PMID:18514073

Citation	Vetrano, S, Rescigno, M, Cera, MR, Correale, C, Rumio, C, Doni, A, Fantini, M, Sturm, A, Borroni, E, Repici, A, Locati, M, Malesci, A, Dejana, E and Danese, S (2008) Unique role of junctional adhesion molecule-a in maintaining mucosal homeostasis in inflammatory bowel disease. Gastroenterology 135:173-84
Abstract	Junctional adhesion molecule-A (JAM-A) is localized at the tight junctions and controls leukocyte migration into the tissues. However, its functional role in inflammatory bowel disease (IBD) is unexplored.
Links	PubMed Online version:10.1053/j.gastro.2008.04.002
Keywords	Animals; Apoptosis; Cell Adhesion Molecules/genetics; Cell Adhesion Molecules/immunology; Cell Adhesion Molecules/metabolism; Cell Movement/immunology; Colitis, Ulcerative/immunology; Colitis, Ulcerative/metabolism; Colitis, Ulcerative/pathology; Crohn Disease/immunology; Crohn Disease/metabolism; Crohn Disease/pathology; Cytokines/metabolism; Disease Models, Animal; Down-Regulation/immunology; Gene Deletion; Homeostasis/immunology; Humans; Immunoglobulins/genetics; Immunoglobulins/immunology; Immunoglobulins/metabolism; Intestinal Mucosa/immunology; Intestinal Mucosa/metabolism; Intestinal Mucosa/pathology; Leukocytes/cytology; Leukocytes/immunology; Male; Mice; Mice, Mutant Strains; Permeability; RNA Interference; Receptors, Cell Surface/genetics; Receptors, Cell Surface/immunology; Receptors, Cell Surface/metabolism
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Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
MOUSE:JAM1	involved_in	GO:0001817: regulation of cytokine production	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
MOUSE:JAM1		GO:0001817: regulation of cytokine production	ECO:0000315:		P		Based on results in Figure 6	complete CACAO 2872

References

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