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PMID:9363890
| Citation |
Kuro-o, M, Matsumura, Y, Aizawa, H, Kawaguchi, H, Suga, T, Utsugi, T, Ohyama, Y, Kurabayashi, M, Kaname, T, Kume, E, Iwasaki, H, Iida, A, Shiraki-Iida, T, Nishikawa, S, Nagai, R and Nabeshima, YI (1997) Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 390:45-51 |
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| Abstract |
A new gene, termed klotho, has been identified that is involved in the suppression of several ageing phenotypes. A defect in klotho gene expression in the mouse results in a syndrome that resembles human ageing, including a short lifespan, infertility, arteriosclerosis, skin atrophy, osteoporosis and emphysema. The gene encodes a membrane protein that shares sequence similarity with the beta-glucosidase enzymes. The klotho gene product may function as part of a signalling pathway that regulates ageing in vivo and morbidity in age-related diseases. |
| Links |
PubMed Online version:10.1038/36285 |
| Keywords |
Aging/genetics; Aging/pathology; Amino Acid Sequence; Animals; Arteriosclerosis/genetics; Arteriosclerosis/pathology; Atrophy; Calcinosis/genetics; Calcinosis/pathology; Cloning, Molecular; Emphysema/genetics; Female; Genitalia/pathology; Humans; Male; Membrane Proteins/genetics; Membrane Proteins/physiology; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Transgenic; Molecular Sequence Data; Mutagenesis, Insertional; Osteoporosis/genetics; Osteoporosis/pathology; Phenotype; Pituitary Gland/pathology; Sequence Homology, Amino Acid; Skin/pathology; Syndrome; Thymus Gland/pathology |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
References
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