MOUSE:ITA5

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Itga5
Protein Name(s)	Integrin alpha-5 CD49 antigen-like family member E Fibronectin receptor subunit alpha Integrin alpha-F VLA-5 Integrin alpha-5 heavy chain Integrin alpha-5 light chain
External Links
UniProt	P11688
EMBL	X79003 AC131721 X15203
CCDS	CCDS27903.1
PIR	S44250
RefSeq	NP_034707.3
UniGene	Mm.16234
ProteinModelPortal	P11688
SMR	P11688
BioGrid	200818
IntAct	P11688
MINT	MINT-4098865
STRING	10090.ENSMUSP00000023128
PhosphoSite	P11688
MaxQB	P11688
PaxDb	P11688
PRIDE	P11688
Ensembl	ENSMUST00000023128
GeneID	16402
KEGG	mmu:16402
UCSC	uc007xyb.3
CTD	3678
MGI	MGI:96604
eggNOG	NOG26407
GeneTree	ENSGT00760000118782
HOGENOM	HOG000231603
HOVERGEN	HBG006186
InParanoid	P11688
KO	K06484
OMA	ERSCSLE
OrthoDB	EOG7HQN77
TreeFam	TF105391
Reactome	REACT_198996 REACT_204211 REACT_215461 REACT_216309 REACT_225233
ChiTaRS	Itga5
NextBio	289561
PRO	PR:P11688
Proteomes	UP000000589
Bgee	P11688
CleanEx	MM_ITGA5
ExpressionAtlas	P11688
Genevestigator	P11688
GO	GO:0009986 GO:0005911 GO:0031410 GO:0005783 GO:0009897 GO:0005925 GO:0005794 GO:0008305 GO:0005886 GO:0032587 GO:0045202 GO:0005178 GO:0046872 GO:0033631 GO:0031589 GO:0007044 GO:0007157 GO:0007229 GO:0007159 GO:0007613 GO:2000811 GO:0030335 GO:0010811 GO:0050731 GO:0035313
InterPro	IPR013517 IPR013519 IPR000413 IPR013649 IPR018184
Pfam	PF01839 PF08441
PRINTS	PR01185
SMART	SM00191
PROSITE	PS51470 PS00242

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0009986	cell surface	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08648	C		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08648	C		Seeded From UniProt	complete
involved_in	GO:0033627	cell adhesion mediated by integrin	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08648	P		Seeded From UniProt	complete
involved_in	GO:0045765	regulation of angiogenesis	PMID:19460962^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	RNAcentral:URS0000329B12_10090	P		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	PMID:12189152^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:12189152^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:12189152^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:12189152^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:23023225^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000811	negative regulation of anoikis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08648	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903672	positive regulation of sprouting angiogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08648	P		Seeded From UniProt	complete
enables	GO:0050839	cell adhesion molecule binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2925	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08648	P		Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:12904471^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035987	endodermal cell differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08648	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034113	heterotypic cell-cell adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08648	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033631	cell-cell adhesion mediated by integrin	PMID:8557754^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033627	cell adhesion mediated by integrin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08648	P		Seeded From UniProt	complete
colocalizes_with	GO:0032587	ruffle membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08648	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031589	cell-substrate adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08648	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030335	positive regulation of cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2925	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010811	positive regulation of cell-substrate adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2925	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:8306881^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16036)	Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08648	C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:9553049^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000057)\|part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:8557754^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000576)	Seeded From UniProt	complete
part_of	GO:0008305	integrin complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2925	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007613	memory	PMID:12904471^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857207	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007229	integrin-mediated signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2925	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007159	leukocyte cell-cell adhesion	PMID:8557754^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	PMID:8557754^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007155	cell adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08648	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007155	cell adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2925	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007044	cell-substrate junction assembly	PMID:12867986^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	PMID:29162887^[9]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08648	C		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08648	C		Seeded From UniProt	complete
colocalizes_with	GO:0005925	focal adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08648	C		Seeded From UniProt	complete
colocalizes_with	GO:0005911	cell-cell junction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08648	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2925	C		Seeded From UniProt	complete
enables	GO:0005178	integrin binding	PMID:8601592^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O54890 UniProtKB:O70309 UniProtKB:P09055 UniProtKB:Q9Z0T9	F		Seeded From UniProt	complete
enables	GO:0005178	integrin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2925	F		Seeded From UniProt	complete
enables	GO:0005154	epidermal growth factor receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2925	F		Seeded From UniProt	complete
involved_in	GO:2000811	negative regulation of anoikis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08648 ensembl:ENSP00000293379	P		Seeded From UniProt	complete
involved_in	GO:1903672	positive regulation of sprouting angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08648 ensembl:ENSP00000293379	P		Seeded From UniProt	complete
involved_in	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08648 ensembl:ENSP00000293379	P		Seeded From UniProt	complete
involved_in	GO:0035987	endodermal cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08648 ensembl:ENSP00000293379	P		Seeded From UniProt	complete
involved_in	GO:0035313	wound healing, spreading of epidermal cells	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08648 ensembl:ENSP00000293379	P		Seeded From UniProt	complete
involved_in	GO:0034113	heterotypic cell-cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08648 ensembl:ENSP00000293379	P		Seeded From UniProt	complete
involved_in	GO:0033627	cell adhesion mediated by integrin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08648 ensembl:ENSP00000293379	P		Seeded From UniProt	complete
part_of	GO:0032587	ruffle membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08648 ensembl:ENSP00000293379	C		Seeded From UniProt	complete
involved_in	GO:0031589	cell-substrate adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08648 ensembl:ENSP00000293379	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08648 ensembl:ENSP00000293379	C		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08648 ensembl:ENSP00000293379	P		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08648 ensembl:ENSP00000293379	C		Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08648 ensembl:ENSP00000293379	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08648 ensembl:ENSP00000293379	C		Seeded From UniProt	complete
enables	GO:0050839	cell adhesion molecule binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K1E2 ensembl:ENSRNOP00000071805	F		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K1E2 ensembl:ENSRNOP00000071805	P		Seeded From UniProt	complete
involved_in	GO:0010811	positive regulation of cell-substrate adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K1E2 ensembl:ENSRNOP00000071805	P		Seeded From UniProt	complete
part_of	GO:0008305	integrin complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K1E2 ensembl:ENSRNOP00000071805	C		Seeded From UniProt	complete
involved_in	GO:0007565	female pregnancy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K1E2 ensembl:ENSRNOP00000071805	P		Seeded From UniProt	complete
involved_in	GO:0007229	integrin-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K1E2 ensembl:ENSRNOP00000071805	P		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K1E2 ensembl:ENSRNOP00000071805	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K1E2 ensembl:ENSRNOP00000071805	C		Seeded From UniProt	complete
enables	GO:0005178	integrin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K1E2 ensembl:ENSRNOP00000071805	F		Seeded From UniProt	complete
enables	GO:0005154	epidermal growth factor receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K1E2 ensembl:ENSRNOP00000071805	F		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000413	P		Seeded From UniProt	complete
part_of	GO:0008305	integrin complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000413	C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
involved_in	GO:0007229	integrin-mediated signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0401	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0130	P		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0118	C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0310	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Bonauer, A et al. (2009) MicroRNA-92a controls angiogenesis and functional recovery of ischemic tissues in mice. Science 324 1710-3 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Wadehra, M et al. (2002) The tetraspan protein epithelial membrane protein-2 interacts with beta1 integrins and regulates adhesion. J. Biol. Chem. 277 41094-100 PubMed GONUTS page
↑ Rossier, O et al. (2012) Integrins β1 and β3 exhibit distinct dynamic nanoscale organizations inside focal adhesions. Nat. Cell Biol. 14 1057-67 PubMed GONUTS page
↑ ^4.0 ^4.1 Chan, CS et al. (2003) Integrin requirement for hippocampal synaptic plasticity and spatial memory. J. Neurosci. 23 7107-16 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Ruppert, M et al. (1995) The L1 adhesion molecule is a cellular ligand for VLA-5. J. Cell Biol. 131 1881-91 PubMed GONUTS page
↑ Sutherland, AE et al. (1993) Developmental regulation of integrin expression at the time of implantation in the mouse embryo. Development 119 1175-86 PubMed GONUTS page
↑ Baudoin, C et al. (1998) Knockout and knockin of the beta1 exon D define distinct roles for integrin splice variants in heart function and embryonic development. Genes Dev. 12 1202-16 PubMed GONUTS page
↑ Jiang, G et al. (2003) Two-piconewton slip bond between fibronectin and the cytoskeleton depends on talin. Nature 424 334-7 PubMed GONUTS page
↑ Rogg, M et al. (2017) The WD40-domain containing protein CORO2B is specifically enriched in glomerular podocytes and regulates the ventral actin cytoskeleton. Sci Rep 7 15910 PubMed GONUTS page
↑ Wada, J et al. (1996) Cloning of mouse integrin alphaV cDNA and role of the alphaV-related matrix receptors in metanephric development. J. Cell Biol. 132 1161-76 PubMed GONUTS page

