MOUSE:IFT88

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Ift88 (synonyms: Tg737, Tg737Rpw, TgN737Rpw, Ttc10)
Protein Name(s)	Intraflagellar transport protein 88 homolog Recessive polycystic kidney disease protein Tg737 Tetratricopeptide repeat protein 10 TPR repeat protein 10 TgN(Imorpk)737Rpw
External Links
UniProt	Q61371
EMBL	L31959 AK135110 AC124462 AC154675 BC012250
PIR	I49564
RefSeq	NP_033402.2
UniGene	Mm.4653
ProteinModelPortal	Q61371
SMR	Q61371
BioGrid	204171
PhosphoSite	Q61371
MaxQB	Q61371
PaxDb	Q61371
PRIDE	Q61371
GeneID	21821
KEGG	mmu:21821
CTD	8100
MGI	MGI:98715
eggNOG	COG0457
HOGENOM	HOG000258203
HOVERGEN	HBG059328
InParanoid	Q61371
KO	K16474
OMA	LILCYYA
Reactome	REACT_269412
ChiTaRS	Ift88
NextBio	301236
PRO	PR:Q61371
Proteomes	UP000000589
Bgee	Q61371
ExpressionAtlas	Q61371
Genevestigator	Q61371
GO	GO:0002080 GO:0045177 GO:0097541 GO:0005930 GO:0005814 GO:0005813 GO:0036064 GO:0097546 GO:0097542 GO:0005929 GO:0030992 GO:0060091 GO:0031512 GO:0032391 GO:0072372 GO:0019894 GO:0009952 GO:0007420 GO:0055007 GO:0060411 GO:0042384 GO:0060271 GO:0090102 GO:0031122 GO:0007368 GO:0009953 GO:0042733 GO:0036334 GO:0008544 GO:0003382 GO:0001654 GO:0048853 GO:0007507 GO:0060914 GO:0060122 GO:0001822 GO:0060173 GO:0001889 GO:0030324 GO:0060426 GO:0050680 GO:0007399 GO:0007219 GO:0009887 GO:0060021 GO:0031016 GO:0043568 GO:0008104 GO:2000785 GO:1902017 GO:0045598 GO:0042487 GO:0070613 GO:0008589 GO:0034405 GO:0007224 GO:0007288 GO:0007290 GO:0021513 GO:0021537
Gene3D	1.25.40.10
InterPro	IPR013026 IPR011990 IPR001440 IPR019734
Pfam	PF00515 PF13174 PF13181
SMART	SM00028
PROSITE	PS50005 PS50293

