MOUSE:KIF3A

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Kif3a (synonyms: Kif3)
Protein Name(s)	Kinesin-like protein KIF3A Microtubule plus end-directed kinesin motor 3A
External Links
UniProt	P28741
EMBL	D12645 AL596095 BC052707
CCDS	CCDS48795.1
PIR	B44259
RefSeq	NP_001277734.1 NP_001277735.1 NP_032469.2
UniGene	Mm.88694
ProteinModelPortal	P28741
SMR	P28741
BioGrid	200941
DIP	DIP-46318N
IntAct	P28741
PhosphoSite	P28741
MaxQB	P28741
PaxDb	P28741
PRIDE	P28741
Ensembl	ENSMUST00000120613
GeneID	16568
KEGG	mmu:16568
UCSC	uc007iwl.1
CTD	11127
MGI	MGI:107689
eggNOG	COG5059
GeneTree	ENSGT00770000120453
HOGENOM	HOG000116164
HOVERGEN	HBG052255
InParanoid	P28741
KO	K10394
TreeFam	TF105223
Reactome	REACT_196550 REACT_199054 REACT_199117 REACT_269412
ChiTaRS	Kif3a
NextBio	290073
PRO	PR:P28741
Proteomes	UP000000589
Bgee	P28741
CleanEx	MM_KIF3A
ExpressionAtlas	P28741
Genevestigator	P28741
GO	GO:0005930 GO:0005929 GO:0005829 GO:0016939 GO:0005874 GO:0043005 GO:0032391 GO:0072372 GO:0008021 GO:0005524 GO:0016887 GO:0008017 GO:0003777 GO:0030507 GO:0009952 GO:0006200 GO:0042384 GO:0060271 GO:0007368 GO:0021904 GO:0009953 GO:0036334 GO:0008544 GO:0007507 GO:0001701 GO:0060122 GO:0001822 GO:0008152 GO:0007018 GO:0050679 GO:0048260 GO:0007224
Gene3D	3.40.850.10
InterPro	IPR027640 IPR019821 IPR001752 IPR027417
PANTHER	PTHR24115
Pfam	PF00225
PRINTS	PR00380
SMART	SM00129
SUPFAM	SSF52540
PROSITE	PS00411 PS50067

