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MOUSE:IL21
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Il21 | |
| Protein Name(s) | Interleukin-21
IL-21 | |
| External Links | ||
| UniProt | Q9ES17 | |
| EMBL | AF254070 AY428162 | |
| CCDS | CCDS17317.1 | |
| RefSeq | NP_068554.1 | |
| UniGene | Mm.157689 | |
| ProteinModelPortal | Q9ES17 | |
| SMR | Q9ES17 | |
| STRING | 10090.ENSMUSP00000029273 | |
| Ensembl | ENSMUST00000029273 | |
| GeneID | 60505 | |
| KEGG | mmu:60505 | |
| UCSC | uc008paj.1 | |
| CTD | 59067 | |
| MGI | MGI:1890474 | |
| eggNOG | NOG40525 | |
| GeneTree | ENSGT00390000010494 | |
| HOGENOM | HOG000113039 | |
| HOVERGEN | HBG052106 | |
| InParanoid | Q9ES17 | |
| KO | K05434 | |
| OrthoDB | EOG7M98JN | |
| PhylomeDB | Q9ES17 | |
| TreeFam | TF336380 | |
| NextBio | 314909 | |
| PRO | PR:Q9ES17 | |
| Proteomes | UP000000589 | |
| Bgee | Q9ES17 | |
| CleanEx | MM_IL21 | |
| ExpressionAtlas | Q9ES17 | |
| Genevestigator | Q9ES17 | |
| GO | GO:0005615 GO:0005126 GO:0001783 GO:0048469 GO:0006955 GO:0045579 GO:0030890 GO:0045078 GO:0032733 GO:0032740 GO:0002729 GO:0032825 GO:0045954 GO:0042102 GO:0042511 GO:0042517 | |
| InterPro | IPR009079 IPR003443 IPR028151 | |
| PANTHER | PTHR14356 | |
| Pfam | PF02372 | |
| SUPFAM | SSF47266 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0045579 |
positive regulation of B cell differentiation |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0001783 |
B cell apoptotic process |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0048469 |
cell maturation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0045954 |
positive regulation of natural killer cell mediated cytotoxicity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0045954 |
positive regulation of natural killer cell mediated cytotoxicity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0045078 |
positive regulation of interferon-gamma biosynthetic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0042531 |
positive regulation of tyrosine phosphorylation of STAT protein |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0042102 |
positive regulation of T cell proliferation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0032825 |
positive regulation of natural killer cell differentiation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0032740 |
positive regulation of interleukin-17 production |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0032733 |
positive regulation of interleukin-10 production |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0030890 |
positive regulation of B cell proliferation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0008284 |
positive regulation of cell population proliferation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0007260 |
tyrosine phosphorylation of STAT protein |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005134 |
interleukin-2 receptor binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005126 |
cytokine receptor binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0002729 |
positive regulation of natural killer cell cytokine production |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0001819 |
positive regulation of cytokine production |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0005125 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005126 |
cytokine receptor binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006955 |
immune response |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005125 |
cytokine activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Ozaki, K et al. (2004) Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of Blimp-1 and Bcl-6. J. Immunol. 173 5361-71 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 Brady, J et al. (2004) IL-21 induces the functional maturation of murine NK cells. J. Immunol. 172 2048-58 PubMed GONUTS page
- ↑ Parrish-Novak, J et al. (2000) Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. Nature 408 57-63 PubMed GONUTS page
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- GO:0045579 ! positive regulation of B cell differentiation
- GO:0001819 ! positive regulation of cytokine production
- GO:0045954 ! positive regulation of natural killer cell mediated cytotoxicity
- GO:0045078 ! positive regulation of interferon-gamma biosynthetic process
- GO:0042531 ! positive regulation of tyrosine phosphorylation of STAT protein
- GO:0042102 ! positive regulation of T cell proliferation
- GO:0032825 ! positive regulation of natural killer cell differentiation
- GO:0032740 ! positive regulation of interleukin-17 production
- GO:0032733 ! positive regulation of interleukin-10 production
- GO:0030890 ! positive regulation of B cell proliferation
- GO:0008284 ! positive regulation of cell population proliferation
- GO:0002729 ! positive regulation of natural killer cell cytokine production
