MOUSE:ITF2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Tcf4 (synonyms: Itf2, Sef2)
Protein Name(s)	Transcription factor 4 TCF-4 Class A helix-loop-helix transcription factor ME2 Immunoglobulin transcription factor 2 ITF-2 MITF-2 SL3-3 enhancer factor 2 SEF-2
External Links
UniProt	Q60722
EMBL	S75870 U16321 U16322 X91753 AK081012 BC043050
CCDS	CCDS29329.1 CCDS50315.1
PIR	I52648
RefSeq	NP_001077436.1 NP_038713.1 XP_006525809.1 XP_006525810.1 XP_006525813.1 XP_006525825.1
UniGene	Mm.4269
ProteinModelPortal	Q60722
SMR	Q60722
BioGrid	204006
DIP	DIP-42841N
IntAct	Q60722
MINT	MINT-2567893
PhosphoSite	Q60722
MaxQB	Q60722
PaxDb	Q60722
PRIDE	Q60722
Ensembl	ENSMUST00000078486 ENSMUST00000114978 ENSMUST00000114980 ENSMUST00000114982 ENSMUST00000114985
GeneID	21413
KEGG	mmu:21413
UCSC	uc008fnq.1 uc008fns.1
CTD	6925
MGI	MGI:98506
eggNOG	NOG282899
GeneTree	ENSGT00510000046438
HOGENOM	HOG000234180
HOVERGEN	HBG003854
InParanoid	Q60722
KO	K15603
PhylomeDB	Q60722
TreeFam	TF321672
ChiTaRS	Tcf4
NextBio	300700
PRO	PR:Q60722
Proteomes	UP000000589
Bgee	Q60722
CleanEx	MM_TCF4
ExpressionAtlas	Q60722
Genevestigator	Q60722
GO	GO:0005634 GO:0005667 GO:0003682 GO:0003677 GO:0070888 GO:0046982 GO:0000978 GO:0001077 GO:0001011 GO:0001087 GO:0001093 GO:0003714 GO:0006352 GO:0000122 GO:0045666 GO:0045944 GO:0065004 GO:0006355 GO:0006367
Gene3D	4.10.280.10
InterPro	IPR011598
Pfam	PF00010
SMART	SM00353
SUPFAM	SSF47459
PROSITE	PS50888

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0070888	E-box binding	PMID:8978694^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0065004	protein-DNA complex assembly	PMID:8978694^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:8978694^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006367	transcription initiation from RNA polymerase II promoter	PMID:8978694^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006352	DNA-templated transcription, initiation	PMID:8978694^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:8978694^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0001093	TFIIB-class transcription factor binding	PMID:8978694^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:8978694^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:8978694^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:8978694^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0070888	E-box binding	PMID:18214987^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:18214987^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045666	positive regulation of neuron differentiation	PMID:18214987^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0267821 MGI:MGI:101877 MGI:MGI:98506 MGI:MGI:98510 PANTHER:PTN000927455 UniProtKB:P15923 UniProtKB:Q70IK3 WB:WBGene00001949	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0267821 MGI:MGI:98506 MGI:MGI:98510 PANTHER:PTN000927455 RGD:3829 RGD:69271 UniProtKB:P15923 UniProtKB:Q99081 WB:WBGene00001949	P		Seeded From UniProt	complete
involved_in	GO:0045666	positive regulation of neuron differentiation	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101877 MGI:MGI:98506 MGI:MGI:98510 PANTHER:PTN000927455	P		Seeded From UniProt	complete
enables	GO:0043425	bHLH transcription factor binding	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000927455 RGD:620914 RGD:69271 UniProtKB:P15923 UniProtKB:Q99081 WB:WBGene00001949	F		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0267821 MGI:MGI:98510 PANTHER:PTN000927455 UniProtKB:P15923 WB:WBGene00001949	F		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0267821 MGI:MGI:101877 MGI:MGI:98506 MGI:MGI:98510 PANTHER:PTN000927455 RGD:620914 UniProtKB:P15923 UniProtKB:Q70IK3	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0267821 MGI:MGI:98506 MGI:MGI:98510 PANTHER:PTN000927455 RGD:3829 UniProtKB:P15884 UniProtKB:P15923 UniProtKB:Q99081 WB:WBGene00001949	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0267821 MGI:MGI:98510 PANTHER:PTN000927455 UniProtKB:P15884 UniProtKB:P15923 UniProtKB:Q99081	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98506 MGI:MGI:98510 PANTHER:PTN000927455 UniProtKB:P15884 UniProtKB:P15923 UniProtKB:Q99081	F		Seeded From UniProt	complete
part_of	GO:1990907	beta-catenin-TCF complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15884	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900746	regulation of vascular endothelial growth factor signaling pathway	PMID:20231428^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0070369	beta-catenin-TCF7L2 complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15884	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69271	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15884	P		Seeded From UniProt	complete
enables	GO:0043621	protein self-association	PMID:20231428^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0043425	bHLH transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69271	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15884	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042118	endothelial cell activation	PMID:20231428^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016525	negative regulation of angiogenesis	PMID:20231428^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010629	negative regulation of gene expression	PMID:20231428^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15884	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006355	regulation of transcription, DNA-templated	PMID:15351717^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:15351717^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:20231428^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19796622^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15884	C		Seeded From UniProt	complete
enables	GO:0003714	transcription corepressor activity	PMID:8999959^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15884	F		Seeded From UniProt	complete
enables	GO:0003690	double-stranded DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69271	F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:24192035^[8]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(MGI:MGI:1890357)	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:14762206^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15884	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:23740243^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15884	F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15884	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:16950124^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:97347)	Seeded From UniProt	complete
enables	GO:0046983	protein dimerization activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011598 InterPro:IPR036638	F		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0524	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 ^1.9 Pscherer, A et al. (1996) The helix-loop-helix transcription factor SEF-2 regulates the activity of a novel initiator element in the promoter of the human somatostatin receptor II gene. EMBO J. 15 6680-90 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Ravanpay, AC & Olson, JM (2008) E protein dosage influences brain development more than family member identity. J. Neurosci. Res. 86 1472-81 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 ^3.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Tanaka, A et al. (2010) Inhibition of endothelial cell activation by bHLH protein E2-2 and its impairment of angiogenesis. Blood 115 4138-47 PubMed GONUTS page
↑ ^5.0 ^5.1 Murakami, M et al. (2004) Differential cooperation between dHAND and three different E-proteins. Biochem. Biophys. Res. Commun. 323 168-74 PubMed GONUTS page
↑ Nishiyama, A et al. (2009) Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell 5 420-33 PubMed GONUTS page
↑ Chen, B & Lim, RW (1997) Physical and functional interactions between the transcriptional inhibitors Id3 and ITF-2b. Evidence toward a novel mechanism regulating muscle-specific gene expression. J. Biol. Chem. 272 2459-63 PubMed GONUTS page
↑ Nishino, J et al. (2013) A network of heterochronic genes including Imp1 regulates temporal changes in stem cell properties. Elife 2 e00924 PubMed GONUTS page
↑ Günther, S et al. (2004) VITO-1 is an essential cofactor of TEF1-dependent muscle-specific gene regulation. Nucleic Acids Res. 32 791-802 PubMed GONUTS page
↑ Nakamura, I et al. (2013) Activation of the transcription factor GLI1 by WNT signaling underlies the role of SULFATASE 2 as a regulator of tissue regeneration. J. Biol. Chem. 288 21389-98 PubMed GONUTS page
↑ Lei, Q et al. (2006) Wnt signaling inhibitors regulate the transcriptional response to morphogenetic Shh-Gli signaling in the neural tube. Dev. Cell 11 325-37 PubMed GONUTS page