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0051236	establishment of RNA localization	PMID:21209331^[1]	ECO:0000315			P		Fig S7B shows the Kif3a knockout alters the RNA localisation of Pax6	complete CACAO 2878
	GO:0021904	dorsal/ventral neural tube patterning	PMID:21209331^[1]	ECO:0000315			P		Fig S7B shows the Kif3a knockout alters the RNA localisation of Pax6 within the neural tube (known to be a ventralising gene). Abnormal dorsal/ventral morphology of the mutant phenotype	complete CACAO 2879
	GO:0035083	cilium axoneme assembly	PMID:21209331^[1]	ECO:0000315			P		Fig S7C shows the Kif3a mouse knockout fibroblast cells do not develop cilia axenomes	complete CACAO 2880
involved_in	GO:0034454	microtubule anchoring at centrosome	PMID:23386061^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010457	centriole-centriole cohesion	PMID:23386061^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005814	centriole	PMID:23386061^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0060271	cilium assembly	PMID:21209331^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0021904	dorsal/ventral neural tube patterning	PMID:21209331^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:21670265^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0060271	cilium assembly	PMID:21670265^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0032391	photoreceptor connecting cilium	PMID:19208653^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0060271	cilium assembly	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107689 PANTHER:PTN001190402 ZFIN:ZDB-GENE-050417-71	P		Seeded From UniProt	complete
enables	GO:0016887	ATPase activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108426 MGI:MGI:1098226 MGI:MGI:2447072 PANTHER:PTN000648413 PomBase:SPBC1604.20c PomBase:SPBC1685.15c PomBase:SPBC2F12.13 RGD:621520 TAIR:locus:2148543 TAIR:locus:2157533 UniProtKB:C8V3Q8 UniProtKB:Q0IMS9 UniProtKB:Q6YZ52 UniProtKB:Q7X7H4 UniProtKB:Q96Q89 dictyBase:DDB_G0280967	F		Seeded From UniProt	complete
involved_in	GO:0008089	anterograde axonal transport	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004380 PANTHER:PTN000650181	P		Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000352 FB:FBgn0001308 FB:FBgn0004378 FB:FBgn0011606 MGI:MGI:107689 MGI:MGI:108391 MGI:MGI:109564 MGI:MGI:1098226 MGI:MGI:2447072 PANTHER:PTN000648413 PomBase:SPAC3A11.14c PomBase:SPAC664.10 PomBase:SPBC1604.20c PomBase:SPBC1685.15c PomBase:SPBC2F12.13 RGD:1304996 RGD:1306815 RGD:621538 RGD:621559 SGD:S000006345 TAIR:locus:2129630 TAIR:locus:2136437 TAIR:locus:2148543 TAIR:locus:2157533 UniProtKB:O00139 UniProtKB:P17120 UniProtKB:P33176 UniProtKB:Q02224 UniProtKB:Q02241 UniProtKB:Q0IMS9 UniProtKB:Q8NI77 UniProtKB:Q96Q89 WB:WBGene00006831 WB:WBGene00006974 dictyBase:DDB_G0276369	F		Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004380 PANTHER:PTN000650181	P		Seeded From UniProt	complete
involved_in	GO:0007018	microtubule-based movement	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0001308 FB:FBgn0004378 FB:FBgn0004381 MGI:MGI:108426 MGI:MGI:2447072 PANTHER:PTN000648413 UniProtKB:Q0IMS9 UniProtKB:Q6YZ52 UniProtKB:Q7X7H4 WB:WBGene00002222 WB:WBGene00002225 WB:WBGene00002230 WB:WBGene00006831 WB:WBGene00006974 dictyBase:DDB_G0281555	P		Seeded From UniProt	complete
part_of	GO:0005874	microtubule	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004378 PANTHER:PTN000648413 RGD:1303035 RGD:1304996 RGD:621538 TAIR:locus:2089358 UniProtKB:O00139 UniProtKB:P52732 UniProtKB:Q02224 UniProtKB:Q15058 UniProtKB:Q9HAQ2 WB:WBGene00002228 WB:WBGene00003884 ZFIN:ZDB-GENE-991019-4	C		Seeded From UniProt	complete
part_of	GO:0005871	kinesin complex	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0001308 FB:FBgn0002948 FB:FBgn0004378 MGI:MGI:109202 MGI:MGI:1098229 PANTHER:PTN000648413 RGD:1303035 UniProtKB:D6XFK9 UniProtKB:O77382 UniProtKB:Q57UW8 UniProtKB:Q57X99 UniProtKB:Q582I0 WB:WBGene00003884	C		Seeded From UniProt	complete
enables	GO:0003777	microtubule motor activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0001308 FB:FBgn0002948 FB:FBgn0003545 MGI:MGI:108426 MGI:MGI:1098229 MGI:MGI:1098264 MGI:MGI:2447072 PANTHER:PTN000648413 PomBase:SPAC3A11.14c RGD:621559 SGD:S000000159 SGD:S000000787 TAIR:locus:2115713 UniProtKB:A0A0B4KFR5 UniProtKB:A0A1D8PT88 UniProtKB:O77382 UniProtKB:P17120 UniProtKB:P33176 UniProtKB:Q02224 UniProtKB:Q0IMS9 UniProtKB:Q2M1P5 UniProtKB:Q5T7B8 UniProtKB:Q6YZ52 WB:WBGene00002222 WB:WBGene00002230 WB:WBGene00003884 WB:WBGene00006974 dictyBase:DDB_G0280967 dictyBase:DDB_G0291039	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000771	positive regulation of establishment or maintenance of cell polarity regulating cell shape	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621536	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1905515	non-motile cilium assembly	PMID:18297065^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2179048,MGI:MGI:2386464	P	occurs_in:(EMAPA:19037)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1905128	positive regulation of axo-dendritic protein transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621536	P		Seeded From UniProt	complete