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0005929	cilium	PMID:21209331^[1]	ECO:0000314			C		Fig 4A shows ciliary localisation in WT	complete CACAO 2899
	GO:0045892	negative regulation of transcription, DNA-templated	PMID:16254602^[2]	ECO:0000315			P		In the absence of Polaris, Gli2 expressing wild type cells show reduced levels of Ptch1 transcription (Figure 3B).	complete CACAO 10673
part_of	GO:0036126	sperm flagellum	PMID:27682589^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:27682589^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005814	centriole	PMID:23386061^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:21209331^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030992	intraciliary transport particle B	PMID:25443296^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030992	intraciliary transport particle B	PMID:24596149^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:21209331^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2000785	regulation of autophagosome assembly	PMID:24089209^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902017	regulation of cilium assembly	PMID:24089209^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060271	cilium assembly	PMID:11062270^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0036064	ciliary basal body	PMID:20230748^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0032391	photoreceptor connecting cilium	PMID:19208653^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:20230748^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005814	centriole	PMID:20230748^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1905515	non-motile cilium assembly	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0016919 MGI:MGI:98715 PANTHER:PTN000555524 WB:WBGene00003885	P		Seeded From UniProt	complete
part_of	GO:0097730	non-motile cilium	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0016919 MGI:MGI:98715 PANTHER:PTN000555524 WB:WBGene00003885	C		Seeded From UniProt	complete
part_of	GO:0097546	ciliary base	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98715 PANTHER:PTN000555524	C		Seeded From UniProt	complete
involved_in	GO:0060122	inner ear receptor cell stereocilium organization	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98715 PANTHER:PTN002891187	P		Seeded From UniProt	complete
part_of	GO:0036064	ciliary basal body	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98715 PANTHER:PTN000555524 UniProtKB:Q13099 WB:WBGene00003885	C		Seeded From UniProt	complete
enables	GO:0019894	kinesin binding	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98715 PANTHER:PTN000555524	F		Seeded From UniProt	complete
part_of	GO:0005814	centriole	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98715 PANTHER:PTN000555524 UniProtKB:Q13099	C		Seeded From UniProt	complete
involved_in	GO:0001822	kidney development	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98715 PANTHER:PTN002891187	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1905515	non-motile cilium assembly	PMID:24927541^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000515)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1905515	non-motile cilium assembly	PMID:21703454^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000312)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1905515	non-motile cilium assembly	PMID:21285373^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2157527	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1905515	non-motile cilium assembly	PMID:16254602^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2157527	P	occurs_in:(EMAPA:35944)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903929	primary palate development	PMID:22228099^[15]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1918742	P	results_in_development_of:(EMAPA:17642)	Seeded From UniProt	complete
part_of	GO:0097730	non-motile cilium	PMID:16254602^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:35944) part_of:(EMAPA:32705)\|part_of:(EMAPA:35944) part_of:(EMAPA:32708)	Seeded From UniProt	complete
part_of	GO:0097546	ciliary base	PMID:21653639^[16]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0097546	ciliary base	PMID:19654211^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0097546	ciliary base	PMID:16775004^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0097542	ciliary tip	PMID:23955340^[19]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0097542	ciliary tip	PMID:21653639^[16]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0097542	ciliary tip	PMID:19654211^[17]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002322)	Seeded From UniProt	complete
part_of	GO:0097542	ciliary tip	PMID:16775004^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0097541	axonemal basal plate	PMID:24302887^[20]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090102	cochlea development	PMID:18066062^[21]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2135272	P	occurs_in:(EMAPA:17597)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070613	regulation of protein processing	PMID:16254602^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1859153	P	has_direct_input:(UniProtKB:Q61602)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070613	regulation of protein processing	PMID:15930098^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3027342	P	regulates_o_occurs_in:(EMAPA:16525) has_regulation_target:(PR:Q61602-1)\|regulates_o_occurs_in(EMAPA:16405) has_regulation_target:(PR:Q61602-1)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061351	neural precursor cell proliferation	PMID:18297065^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2157527	P	occurs_in:(EMAPA:19037)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060914	heart formation	PMID:19654211^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1859153	P	occurs_in:(EMAPA:16105)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060426	lung vasculature development	PMID:19036983^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3823090	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060411	cardiac septum morphogenesis	PMID:19036983^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3823090	