MOUSE:GREM1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Grem1 (synonyms: Cktsf1b1, Drm)
Protein Name(s)	Gremlin-1 Cysteine knot superfamily 1, BMP antagonist 1 Down-regulated in Mos-transformed cells protein
External Links
UniProt	O70326
EMBL	AF045801 AF108189 BC015293
CCDS	CCDS16560.1
RefSeq	NP_035954.1
UniGene	Mm.166318
ProteinModelPortal	O70326
SMR	O70326
STRING	10090.ENSMUSP00000097170
PhosphoSite	O70326
PRIDE	O70326
Ensembl	ENSMUST00000099575
GeneID	23892
KEGG	mmu:23892
UCSC	uc008lpp.2
CTD	26585
MGI	MGI:1344337
eggNOG	NOG41424
GeneTree	ENSGT00510000046909
HOVERGEN	HBG051837
InParanoid	O70326
OMA	RVKECRC
OrthoDB	EOG7Q2N7B
TreeFam	TF106445
NextBio	303649
PRO	PR:O70326
Proteomes	UP000000589
Bgee	O70326
CleanEx	MM_GREM1
ExpressionAtlas	O70326
Genevisible	O70326
GO	GO:0009986 GO:0005615 GO:0043395 GO:0048018 GO:0030297 GO:0043184 GO:0007171 GO:0001525 GO:0006915 GO:0001658 GO:0002042 GO:0000902 GO:0007267 GO:0030199 GO:0048263 GO:0030326 GO:0043542 GO:0060173 GO:0003337 GO:0043066 GO:0030514 GO:0030502 GO:1900158 GO:0046851 GO:1900155 GO:0090191 GO:0090090 GO:0030308 GO:0032331 GO:0090027 GO:0033689 GO:0090291 GO:0060394 GO:0045892 GO:0009887 GO:0045766 GO:0090190 GO:2000727 GO:0008284 GO:0042346 GO:0051092 GO:1900086 GO:0061098 GO:2000273 GO:0002092 GO:0051973 GO:0045944 GO:0003257 GO:0045893 GO:0009954 GO:0010717 GO:0051893 GO:0007165 GO:0060676
InterPro	IPR006207 IPR004133 IPR017159
Pfam	PF03045
PIRSF	PIRSF037254
SMART	SM00041