part_of	GO:1904115	axon cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621536	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902414	protein localization to cell junction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y496	P		Seeded From UniProt	complete
enables	GO:0120170	intraciliary transport particle B binding	PMID:12821668^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(EMAPA:17373)\|occurs_in:(EMAPA:17168)\|occurs_in:(EMAPA:17972)	Seeded From UniProt	complete
colocalizes_with	GO:0097470	ribbon synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621536	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090316	positive regulation of intracellular protein transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621536	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061351	neural precursor cell proliferation	PMID:18297065^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2179048,MGI:MGI:2386464	P	occurs_in:(EMAPA:19037)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060271	cilium assembly	PMID:21703454^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1926500,MGI:MGI:2386464	P	occurs_in:(CL:0000312)\|occurs_in:(EMAPA:17528)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060271	cilium assembly	PMID:19684112^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060271	cilium assembly	PMID:18729223^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386464	P	occurs_in:(EMAPA:16105)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060271	cilium assembly	PMID:10220415^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1861960	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060122	inner ear receptor cell stereocilium organization	PMID:18066062^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386464	P	occurs_in:(EMAPA:17597)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050679	positive regulation of epithelial cell proliferation	PMID:21703454^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1926500,MGI:MGI:2386464	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048260	positive regulation of receptor-mediated endocytosis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621536	P		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621536	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0044458	motile cilium assembly	PMID:10330409^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2181727	P	occurs_in:(EMAPA:16075)	Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621536	C		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:17360631^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0036334	epidermal stem cell homeostasis	PMID:21429982^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386464,MGI:MGI:2446606	P	occurs_in:(EMAPA:17525)	Seeded From UniProt	complete
part_of	GO:0031514	motile cilium	PMID:10330409^[13]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16075)	Seeded From UniProt	complete
enables	GO:0030507	spectrin binding	PMID:23704327^[16]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y496	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021915	neural tube development	PMID:10330409^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2181727	P	occurs_in:(EMAPA:16530)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021904	dorsal/ventral neural tube patterning	PMID:18590716^[17]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1341070 MGI:MGI:95728	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021904	dorsal/ventral neural tube patterning	PMID:19286674^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1861960	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021904	dorsal/ventral neural tube patterning	PMID:18590716^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1861960	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021542	dentate gyrus development	PMID:18297065^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2179048,MGI:MGI:2386464	P	occurs_in:(EMAPA:19037)	Seeded From UniProt	complete
enables	GO:0019903	protein phosphatase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y496	F		Seeded From UniProt	complete
enables	GO:0019894	kinesin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621536	F		Seeded From UniProt	complete
enables	GO:0017137	Rab GTPase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y496	F		Seeded From UniProt	complete
part_of	GO:0016939	kinesin II complex	PMID:19384852^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016939	kinesin II complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y496	C		Seeded From UniProt	complete
