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MOUSE:KMT2B
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Kmt2b (synonyms: Mll2, Trx2, Wbp7) | |
| Protein Name(s) | Histone-lysine N-methyltransferase 2B
Lysine N-methyltransferase 2B Myeloid/lymphoid or mixed-lineage leukemia protein 4 homolog Trithorax homolog 2 WW domain-binding protein 7 WBP-7 | |
| External Links | ||
| UniProt | O08550 | |
| EMBL | AB182318 AC167970 U92455 | |
| CCDS | CCDS21101.1 | |
| RefSeq | NP_083550.2 | |
| UniGene | Mm.168688 | |
| ProteinModelPortal | O08550 | |
| SMR | O08550 | |
| BioGrid | 217461 | |
| IntAct | O08550 | |
| MINT | MINT-1525361 | |
| PhosphoSite | O08550 | |
| MaxQB | O08550 | |
| PaxDb | O08550 | |
| PRIDE | O08550 | |
| Ensembl | ENSMUST00000108154 | |
| GeneID | 75410 | |
| KEGG | mmu:75410 | |
| UCSC | uc009gfg.1 | |
| CTD | 9757 | |
| MGI | MGI:109565 | |
| eggNOG | COG2940 | |
| GeneTree | ENSGT00760000119228 | |
| HOGENOM | HOG000015326 | |
| HOVERGEN | HBG100043 | |
| InParanoid | O08550 | |
| KO | K14959 | |
| TreeFam | TF319820 | |
| NextBio | 342938 | |
| PRO | PR:O08550 | |
| Proteomes | UP000000589 | |
| Bgee | O08550 | |
| CleanEx | MM_WBP7 | |
| ExpressionAtlas | O08550 | |
| Genevestigator | O08550 | |
| GO | GO:0035097 GO:0005634 GO:0003677 GO:0042800 GO:0008270 GO:0016458 GO:0080182 GO:0034968 GO:0009994 GO:0001541 GO:0030728 GO:0051569 GO:0006355 GO:0006351 | |
| Gene3D | 3.30.40.10 | |
| InterPro | IPR017956 IPR003889 IPR003888 IPR003616 IPR001214 IPR002857 IPR011011 IPR001965 IPR019787 IPR013083 | |
| Pfam | PF05965 PF05964 PF00628 PF00856 PF02008 | |
| SMART | SM00384 SM00542 SM00541 SM00249 SM00508 SM00317 | |
| SUPFAM | SSF57903 | |
| PROSITE | PS51543 PS51542 PS50868 PS50280 PS51058 PS01359 PS50016 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
acts_upstream_of_or_within |
GO:0080182 |
histone H3-K4 trimethylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3056522,MGI:MGI:3623309 |
P |
occurs_in:(CL:0000023) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0080182 |
histone H3-K4 trimethylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2176052,MGI:MGI:3623309 |
P |
occurs_in:(CL:0000023) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0051569 |
regulation of histone H3-K4 methylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3056522,MGI:MGI:3623309 |
P |
regulates_o_occurs_in:(CL:0000023) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0051569 |
regulation of histone H3-K4 methylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2176052,MGI:MGI:3623309 |
P |
regulates_o_occurs_in:(CL:0000023) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0051568 |
histone H3-K4 methylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042800 |
histone methyltransferase activity (H3-K4 specific) |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0035097 |
histone methyltransferase complex |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0034968 |
histone lysine methylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3056522,MGI:MGI:3623309 |
P |
occurs_in:(CL:0000023) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0030728 |
ovulation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3056522,MGI:MGI:3623309 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0030728 |
ovulation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2176052,MGI:MGI:3623309 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0016458 |
gene silencing |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3056522,MGI:MGI:3623309 |
P |
occurs_in:(CL:0000023) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0009994 |
oocyte differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3056522,MGI:MGI:3623309 |
P |
results_in_acquisition_of_features_of:(CL:0000023) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0009994 |
oocyte differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2176052,MGI:MGI:3623309 |
P |
results_in_acquisition_of_features_of:(CL:0000023) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0007613 |
memory |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3623310 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0001541 |
ovarian follicle development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3056522,MGI:MGI:3623309 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0001541 |
ovarian follicle development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2176052,MGI:MGI:3623309 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051568 |
histone H3-K4 methylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9UMN6 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0042800 |
histone methyltransferase activity (H3-K4 specific) |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9UMN6 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0035097 |
histone methyltransferase complex |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9UMN6 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9UMN6 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008270 |
zinc ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0035097 |
histone methyltransferase complex |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042800 |
histone methyltransferase activity (H3-K4 specific) |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051568 |
histone H3-K4 methylation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0018024 |
histone-lysine N-methyltransferase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032259 |
methylation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008168 |
methyltransferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006325 |
chromatin organization |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 Andreu-Vieyra, CV et al. (2010) MLL2 is required in oocytes for bulk histone 3 lysine 4 trimethylation and transcriptional silencing. PLoS Biol. 8 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Cho, YW et al. (2007) PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex. J. Biol. Chem. 282 20395-406 PubMed GONUTS page
- ↑ Jakovcevski, M et al. (2015) Neuronal Kmt2a/Mll1 histone methyltransferase is essential for prefrontal synaptic plasticity and working memory. J. Neurosci. 35 5097-108 PubMed GONUTS page
g
h
m
o
- GO:0016458 ! obsolete gene silencing
- GO:0080182 ! obsolete histone H3-K4 trimethylation
- GO:0034968 ! obsolete histone lysine methylation
- GO:0018024 ! obsolete histone lysine N-methyltransferase activity
- GO:0051568 ! obsolete histone H3-K4 methylation
- GO:0051569 ! obsolete regulation of histone H3-K4 methylation
- GO:0009994 ! oocyte differentiation
- GO:0001541 ! ovarian follicle development
- GO:0030728 ! ovulation
