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MOUSE:KLOT
Contents
Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
Gene Name(s) | Kl | |
Protein Name(s) | Klotho
Klotho peptide | |
External Links | ||
UniProt | O35082 | |
EMBL | AB005141 AB010088 AB010091 AB010091 BC138258 BC138259 | |
CCDS | CCDS19889.1 | |
RefSeq | NP_038851.2 | |
UniGene | Mm.6500 | |
ProteinModelPortal | O35082 | |
SMR | O35082 | |
BioGrid | 200958 | |
DIP | DIP-39894N | |
IntAct | O35082 | |
MINT | MINT-8175062 | |
STRING | 10090.ENSMUSP00000077899 | |
CAZy | GH1 | |
PhosphoSite | O35082 | |
PaxDb | O35082 | |
PRIDE | O35082 | |
Ensembl | ENSMUST00000078856 | |
GeneID | 16591 | |
KEGG | mmu:16591 | |
UCSC | uc009auk.2 uc009aul.2 | |
CTD | 9365 | |
MGI | MGI:1101771 | |
eggNOG | COG2723 | |
GeneTree | ENSGT00550000074452 | |
HOGENOM | HOG000060126 | |
HOVERGEN | HBG081856 | |
InParanoid | O35082 | |
KO | K14756 | |
OMA | ALSSHWI | |
OrthoDB | EOG7MH0XV | |
TreeFam | TF314803 | |
Reactome | REACT_196588 REACT_198525 REACT_202336 REACT_223993 REACT_226341 REACT_230708 REACT_234357 REACT_240139 REACT_94437 | |
NextBio | 290141 | |
PRO | PR:O35082 | |
Proteomes | UP000000589 | |
Bgee | O35082 | |
CleanEx | MM_KL | |
ExpressionAtlas | O35082 | |
Genevestigator | O35082 | |
GO | GO:0005576 GO:0005615 GO:0070062 GO:0016021 GO:0005886 GO:0004566 GO:0017134 GO:0005104 GO:0004871 GO:0002526 GO:0007568 GO:0055074 GO:0005975 GO:0006112 GO:0008286 GO:0030501 GO:0090080 | |
Gene3D | 3.20.20.80 | |
InterPro | IPR001360 IPR018120 IPR013781 IPR017853 IPR028546 | |
PANTHER | PTHR10353 PTHR10353:SF10 | |
Pfam | PF00232 | |
PRINTS | PR00131 | |
SUPFAM | SSF51445 | |
PROSITE | PS00653 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
GO:0005104 |
fibroblast growth factor receptor binding |
ECO:0000314 |
F |
Figure 1: Klotho expression was suppressed in the diabetic rats, but was increased by rAAV.mKL delivery. rAAV.mKL significantly suppressed diabetes‑induced renal hypertrophy and histopathological changes, reduced renal collagen fiber generation and decreased kidney hypertrophy index. |
complete | |||||
enables |
GO:0017134 |
fibroblast growth factor binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0005104 |
fibroblast growth factor receptor binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0017134 |
fibroblast growth factor binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1101771 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0008422 |
beta-glucosidase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000039458 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0005104 |
fibroblast growth factor receptor binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1101771 |
F |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0090080 |
positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1890427 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0055074 |
calcium ion homeostasis |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1316731 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0042421 |
norepinephrine biosynthetic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620396 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0030501 |
positive regulation of bone mineralization |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0017134 |
fibroblast growth factor binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
Missing: with/from | |||
acts_upstream_of_or_within |
GO:0007568 |
aging |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1889570 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0007568 |
aging |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0006112 |
energy reserve metabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1889570 |
P |
occurs_in:(EMAPA:19209)|occurs_in:(EMAPA:35926) |
Seeded From UniProt |
complete | |
part_of |
GO:0005576 |
extracellular region |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
Missing: with/from | |||
acts_upstream_of_or_within |
GO:0003085 |
negative regulation of systemic arterial blood pressure |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620396 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0002526 |
acute inflammatory response |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620396 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030501 |
positive regulation of bone mineralization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9UEF7 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0017134 |
fibroblast growth factor binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9UEF7 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007568 |
aging |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9UEF7 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0004553 |
hydrolase activity, hydrolyzing O-glycosyl compounds |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005615 |
extracellular space |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0005975 |
carbohydrate metabolic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007568 |
aging |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0008286 |
insulin receptor signaling pathway |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0008543 |
fibroblast growth factor receptor signaling pathway |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0004566 |
beta-glucuronidase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0016798 |
hydrolase activity, acting on glycosyl bonds |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0008152 |
metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0016324 |
apical plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Deng, M et al. (2015) Klotho gene delivery ameliorates renal hypertrophy and fibrosis in streptozotocin-induced diabetic rats by suppressing the Rho-associated coiled-coil kinase signaling pathway. Mol Med Rep 12 45-54 PubMed GONUTS page
- ↑ 2.0 2.1 Urakawa, I et al. (2006) Klotho converts canonical FGF receptor into a specific receptor for FGF23. Nature 444 770-4 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Kurosu, H et al. (2006) Regulation of fibroblast growth factor-23 signaling by klotho. J. Biol. Chem. 281 6120-3 PubMed GONUTS page
- ↑ Takei, Y et al. (2012) Stanniocalcin 2 is associated with ectopic calcification in α-klotho mutant mice and inhibits hyperphosphatemia-induced calcification in aortic vascular smooth muscle cells. Bone 50 998-1005 PubMed GONUTS page
- ↑ 6.0 6.1 Shiraki-Iida, T et al. (1998) Structure of the mouse klotho gene and its two transcripts encoding membrane and secreted protein. FEBS Lett. 424 6-10 PubMed GONUTS page
- ↑ Kuro-o, M et al. (1997) Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 390 45-51 PubMed GONUTS page
- ↑ Mori, K et al. (2000) Disruption of klotho gene causes an abnormal energy homeostasis in mice. Biochem. Biophys. Res. Commun. 278 665-70 PubMed GONUTS page
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