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MOUSE:HAP1
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Hap1 | |
| Protein Name(s) | Huntingtin-associated protein 1
HAP-1 | |
| External Links | ||
| UniProt | O35668 | |
| EMBL | AJ000262 AJ002271 AJ003128 BC034089 BC053043 | |
| CCDS | CCDS25419.1 CCDS56806.1 | |
| RefSeq | NP_034534.1 NP_817090.1 XP_006532313.1 | |
| UniGene | Mm.281700 | |
| ProteinModelPortal | O35668 | |
| BioGrid | 200207 | |
| DIP | DIP-32510N | |
| IntAct | O35668 | |
| MINT | MINT-3978384 | |
| STRING | 10090.ENSMUSP00000050541 | |
| PhosphoSite | O35668 | |
| MaxQB | O35668 | |
| PaxDb | O35668 | |
| PRIDE | O35668 | |
| Ensembl | ENSMUST00000103124 ENSMUST00000138603 | |
| GeneID | 15114 | |
| KEGG | mmu:15114 | |
| UCSC | uc007lky.2 | |
| CTD | 9001 | |
| MGI | MGI:1261831 | |
| eggNOG | NOG246428 | |
| GeneTree | ENSGT00390000003132 | |
| HOGENOM | HOG000230957 | |
| HOVERGEN | HBG031599 | |
| InParanoid | O35668 | |
| KO | K04647 | |
| OMA | IWKTPAA | |
| OrthoDB | EOG7CRTSM | |
| PhylomeDB | O35668 | |
| TreeFam | TF323495 | |
| ChiTaRS | Hap1 | |
| NextBio | 287522 | |
| PRO | PR:O35668 | |
| Proteomes | UP000000589 | |
| Bgee | O35668 | |
| CleanEx | MM_HAP1 | |
| ExpressionAtlas | O35668 | |
| Genevestigator | O35668 | |
| GO | GO:0005776 GO:0030424 GO:0030054 GO:0016023 GO:0005856 GO:0005783 GO:0005764 GO:0005739 GO:0005634 GO:0008021 GO:0048403 GO:0044325 GO:0008089 GO:0006914 GO:0030030 GO:0021549 GO:0006887 GO:0021979 GO:1902430 GO:0048011 GO:0045742 GO:0031587 GO:0050769 GO:0032901 GO:1902857 GO:0032230 GO:0015031 GO:0017157 GO:1902513 GO:0008090 GO:0047496 | |
| InterPro | IPR006933 | |
| Pfam | PF04849 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0048471 |
perinuclear region of cytoplasm |
ECO:0000314 |
C |
Figure 1 |
complete | |||||
| GO:2000766 |
negative regulation of cytoplasmic translation |
ECO:0000315 |
P |
fig. 4 |
complete | |||||
| GO:0006917 |
induction of apoptosis |
ECO:0000314 |
P |
fig. 6 |
complete | |||||
| GO:0005813 |
centrosome |
ECO:0000314 |
C |
Figure1 |
complete | |||||
| GO:2000154 |
negative regulation of flagellar cell motility |
ECO:0000314 |
P |
Figure 5: PolyQ-Htt accumulates PCM1 at centrosome and increases cilia length. |
complete | |||||
| GO:0022008 |
neurogenesis |
ECO:0000315 |
P |
Supplemental Figure 4 (b): We observed a significant reduction in the number of BrdU-positive cells in the absence of Hap1. |
complete | |||||
| GO:0021549 |
cerebellum development |
ECO:0000315 |
P |
Figure 5A: There was a reduction in the size of cerebellar folia in Hap1-null mice compared with littermate controls. |
complete | |||||
| GO:0001934 |
positive regulation of protein phosphorylation |
ECO:0000314 |
P |
Suppressing Hap1 expression by siRNA also reduced the level of phosphorylated Erk and Akt (Figure 7 C). Quantification of the ratio of phosphorylated Erk or Akt to the total amount of Erk and Akt confirmed the decreased phosphorylation of these proteins (Figure 7D). |
complete | |||||
| GO:0001920 |
negative regulation of receptor recycling |
ECO:0000314 |
P |
Figure 6 (B): of the relative levels of TrkB (the ratio of TrkB to tubulin) confirmed the decreased levels of TrkB in Hap1-KO mouse brains. |
complete | |||||
|
part_of |
GO:0005813 |
centrosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0021549 |
cerebellum development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0022008 |
neurogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0048403 |
brain-derived neurotrophic factor binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0044325 |
ion channel binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1902430 |
negative regulation of amyloid-beta formation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045742 |
positive regulation of epidermal growth factor receptor signaling pathway |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032901 |
positive regulation of neurotrophin production |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032230 |
positive regulation of synaptic transmission, GABAergic |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0031587 |
positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008090 |
retrograde axonal transport |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008089 |
anterograde axonal transport |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005776 |
autophagosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1902513 |
regulation of organelle transport along microtubule |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0017157 |
regulation of exocytosis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050769 |
positive regulation of neurogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0048011 |
neurotrophin TRK receptor signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008089 |
anterograde axonal transport |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0021979 |
hypothalamus cell differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1902857 |
positive regulation of non-motile cilium assembly |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0021549 |
cerebellum development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0031587 |
positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0098957 |
anterograde axonal transport of mitochondrion |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1914345 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0048311 |
mitochondrion distribution |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0262872 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0048011 |
neurotrophin TRK receptor signaling pathway |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1261831 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0047496 |
vesicle transport along microtubule |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1261831 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0032839 |
dendrite cytoplasm |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1918077 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0031410 |
cytoplasmic vesicle |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1261831 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0030425 |
dendrite |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1918077 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0022008 |
neurogenesis |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1261831 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0017022 |
myosin binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0262872 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0008104 |
protein localization |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001039683 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0008089 |
anterograde axonal transport |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1261831 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006605 |
protein targeting |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001039683 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0262872 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001039683 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005102 |
signaling receptor binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001813314 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:1902857 |
positive regulation of non-motile cilium assembly |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
occurs_in:(CL:0000540) |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:1902430 |
negative regulation of amyloid-beta formation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:68327 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0099524 |
postsynaptic cytosol |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:68327 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0099523 |
presynaptic cytosol |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:68327 |
C |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0099149 |
regulation of postsynaptic neurotransmitter receptor internalization |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:68327 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0098982 |
GABA-ergic synapse |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:68327 |
