MOUSE:KLF2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Klf2 (synonyms: Lklf)
Protein Name(s)	Krueppel-like factor 2 Lung krueppel-like factor
External Links
UniProt	Q60843
EMBL	U25096 BC138737 BC138738
CCDS	CCDS22412.1
RefSeq	NP_032478.2
UniGene	Mm.26938
ProteinModelPortal	Q60843
SMR	Q60843
BioGrid	200964
STRING	10090.ENSMUSP00000064823
iPTMnet	Q60843
PhosphoSitePlus	Q60843
MaxQB	Q60843
PaxDb	Q60843
PRIDE	Q60843
Ensembl	ENSMUST00000067912
GeneID	16598
KEGG	mmu:16598
UCSC	uc009mfq.2
CTD	10365
MGI	MGI:1342772
eggNOG	KOG1721 COG5048
GeneTree	ENSGT00760000118998
HOGENOM	HOG000060173
HOVERGEN	HBG006220
InParanoid	Q60843
KO	K17845
OMA	FYYPEPG
OrthoDB	EOG090B080H
TreeFam	TF350556
PRO	PR:Q60843
Proteomes	UP000000589
Bgee	ENSMUSG00000055148
CleanEx	MM_KLF2
Genevisible	Q60843
GO	GO:0005634 GO:0003677 GO:0046872 GO:0043565 GO:0003700 GO:0000902 GO:0071409 GO:0070301 GO:0071347 GO:0071499 GO:1901653 GO:0071356 GO:0034101 GO:0043249 GO:0001701 GO:0035264 GO:0032715 GO:0045429 GO:0051247 GO:0045944 GO:0036003 GO:0045893 GO:0040029 GO:0006351 GO:0060509
Gene3D	3.30.160.60
InterPro	IPR007087 IPR015880 IPR013087
Pfam	PF00096
SMART	SM00355
PROSITE	PS00028 PS50157