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060271	cilium assembly	PMID:21565611^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:1000547)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060271	cilium assembly	PMID:21289087^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:1000546)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060271	cilium assembly	PMID:19654211^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002322)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060259	regulation of feeding behavior	PMID:23599282^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2182767,MGI:MGI:3710185	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060173	limb development	PMID:22228099^[15]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1918742	P	results_in_development_of:(EMAPA:16405)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060122	inner ear receptor cell stereocilium organization	PMID:18066062^[21]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2135272	P	occurs_in:(EMAPA:17598)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060122	inner ear receptor cell stereocilium organization	PMID:18066062^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1932522,MGI:MGI:3710185	P	occurs_in:(EMAPA:17600)	Seeded From UniProt	complete
part_of	GO:0060091	kinocilium	PMID:18066062^[21]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:19061)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0055007	cardiac muscle cell differentiation	PMID:19654211^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0055007	cardiac muscle cell differentiation	PMID:19654211^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1859153	P	occurs_in:(EMAPA:16105)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050680	negative regulation of epithelial cell proliferation	PMID:21703454^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050680	negative regulation of epithelial cell proliferation	PMID:21703454^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1926500,MGI:MGI:3710185	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048853	forebrain morphogenesis	PMID:19036983^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3823090	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045598	regulation of fat cell differentiation	PMID:19596798^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002334)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway	PMID:19596798^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002334)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042733	embryonic digit morphogenesis	PMID:15930098^[22]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98297	P	has_participant:(EMAPA:17428)\|has_participant:(EMAPA:17459)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042733	embryonic digit morphogenesis	PMID:19036983^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3823090	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042733	embryonic digit morphogenesis	PMID:16254602^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2157527	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042733	embryonic digit morphogenesis	PMID:15930098^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3027342	P	has_participant:(EMAPA:17428)\|has_participant:(EMAPA:17459)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042733	embryonic digit morphogenesis	PMID:15755804^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3027342	P	has_participant:(EMAPA:16405)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042733	embryonic digit morphogenesis	PMID:12701101^[30]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2157527	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042487	regulation of odontogenesis of dentin-containing tooth	PMID:12701101^[30]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2157527	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0036334	epidermal stem cell homeostasis	PMID:21429982^[31]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2445832,MGI:MGI:3710185	P	occurs_in:(EMAPA:17525)	Seeded From UniProt	complete
part_of	GO:0036064	ciliary basal body	PMID:23955340^[19]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0036064	ciliary basal body	PMID:11854326^[32]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0036064	ciliary basal body	PMID:11251073^[33]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:32860) part_of:(CL:0000064)\|part_of:(EMAPA:16894) part_of:(CL:0000065)\|part_of:(EMAPA:29747) part_of:(CL:0000064)	Seeded From UniProt	complete
part_of	GO:0036064	ciliary basal body	PMID:22922713^[34]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:G5ED37	C		Seeded From UniProt	complete
part_of	GO:0036064	ciliary basal body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13099	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034405	response to fluid shear stress	PMID:18285569^[35]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2157527	P	occurs_in:(CL:0000115) occurs_in:(EMAPA:18601)	Seeded From UniProt	complete
part_of	GO:0032391	photoreceptor connecting cilium	PMID:20368623^[36]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:35686) part_of:(CL:0000210)	Seeded From UniProt	complete
part_of	GO:0031514	motile cilium	PMID:18590716^[37]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16164)\|part_of:(EMAPA:32930)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031122	cytoplasmic microtubule organization	PMID:21703454^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000312)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031016	pancreas development	PMID:11773599^[38]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2157527	P	occurs_in:(EMAPA:17503)	Seeded From UniProt	complete
part_of	GO:0030992	intraciliary transport particle B	PMID:23810713^[39]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000437)	Seeded From UniProt	complete