part_of	GO:0015630	microtubule cytoskeleton	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y496	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0015031	protein transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y496	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009953	dorsal/ventral pattern formation	PMID:15755804^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3580660	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009952	anterior/posterior pattern specification	PMID:10220415^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1861960	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008544	epidermis development	PMID:21703454^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1926500,MGI:MGI:2386464	P	results_in_development_of:(EMAPA:17528)	Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	PMID:17360631^[14]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007507	heart development	PMID:18729223^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386464	P	results_in_development_of:(EMAPA:16105)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007368	determination of left/right symmetry	PMID:15755804^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3580660	P	has_participant:(EMAPA:16039)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007368	determination of left/right symmetry	PMID:10220415^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1861960	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007224	smoothened signaling pathway	PMID:19286674^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1861960	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007224	smoothened signaling pathway	PMID:18297065^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2179048,MGI:MGI:2386464	P	occurs_in:(EMAPA:19037)	Seeded From UniProt	complete
part_of	GO:0005930	axoneme	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621536	C		Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:17825299^[21]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:1000497)	Seeded From UniProt	complete
colocalizes_with	GO:0005876	spindle microtubule	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y496	C		Seeded From UniProt	complete
part_of	GO:0005814	centriole	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y496	C		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y496	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001947	heart looping	PMID:10330409^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2181727	P	occurs_in:(EMAPA:16105)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001822	kidney development	PMID:15067314^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386464	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001701	in utero embryonic development	PMID:19286674^[18]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1329045	P		Seeded From UniProt	complete
involved_in	GO:2000771	positive regulation of establishment or maintenance of cell polarity regulating cell shape	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LQZ3 ensembl:ENSRNOP00000009999	P		Seeded From UniProt	complete
involved_in	GO:1905128	positive regulation of axo-dendritic protein transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LQZ3 ensembl:ENSRNOP00000009999	P		Seeded From UniProt	complete
part_of	GO:1904115	axon cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LQZ3 ensembl:ENSRNOP00000009999	C		Seeded From UniProt	complete
part_of	GO:0097470	ribbon synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LQZ3 ensembl:ENSRNOP00000009999	C		Seeded From UniProt	complete
involved_in	GO:0090316	positive regulation of intracellular protein transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LQZ3 ensembl:ENSRNOP00000009999	P		Seeded From UniProt	complete
involved_in	GO:0048260	positive regulation of receptor-mediated endocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LQZ3 ensembl:ENSRNOP00000009999	P		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LQZ3 ensembl:ENSRNOP00000009999	F		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LQZ3 ensembl:ENSRNOP00000009999	C		Seeded From UniProt	complete
enables	GO:0019894	kinesin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LQZ3 ensembl:ENSRNOP00000009999	F		Seeded From UniProt	complete
part_of	GO:0005930	axoneme	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LQZ3 ensembl:ENSRNOP00000009999	C		Seeded From UniProt	complete
enables	GO:0003777	microtubule motor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001752 InterPro:IPR019821 InterPro:IPR027640	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001752 InterPro:IPR019821	F		Seeded From UniProt	complete
