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MOUSE:KCNQ2
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Kcnq2 (synonyms: Kqt2) | |
| Protein Name(s) | Potassium voltage-gated channel subfamily KQT member 2
KQT-like 2 Potassium channel subunit alpha KvLQT2 Voltage-gated potassium channel subunit Kv7.2 | |
| External Links | ||
| UniProt | Q9Z351 | |
| EMBL | AB000494 AB000495 AB000496 AB000497 AB000498 AB000499 AB000500 AB000501 AB000502 AB000503 AB000504 AF490773 AK139411 | |
| CCDS | CCDS17193.1 CCDS17194.1 CCDS17195.1 CCDS17196.1 CCDS17197.1 CCDS17198.1 | |
| RefSeq | NP_001006675.1 NP_001289817.1 NP_034741.2 | |
| UniGene | Mm.40615 Mm.440175 | |
| ProteinModelPortal | Q9Z351 | |
| BioGrid | 200918 | |
| IntAct | Q9Z351 | |
| BindingDB | Q9Z351 | |
| ChEMBL | CHEMBL2985 | |
| iPTMnet | Q9Z351 | |
| PhosphoSitePlus | Q9Z351 | |
| PRIDE | Q9Z351 | |
| DNASU | 16536 | |
| GeneID | 16536 | |
| KEGG | mmu:16536 | |
| UCSC | uc008olg.2 | |
| CTD | 3785 | |
| MGI | MGI:1309503 | |
| HOVERGEN | HBG059014 | |
| InParanoid | Q9Z351 | |
| KO | K04927 | |
| PRO | PR:Q9Z351 | |
| Proteomes | UP000000589 | |
| Bgee | ENSMUSG00000016346 | |
| GO | GO:0043194 GO:0009986 GO:0033268 GO:0005886 GO:0008076 GO:0030506 GO:0005516 GO:0005244 GO:0005249 GO:0071805 GO:0019226 | |
| InterPro | IPR005821 IPR003937 IPR003947 IPR013821 IPR028325 | |
| PANTHER | PTHR11537 | |
| Pfam | PF00520 PF03520 | |
| PRINTS | PR00169 PR01461 PR01459 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0045163 |
clustering of voltage-gated potassium channels |
ECO:0000314 |
P |
KCNQ2 forms clusters of voltage-gated potassium channels with KCNQ3, as seen in Figure 3A-D. Uniprot Nomenclature: Potassium voltage-gated channel subfamily KQT member 2 (KCNQ2_MOUSE) Uniprot ID: Q9Z351 Organism: Mus musculus |
complete | |||||
|
enables |
GO:0005249 |
voltage-gated potassium channel activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071805 |
potassium ion transmembrane transport |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0043194 |
axon initial segment |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0033268 |
node of Ranvier |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071805 |
potassium ion transmembrane transport |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:102663 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0043194 |
axon initial segment |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1309503 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0003380 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0008076 |
voltage-gated potassium channel complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0003380 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005516 |
calmodulin binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1309503 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005251 |
delayed rectifier potassium channel activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000899150 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005249 |
voltage-gated potassium channel activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:108083 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0071805 |
potassium ion transmembrane transport |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0071805 |
potassium ion transmembrane transport |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:621504 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0047485 |
protein N-terminus binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:621504 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0032991 |
protein-containing complex |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:621504 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0030506 |
ankyrin binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0019226 |
transmission of nerve impulse |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2386963 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0009986 |
cell surface |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0008076 |
voltage-gated potassium channel complex |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1336181 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0008076 |
voltage-gated potassium channel complex |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0008076 |
voltage-gated potassium channel complex |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:621504 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:621504 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:621504 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005516 |
calmodulin binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005516 |
calmodulin binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005249 |
voltage-gated potassium channel activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005249 |
voltage-gated potassium channel activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:621504 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005244 |
voltage-gated ion channel activity |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1336181 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005216 |
ion channel activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005249 |
voltage-gated potassium channel activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006811 |
ion transport |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006813 |
potassium ion transport |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0008076 |
voltage-gated potassium channel complex |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0055085 |
transmembrane transport |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005244 |
voltage-gated ion channel activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006813 |
potassium ion transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005267 |
potassium channel activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0034765 |
regulation of ion transmembrane transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006811 |
ion transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071805 |
potassium ion transmembrane transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Zhang, J et al. (2016) Clustering and Functional Coupling of Diverse Ion Channels and Signaling Proteins Revealed by Super-resolution STORM Microscopy in Neurons. Neuron 92 461-478 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Pan, Z et al. (2006) A common ankyrin-G-based mechanism retains KCNQ and NaV channels at electrically active domains of the axon. J. Neurosci. 26 2599-613 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Watanabe, H et al. (2000) Disruption of the epilepsy KCNQ2 gene results in neural hyperexcitability. J. Neurochem. 75 28-33 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 Wen, H & Levitan, IB (2002) Calmodulin is an auxiliary subunit of KCNQ2/3 potassium channels. J. Neurosci. 22 7991-8001 PubMed GONUTS page
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