[PMID:8978694-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 ^1.9 Pscherer, A et al. (1996) The helix-loop-helix transcription factor SEF-2 regulates the activity of a novel initiator element in the promoter of the human somatostatin receptor II gene. EMBO J. 15 6680-90 PubMed GONUTS page

[PMID:18214987-2] 2.0 ^2.1 ^2.2 Ravanpay, AC & Olson, JM (2008) E protein dosage influences brain development more than family member identity. J. Neurosci. Res. 86 1472-81 PubMed GONUTS page

[PMID:21873635-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 ^3.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:20231428-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Tanaka, A et al. (2010) Inhibition of endothelial cell activation by bHLH protein E2-2 and its impairment of angiogenesis. Blood 115 4138-47 PubMed GONUTS page

[PMID:15351717-5] 5.0 ^5.1 Murakami, M et al. (2004) Differential cooperation between dHAND and three different E-proteins. Biochem. Biophys. Res. Commun. 323 168-74 PubMed GONUTS page

[PMID:19796622-6] Nishiyama, A et al. (2009) Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell 5 420-33 PubMed GONUTS page

[PMID:8999959-7] Chen, B & Lim, RW (1997) Physical and functional interactions between the transcriptional inhibitors Id3 and ITF-2b. Evidence toward a novel mechanism regulating muscle-specific gene expression. J. Biol. Chem. 272 2459-63 PubMed GONUTS page

[PMID:24192035-8] Nishino, J et al. (2013) A network of heterochronic genes including Imp1 regulates temporal changes in stem cell properties. Elife 2 e00924 PubMed GONUTS page

[PMID:14762206-9] Günther, S et al. (2004) VITO-1 is an essential cofactor of TEF1-dependent muscle-specific gene regulation. Nucleic Acids Res. 32 791-802 PubMed GONUTS page

[PMID:23740243-10] Nakamura, I et al. (2013) Activation of the transcription factor GLI1 by WNT signaling underlies the role of SULFATASE 2 as a regulator of tissue regeneration. J. Biol. Chem. 288 21389-98 PubMed GONUTS page

[PMID:16950124-11] Lei, Q et al. (2006) Wnt signaling inhibitors regulate the transcriptional response to morphogenetic Shh-Gli signaling in the neural tube. Dev. Cell 11 325-37 PubMed GONUTS page

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MOUSE:ITF2

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References

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