part_of	GO:0030992	intraciliary transport particle B	PMID:19253336^[40]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030992	intraciliary transport particle B	PMID:12821668^[41]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17972)\|part_of:(EMAPA:17373)\|part_of:(EMAPA:17168)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030324	lung development	PMID:19036983^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3823090	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021537	telencephalon development	PMID:19036983^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3823090	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021513	spinal cord dorsal/ventral patterning	PMID:21761479^[42]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1859153	P	has_participant:(EMAPA:16525)	Seeded From UniProt	complete
enables	GO:0019894	kinesin binding	PMID:19384852^[43]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q99PW8	F	occurs_in:(EMAPA:17168)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009953	dorsal/ventral pattern formation	PMID:15930098^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3027342	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009953	dorsal/ventral pattern formation	PMID:15755804^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3027342	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009952	anterior/posterior pattern specification	PMID:15930098^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3027342	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009952	anterior/posterior pattern specification	PMID:12701101^[30]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2157527	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009887	animal organ morphogenesis	PMID:15226261^[44]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2157527	P	has_participant:(EMAPA:17503)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008589	regulation of smoothened signaling pathway	PMID:21429982^[31]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2445832,MGI:MGI:3710185	P	occurs_in:(EMAPA:17525)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008544	epidermis development	PMID:21703454^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1926500,MGI:MGI:3710185	P	results_in_development_of:(EMAPA:17528)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008104	protein localization	PMID:22228099^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2157527	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007507	heart development	PMID:22228099^[15]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1918742	P	results_in_development_of:(EMAPA:16105)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007420	brain development	PMID:22228099^[15]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1918742	P	results_in_development_of:(EMAPA:16894)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007420	brain development	PMID:19036983^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3823090	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007399	nervous system development	PMID:19036983^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3823090	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007368	determination of left/right symmetry	PMID:15755804^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3027342	P	has_participant:(EMAPA:16039)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007368	determination of left/right symmetry	PMID:10804177^[45]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1859153	P	has_participant:(EMAPA:16105)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007290	spermatid nucleus elongation	PMID:21337470^[46]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2157527	P	occurs_in:(CL:0000018)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007288	sperm axoneme assembly	PMID:21337470^[46]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2157527	P	occurs_in:(CL:0000018)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007224	smoothened signaling pathway	PMID:15930098^[22]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98297	P	occurs_in:(EMAPA:16405)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007224	smoothened signaling pathway	PMID:22228099^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2157527	P	occurs_in:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007224	smoothened signaling pathway	PMID:19654211^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002322)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007224	smoothened signaling pathway	PMID:19036983^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3823090	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007224	smoothened signaling pathway	PMID:15930098^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3027342	P	occurs_in:(EMAPA:16405)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007219	Notch signaling pathway	PMID:21703454^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000312)	Seeded From UniProt	complete
part_of	GO:0005930	axoneme	PMID:24302887^[20]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005930	axoneme	PMID:20368623^[36]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:35686) part_of:(CL:0000210)	Seeded From UniProt	complete
part_of	GO:0005930	axoneme	PMID:18066062^[21]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:19061)	Seeded From UniProt	complete
part_of	GO:0005930	axoneme	PMID:11854326^[32]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005930	axoneme	PMID:11251073^[33]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16894) part_of:(CL:0000065)\|part_of:(EMAPA:29747) part_of:(CL:0000064)\|part_of:(EMAPA:32860) part_of:(CL:0000064)	Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:25294941^[47]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:24927541^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000515)	Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:24469809^[48]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:22689656^[49]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16530)	Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:20159594^[50]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16164)	Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:19253336^[40]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:18285569^[35]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000115) part_of:(EMAPA:18601)	Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:24421332^[51]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13099	C		Seeded From UniProt	complete