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Y5W3	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1342771 MGI:MGI:1342772 PANTHER:PTN002555475 UniProtKB:Q9Y5W3	P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1338056 MGI:MGI:1342287 MGI:MGI:1354948 MGI:MGI:2153049 MGI:MGI:2153568 MGI:MGI:2181068 MGI:MGI:98968 PANTHER:PTN001145452 RGD:3738 UniProtKB:A0A1D8PNL1 UniProtKB:Q02446 UniProtKB:Q7RTV3 ZFIN:ZDB-GENE-021115-9	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1342772 PANTHER:PTN002555475 UniProtKB:Q13351	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0043364 FB:FBgn0261434 FB:FBgn0263239 MGI:MGI:1101353 MGI:MGI:1277166 MGI:MGI:1333856 MGI:MGI:1338056 MGI:MGI:1342287 MGI:MGI:1342772 MGI:MGI:1346318 MGI:MGI:1929988 MGI:MGI:1932575 MGI:MGI:2153568 MGI:MGI:95295 MGI:MGI:95296 MGI:MGI:98372 MGI:MGI:98968 PANTHER:PTN001145452 RGD:1306768 RGD:2544 RGD:3738 RGD:3741 RGD:3974 RGD:621445 RGD:621652 RGD:62389 UniProtKB:A0A0B4KHC8 UniProtKB:A0A0G2K5M1 UniProtKB:P18146 UniProtKB:P19544 UniProtKB:Q02086 UniProtKB:Q13351 UniProtKB:Q13886 UniProtKB:Q7RTV3 UniProtKB:Q8TDD2 UniProtKB:Q99612 UniProtKB:Q9UIH9 WB:WBGene00007772 WB:WBGene00012735	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002555475 UniProtKB:Q9Y5W3	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001145452 UniProtKB:O14901 UniProtKB:Q9Y5W3 WB:WBGene00012735 ZFIN:ZDB-GENE-021115-9	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0036003	positive regulation of transcription from RNA polymerase II promoter in response to stress	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y5W3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035264	multicellular organism growth	PMID:15947087^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3047647	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034101	erythrocyte homeostasis	PMID:15947087^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3047647	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032715	negative regulation of interleukin-6 production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1359220	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:22001906^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16728) part_of:(CL:0000082)	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y5W3	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:7565748^[4]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:O89090	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y5W3	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:15820306^[5]	ECO:0000250	sequence similarity evidence used in manual assertion		F		Seeded From UniProt	Missing: with/from
acts_upstream_of_or_within	GO:0001701	in utero embryonic development	PMID:9859212^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3047647	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001701	in utero embryonic development	PMID:15947087^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3047647	P		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y5W3	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000902	cell morphogenesis	PMID:15947087^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3047647	P		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y5W3	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y5W3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903671	negative regulation of sprouting angiogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y5W3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097533	cellular stress response to acid chemical	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y5W3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071499	cellular response to laminar fluid shear stress	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y5W3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071498	cellular response to fluid shear stress	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y5W3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060509	type I pneumocyte differentiation	PMID:22001906^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(EMAPA:16728)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051247	positive regulation of protein metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y5W3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15947087^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3047647	P	has_regulation_target:(MGI:MGI:96027)\|has_regulation_target:(MGI:MGI:96024)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:22001906^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y5W3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	PMID:7565748^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y5W3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1359220	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045429	positive regulation of nitric oxide biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y5W3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043249	erythrocyte maturation	PMID:15947087^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3047647	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0040029	regulation of gene expression, epigenetic	PMID:22482507^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:3588194	P		Seeded From UniProt	complete
involved_in	GO:1901653	cellular response to peptide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ET58 ensembl:ENSRNOP00000019052	P		Seeded From UniProt	complete
involved_in	GO:0071409	cellular response to cycloheximide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ET58 ensembl:ENSRNOP00000019052	P		Seeded From UniProt	complete
involved_in	GO:0071407	cellular response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ET58 ensembl:ENSRNOP00000019052	P		Seeded From UniProt	complete
involved_in	GO:0071356	cellular response to tumor necrosis factor	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ET58 ensembl:ENSRNOP00000019052	P		Seeded From UniProt	complete
involved_in	GO:0071347	cellular response to interleukin-1	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ET58 ensembl:ENSRNOP00000019052	P		Seeded From UniProt	complete
involved_in	GO:0070301	cellular response to hydrogen peroxide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ET58 ensembl:ENSRNOP00000019052	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ET58 ensembl:ENSRNOP00000019052	P		Seeded From UniProt	complete
involved_in	GO:0034616	response to laminar fluid shear stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ET58 ensembl:ENSRNOP00000019052	P		Seeded From UniProt	complete
involved_in	GO:0032715	negative regulation of interleukin-6 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ET58 ensembl:ENSRNOP00000019052	P		Seeded From UniProt	complete
involved_in	GO:1903671	negative regulation of sprouting angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y5W3 ensembl:ENSP00000248071	P		Seeded From UniProt	complete
involved_in	GO:0097533	cellular stress response to acid chemical	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y5W3 ensembl:ENSP00000248071	P		Seeded From UniProt	complete
involved_in	GO:0071499	cellular response to laminar fluid shear stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y5W3 ensembl:ENSP00000248071	P		Seeded From UniProt	complete
involved_in	GO:0071498	cellular response to fluid shear stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y5W3 ensembl:ENSP00000248071	P		Seeded From UniProt	complete
involved_in	GO:0051247	positive regulation of protein metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y5W3 ensembl:ENSP00000248071	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y5W3 ensembl:ENSP00000248071	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y5W3 ensembl:ENSP00000248071	P		Seeded From UniProt	complete
involved_in	GO:0045429	positive regulation of nitric oxide biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y5W3 ensembl:ENSP00000248071	P		Seeded From UniProt	complete
involved_in	GO:0036003	positive regulation of transcription from RNA polymerase II promoter in response to stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y5W3 ensembl:ENSP00000248071	P		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y5W3 ensembl:ENSP00000248071	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y5W3 ensembl:ENSP00000248071	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y5W3 ensembl:ENSP00000248071	F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y5W3 ensembl:ENSP00000248071	C		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y5W3 ensembl:ENSP00000248071	P		Seeded From UniProt	complete
enables	GO:0003676	nucleic acid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013087	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Basu, P et al. (2005) KLF2 is essential for primitive erythropoiesis and regulates the human and murine embryonic beta-like globin genes in vivo. Blood 106 2566-71 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Pei, L et al. (2011) Thyroid hormone receptor repression is linked to type I pneumocyte-associated respiratory distress syndrome. Nat. Med. 17 1466-72 PubMed GONUTS page
↑ ^4.0 ^4.1 Anderson, KP et al. (1995) Isolation of a gene encoding a functional zinc finger protein homologous to erythroid Krüppel-like factor: identification of a new multigene family. Mol. Cell. Biol. 15 5957-65 PubMed GONUTS page
↑ Suske, G et al. (2005) Mammalian SP/KLF transcription factors: bring in the family. Genomics 85 551-6 PubMed GONUTS page
↑ Wani, MA et al. (1998) Loss of LKLF function results in embryonic lethality in mice. Transgenic Res. 7 229-38 PubMed GONUTS page
↑ Gillich, A et al. (2012) Epiblast stem cell-based system reveals reprogramming synergy of germline factors. Cell Stem Cell 10 425-39 PubMed GONUTS page

[PMID:21873635-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:15947087-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Basu, P et al. (2005) KLF2 is essential for primitive erythropoiesis and regulates the human and murine embryonic beta-like globin genes in vivo. Blood 106 2566-71 PubMed GONUTS page

[PMID:22001906-3] 3.0 ^3.1 ^3.2 Pei, L et al. (2011) Thyroid hormone receptor repression is linked to type I pneumocyte-associated respiratory distress syndrome. Nat. Med. 17 1466-72 PubMed GONUTS page

[PMID:7565748-4] 4.0 ^4.1 Anderson, KP et al. (1995) Isolation of a gene encoding a functional zinc finger protein homologous to erythroid Krüppel-like factor: identification of a new multigene family. Mol. Cell. Biol. 15 5957-65 PubMed GONUTS page

[PMID:15820306-5] Suske, G et al. (2005) Mammalian SP/KLF transcription factors: bring in the family. Genomics 85 551-6 PubMed GONUTS page

[PMID:9859212-6] Wani, MA et al. (1998) Loss of LKLF function results in embryonic lethality in mice. Transgenic Res. 7 229-38 PubMed GONUTS page

[PMID:22482507-7] Gillich, A et al. (2012) Epiblast stem cell-based system reveals reprogramming synergy of germline factors. Cell Stem Cell 10 425-39 PubMed GONUTS page

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MOUSE:KLF2

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