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PMID:17825299

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Citation

Lolkema, MP, Mans, DA, Snijckers, CM, van Noort, M, van Beest, M, Voest, EE and Giles, RH (2007) The von Hippel-Lindau tumour suppressor interacts with microtubules through kinesin-2. FEBS Lett. 581:4571-6

Abstract

Synthesis and maintenance of primary cilia are regulated by the von Hippel-Lindau (VHL) tumour suppressor protein. Recent studies indicate that this regulation is linked to microtubule-dependent functions of pVHL such as orienting microtubule growth and increasing plus-end microtubule stability, however little is known how this occurs. We have identified the kinesin-2 motor complex, known to regulate cilia, as a novel and endogenous pVHL binding partner. The interaction with kinesin-2 facilitates pVHL binding to microtubules. These data suggest that microtubule-dependent functions of pVHL are influenced by kinesin-2.

Links

PubMed Online version:10.1016/j.febslet.2007.08.050

Keywords

Alleles; Animals; Cell Line; Humans; Kinesin/classification; Kinesin/genetics; Kinesin/metabolism; Mice; Microtubules/metabolism; Mutation/genetics; Protein Binding; Von Hippel-Lindau Tumor Suppressor Protein/genetics; Von Hippel-Lindau Tumor Suppressor Protein/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:KIF3A

located_in

GO:0005929: cilium

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(CL:1000497)

Seeded From UniProt

complete

MOUSE:KIF3A

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:P70188

F

Seeded From UniProt

complete

MOUSE:KIF3A

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q61771

F

Seeded From UniProt

complete

MOUSE:VHL

located_in

GO:0005929: cilium

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(CL:1000497)

Seeded From UniProt

complete

MOUSE:VHL

enables

GO:0044877: protein-containing complex binding

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

MOUSE:KIFA3

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:P28741

F

Seeded From UniProt

complete

MOUSE:KIF3B

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:P28741

F

Seeded From UniProt

complete

MOUSE:KIF3A

part_of

GO:0005929: cilium

ECO:0000314: direct assay evidence used in manual assertion

C

part_of:(CL:1000497)

Seeded From UniProt

complete

Notes

See also

References

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