MOUSE:JAM1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	F11r (synonyms: Jam1, Jcam, Jcam1)
Protein Name(s)	Junctional adhesion molecule A JAM-A Junctional adhesion molecule 1 JAM-1
External Links
UniProt	O88792
EMBL	U89915 AK033574 CT010347 AC087229 BC021876
CCDS	CCDS15496.1
RefSeq	NP_766235.1
UniGene	Mm.294882
PDB	1F97
PDBsum	1F97
ProteinModelPortal	O88792
SMR	O88792
IntAct	O88792
MINT	MINT-247376
STRING	10090.ENSMUSP00000041907
PhosphoSite	O88792
PaxDb	O88792
PRIDE	O88792
Ensembl	ENSMUST00000043839
GeneID	16456
KEGG	mmu:16456
UCSC	uc007doo.1
CTD	50848
MGI	MGI:1321398
eggNOG	NOG150281
GeneTree	ENSGT00730000110678
HOGENOM	HOG000247041
HOVERGEN	HBG000518
InParanoid	O88792
KO	K06089
OMA	SCSYSGF
OrthoDB	EOG7MH0Z1
TreeFam	TF331459
Reactome	REACT_196549 REACT_216309 REACT_225233 REACT_236746
ChiTaRS	F11r
EvolutionaryTrace	O88792
NextBio	289731
PRO	PR:O88792
Proteomes	UP000000589
CleanEx	MM_F11R
Genevestigator	O88792
GO	GO:0031410 GO:0070062 GO:0016021 GO:0015630 GO:0005886 GO:0036057 GO:0005923 GO:0007155 GO:0030855 GO:0045777 GO:0009314 GO:0016032
Gene3D	2.60.40.10
InterPro	IPR007110 IPR013783 IPR013098 IPR003598 IPR003596
Pfam	PF07679
SMART	SM00408 SM00406
PROSITE	PS50835

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0001817	regulation of cytokine production	PMID:18514073^[1]	ECO:0000315			P		Based on results in Figure 6	complete CACAO 2872
involved_in	GO:0001817	regulation of cytokine production	PMID:18514073^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090559	regulation of membrane permeability	PMID:23885123^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0000160)	Seeded From UniProt	complete
involved_in	GO:0050892	intestinal absorption	PMID:23885123^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090559	regulation of membrane permeability	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1321398 PANTHER:PTN002895217 UniProtKB:Q9Y624	P		Seeded From UniProt	complete
involved_in	GO:0090557	establishment of endothelial intestinal barrier	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002895217 UniProtKB:Q9Y624	P		Seeded From UniProt	complete
involved_in	GO:0050892	intestinal absorption	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1321398 PANTHER:PTN002895217 UniProtKB:Q9Y624	P		Seeded From UniProt	complete
part_of	GO:0005923	bicellular tight junction	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1321398 PANTHER:PTN002895217 UniProtKB:Q9Y624	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000249	regulation of actin cytoskeleton reorganization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y624	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090559	regulation of membrane permeability	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y624	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090557	establishment of endothelial intestinal barrier	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y624	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072659	protein localization to plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y624	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050892	intestinal absorption	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y624	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045777	positive regulation of blood pressure	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621842	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043547	positive regulation of GTPase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y624	P		Seeded From UniProt	complete
part_of	GO:0036057	slit diaphragm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621842	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034260	negative regulation of GTPase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y624	P		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621842	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031032	actomyosin structure organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y624	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030855	epithelial cell differentiation	PMID:15494378^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(EMAPA:16046) results_in_acquisition_of_features_of:(CL:0000007)\|occurs_in(EMAPA:16046) results_in_acquisition_of_features_of:(CL:0000066)	Seeded From UniProt	complete
enables	GO:0030165	PDZ domain binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y624	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007155	cell adhesion	PMID:15494378^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005923	bicellular tight junction	PMID:15494378^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		C	part_of:(EMAPA:16046) part_of:(CL:0000007)\|part_of:(EMAPA:16046) part_of:(CL:0000066)	Seeded From UniProt	complete
part_of	GO:0005923	bicellular tight junction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y624	C		Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621842	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y624	C		Seeded From UniProt	complete
involved_in	GO:0045777	positive regulation of blood pressure	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHY1 ensembl:ENSRNOP00000006141	P		Seeded From UniProt	complete
part_of	GO:0036057	slit diaphragm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHY1 ensembl:ENSRNOP00000006141	C		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHY1 ensembl:ENSRNOP00000006141	C		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHY1 ensembl:ENSRNOP00000006141	P		Seeded From UniProt	complete
involved_in	GO:0009314	response to radiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHY1 ensembl:ENSRNOP00000006141	P		Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHY1 ensembl:ENSRNOP00000006141	C		Seeded From UniProt	complete
involved_in	GO:2000249	regulation of actin cytoskeleton reorganization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y624 ensembl:ENSP00000357005	P		Seeded From UniProt	complete
involved_in	GO:0090559	regulation of membrane permeability	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y624 ensembl:ENSP00000357005	P		Seeded From UniProt	complete
involved_in	GO:0090557	establishment of endothelial intestinal barrier	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y624 ensembl:ENSP00000357005	P		Seeded From UniProt	complete
involved_in	GO:0072659	protein localization to plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y624 ensembl:ENSP00000357005	P		Seeded From UniProt	complete
involved_in	GO:0050892	intestinal absorption	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y624 ensembl:ENSP00000357005	P		Seeded From UniProt	complete
involved_in	GO:0043547	positive regulation of GTPase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y624 ensembl:ENSP00000357005	P		Seeded From UniProt	complete
involved_in	GO:0034260	negative regulation of GTPase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y624 ensembl:ENSP00000357005	P		Seeded From UniProt	complete
involved_in	GO:0031032	actomyosin structure organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y624 ensembl:ENSP00000357005	P		Seeded From UniProt	complete
enables	GO:0030165	PDZ domain binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y624 ensembl:ENSP00000357005	F		Seeded From UniProt	complete
part_of	GO:0005923	bicellular tight junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y624 ensembl:ENSP00000357005	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y624 ensembl:ENSP00000357005	C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
part_of	GO:0005923	bicellular tight junction	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0796 UniProtKB-SubCell:SL-0265	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Vetrano, S et al. (2008) Unique role of junctional adhesion molecule-a in maintaining mucosal homeostasis in inflammatory bowel disease. Gastroenterology 135 173-84 PubMed GONUTS page
↑ ^2.0 ^2.1 Monteiro, AC et al. (2013) JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function. Mol. Biol. Cell 24 2849-60 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Thomas, FC et al. (2004) Contribution of JAM-1 to epithelial differentiation and tight-junction biogenesis in the mouse preimplantation embryo. J. Cell. Sci. 117 5599-608 PubMed GONUTS page

[PMID:18514073-1] 1.0 ^1.1 Vetrano, S et al. (2008) Unique role of junctional adhesion molecule-a in maintaining mucosal homeostasis in inflammatory bowel disease. Gastroenterology 135 173-84 PubMed GONUTS page

[PMID:23885123-2] 2.0 ^2.1 Monteiro, AC et al. (2013) JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function. Mol. Biol. Cell 24 2849-60 PubMed GONUTS page

[PMID:21873635-3] 3.0 ^3.1 ^3.2 ^3.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:15494378-4] 4.0 ^4.1 ^4.2 Thomas, FC et al. (2004) Contribution of JAM-1 to epithelial differentiation and tight-junction biogenesis in the mouse preimplantation embryo. J. Cell. Sci. 117 5599-608 PubMed GONUTS page

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MOUSE:JAM1

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