involved_in	GO:0007018	microtubule-based movement	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001752 InterPro:IPR019821 InterPro:IPR027640	P		Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001752	F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-MMU-984713 Reactome:R-MMU-5632657 Reactome:R-MMU-2316350	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206 UniProtKB-SubCell:SL-0090	C		Seeded From UniProt	complete
part_of	GO:0005874	microtubule	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0493	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
part_of	GO:0005929	cilium	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0969 UniProtKB-SubCell:SL-0066	C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
involved_in	GO:0030030	cell projection organization	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0970	P		Seeded From UniProt	complete
part_of	GO:0005814	centriole	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0046	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Qin, J et al. (2011) Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components. Proc. Natl. Acad. Sci. U.S.A. 108 1456-61 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Kodani, A et al. (2013) Kif3a interacts with Dynactin subunit p150 Glued to organize centriole subdistal appendages. EMBO J. 32 597-607 PubMed GONUTS page
↑ ^3.0 ^3.1 Choi, YH et al. (2011) Polycystin-2 and phosphodiesterase 4C are components of a ciliary A-kinase anchoring protein complex that is disrupted in cystic kidney diseases. Proc. Natl. Acad. Sci. U.S.A. 108 10679-84 PubMed GONUTS page
↑ Jiang, ST et al. (2009) Essential role of nephrocystin in photoreceptor intraflagellar transport in mouse. Hum. Mol. Genet. 18 1566-77 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 ^5.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Han, YG et al. (2008) Hedgehog signaling and primary cilia are required for the formation of adult neural stem cells. Nat. Neurosci. 11 277-84 PubMed GONUTS page
↑ Baker, SA et al. (2003) IFT20 links kinesin II with a mammalian intraflagellar transport complex that is conserved in motile flagella and sensory cilia. J. Biol. Chem. 278 34211-8 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Ezratty, EJ et al. (2011) A role for the primary cilium in Notch signaling and epidermal differentiation during skin development. Cell 145 1129-41 PubMed GONUTS page
↑ Chen, MH et al. (2009) Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved. Genes Dev. 23 1910-28 PubMed GONUTS page
↑ ^10.0 ^10.1 Slough, J et al. (2008) Monocilia in the embryonic mouse heart suggest a direct role for cilia in cardiac morphogenesis. Dev. Dyn. 237 2304-14 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Marszalek, JR et al. (1999) Situs inversus and embryonic ciliary morphogenesis defects in mouse mutants lacking the KIF3A subunit of kinesin-II. Proc. Natl. Acad. Sci. U.S.A. 96 5043-8 PubMed GONUTS page
↑ Jones, C et al. (2008) Ciliary proteins link basal body polarization to planar cell polarity regulation. Nat. Genet. 40 69-77 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 Takeda, S et al. (1999) Left-right asymmetry and kinesin superfamily protein KIF3A: new insights in determination of laterality and mesoderm induction by kif3A-/- mice analysis. J. Cell Biol. 145 825-36 PubMed GONUTS page
↑ ^14.0 ^14.1 Ikegami, K et al. (2007) Loss of alpha-tubulin polyglutamylation in ROSA22 mice is associated with abnormal targeting of KIF1A and modulated synaptic function. Proc. Natl. Acad. Sci. U.S.A. 104 3213-8 PubMed GONUTS page
↑ Croyle, MJ et al. (2011) Role of epidermal primary cilia in the homeostasis of skin and hair follicles. Development 138 1675-85 PubMed GONUTS page
↑ Papal, S et al. (2013) The giant spectrin βV couples the molecular motors to phototransduction and Usher syndrome type I proteins along their trafficking route. Hum. Mol. Genet. 22 3773-88 PubMed GONUTS page
↑ ^17.0 ^17.1 Cho, A et al. (2008) FKBP8 cell-autonomously controls neural tube patterning through a Gli2- and Kif3a-dependent mechanism. Dev. Biol. 321 27-39 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 Norman, RX et al. (2009) Tubby-like protein 3 (TULP3) regulates patterning in the mouse embryo through inhibition of Hedgehog signaling. Hum. Mol. Genet. 18 1740-54 PubMed GONUTS page
↑ Insinna, C et al. (2009) Different roles for KIF17 and kinesin II in photoreceptor development and maintenance. Dev. Dyn. 238 2211-22 PubMed GONUTS page
↑ ^20.0 ^20.1 García-García, MJ et al. (2005) Analysis of mouse embryonic patterning and morphogenesis by forward genetics. Proc. Natl. Acad. Sci. U.S.A. 102 5913-9 PubMed GONUTS page
↑ Lolkema, MP et al. (2007) The von Hippel-Lindau tumour suppressor interacts with microtubules through kinesin-2. FEBS Lett. 581 4571-6 PubMed GONUTS page
↑ Hiesberger, T et al. (2004) Mutation of hepatocyte nuclear factor-1beta inhibits Pkhd1 gene expression and produces renal cysts in mice. J. Clin. Invest. 113 814-25 PubMed GONUTS page

