MOUSE:GIT1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Git1
Protein Name(s)	ARF GTPase-activating protein GIT1 ARF GAP GIT1 G protein-coupled receptor kinase-interactor 1 GRK-interacting protein 1
External Links
UniProt	Q68FF6
EMBL	AL607072 BC079870
CCDS	CCDS25080.1
RefSeq	NP_001004144.1
UniGene	Mm.290182
ProteinModelPortal	Q68FF6
SMR	Q68FF6
BioGrid	229822
IntAct	Q68FF6
PhosphoSite	Q68FF6
MaxQB	Q68FF6
PaxDb	Q68FF6
PRIDE	Q68FF6
Ensembl	ENSMUST00000037285
GeneID	216963
KEGG	mmu:216963
UCSC	uc007kgy.1
CTD	28964
MGI	MGI:1927140
eggNOG	COG5347
GeneTree	ENSGT00730000110864
HOGENOM	HOG000232135
HOVERGEN	HBG012506
InParanoid	Q68FF6
KO	K05737
OMA	SARSQSD
OrthoDB	EOG7KQ212
PhylomeDB	Q68FF6
TreeFam	TF317762
Reactome	REACT_241951
ChiTaRS	Git1
NextBio	375468
PRO	PR:Q68FF6
Proteomes	UP000000589
Bgee	Q68FF6
CleanEx	MM_GIT1
ExpressionAtlas	Q68FF6
Genevestigator	Q68FF6
GO	GO:0016235 GO:0005737 GO:0005925 GO:0016020 GO:0008060 GO:0008270 GO:0032312
Gene3D	1.25.40.20
InterPro	IPR002110 IPR020683 IPR001164 IPR022018 IPR013724
Pfam	PF12796 PF01412 PF12205 PF08518
PRINTS	PR00405
SMART	SM00248 SM00105 SM00555
SUPFAM	SSF48403
PROSITE	PS50297 PS50088 PS50115

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0005096	GTPase activator activity	PMID:25694429^[1]	ECO:0000314			F		αPIX overexpression in the absence of IL-2 resulted in a significant increase of the PYGM activity when compared to control cells (Figure 1A, second empty bar compared to first empty bar). Western blot shows αPIX expression levels As shown in Figure 2 A, in the absence of αPIX (knockdown), IL-2 was unable to stimulate Rac 1 activation	complete CACAO 10697
involved_in	GO:2000300	regulation of synaptic vesicle exocytosis	PMID:26637799^[2]	ECO:0001225	knockout evidence used in manual assertion		P	occurs_in:(GO:0044305) occurs_in:(UBERON:0000061)	Seeded From UniProt	complete
involved_in	GO:0099171	presynaptic modulation of chemical synaptic transmission	PMID:26637799^[2]	ECO:0001225	knockout evidence used in manual assertion		P	occurs_in:(GO:0044305) occurs_in:(UBERON:0000061)	Seeded From UniProt	complete
part_of	GO:0044305	calyx of Held	PMID:26637799^[2]	ECO:0001225	knockout evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005096	GTPase activator activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69331	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001771	immunological synapse formation	PMID:17310244^[3]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Z272	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000646	positive regulation of receptor catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69331	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0099645	neurotransmitter receptor localization to postsynaptic specialization membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69331	P		Seeded From UniProt	complete
part_of	GO:0098982	GABA-ergic synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69331	C		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69331	C		Seeded From UniProt	complete
enables	GO:0098879	structural constituent of postsynaptic specialization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69331	F		Seeded From UniProt	complete
part_of	GO:0098794	postsynapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69331	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071364	cellular response to epidermal growth factor stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69331	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060996	dendritic spine development	PMID:17310244^[3]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Z272	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048013	ephrin receptor signaling pathway	PMID:17310244^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69331	C		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	PMID:17310244^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O55033 UniProtKB:Q8CBF3 UniProtKB:Q9JLQ2	F		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69331	C		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69331	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032465	regulation of cytokinesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y2X7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032013	negative regulation of ARF protein signal transduction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69331	P		Seeded From UniProt	complete
enables	GO:0031267	small GTPase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69331	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008277	regulation of G protein-coupled receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69331	P		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y2X7	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y2X7	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69331	C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69331	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0099645	C		Seeded From UniProt	complete
involved_in	GO:0043547	positive regulation of GTPase activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005096	P		Seeded From UniProt	complete
involved_in	GO:0043547	positive regulation of GTPase activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005096	P		Seeded From UniProt	complete
involved_in	GO:0043547	positive regulation of GTPase activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005096	P		Seeded From UniProt	complete
involved_in	GO:0098880	maintenance of postsynaptic specialization structure	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0098879	P		Seeded From UniProt	complete
involved_in	GO:0032465	regulation of cytokinesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y2X7 ensembl:ENSP00000378338	P		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y2X7 ensembl:ENSP00000378338	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y2X7 ensembl:ENSP00000378338	C		Seeded From UniProt	complete
enables	GO:0005096	GTPase activator activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001164	F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-MMU-3928622	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0005096	GTPase activator activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0343	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Llavero, F et al. (2015) Guanine nucleotide exchange factor αPIX leads to activation of the Rac 1 GTPase/glycogen phosphorylase pathway in interleukin (IL)-2-stimulated T cells. J. Biol. Chem. 290 9171-82 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Montesinos, MS et al. (2015) Presynaptic Deletion of GIT Proteins Results in Increased Synaptic Strength at a Mammalian Central Synapse. Neuron 88 918-925 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Segura, I et al. (2007) Grb4 and GIT1 transduce ephrinB reverse signals modulating spine morphogenesis and synapse formation. Nat. Neurosci. 10 301-10 PubMed GONUTS page

[PMID:25694429-1] Llavero, F et al. (2015) Guanine nucleotide exchange factor αPIX leads to activation of the Rac 1 GTPase/glycogen phosphorylase pathway in interleukin (IL)-2-stimulated T cells. J. Biol. Chem. 290 9171-82 PubMed GONUTS page

[PMID:26637799-2] 2.0 ^2.1 ^2.2 Montesinos, MS et al. (2015) Presynaptic Deletion of GIT Proteins Results in Increased Synaptic Strength at a Mammalian Central Synapse. Neuron 88 918-925 PubMed GONUTS page

[PMID:17310244-3] 3.0 ^3.1 ^3.2 ^3.3 Segura, I et al. (2007) Grb4 and GIT1 transduce ephrinB reverse signals modulating spine morphogenesis and synapse formation. Nat. Neurosci. 10 301-10 PubMed GONUTS page

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MOUSE:GIT1

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