C |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0090261 |
positive regulation of inclusion body assembly |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:68327 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0048471 |
perinuclear region of cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:68327 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0048403 |
brain-derived neurotrophic factor binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:68327 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0047496 |
vesicle transport along microtubule |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0045742 |
positive regulation of epidermal growth factor receptor signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:68327 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0044325 |
ion channel binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:68327 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0043679 |
axon terminus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:68327 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0043005 |
neuron projection |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:68327 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:68327 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0032901 |
positive regulation of neurotrophin production |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:68327 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0032230 |
positive regulation of synaptic transmission, GABAergic |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:68327 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0031587 |
positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:68327 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0031410 |
cytoplasmic vesicle |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0031175 |
neuron projection development |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:68327 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0030426 |
growth cone |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:68327 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0030425 |
dendrite |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:68327 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0019904 |
protein domain specific binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:68327 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0016234 |
inclusion body |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0010976 |
positive regulation of neuron projection development |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:68327 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0008104 |
protein localization |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0008090 |
retrograde axonal transport |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:68327 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0008089 |
anterograde axonal transport |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:68327 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005814 |
centriole |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(CL:0000540) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:68327 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005102 |
signaling receptor binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:68327 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:1904115 |
axon cytoplasm |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0008089 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:1904115 |
axon cytoplasm |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0008089 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:1904115 |
axon cytoplasm |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0008089 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:1904115 |
axon cytoplasm |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0008089 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:1904115 |
axon cytoplasm |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0098957 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0016234 |
inclusion body |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P54257 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0008104 |
protein localization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P54257 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006914 |
autophagy |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0042995 |
cell projection |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006887 |
exocytosis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0015031 |
protein transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030030 |
cell projection organization |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0045202 |
synapse |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005856 |
cytoskeleton |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030054 |
cell junction |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031410 |
cytoplasmic vesicle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005764 |
lysosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030424 |
axon |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005776 |
autophagosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0008021 |
synaptic vesicle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Keryer, G et al. (2011) Ciliogenesis is regulated by a huntingtin-HAP1-PCM1 pathway and is altered in Huntington disease. J. Clin. Invest. 121 4372-82 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Sheng, G et al. (2008) Huntingtin-associated protein 1 interacts with Ahi1 to regulate cerebellar and brainstem development in mice. J. Clin. Invest. 118 2785-95 PubMed GONUTS page
- ↑ 3.0 3.1 Wong, YC & Holzbaur, EL (2014) The regulation of autophagosome dynamics by huntingtin and HAP1 is disrupted by expression of mutant huntingtin, leading to defective cargo degradation. J. Neurosci. 34 1293-305 PubMed GONUTS page
- ↑ Mackenzie, KD et al. (2014) Huntingtin-associated protein 1 regulates exocytosis, vesicle docking, readily releasable pool size and fusion pore stability in mouse chromaffin cells. J. Physiol. (Lond.) 592 1505-18 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 Xiang, J et al. (2014) Huntingtin-associated protein 1 regulates postnatal neurogenesis and neurotrophin receptor sorting. J. Clin. Invest. 124 85-98 PubMed GONUTS page
- ↑ Tang, TS et al. (2004) HAP1 facilitates effects of mutant huntingtin on inositol 1,4,5-trisphosphate-induced Ca release in primary culture of striatal medium spiny neurons. Eur. J. Neurosci. 20 1779-87 PubMed GONUTS page
- ↑ 7.00 7.01 7.02 7.03 7.04 7.05 7.06 7.07 7.08 7.09 7.10 7.11 7.12 7.13 7.14 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 8.0 8.1 Gauthier, LR et al. (2004) Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules. Cell 118 127-38 PubMed GONUTS page
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- GO:0001920 ! negative regulation of receptor recycling
- GO:2000766 ! negative regulation of cytoplasmic translation
- GO:1902430 ! negative regulation of amyloid-beta formation
- GO:0022008 ! neurogenesis
- GO:0031175 ! neuron projection development
- GO:0043005 ! neuron projection
- GO:0048011 ! neurotrophin TRK receptor signaling pathway
- GO:0005634 ! nucleus
p
- GO:0048471 ! perinuclear region of cytoplasm
- GO:0010976 ! positive regulation of neuron projection development
- GO:1902857 ! positive regulation of non-motile cilium assembly
- GO:0001934 ! positive regulation of protein phosphorylation
- GO:0045742 ! positive regulation of epidermal growth factor receptor signaling pathway
- GO:0032901 ! positive regulation of neurotrophin production
- GO:0032230 ! positive regulation of synaptic transmission, GABAergic
- GO:0031587 ! positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
- GO:0050769 ! positive regulation of neurogenesis
- GO:0090261 ! positive regulation of inclusion body assembly
- GO:0099524 ! postsynaptic cytosol
- GO:0099523 ! presynaptic cytosol
- GO:0019904 ! protein domain specific binding
- GO:0008104 ! protein localization
- GO:0006605 ! protein targeting
- GO:0015031 ! protein transport
r
s
