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MOUSE:KLOT

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Kl
Protein Name(s) Klotho

Klotho peptide

External Links
UniProt O35082
EMBL AB005141
AB010088
AB010091
AB010091
BC138258
BC138259
CCDS CCDS19889.1
RefSeq NP_038851.2
UniGene Mm.6500
ProteinModelPortal O35082
SMR O35082
BioGrid 200958
DIP DIP-39894N
IntAct O35082
MINT MINT-8175062
STRING 10090.ENSMUSP00000077899
CAZy GH1
PhosphoSite O35082
PaxDb O35082
PRIDE O35082
Ensembl ENSMUST00000078856
GeneID 16591
KEGG mmu:16591
UCSC uc009auk.2
uc009aul.2
CTD 9365
MGI MGI:1101771
eggNOG COG2723
GeneTree ENSGT00550000074452
HOGENOM HOG000060126
HOVERGEN HBG081856
InParanoid O35082
KO K14756
OMA ALSSHWI
OrthoDB EOG7MH0XV
TreeFam TF314803
Reactome REACT_196588
REACT_198525
REACT_202336
REACT_223993
REACT_226341
REACT_230708
REACT_234357
REACT_240139
REACT_94437
NextBio 290141
PRO PR:O35082
Proteomes UP000000589
Bgee O35082
CleanEx MM_KL
ExpressionAtlas O35082
Genevestigator O35082
GO GO:0005576
GO:0005615
GO:0070062
GO:0016021
GO:0005886
GO:0004566
GO:0017134
GO:0005104
GO:0004871
GO:0002526
GO:0007568
GO:0055074
GO:0005975
GO:0006112
GO:0008286
GO:0030501
GO:0090080
Gene3D 3.20.20.80
InterPro IPR001360
IPR018120
IPR013781
IPR017853
IPR028546
PANTHER PTHR10353
PTHR10353:SF10
Pfam PF00232
PRINTS PR00131
SUPFAM SSF51445
PROSITE PS00653

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0005104

fibroblast growth factor receptor binding

PMID:25695625[1]

ECO:0000314

F

Figure 1: Klotho expression was suppressed in the diabetic rats, but was increased by rAAV.mKL delivery. rAAV.mKL significantly suppressed diabetes‑induced renal hypertrophy and histopathological changes, reduced renal collagen fiber generation and decreased kidney hypertrophy index.

complete
CACAO 10696

enables

GO:0017134

fibroblast growth factor binding

PMID:17086194[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9EPC2

F

Seeded From UniProt

complete

enables

GO:0005104

fibroblast growth factor receptor binding

PMID:17086194[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P16092

F

Seeded From UniProt

complete

enables

GO:0017134

fibroblast growth factor binding

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1101771
PANTHER:PTN000039496
UniProtKB:Q9UEF7

F

Seeded From UniProt

complete

enables

GO:0008422

beta-glucosidase activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000039458
TAIR:locus:2018179
TAIR:locus:2033928
TAIR:locus:2083524
TAIR:locus:2092767
TAIR:locus:2180597
TAIR:locus:2201492
TAIR:locus:2201502
UniProtKB:O80689
UniProtKB:O80690
UniProtKB:P49235
UniProtKB:Q75I93
UniProtKB:Q75I94
UniProtKB:Q8GRX1
UniProtKB:Q8L7J2
UniProtKB:Q9H227

F

Seeded From UniProt

complete

enables

GO:0005104

fibroblast growth factor receptor binding

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1101771
PANTHER:PTN000039496

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0090080

positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway

PMID:16436388[4]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1890427

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0055074

calcium ion homeostasis

PMID:22285620[5]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1316731

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042421

norepinephrine biosynthetic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620396

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030501

positive regulation of bone mineralization

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9UEF7

P

Seeded From UniProt

complete

enables

GO:0017134

fibroblast growth factor binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9UEF7

F

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

PMID:9537505[6]

ECO:0000250

sequence similarity evidence used in manual assertion

C

Seeded From UniProt

Missing: with/from

acts_upstream_of_or_within

GO:0007568

aging

PMID:9363890[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1889570

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007568

aging

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9UEF7

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006112

energy reserve metabolic process

PMID:11095966[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1889570

P

occurs_in:(EMAPA:19209)|occurs_in:(EMAPA:35926)

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

PMID:9537505[6]

ECO:0000250

sequence similarity evidence used in manual assertion

C

Seeded From UniProt

Missing: with/from

acts_upstream_of_or_within

GO:0003085

negative regulation of systemic arterial blood pressure

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620396

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0002526

acute inflammatory response

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620396

P

Seeded From UniProt

complete

involved_in

GO:0030501

positive regulation of bone mineralization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9UEF7
ensembl:ENSP00000369442

P

Seeded From UniProt

complete

enables

GO:0017134

fibroblast growth factor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9UEF7
ensembl:ENSP00000369442

F

Seeded From UniProt

complete

involved_in

GO:0007568

aging

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9UEF7
ensembl:ENSP00000369442

P

Seeded From UniProt

complete

enables

GO:0004553

hydrolase activity, hydrolyzing O-glycosyl compounds

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001360

F

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR028546

C

Seeded From UniProt

complete

involved_in

GO:0005975

carbohydrate metabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001360

P

Seeded From UniProt

complete

involved_in

GO:0007568

aging

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR028546

P

Seeded From UniProt

complete

involved_in

GO:0008286

insulin receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR028546

P

Seeded From UniProt

complete

involved_in

GO:0008543

fibroblast growth factor receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR028546

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR028546

C

Seeded From UniProt

complete

enables

GO:0004566

beta-glucuronidase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:3.2.1.31

F

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

enables

GO:0016798

hydrolase activity, acting on glycosyl bonds

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0326

F

Seeded From UniProt

complete

involved_in

GO:0008152

metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0326

P

Seeded From UniProt

complete

part_of

GO:0016324

apical plasma membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0015

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Deng, M et al. (2015) Klotho gene delivery ameliorates renal hypertrophy and fibrosis in streptozotocin-induced diabetic rats by suppressing the Rho-associated coiled-coil kinase signaling pathway. Mol Med Rep 12 45-54 PubMed GONUTS page
  2. ↑ 2.0 2.1 Urakawa, I et al. (2006) Klotho converts canonical FGF receptor into a specific receptor for FGF23. Nature 444 770-4 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  4. ↑ Kurosu, H et al. (2006) Regulation of fibroblast growth factor-23 signaling by klotho. J. Biol. Chem. 281 6120-3 PubMed GONUTS page
  5. ↑ Takei, Y et al. (2012) Stanniocalcin 2 is associated with ectopic calcification in α-klotho mutant mice and inhibits hyperphosphatemia-induced calcification in aortic vascular smooth muscle cells. Bone 50 998-1005 PubMed GONUTS page
  6. ↑ 6.0 6.1 Shiraki-Iida, T et al. (1998) Structure of the mouse klotho gene and its two transcripts encoding membrane and secreted protein. FEBS Lett. 424 6-10 PubMed GONUTS page
  7. ↑ Kuro-o, M et al. (1997) Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 390 45-51 PubMed GONUTS page
  8. ↑ Mori, K et al. (2000) Disruption of klotho gene causes an abnormal energy homeostasis in mice. Biochem. Biophys. Res. Commun. 278 665-70 PubMed GONUTS page
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