part_of	GO:0005929	cilium	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13099	C		Seeded From UniProt	complete
part_of	GO:0005814	centriole	PMID:24469809^[48]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005814	centriole	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13099	C		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	PMID:25564561^[52]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0005813	centrosome	PMID:19253336^[40]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13099	C		Seeded From UniProt	complete
part_of	GO:0005802	trans-Golgi network	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:D4ACI9	C		Seeded From UniProt	complete
part_of	GO:0002081	outer acrosomal membrane	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:D4ACI9	C		Seeded From UniProt	complete
part_of	GO:0002080	acrosomal membrane	PMID:21337470^[46]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000018)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001889	liver development	PMID:9176412^[53]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2157527	P	occurs_in:(EMAPA:16846)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001889	liver development	PMID:11773599^[38]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2157527	P	occurs_in:(EMAPA:16846)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001886	endothelial cell morphogenesis	PMID:21285373^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2157527	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001822	kidney development	PMID:9176412^[53]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2157527	P	occurs_in:(EMAPA:17373)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001822	kidney development	PMID:11773599^[38]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2157527	P	occurs_in:(EMAPA:17373)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001654	eye development	PMID:22228099^[15]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1918742	P	results_in_development_of:(EMAPA:16198)	Seeded From UniProt	complete
part_of	GO:0005929	cilium	Reactome:R-MMU-5617824	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206	C		Seeded From UniProt	complete
part_of	GO:0005929	cilium	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0969 UniProtKB-SubCell:SL-0066	C		Seeded From UniProt	complete
involved_in	GO:0030030	cell projection organization	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0970	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0031514	motile cilium	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0282 UniProtKB-SubCell:SL-0117	C		Seeded From UniProt	complete
part_of	GO:0005814	centriole	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0046	C		Seeded From UniProt	complete
part_of	GO:0005815	microtubule organizing center	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0048	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Qin, J et al. (2011) Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components. Proc. Natl. Acad. Sci. U.S.A. 108 1456-61 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Haycraft, CJ et al. (2005) Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function. PLoS Genet. 1 e53 PubMed GONUTS page
↑ ^3.0 ^3.1 Zhang, Z et al. (2016) Intraflagellar transport protein IFT20 is essential for male fertility and spermiogenesis in mice. Mol. Biol. Cell PubMed GONUTS page
↑ Kodani, A et al. (2013) Kif3a interacts with Dynactin subunit p150 Glued to organize centriole subdistal appendages. EMBO J. 32 597-607 PubMed GONUTS page
↑ Liew, GM et al. (2014) The intraflagellar transport protein IFT27 promotes BBSome exit from cilia through the GTPase ARL6/BBS3. Dev. Cell 31 265-78 PubMed GONUTS page
↑ Ishikawa, H et al. (2014) TTC26/DYF13 is an intraflagellar transport protein required for transport of motility-related proteins into flagella. Elife 3 e01566 PubMed GONUTS page
↑ ^7.0 ^7.1 Pampliega, O et al. (2013) Functional interaction between autophagy and ciliogenesis. Nature 502 194-200 PubMed GONUTS page
↑ Pazour, GJ et al. (2000) Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagella. J. Cell Biol. 151 709-18 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Singla, V et al. (2010) Ofd1, a human disease gene, regulates the length and distal structure of centrioles. Dev. Cell 18 410-24 PubMed GONUTS page
↑ Jiang, ST et al. (2009) Essential role of nephrocystin in photoreceptor intraflagellar transport in mouse. Hum. Mol. Genet. 18 1566-77 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 ^11.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^12.0 ^12.1 Fu, W et al. (2014) Primary cilia control hedgehog signaling during muscle differentiation and are deregulated in rhabdomyosarcoma. Proc. Natl. Acad. Sci. U.S.A. 111 9151-6 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 Ezratty, EJ et al. (2011) A role for the primary cilium in Notch signaling and epidermal differentiation during skin development. Cell 145 1129-41 PubMed GONUTS page
↑ ^14.0 ^14.1 Blitzer, AL et al. (2011) Primary cilia dynamics instruct tissue patterning and repair of corneal endothelium. Proc. Natl. Acad. Sci. U.S.A. 108 2819-24 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 ^15.4 ^15.5 ^15.6 Zhang, Q et al. (2012) BBS proteins interact genetically with the IFT pathway to influence SHH-related phenotypes. Hum. Mol. Genet. 21 1945-53 PubMed GONUTS page
↑ ^16.0 ^16.1 Friedland-Little, JM et al. (2011) A novel murine allele of Intraflagellar Transport Protein 172 causes a syndrome including VACTERL-like features with hydrocephalus. Hum. Mol. Genet. 20 3725-37 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 ^17.4 ^17.5 ^17.6 Clement, CA et al. (2009) The primary cilium coordinates early cardiogenesis and hedgehog signaling in cardiomyocyte differentiation. J. Cell. Sci. 122 3070-82 PubMed GONUTS page
↑ ^18.0 ^18.1 Follit, JA et al. (2006) The intraflagellar transport protein IFT20 is associated with the Golgi complex and is required for cilia assembly. Mol. Biol. Cell 17 3781-92 PubMed GONUTS page
↑ ^19.0 ^19.1 Wang, C et al. (2013) Centrosomal protein DZIP1 regulates Hedgehog signaling by promoting cytoplasmic retention of transcription factor GLI3 and affecting ciliogenesis. J. Biol. Chem. 288 29518-29 PubMed GONUTS page
