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MOUSE:HERC2

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Herc2 (ECO:0000312 with EMBL:AAD08658.1, ECO:0000312 with MGI:MGI:103234) (synonyms: Jdf2, Kiaa0393 (ECO:0000312 with EMBL:BAD90404.1), Rjs)
Protein Name(s) E3 ubiquitin-protein ligase HERC2

HECT domain and RCC1-like domain-containing protein 2

External Links
UniProt Q4U2R1
EMBL AF061529
AF071173
AC102121
AC102150
AK141515
AK148361
AK161826
AK162270
AK162708
AK220338
BC044667
BC054829
CCDS CCDS21318.1
RefSeq NP_034548.2
XP_006540700.1
XP_006540701.1
XP_006540702.1
UniGene Mm.20929
ProteinModelPortal Q4U2R1
SMR Q4U2R1
BioGrid 200274
PhosphoSite Q4U2R1
MaxQB Q4U2R1
PaxDb Q4U2R1
PRIDE Q4U2R1
Ensembl ENSMUST00000076226
ENSMUST00000164095
GeneID 15204
KEGG mmu:15204
UCSC uc009hdv.1
CTD 8924
MGI MGI:103234
eggNOG COG5021
GeneTree ENSGT00770000120501
HOVERGEN HBG081598
InParanoid Q4U2R1
KO K10595
OMA GHGTDVH
OrthoDB EOG70KGNN
TreeFam TF320636
Reactome REACT_199115
UniPathway UPA00143
ChiTaRS Herc2
NextBio 287753
PRO PR:Q4U2R1
Proteomes UP000000589
Bgee Q4U2R1
Genevestigator Q4U2R1
GO GO:0005814
GO:0005737
GO:0005743
GO:0005634
GO:0020037
GO:0016874
GO:0032183
GO:0004842
GO:0008270
GO:0006974
GO:0006281
GO:0016567
GO:0042787
GO:0007283
Gene3D 2.130.10.30
2.30.30.30
2.60.120.260
3.10.120.10
InterPro IPR004939
IPR006624
IPR021097
IPR001199
IPR008979
IPR000569
IPR010606
IPR009091
IPR000408
IPR014722
IPR000433
Pfam PF03256
PF11515
PF00173
PF00632
PF06701
PF00415
PF00569
PRINTS PR00633
SMART SM00119
SM00706
SM00291
SUPFAM SSF49785
SSF50985
SSF55856
SSF56204
PROSITE PS50255
PS51284
PS50237
PS51416
PS00626
PS50012
PS01357
PS50135

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

PMID:26692333[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0032183

SUMO binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O95714

F

Seeded From UniProt

complete

involved_in

GO:0016567

protein ubiquitination

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O95714

P

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O95714

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O95714

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O95714

C

Seeded From UniProt

complete

enables

GO:0004842

ubiquitin-protein transferase activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O95714

F

Seeded From UniProt

complete

involved_in

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103234
PANTHER:PTN000134460

P

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000882682
UniProtKB:O95714

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000882682
UniProtKB:O95714

C

Seeded From UniProt

complete

enables

GO:0032183

SUMO binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O95714

F

Seeded From UniProt

complete

enables

GO:0031625

ubiquitin protein ligase binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O95714

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0016567

protein ubiquitination

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O95714

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007283

spermatogenesis

PMID:5565073[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857705
MGI:MGI:1857706

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006974

cellular response to DNA damage stimulus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O95714

P

Seeded From UniProt

complete

part_of

GO:0005743

mitochondrial inner membrane

PMID:12865426[4]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O95714

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O95714

C

Seeded From UniProt

complete

enables

GO:0004842

ubiquitin-protein transferase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O95714

F

Seeded From UniProt

complete

enables

GO:0032183

SUMO binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O95714
ensembl:ENSP00000261609

F

Seeded From UniProt

complete

enables

GO:0031625

ubiquitin protein ligase binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O95714
ensembl:ENSP00000261609

F

Seeded From UniProt

complete

involved_in

GO:0016567

protein ubiquitination

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O95714
ensembl:ENSP00000261609

P

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O95714
ensembl:ENSP00000261609

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O95714
ensembl:ENSP00000261609

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O95714
ensembl:ENSP00000261609

C

Seeded From UniProt

complete

enables

GO:0004842

ubiquitin-protein transferase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O95714
ensembl:ENSP00000261609

F

Seeded From UniProt

complete

enables

GO:0004842

ubiquitin-protein transferase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000569
InterPro:IPR010606
InterPro:IPR035983
InterPro:IPR037252

F

Seeded From UniProt

complete

enables

GO:0008270

zinc ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000433

F

Seeded From UniProt

complete

involved_in

GO:0016567

protein ubiquitination

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR010606

P

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR010606
InterPro:IPR037252

F

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0227

P

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0234

P

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0206

C

Seeded From UniProt

complete

part_of

GO:0005814

centriole

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0046

C

Seeded From UniProt

complete

involved_in

GO:0016567

protein ubiquitination

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00143

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Osorio, FG et al. (2016) Loss of the proteostasis factor AIRAPL causes myeloid transformation by deregulating IGF-1 signaling. Nat. Med. 22 91-6 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  3. ↑ Hunt, DM & Johnson, DR (1971) Abnormal spermiogenesis in two pink-eyed sterile mutants in the mouse. J Embryol Exp Morphol 26 111-21 PubMed GONUTS page
  4. ↑ Da Cruz, S et al. (2003) Proteomic analysis of the mouse liver mitochondrial inner membrane. J. Biol. Chem. 278 41566-71 PubMed GONUTS page
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