[PMID:21209331-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Qin, J et al. (2011) Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components. Proc. Natl. Acad. Sci. U.S.A. 108 1456-61 PubMed GONUTS page

[PMID:23386061-2] 2.0 ^2.1 ^2.2 Kodani, A et al. (2013) Kif3a interacts with Dynactin subunit p150 Glued to organize centriole subdistal appendages. EMBO J. 32 597-607 PubMed GONUTS page

[PMID:21670265-3] 3.0 ^3.1 Choi, YH et al. (2011) Polycystin-2 and phosphodiesterase 4C are components of a ciliary A-kinase anchoring protein complex that is disrupted in cystic kidney diseases. Proc. Natl. Acad. Sci. U.S.A. 108 10679-84 PubMed GONUTS page

[PMID:19208653-4] Jiang, ST et al. (2009) Essential role of nephrocystin in photoreceptor intraflagellar transport in mouse. Hum. Mol. Genet. 18 1566-77 PubMed GONUTS page

[PMID:21873635-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 ^5.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:18297065-6] 6.0 ^6.1 ^6.2 ^6.3 Han, YG et al. (2008) Hedgehog signaling and primary cilia are required for the formation of adult neural stem cells. Nat. Neurosci. 11 277-84 PubMed GONUTS page

[PMID:12821668-7] Baker, SA et al. (2003) IFT20 links kinesin II with a mammalian intraflagellar transport complex that is conserved in motile flagella and sensory cilia. J. Biol. Chem. 278 34211-8 PubMed GONUTS page

[PMID:21703454-8] 8.0 ^8.1 ^8.2 Ezratty, EJ et al. (2011) A role for the primary cilium in Notch signaling and epidermal differentiation during skin development. Cell 145 1129-41 PubMed GONUTS page

[PMID:19684112-9] Chen, MH et al. (2009) Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved. Genes Dev. 23 1910-28 PubMed GONUTS page

[PMID:18729223-10] 10.0 ^10.1 Slough, J et al. (2008) Monocilia in the embryonic mouse heart suggest a direct role for cilia in cardiac morphogenesis. Dev. Dyn. 237 2304-14 PubMed GONUTS page

[PMID:10220415-11] 11.0 ^11.1 ^11.2 Marszalek, JR et al. (1999) Situs inversus and embryonic ciliary morphogenesis defects in mouse mutants lacking the KIF3A subunit of kinesin-II. Proc. Natl. Acad. Sci. U.S.A. 96 5043-8 PubMed GONUTS page

[PMID:18066062-12] Jones, C et al. (2008) Ciliary proteins link basal body polarization to planar cell polarity regulation. Nat. Genet. 40 69-77 PubMed GONUTS page

[PMID:10330409-13] 13.0 ^13.1 ^13.2 ^13.3 Takeda, S et al. (1999) Left-right asymmetry and kinesin superfamily protein KIF3A: new insights in determination of laterality and mesoderm induction by kif3A-/- mice analysis. J. Cell Biol. 145 825-36 PubMed GONUTS page

[PMID:17360631-14] 14.0 ^14.1 Ikegami, K et al. (2007) Loss of alpha-tubulin polyglutamylation in ROSA22 mice is associated with abnormal targeting of KIF1A and modulated synaptic function. Proc. Natl. Acad. Sci. U.S.A. 104 3213-8 PubMed GONUTS page

[PMID:21429982-15] Croyle, MJ et al. (2011) Role of epidermal primary cilia in the homeostasis of skin and hair follicles. Development 138 1675-85 PubMed GONUTS page

[PMID:23704327-16] Papal, S et al. (2013) The giant spectrin βV couples the molecular motors to phototransduction and Usher syndrome type I proteins along their trafficking route. Hum. Mol. Genet. 22 3773-88 PubMed GONUTS page

[PMID:18590716-17] 17.0 ^17.1 Cho, A et al. (2008) FKBP8 cell-autonomously controls neural tube patterning through a Gli2- and Kif3a-dependent mechanism. Dev. Biol. 321 27-39 PubMed GONUTS page

[PMID:19286674-18] 18.0 ^18.1 ^18.2 Norman, RX et al. (2009) Tubby-like protein 3 (TULP3) regulates patterning in the mouse embryo through inhibition of Hedgehog signaling. Hum. Mol. Genet. 18 1740-54 PubMed GONUTS page

[PMID:19384852-19] Insinna, C et al. (2009) Different roles for KIF17 and kinesin II in photoreceptor development and maintenance. Dev. Dyn. 238 2211-22 PubMed GONUTS page

[PMID:15755804-20] 20.0 ^20.1 García-García, MJ et al. (2005) Analysis of mouse embryonic patterning and morphogenesis by forward genetics. Proc. Natl. Acad. Sci. U.S.A. 102 5913-9 PubMed GONUTS page

[PMID:17825299-21] Lolkema, MP et al. (2007) The von Hippel-Lindau tumour suppressor interacts with microtubules through kinesin-2. FEBS Lett. 581 4571-6 PubMed GONUTS page

[PMID:15067314-22] Hiesberger, T et al. (2004) Mutation of hepatocyte nuclear factor-1beta inhibits Pkhd1 gene expression and produces renal cysts in mice. J. Clin. Invest. 113 814-25 PubMed GONUTS page

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MOUSE:KIF3A

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