↑ ^20.0 ^20.1 Cui, C et al. (2013) Wdpcp, a PCP protein required for ciliogenesis, regulates directional cell migration and cell polarity by direct modulation of the actin cytoskeleton. PLoS Biol. 11 e1001720 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 ^21.3 ^21.4 Jones, C et al. (2008) Ciliary proteins link basal body polarization to planar cell polarity regulation. Nat. Genet. 40 69-77 PubMed GONUTS page
↑ ^22.0 ^22.1 ^22.2 ^22.3 ^22.4 ^22.5 ^22.6 Liu, A et al. (2005) Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors. Development 132 3103-11 PubMed GONUTS page
↑ Han, YG et al. (2008) Hedgehog signaling and primary cilia are required for the formation of adult neural stem cells. Nat. Neurosci. 11 277-84 PubMed GONUTS page
↑ ^24.0 ^24.1 ^24.2 ^24.3 ^24.4 ^24.5 ^24.6 ^24.7 ^24.8 Willaredt, MA et al. (2008) A crucial role for primary cilia in cortical morphogenesis. J. Neurosci. 28 12887-900 PubMed GONUTS page
↑ Sang, L et al. (2011) Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. Cell 145 513-28 PubMed GONUTS page
↑ Lai, CK et al. (2011) Functional characterization of putative cilia genes by high-content analysis. Mol. Biol. Cell 22 1104-19 PubMed GONUTS page
↑ Berbari, NF et al. (2013) Leptin resistance is a secondary consequence of the obesity in ciliopathy mutant mice. Proc. Natl. Acad. Sci. U.S.A. 110 7796-801 PubMed GONUTS page
↑ ^28.0 ^28.1 Zhu, D et al. (2009) Growth arrest induces primary-cilium formation and sensitizes IGF-1-receptor signaling during differentiation induction of 3T3-L1 preadipocytes. J. Cell. Sci. 122 2760-8 PubMed GONUTS page
↑ ^29.0 ^29.1 ^29.2 García-García, MJ et al. (2005) Analysis of mouse embryonic patterning and morphogenesis by forward genetics. Proc. Natl. Acad. Sci. U.S.A. 102 5913-9 PubMed GONUTS page
↑ ^30.0 ^30.1 ^30.2 Zhang, Q et al. (2003) Loss of the Tg737 protein results in skeletal patterning defects. Dev. Dyn. 227 78-90 PubMed GONUTS page
↑ ^31.0 ^31.1 Croyle, MJ et al. (2011) Role of epidermal primary cilia in the homeostasis of skin and hair follicles. Development 138 1675-85 PubMed GONUTS page
↑ ^32.0 ^32.1 Hou, X et al. (2002) Cystin, a novel cilia-associated protein, is disrupted in the cpk mouse model of polycystic kidney disease. J. Clin. Invest. 109 533-40 PubMed GONUTS page
↑ ^33.0 ^33.1 Taulman, PD et al. (2001) Polaris, a protein involved in left-right axis patterning, localizes to basal bodies and cilia. Mol. Biol. Cell 12 589-99 PubMed GONUTS page
↑ Wei, Q et al. (2012) The BBSome controls IFT assembly and turnaround in cilia. Nat. Cell Biol. 14 950-7 PubMed GONUTS page
↑ ^35.0 ^35.1 Nauli, SM et al. (2008) Endothelial cilia are fluid shear sensors that regulate calcium signaling and nitric oxide production through polycystin-1. Circulation 117 1161-71 PubMed GONUTS page
↑ ^36.0 ^36.1 Sedmak, T & Wolfrum, U (2010) Intraflagellar transport molecules in ciliary and nonciliary cells of the retina. J. Cell Biol. 189 171-86 PubMed GONUTS page
↑ Cho, A et al. (2008) FKBP8 cell-autonomously controls neural tube patterning through a Gli2- and Kif3a-dependent mechanism. Dev. Biol. 321 27-39 PubMed GONUTS page
↑ ^38.0 ^38.1 ^38.2 Sommardahl, C et al. (2001) Phenotypic variations of orpk mutation and chromosomal localization of modifiers influencing kidney phenotype. Physiol. Genomics 7 127-34 PubMed GONUTS page
↑ Howard, PW et al. (2013) Interaction of mouse TTC30/DYF-1 with multiple intraflagellar transport complex B proteins and KIF17. Exp. Cell Res. 319 2275-81 PubMed GONUTS page
↑ ^40.0 ^40.1 ^40.2 Follit, JA et al. (2009) Characterization of mouse IFT complex B. Cell Motil. Cytoskeleton 66 457-68 PubMed GONUTS page
↑ Baker, SA et al. (2003) IFT20 links kinesin II with a mammalian intraflagellar transport complex that is conserved in motile flagella and sensory cilia. J. Biol. Chem. 278 34211-8 PubMed GONUTS page
↑ Heydeck, W & Liu, A (2011) PCP effector proteins inturned and fuzzy play nonredundant roles in the patterning but not convergent extension of mammalian neural tube. Dev. Dyn. 240 1938-48 PubMed GONUTS page
↑ Insinna, C et al. (2009) Different roles for KIF17 and kinesin II in photoreceptor development and maintenance. Dev. Dyn. 238 2211-22 PubMed GONUTS page
↑ Cano, DA et al. (2004) Orpk mouse model of polycystic kidney disease reveals essential role of primary cilia in pancreatic tissue organization. Development 131 3457-67 PubMed GONUTS page
↑ Murcia, NS et al. (2000) The Oak Ridge Polycystic Kidney (orpk) disease gene is required for left-right axis determination. Development 127 2347-55 PubMed GONUTS page
↑ ^46.0 ^46.1 ^46.2 Kierszenbaum, AL et al. (2011) GMAP210 and IFT88 are present in the spermatid golgi apparatus and participate in the development of the acrosome-acroplaxome complex, head-tail coupling apparatus and tail. Dev. Dyn. 240 723-36 PubMed GONUTS page
↑ Goggolidou, P et al. (2014) ATMIN is a transcriptional regulator of both lung morphogenesis and ciliogenesis. Development 141 3966-77 PubMed GONUTS page
↑ ^48.0 ^48.1 Ye, X et al. (2014) C2cd3 is critical for centriolar distal appendage assembly and ciliary vesicle docking in mammals. Proc. Natl. Acad. Sci. U.S.A. 111 2164-9 PubMed GONUTS page
↑ Liem, KF Jr et al. (2012) The IFT-A complex regulates Shh signaling through cilia structure and membrane protein trafficking. J. Cell Biol. 197 789-800 PubMed GONUTS page
↑ Ko, HW et al. (2010) Broad-minded links cell cycle-related kinase to cilia assembly and hedgehog signal transduction. Dev. Cell 18 237-47 PubMed GONUTS page
↑ Kobayashi, T et al. (2014) The CP110-interacting proteins Talpid3 and Cep290 play overlapping and distinct roles in cilia assembly. J. Cell Biol. 204 215-29 PubMed GONUTS page
↑ Waters, AM et al. (2015) The kinetochore protein, CENPF, is mutated in human ciliopathy and microcephaly phenotypes. J. Med. Genet. 52 147-56 PubMed GONUTS page
↑ ^53.0 ^53.1 Yoder, BK et al. (1997) Differential rescue of the renal and hepatic disease in an autosomal recessive polycystic kidney disease mouse mutant. A new model to study the liver lesion. Am. J. Pathol. 150 2231-41 PubMed GONUTS page