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0036122	BMP binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O60565	F		Seeded From UniProt	complete
involved_in	GO:0045668	negative regulation of osteoblast differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O60565	P		Seeded From UniProt	complete
involved_in	GO:0030514	negative regulation of BMP signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O60565	P		Seeded From UniProt	complete
involved_in	GO:2000727	positive regulation of cardiac muscle cell differentiation	PMID:18545679^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000273	positive regulation of signaling receptor activity	PMID:20660291^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1900086	positive regulation of peptidyl-tyrosine autophosphorylation	PMID:20660291^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P35918)	Seeded From UniProt	complete
NOT\|involved_in	GO:0072331	signal transduction by p53 class mediator	PMID:12135612^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P04637	P		Seeded From UniProt	complete
involved_in	GO:0061098	positive regulation of protein tyrosine kinase activity	PMID:17077323^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051893	regulation of focal adhesion assembly	PMID:17077323^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0048018	receptor ligand activity	PMID:20660291^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P35918	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:12135612^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P38936)	Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	PMID:17077323^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043542	endothelial cell migration	PMID:17077323^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043184	vascular endothelial growth factor receptor 2 binding	PMID:20660291^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P35968-2	F		Seeded From UniProt	complete
NOT\|involved_in	GO:0032872	regulation of stress-activated MAPK cascade	PMID:12135612^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity	PMID:20660291^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
colocalizes_with	GO:0009986	cell surface	PMID:17077323^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:20660291^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:17077323^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0003257	positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation	PMID:18545679^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002092	positive regulation of receptor internalization	PMID:20660291^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P35918)	Seeded From UniProt	complete
involved_in	GO:0002042	cell migration involved in sprouting angiogenesis	PMID:17077323^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002042	cell migration involved in sprouting angiogenesis	PMID:20660291^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	PMID:17522159^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060676	ureteric bud formation	PMID:17522159^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:17522159^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:17522159^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0003337	mesenchymal to epithelial transition involved in metanephros morphogenesis	PMID:17522159^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901224	positive regulation of NIK/NF-kappaB signaling	PMID:18505784^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900158	negative regulation of bone mineralization involved in bone maturation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60565	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900155	negative regulation of bone trabecula formation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60565	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090291	negative regulation of osteoclast proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60565	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	PMID:21281623^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090090	negative regulation of canonical Wnt signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60565	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090027	negative regulation of monocyte chemotaxis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2359	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60565	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060173	limb development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60565	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051973	positive regulation of telomerase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60565	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:18505784^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048263	determination of dorsal identity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60565	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046851	negative regulation of bone remodeling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60565	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045766	positive regulation of angiogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2359	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045668	negative regulation of osteoblast differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60565	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60565	P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60565	F		Seeded From UniProt	complete
enables	GO:0036122	BMP binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60565	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033689	negative regulation of osteoblast proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60565	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032331	negative regulation of chondrocyte differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60565	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030514	negative regulation of BMP signaling pathway	PMID:17522159^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3046937	P	has_regulation_target:(MGI:MGI:88180)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030514	negative regulation of BMP signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60565	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030502	negative regulation of bone mineralization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60565	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030326	embryonic limb morphogenesis	PMID:12808456^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3054923	P	has_participant:(EMAPA:16405)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030308	negative regulation of cell growth	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2359	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030199	collagen fibril organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60565	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010717	regulation of epithelial to mesenchymal transition	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60565	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2359	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009954	proximal/distal pattern formation	PMID:12808456^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3054923	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009887	animal organ morphogenesis	PMID:15198975^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856289	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60565	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007267	cell-cell signaling	PMID:15201225^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3046937	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2359	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002689	negative regulation of leukocyte chemotaxis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2359	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001658	branching involved in ureteric bud morphogenesis	PMID:17522159^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88180	P	has_participant:(EMAPA:17376)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001525	angiogenesis	PMID:18505784^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000902	cell morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60565	P		Seeded From UniProt	complete
involved_in	GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0030297	P		Seeded From UniProt	complete
involved_in	GO:0090027	negative regulation of monocyte chemotaxis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35793 ensembl:ENSRNOP00000035888	P		Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35793 ensembl:ENSRNOP00000035888	P		Seeded From UniProt	complete
involved_in	GO:0030308	negative regulation of cell growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35793 ensembl:ENSRNOP00000035888	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35793 ensembl:ENSRNOP00000035888	C		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35793 ensembl:ENSRNOP00000035888	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35793 ensembl:ENSRNOP00000035888	C		Seeded From UniProt	complete
involved_in	GO:0002689	negative regulation of leukocyte chemotaxis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35793 ensembl:ENSRNOP00000035888	P		Seeded From UniProt	complete
involved_in	GO:1900158	negative regulation of bone mineralization involved in bone maturation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60565 ensembl:ENSP00000478319	P		Seeded From UniProt	complete
involved_in	GO:1900155	negative regulation of bone trabecula formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60565 ensembl:ENSP00000478319	P		Seeded From UniProt	complete
involved_in	GO:0090291	negative regulation of osteoclast proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60565 ensembl:ENSP00000478319	P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60565 ensembl:ENSP00000478319	P		Seeded From UniProt	complete
involved_in	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60565 ensembl:ENSP00000478319	P		Seeded From UniProt	complete
involved_in	GO:0060173	limb development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60565 ensembl:ENSP00000478319	P		Seeded From UniProt	complete
involved_in	GO:0051973	positive regulation of telomerase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60565 ensembl:ENSP00000478319	P		Seeded From UniProt	complete
involved_in	GO:0048263	determination of dorsal identity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60565 ensembl:ENSP00000478319	P		Seeded From UniProt	complete
involved_in	GO:0046851	negative regulation of bone remodeling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60565 ensembl:ENSP00000478319	P		Seeded From UniProt	complete
involved_in	GO:0045668	negative regulation of osteoblast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60565 ensembl:ENSP00000478319	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60565 ensembl:ENSP00000478319	P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60565 ensembl:ENSP00000478319	F		Seeded From UniProt	complete
enables	GO:0036122	BMP binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60565 ensembl:ENSP00000478319	F		Seeded From UniProt	complete
involved_in	GO:0033689	negative regulation of osteoblast proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60565 ensembl:ENSP00000478319	P		Seeded From UniProt	complete
involved_in	GO:0032331	negative regulation of chondrocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60565 ensembl:ENSP00000478319	P		Seeded From UniProt	complete
involved_in	GO:0030514	negative regulation of BMP signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60565 ensembl:ENSP00000478319	P		Seeded From UniProt	complete
involved_in	GO:0030502	negative regulation of bone mineralization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60565 ensembl:ENSP00000478319	P		Seeded From UniProt	complete
involved_in	GO:0030199	collagen fibril organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60565 ensembl:ENSP00000478319	P		Seeded From UniProt	complete
involved_in	GO:0010717	regulation of epithelial to mesenchymal transition	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60565 ensembl:ENSP00000478319	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60565 ensembl:ENSP00000478319	P		Seeded From UniProt	complete
involved_in	GO:0000902	cell morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60565 ensembl:ENSP00000478319	P		Seeded From UniProt	complete
enables	GO:0043395	heparan sulfate proteoglycan binding	PMID:17077323^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	C		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Kami, D et al. (2008) Gremlin enhances the determined path to cardiomyogenesis. PLoS ONE 3 e2407 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Mitola, S et al. (2010) Gremlin is a novel agonist of the major proangiogenic receptor VEGFR2. Blood 116 3677-80 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Chen, B et al. (2002) Drm/Gremlin transcriptionally activates p21(Cip1) via a novel mechanism and inhibits neoplastic transformation. Biochem. Biophys. Res. Commun. 295 1135-41 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 Stabile, H et al. (2007) Bone morphogenic protein antagonist Drm/gremlin is a novel proangiogenic factor. Blood 109 1834-40 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 Michos, O et al. (2007) Reduction of BMP4 activity by gremlin 1 enables ureteric bud outgrowth and GDNF/WNT11 feedback signalling during kidney branching morphogenesis. Development 134 2397-405 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Mitola, S et al. (2008) Angiopoietin-1 mediates the proangiogenic activity of the bone morphogenic protein antagonist Drm. Blood 112 1154-7 PubMed GONUTS page
↑ Nie, X et al. (2011) Six1 regulates Grem1 expression in the metanephric mesenchyme to initiate branching morphogenesis. Dev. Biol. 352 141-51 PubMed GONUTS page
↑ ^8.0 ^8.1 Khokha, MK et al. (2003) Gremlin is the BMP antagonist required for maintenance of Shh and Fgf signals during limb patterning. Nat. Genet. 34 303-7 PubMed GONUTS page
↑ Zuniga, A et al. (2004) Mouse limb deformity mutations disrupt a global control region within the large regulatory landscape required for Gremlin expression. Genes Dev. 18 1553-64 PubMed GONUTS page
↑ Michos, O et al. (2004) Gremlin-mediated BMP antagonism induces the epithelial-mesenchymal feedback signaling controlling metanephric kidney and limb organogenesis. Development 131 3401-10 PubMed GONUTS page

