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MOUSE:IMA7

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Kpna6 (synonyms: Kpna5)
Protein Name(s) Importin subunit alpha-7

Importin alpha-S2 Karyopherin subunit alpha-6

External Links
UniProt O35345
EMBL AK007053
AK154882
BC004833
AF020773
CCDS CCDS18701.1
RefSeq NP_032494.3
UniGene Mm.202358
ProteinModelPortal O35345
SMR O35345
BioGrid 201010
DIP DIP-48616N
PhosphoSite O35345
MaxQB O35345
PaxDb O35345
PRIDE O35345
Ensembl ENSMUST00000102590
GeneID 16650
KEGG mmu:16650
UCSC uc008uxz.2
CTD 23633
MGI MGI:1100836
eggNOG COG5064
HOGENOM HOG000167616
HOVERGEN HBG001846
InParanoid O35345
OMA SSTTCGE
OrthoDB EOG7VHSWV
PhylomeDB O35345
TreeFam TF354205
ChiTaRS Kpna6
NextBio 290337
PRO PR:O35345
Proteomes UP000000589
Bgee O35345
CleanEx MM_KPNA6
ExpressionAtlas O35345
Genevestigator O35345
GO GO:0005737
GO:0016020
GO:0005634
GO:0008565
GO:0060135
GO:0045944
GO:0006606
Gene3D 1.25.10.10
InterPro IPR011989
IPR016024
IPR000225
IPR002652
IPR024931
Pfam PF00514
PF01749
PIRSF PIRSF005673
SMART SM00185
SUPFAM SSF48371
PROSITE PS50176
PS51214

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0040016

embryonic cleavage

PMID:21479251[1]

ECO:0000315

P

Fig 2. and Table 1. When embryos developed in vivo were isolated at 2.5 days after fertilization, all wildtype embryos had developed to four-cell and eight-cell stages, while only 6% of recovered embryos of importin α7ΔIBB/ΔIBB females had reached the two-cell stage and no single four-cell-embryo could be detected. Whereas first cleavage occurred in most of the in vitro cultured wildtype embryos, only very few two-cell embryos of importin α7ΔIBB/ΔIBB and importin α7−/− females. Further in vitro culture revealed complete arrest at the two-cell stage.

complete

enables

GO:0008565

obsolete protein transporter activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1100836
PANTHER:PTN000593662
SGD:S000005133
WB:WBGene00002072

F

Seeded From UniProt

complete

enables

GO:0008139

nuclear localization sequence binding

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000593662
RGD:735064

F

Seeded From UniProt

complete

involved_in

GO:0006607

NLS-bearing protein import into nucleus

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000593662
PomBase:SPBC1604.08c
RGD:735064
UniProtKB:Q8IAW0

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000593662
TAIR:locus:2083313
TAIR:locus:2132238
TAIR:locus:2143423
TAIR:locus:2195351
TAIR:locus:505006475
UniProtKB:O15131
UniProtKB:P52294

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000593662
PomBase:SPBC1604.08c
UniProtKB:P52294
WB:WBGene00002072

C

Seeded From UniProt

complete

part_of

GO:0005643

nuclear pore

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000593662
PomBase:SPBC1604.08c
WB:WBGene00002072

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1903902

positive regulation of viral life cycle

PMID:28189564[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3856636

P

occurs_in:(EMAPA:16728)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1903902

positive regulation of viral life cycle

PMID:28189564[3]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O60684

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1900017

positive regulation of cytokine production involved in inflammatory response

PMID:28189564[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3856636

P

occurs_in:(EMAPA:16728)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0075506

entry of viral genome into host nucleus through nuclear pore complex via importin

PMID:28189564[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3856636

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0075506

entry of viral genome into host nucleus through nuclear pore complex via importin

PMID:28189564[3]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O60684

P

Seeded From UniProt

complete

enables

GO:0061608

nuclear import signal receptor activity

PMID:15689618[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060135

maternal process involved in female pregnancy

PMID:21479251[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3856636
MGI:MGI:5004867

P

has_participant:(EMAPA:16036)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:21479251[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3856636

P

regulates_o_occurs_in:(EMAPA:16036)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030683

evasion or tolerance by virus of host immune response

PMID:28189564[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3856636

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006606

protein import into nucleus

PMID:15689618[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0043657

host cell

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0075506

C

Seeded From UniProt

complete

part_of

GO:0043657

host cell

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0075506

C

Seeded From UniProt

complete

part_of

GO:0043657

host cell

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0075506

C

Seeded From UniProt

complete

involved_in

GO:1903902

positive regulation of viral life cycle

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O60684
ensembl:ENSP00000362728

P

Seeded From UniProt

complete

involved_in

GO:0075506

entry of viral genome into host nucleus through nuclear pore complex via importin

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O60684
ensembl:ENSP00000362728

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR024931
InterPro:IPR036975

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR024931
InterPro:IPR036975

C

Seeded From UniProt

complete

involved_in

GO:0006606

protein import into nucleus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002652
InterPro:IPR024931
InterPro:IPR036975

P

Seeded From UniProt

complete

enables

GO:0008565

obsolete protein transporter activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR036975

F

Seeded From UniProt

complete

enables

GO:0061608

nuclear import signal receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002652
InterPro:IPR024931

F

Seeded From UniProt

complete

involved_in

GO:0015031

protein transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0653

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 Rother, F et al. (2011) Importin α7 is essential for zygotic genome activation and early mouse development. PLoS ONE 6 e18310 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 3.4 3.5 Bertram, S et al. (2017) H7N9 Influenza A Virus Exhibits Importin-α7-Mediated Replication in the Mammalian Respiratory Tract. Am. J. Pathol. 187 831-840 PubMed GONUTS page
  4. ↑ 4.0 4.1 Sakakida, Y et al. (2005) Importin alpha/beta mediates nuclear transport of a mammalian circadian clock component, mCRY2, together with mPER2, through a bipartite nuclear localization signal. J. Biol. Chem. 280 13272-8 PubMed GONUTS page
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