[PMID:21209331-1] 1.0 ^1.1 ^1.2 Qin, J et al. (2011) Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components. Proc. Natl. Acad. Sci. U.S.A. 108 1456-61 PubMed GONUTS page

[PMID:16254602-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Haycraft, CJ et al. (2005) Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function. PLoS Genet. 1 e53 PubMed GONUTS page

[PMID:27682589-3] 3.0 ^3.1 Zhang, Z et al. (2016) Intraflagellar transport protein IFT20 is essential for male fertility and spermiogenesis in mice. Mol. Biol. Cell PubMed GONUTS page

[PMID:23386061-4] Kodani, A et al. (2013) Kif3a interacts with Dynactin subunit p150 Glued to organize centriole subdistal appendages. EMBO J. 32 597-607 PubMed GONUTS page

[PMID:25443296-5] Liew, GM et al. (2014) The intraflagellar transport protein IFT27 promotes BBSome exit from cilia through the GTPase ARL6/BBS3. Dev. Cell 31 265-78 PubMed GONUTS page

[PMID:24596149-6] Ishikawa, H et al. (2014) TTC26/DYF13 is an intraflagellar transport protein required for transport of motility-related proteins into flagella. Elife 3 e01566 PubMed GONUTS page

[PMID:24089209-7] 7.0 ^7.1 Pampliega, O et al. (2013) Functional interaction between autophagy and ciliogenesis. Nature 502 194-200 PubMed GONUTS page

[PMID:11062270-8] Pazour, GJ et al. (2000) Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagella. J. Cell Biol. 151 709-18 PubMed GONUTS page

[PMID:20230748-9] 9.0 ^9.1 ^9.2 Singla, V et al. (2010) Ofd1, a human disease gene, regulates the length and distal structure of centrioles. Dev. Cell 18 410-24 PubMed GONUTS page

[PMID:19208653-10] Jiang, ST et al. (2009) Essential role of nephrocystin in photoreceptor intraflagellar transport in mouse. Hum. Mol. Genet. 18 1566-77 PubMed GONUTS page

[PMID:21873635-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 ^11.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:24927541-12] 12.0 ^12.1 Fu, W et al. (2014) Primary cilia control hedgehog signaling during muscle differentiation and are deregulated in rhabdomyosarcoma. Proc. Natl. Acad. Sci. U.S.A. 111 9151-6 PubMed GONUTS page

[PMID:21703454-13] 13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 Ezratty, EJ et al. (2011) A role for the primary cilium in Notch signaling and epidermal differentiation during skin development. Cell 145 1129-41 PubMed GONUTS page

[PMID:21285373-14] 14.0 ^14.1 Blitzer, AL et al. (2011) Primary cilia dynamics instruct tissue patterning and repair of corneal endothelium. Proc. Natl. Acad. Sci. U.S.A. 108 2819-24 PubMed GONUTS page

[PMID:22228099-15] 15.0 ^15.1 ^15.2 ^15.3 ^15.4 ^15.5 ^15.6 Zhang, Q et al. (2012) BBS proteins interact genetically with the IFT pathway to influence SHH-related phenotypes. Hum. Mol. Genet. 21 1945-53 PubMed GONUTS page

[PMID:21653639-16] 16.0 ^16.1 Friedland-Little, JM et al. (2011) A novel murine allele of Intraflagellar Transport Protein 172 causes a syndrome including VACTERL-like features with hydrocephalus. Hum. Mol. Genet. 20 3725-37 PubMed GONUTS page

[PMID:19654211-17] 17.0 ^17.1 ^17.2 ^17.3 ^17.4 ^17.5 ^17.6 Clement, CA et al. (2009) The primary cilium coordinates early cardiogenesis and hedgehog signaling in cardiomyocyte differentiation. J. Cell. Sci. 122 3070-82 PubMed GONUTS page

[PMID:16775004-18] 18.0 ^18.1 Follit, JA et al. (2006) The intraflagellar transport protein IFT20 is associated with the Golgi complex and is required for cilia assembly. Mol. Biol. Cell 17 3781-92 PubMed GONUTS page

[PMID:23955340-19] 19.0 ^19.1 Wang, C et al. (2013) Centrosomal protein DZIP1 regulates Hedgehog signaling by promoting cytoplasmic retention of transcription factor GLI3 and affecting ciliogenesis. J. Biol. Chem. 288 29518-29 PubMed GONUTS page

[PMID:24302887-20] 20.0 ^20.1 Cui, C et al. (2013) Wdpcp, a PCP protein required for ciliogenesis, regulates directional cell migration and cell polarity by direct modulation of the actin cytoskeleton. PLoS Biol. 11 e1001720 PubMed GONUTS page

[PMID:18066062-21] 21.0 ^21.1 ^21.2 ^21.3 ^21.4 Jones, C et al. (2008) Ciliary proteins link basal body polarization to planar cell polarity regulation. Nat. Genet. 40 69-77 PubMed GONUTS page

[PMID:15930098-22] 22.0 ^22.1 ^22.2 ^22.3 ^22.4 ^22.5 ^22.6 Liu, A et al. (2005) Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors. Development 132 3103-11 PubMed GONUTS page

[PMID:18297065-23] Han, YG et al. (2008) Hedgehog signaling and primary cilia are required for the formation of adult neural stem cells. Nat. Neurosci. 11 277-84 PubMed GONUTS page

[PMID:19036983-24] 24.0 ^24.1 ^24.2 ^24.3 ^24.4 ^24.5 ^24.6 ^24.7 ^24.8 Willaredt, MA et al. (2008) A crucial role for primary cilia in cortical morphogenesis. J. Neurosci. 28 12887-900 PubMed GONUTS page

[PMID:21565611-25] Sang, L et al. (2011) Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. Cell 145 513-28 PubMed GONUTS page

[PMID:21289087-26] Lai, CK et al. (2011) Functional characterization of putative cilia genes by high-content analysis. Mol. Biol. Cell 22 1104-19 PubMed GONUTS page

[PMID:23599282-27] Berbari, NF et al. (2013) Leptin resistance is a secondary consequence of the obesity in ciliopathy mutant mice. Proc. Natl. Acad. Sci. U.S.A. 110 7796-801 PubMed GONUTS page

