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

involved_in

GO:0002250

adaptive immune response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1064

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 Zhu, M et al. (2005) Negative regulation of lymphocyte activation by the adaptor protein LAX. J. Immunol. 174 5612-9 PubMed GONUTS page