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MOUSE:IRPL1

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Il1rapl1
Protein Name(s) Interleukin-1 receptor accessory protein-like 1

IL-1-RAPL-1 IL-1RAPL-1 IL1RAPL-1 X-linked interleukin-1 receptor accessory protein-like 1

External Links
UniProt P59823
EMBL AL844900
AL672059
AK081272
UniGene Mm.121680
Mm.400887
Mm.426143
ProteinModelPortal P59823
SMR P59823
IntAct P59823
PhosphoSite P59823
PaxDb P59823
PRIDE P59823
MGI MGI:2687319
eggNOG NOG41227
HOVERGEN HBG052148
InParanoid P59823
ChiTaRS Il1rapl1
PRO PR:P59823
Proteomes UP000000589
CleanEx MM_IL1RAPL1
Genevestigator P59823
GO GO:0030424
GO:0009986
GO:0005737
GO:0030425
GO:0016021
GO:0005886
GO:0045211
GO:0005102
GO:0005245
GO:0070588
GO:0007157
GO:0045920
GO:0030182
GO:0050775
GO:0097105
GO:0010975
GO:0007165
Gene3D 2.60.40.10
3.40.50.10140
InterPro IPR007110
IPR013783
IPR003599
IPR003598
IPR015621
IPR000157
PANTHER PTHR11890
Pfam PF01582
SMART SM00409
SM00408
SM00255
SUPFAM SSF52200
PROSITE PS50835
PS50104

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0030425

dendrite

PMID:21940441[1]

ECO:0000314

C

Figure 1A shows antibody of endogenous Il1rapl1 clustered at dendrites colocalized with Shank1 protein.

complete
CACAO 2154

GO:0097105

presynaptic membrane assembly

PMID:21940441[1]

ECO:0000315

P

Knock down of Il1rapl1 by siRNA: Figure 1C shows decrease in Bassoon protein (presynaptic marker at the presynaptic active zone which is part of the plasma membrane of the presynaptic neuron). Also seen in figure 1D and E When the mouse Il1rapl1 was rescued synapse formation was restorde by increasing Bassoon marker. (figure 1C-E)

complete
CACAO 2155

GO:0050775

positive regulation of dendrite morphogenesis

PMID:21940441[1]

ECO:0000315

P

Knockdown of Il1rapl1 by siRNA: Figure 1C shows decrease in dendritic protrusion, also seen in figure 1D and E. When the mouse Il1rapl1 was rescued synapse formation was restore by increasing dendrite density (figure 1C-E)

complete
CACAO 2156

GO:0009986

cell surface

PMID:21940441[1]

ECO:0000314

C

HEK293T cells transfected with mouse Il1rapl1 co cultured on cortical neurons, after 24 hours there was an increase in Bassoon expression and VGluT1 on the surface of HEK293T (figure 2A,B). Immunostaining of Il1rapl1 and Bassoon co-localized on the surface of HEK293T cells.

complete
CACAO 2157

GO:0007157

heterophilic cell-cell adhesion

PMID:21940441[1]

ECO:0000314

P

Figure 4C, HEK293T cell transfected with mouse Il1rapl1 labeled with EGFP and Receptor-type tyrosine-protein phosphatase delta (R-PTP-delta)labeled with RFP. Cell aggregated into large clumps suggesting that both Il1rapl1 and R-PTP-delta function as heterophilic cell adhesion molecules. But cell expressing either Il1rapl1 or R-PTP-delta did not show homophilic aggregation.

complete
CACAO 2159

involved_in

GO:0051965

positive regulation of synapse assembly

PMID:25908590[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007157

heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules

PMID:21940441[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0009986

cell surface

PMID:21940441[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0050775

positive regulation of dendrite morphogenesis

PMID:21940441[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0097105

presynaptic membrane assembly

PMID:21940441[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0030425

dendrite

PMID:21940441[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0097105

presynaptic membrane assembly

PMID:21940441[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050775

positive regulation of dendrite morphogenesis

PMID:21940441[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0045211

postsynaptic membrane

PMID:21940441[1]

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0030425

dendrite

PMID:21940441[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0030182

neuron differentiation

PMID:21940441[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0009986

cell surface

PMID:21940441[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0007157

heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules

PMID:21940441[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0005102

signaling receptor binding

PMID:21940441[1]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q64487

F

Seeded From UniProt

complete

involved_in

GO:0045920

negative regulation of exocytosis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9NZN1

P

Seeded From UniProt

complete

NOT|enables

GO:0019966

interleukin-1 binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9NZN1

F

Seeded From UniProt

complete

involved_in

GO:0010975

regulation of neuron projection development

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P59824

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9NZN1

C

Seeded From UniProt

complete

enables

GO:0005245

voltage-gated calcium channel activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P59824

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1905606

regulation of presynapse assembly

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9NZN1

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0099545

trans-synaptic signaling by trans-synaptic complex

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9NZN1

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0099175

regulation of postsynapse organization

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9NZN1

P

Seeded From UniProt

complete

part_of

GO:0099061

integral component of postsynaptic density membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:727891

C

Seeded From UniProt

complete

part_of

GO:0098978

glutamatergic synapse

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9NZN1

C

Seeded From UniProt

complete

part_of

GO:0098978

glutamatergic synapse

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:727891

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045920

negative regulation of exocytosis

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9NZN1

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045920

negative regulation of exocytosis

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:727891

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010975

regulation of neuron projection development

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:727891

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9NZN1

C

Seeded From UniProt

complete

enables

GO:0005245

voltage-gated calcium channel activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:727891

F

Seeded From UniProt

complete

involved_in

GO:0070588

calcium ion transmembrane transport

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005245

P

Seeded From UniProt

complete

involved_in

GO:0070588

calcium ion transmembrane transport

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005245

P

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000157

P

Seeded From UniProt

complete

part_of

GO:0042995

cell projection

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0966

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

part_of

GO:0030425

dendrite

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0283

C

Seeded From UniProt

complete

part_of

GO:0030424

axon

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0279

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 1.13 1.14 1.15 1.16 1.17 Yoshida, T et al. (2011) IL-1 receptor accessory protein-like 1 associated with mental retardation and autism mediates synapse formation by trans-synaptic interaction with protein tyrosine phosphatase δ. J. Neurosci. 31 13485-99 PubMed GONUTS page
  2. ↑ Yamagata, A et al. (2015) Mechanisms of splicing-dependent trans-synaptic adhesion by PTPδ-IL1RAPL1/IL-1RAcP for synaptic differentiation. Nat Commun 6 6926 PubMed GONUTS page
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