[PMID:19596798-28] 28.0 ^28.1 Zhu, D et al. (2009) Growth arrest induces primary-cilium formation and sensitizes IGF-1-receptor signaling during differentiation induction of 3T3-L1 preadipocytes. J. Cell. Sci. 122 2760-8 PubMed GONUTS page

[PMID:15755804-29] 29.0 ^29.1 ^29.2 García-García, MJ et al. (2005) Analysis of mouse embryonic patterning and morphogenesis by forward genetics. Proc. Natl. Acad. Sci. U.S.A. 102 5913-9 PubMed GONUTS page

[PMID:12701101-30] 30.0 ^30.1 ^30.2 Zhang, Q et al. (2003) Loss of the Tg737 protein results in skeletal patterning defects. Dev. Dyn. 227 78-90 PubMed GONUTS page

[PMID:21429982-31] 31.0 ^31.1 Croyle, MJ et al. (2011) Role of epidermal primary cilia in the homeostasis of skin and hair follicles. Development 138 1675-85 PubMed GONUTS page

[PMID:11854326-32] 32.0 ^32.1 Hou, X et al. (2002) Cystin, a novel cilia-associated protein, is disrupted in the cpk mouse model of polycystic kidney disease. J. Clin. Invest. 109 533-40 PubMed GONUTS page

[PMID:11251073-33] 33.0 ^33.1 Taulman, PD et al. (2001) Polaris, a protein involved in left-right axis patterning, localizes to basal bodies and cilia. Mol. Biol. Cell 12 589-99 PubMed GONUTS page

[PMID:22922713-34] Wei, Q et al. (2012) The BBSome controls IFT assembly and turnaround in cilia. Nat. Cell Biol. 14 950-7 PubMed GONUTS page

[PMID:18285569-35] 35.0 ^35.1 Nauli, SM et al. (2008) Endothelial cilia are fluid shear sensors that regulate calcium signaling and nitric oxide production through polycystin-1. Circulation 117 1161-71 PubMed GONUTS page

[PMID:20368623-36] 36.0 ^36.1 Sedmak, T & Wolfrum, U (2010) Intraflagellar transport molecules in ciliary and nonciliary cells of the retina. J. Cell Biol. 189 171-86 PubMed GONUTS page

[PMID:18590716-37] Cho, A et al. (2008) FKBP8 cell-autonomously controls neural tube patterning through a Gli2- and Kif3a-dependent mechanism. Dev. Biol. 321 27-39 PubMed GONUTS page

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[PMID:23810713-39] Howard, PW et al. (2013) Interaction of mouse TTC30/DYF-1 with multiple intraflagellar transport complex B proteins and KIF17. Exp. Cell Res. 319 2275-81 PubMed GONUTS page

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[PMID:12821668-41] Baker, SA et al. (2003) IFT20 links kinesin II with a mammalian intraflagellar transport complex that is conserved in motile flagella and sensory cilia. J. Biol. Chem. 278 34211-8 PubMed GONUTS page

[PMID:21761479-42] Heydeck, W & Liu, A (2011) PCP effector proteins inturned and fuzzy play nonredundant roles in the patterning but not convergent extension of mammalian neural tube. Dev. Dyn. 240 1938-48 PubMed GONUTS page

[PMID:19384852-43] Insinna, C et al. (2009) Different roles for KIF17 and kinesin II in photoreceptor development and maintenance. Dev. Dyn. 238 2211-22 PubMed GONUTS page

[PMID:15226261-44] Cano, DA et al. (2004) Orpk mouse model of polycystic kidney disease reveals essential role of primary cilia in pancreatic tissue organization. Development 131 3457-67 PubMed GONUTS page

[PMID:10804177-45] Murcia, NS et al. (2000) The Oak Ridge Polycystic Kidney (orpk) disease gene is required for left-right axis determination. Development 127 2347-55 PubMed GONUTS page

[PMID:21337470-46] 46.0 ^46.1 ^46.2 Kierszenbaum, AL et al. (2011) GMAP210 and IFT88 are present in the spermatid golgi apparatus and participate in the development of the acrosome-acroplaxome complex, head-tail coupling apparatus and tail. Dev. Dyn. 240 723-36 PubMed GONUTS page

[PMID:25294941-47] Goggolidou, P et al. (2014) ATMIN is a transcriptional regulator of both lung morphogenesis and ciliogenesis. Development 141 3966-77 PubMed GONUTS page

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[PMID:22689656-49] Liem, KF Jr et al. (2012) The IFT-A complex regulates Shh signaling through cilia structure and membrane protein trafficking. J. Cell Biol. 197 789-800 PubMed GONUTS page

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MOUSE:IFT88

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