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MOUSE:GUC2F

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Gucy2f
Protein Name(s) Retinal guanylyl cyclase 2
External Links
UniProt Q5SDA5
EMBL AY651761
AL671916
BX324191
BX324191
AL671916
BC115714
AK044234
CCDS CCDS30446.1
RefSeq NP_001007577.1
XP_006528904.1
UniGene Mm.208511
ProteinModelPortal Q5SDA5
SMR Q5SDA5
STRING 10090.ENSMUSP00000044521
PhosphoSite Q5SDA5
PRIDE Q5SDA5
Ensembl ENSMUST00000042530
GeneID 245650
KEGG mmu:245650
UCSC uc009ulq.2
CTD 2986
MGI MGI:105119
eggNOG COG0515
GeneTree ENSGT00760000118959
HOGENOM HOG000293307
HOVERGEN HBG098487
InParanoid Q5SDA5
KO K12321
OMA NSIYFIA
OrthoDB EOG7QVM1V
PhylomeDB Q5SDA5
TreeFam TF106338
Reactome REACT_188266
NextBio 386884
PRO PR:Q5SDA5
Proteomes UP000000589
Bgee Q5SDA5
CleanEx MM_GUCY2F
Genevestigator Q5SDA5
GO GO:0016021
GO:0005524
GO:0005525
GO:0004383
GO:0004672
GO:0035556
GO:0007601
Gene3D 3.30.70.1230
InterPro IPR001054
IPR018297
IPR001828
IPR011009
IPR029787
IPR028082
IPR000719
IPR001245
Pfam PF01094
PF00211
PF07714
SMART SM00044
SUPFAM SSF53822
SSF55073
SSF56112
PROSITE PS00452
PS50125
PS50011

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0050908

detection of light stimulus involved in visual perception

PMID:17255100[1]

ECO:0000315

P

Figure 2B: At high intensity light stimulus, the a-wave and sensitivity of the scotopic GC2 (GUCY2F) -/- mouse were slightly reduced compared to the WT.

complete
CACAO 4455

involved_in

GO:0050908

detection of light stimulus involved in visual perception

PMID:17255100[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007168

receptor guanylyl cyclase signaling pathway

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000229249
UniProtKB:P16066
UniProtKB:P20594

P

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000228924
dictyBase:DDB_G0274569

P

Seeded From UniProt

complete

involved_in

GO:0006182

cGMP biosynthetic process

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000229249
UniProtKB:P16066
UniProtKB:P20594

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000228924
RGD:3195
RGD:620438
RGD:620439
RGD:620851
UniProtKB:P20594
UniProtKB:P9WQ35

C

Seeded From UniProt

complete

enables

GO:0004383

guanylate cyclase activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0266136
MGI:MGI:106025
MGI:MGI:106903
MGI:MGI:97371
MGI:MGI:97372
PANTHER:PTN000229249
RGD:2771
RGD:3195
RGD:620438
RGD:620439
UniProtKB:P16066
UniProtKB:P20594
WB:WBGene00001535
WB:WBGene00001538
WB:WBGene00020131
ZFIN:ZDB-GENE-011128-7

F

Seeded From UniProt

complete

enables

GO:0001653

peptide receptor activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0266136
PANTHER:PTN000229249

F

Seeded From UniProt

complete

enables

GO:0046982

protein heterodimerization activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620439

F

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620439

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0019934

cGMP-mediated signaling

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620439

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620439

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620439

C

Seeded From UniProt

complete

enables

GO:0004383

guanylate cyclase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620439

F

Seeded From UniProt

complete

enables

GO:0046982

protein heterodimerization activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P51842
ensembl:ENSRNOP00000049500

F

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P51842
ensembl:ENSRNOP00000049500

F

Seeded From UniProt

complete

involved_in

GO:0019934

cGMP-mediated signaling

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P51842
ensembl:ENSRNOP00000049500

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P51842
ensembl:ENSRNOP00000049500

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P51842
ensembl:ENSRNOP00000049500

C

Seeded From UniProt

complete

enables

GO:0004383

guanylate cyclase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P51842
ensembl:ENSRNOP00000049500

F

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR001245

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719

F

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR001245

P

Seeded From UniProt

complete

involved_in

GO:0009190

cyclic nucleotide biosynthetic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001054
InterPro:IPR018297

P

Seeded From UniProt

complete

enables

GO:0016849

phosphorus-oxygen lyase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001054
InterPro:IPR018297

F

Seeded From UniProt

complete

involved_in

GO:0035556

intracellular signal transduction

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001054
InterPro:IPR018297

P

Seeded From UniProt

complete

enables

GO:0004383

guanylate cyclase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:4.6.1.2

F

Seeded From UniProt

complete

enables

GO:0016829

lyase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0456

F

Seeded From UniProt

complete

enables

GO:0005525

GTP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0342

F

Seeded From UniProt

complete

involved_in

GO:0006182

cGMP biosynthetic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0141

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

involved_in

GO:0050896

response to stimulus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0716

P

Seeded From UniProt

complete

involved_in

GO:0007601

visual perception

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0844

P

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472
UniProtKB-SubCell:SL-0162

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Baehr, W et al. (2007) The function of guanylate cyclase 1 and guanylate cyclase 2 in rod and cone photoreceptors. J. Biol. Chem. 282 8837-47 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page