[PMID:18545679-1] 1.0 ^1.1 Kami, D et al. (2008) Gremlin enhances the determined path to cardiomyogenesis. PLoS ONE 3 e2407 PubMed GONUTS page

[PMID:20660291-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Mitola, S et al. (2010) Gremlin is a novel agonist of the major proangiogenic receptor VEGFR2. Blood 116 3677-80 PubMed GONUTS page

[PMID:12135612-3] 3.0 ^3.1 ^3.2 Chen, B et al. (2002) Drm/Gremlin transcriptionally activates p21(Cip1) via a novel mechanism and inhibits neoplastic transformation. Biochem. Biophys. Res. Commun. 295 1135-41 PubMed GONUTS page

[PMID:17077323-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 Stabile, H et al. (2007) Bone morphogenic protein antagonist Drm/gremlin is a novel proangiogenic factor. Blood 109 1834-40 PubMed GONUTS page

[PMID:17522159-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 Michos, O et al. (2007) Reduction of BMP4 activity by gremlin 1 enables ureteric bud outgrowth and GDNF/WNT11 feedback signalling during kidney branching morphogenesis. Development 134 2397-405 PubMed GONUTS page

[PMID:18505784-6] 6.0 ^6.1 ^6.2 Mitola, S et al. (2008) Angiopoietin-1 mediates the proangiogenic activity of the bone morphogenic protein antagonist Drm. Blood 112 1154-7 PubMed GONUTS page

[PMID:21281623-7] Nie, X et al. (2011) Six1 regulates Grem1 expression in the metanephric mesenchyme to initiate branching morphogenesis. Dev. Biol. 352 141-51 PubMed GONUTS page

[PMID:12808456-8] 8.0 ^8.1 Khokha, MK et al. (2003) Gremlin is the BMP antagonist required for maintenance of Shh and Fgf signals during limb patterning. Nat. Genet. 34 303-7 PubMed GONUTS page

[PMID:15198975-9] Zuniga, A et al. (2004) Mouse limb deformity mutations disrupt a global control region within the large regulatory landscape required for Gremlin expression. Genes Dev. 18 1553-64 PubMed GONUTS page

[PMID:15201225-10] Michos, O et al. (2004) Gremlin-mediated BMP antagonism induces the epithelial-mesenchymal feedback signaling controlling metanephric kidney and limb organogenesis. Development 131 3401-10 PubMed GONUTS page

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MOUSE:GREM1

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