[PMID:19460962-1] Bonauer, A et al. (2009) MicroRNA-92a controls angiogenesis and functional recovery of ischemic tissues in mice. Science 324 1710-3 PubMed GONUTS page

[PMID:12189152-2] 2.0 ^2.1 ^2.2 ^2.3 Wadehra, M et al. (2002) The tetraspan protein epithelial membrane protein-2 interacts with beta1 integrins and regulates adhesion. J. Biol. Chem. 277 41094-100 PubMed GONUTS page

[PMID:23023225-3] Rossier, O et al. (2012) Integrins β1 and β3 exhibit distinct dynamic nanoscale organizations inside focal adhesions. Nat. Cell Biol. 14 1057-67 PubMed GONUTS page

[PMID:12904471-4] 4.0 ^4.1 Chan, CS et al. (2003) Integrin requirement for hippocampal synaptic plasticity and spatial memory. J. Neurosci. 23 7107-16 PubMed GONUTS page

[PMID:8557754-5] 5.0 ^5.1 ^5.2 ^5.3 Ruppert, M et al. (1995) The L1 adhesion molecule is a cellular ligand for VLA-5. J. Cell Biol. 131 1881-91 PubMed GONUTS page

[PMID:8306881-6] Sutherland, AE et al. (1993) Developmental regulation of integrin expression at the time of implantation in the mouse embryo. Development 119 1175-86 PubMed GONUTS page

[PMID:9553049-7] Baudoin, C et al. (1998) Knockout and knockin of the beta1 exon D define distinct roles for integrin splice variants in heart function and embryonic development. Genes Dev. 12 1202-16 PubMed GONUTS page

[PMID:12867986-8] Jiang, G et al. (2003) Two-piconewton slip bond between fibronectin and the cytoskeleton depends on talin. Nature 424 334-7 PubMed GONUTS page

[PMID:29162887-9] Rogg, M et al. (2017) The WD40-domain containing protein CORO2B is specifically enriched in glomerular podocytes and regulates the ventral actin cytoskeleton. Sci Rep 7 15910 PubMed GONUTS page

[PMID:8601592-10] Wada, J et al. (1996) Cloning of mouse integrin alphaV cDNA and role of the alphaV-related matrix receptors in metanephric development. J. Cell Biol. 132 1161-76 PubMed GONUTS page

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MOUSE:ITA5

Contents

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Notes

References

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