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MOUSE:GFAP

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Gfap
Protein Name(s) Glial fibrillary acidic protein

GFAP

External Links
UniProt P03995
EMBL X02801
AK140151
AL731670
AY279974
X78141
BC100728
BC100737
BC101968
BC103571
BC139357
BC139358
K01347
M25937
AF332061
AF332062
EF101554
DQ887822
AY142200
CCDS CCDS25507.1
CCDS48950.1
PIR B60052
RefSeq NP_001124492.1
NP_034407.2
UniGene Mm.1239
ProteinModelPortal P03995
SMR P03995
BioGrid 199899
DIP DIP-1084N
IntAct P03995
MINT MINT-4095997
PhosphoSite P03995
UCD-2DPAGE P03995
MaxQB P03995
PaxDb P03995
PRIDE P03995
Ensembl ENSMUST00000067444
ENSMUST00000077902
GeneID 14580
KEGG mmu:14580
UCSC uc007lsw.2
uc007lsx.2
CTD 2670
MGI MGI:95697
eggNOG NOG259463
GeneTree ENSGT00760000118905
HOVERGEN HBG013015
InParanoid P03995
KO K05640
OMA TYRQEAD
OrthoDB EOG7FV3Q8
PhylomeDB P03995
TreeFam TF330122
Reactome REACT_198574
NextBio 286306
PRO PR:P03995
Proteomes UP000000589
Bgee P03995
CleanEx MM_GFAP
ExpressionAtlas P03995
Genevestigator P03995
GO GO:0097450
GO:0097449
GO:0044297
GO:0042995
GO:0005737
GO:0005882
GO:0016020
GO:0005200
GO:0005198
GO:0014002
GO:0060020
GO:0030198
GO:0045109
GO:0045103
GO:0060291
GO:0010977
GO:0031102
GO:0010625
GO:0051580
GO:0009611
InterPro IPR027701
IPR001664
IPR006821
IPR018039
PANTHER PTHR23239
PTHR23239:SF41
Pfam PF00038
PF04732
PROSITE PS00226

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0045109

intermediate filament organization

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P14136

P

Seeded From UniProt

complete

involved_in

GO:1904714

regulation of chaperone-mediated autophagy

PMID:20797626[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0043209

myelin sheath

PMID:17634366[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(CL:0000128)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060291

long-term synaptic potentiation

PMID:8692820[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857176

P

has_participant:(EMAPA:32845)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060252

positive regulation of glial cell proliferation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2679

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060020

Bergmann glial cell differentiation

PMID:10816608[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2183221

P

  • occurs_in:(EMAPA:17787)
  • results_in_acquisition_of_features_of:(CL:0000644)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051580

regulation of neurotransmitter uptake

PMID:15135219[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857176

P

regulates_o_occurs_in:(CL:0000540)|regulates_o_occurs_in:(CL:0000127)

Seeded From UniProt

complete

part_of

GO:0045111

intermediate filament cytoskeleton

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P14136

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045109

intermediate filament organization

PMID:11487638[6]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:98932

P

  • occurs_in:(EMAPA:17544)
  • occurs_in:(CL:0000127)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045109

intermediate filament organization

PMID:8692820[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857176

P

  • occurs_in:(EMAPA:17575)
  • occurs_in:(CL:0000127)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045109

intermediate filament organization

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P14136

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045103

intermediate filament-based process

PMID:12177195[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2384719

P

Seeded From UniProt

complete

part_of

GO:0044297

cell body

PMID:8793730[8]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000127)

Seeded From UniProt

complete

part_of

GO:0044297

cell body

PMID:24035762[9]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0044297

cell body

PMID:20578039[10]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000127)

Seeded From UniProt

complete

part_of

GO:0042995

cell projection

PMID:10989258[11]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000127)

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P14136

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0031102

neuron projection regeneration

PMID:16988027[12]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857176

P

  • occurs_in:(EMAPA:18577)
  • occurs_in:(CL:0000540)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030198

extracellular matrix organization

PMID:11487638[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2183221

P

Seeded From UniProt

complete

enables

GO:0019900

kinase binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2679

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:11283023[13]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(EMAPA:16894)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0014002

astrocyte development

PMID:11487638[6]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:98932

P

  • occurs_in:(EMAPA:17544)
  • results_in_development_of:(CL:0000127)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010977

negative regulation of neuron projection development

PMID:11487638[6]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:98932

P

  • regulates_o_occurs_in:(EMAPA:17544)
  • regulates_o_occurs_in:(CL:0000117)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010977

negative regulation of neuron projection development

PMID:11487638[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2183221

P

  • regulates_o_occurs_in:(EMAPA:17544)
  • regulates_o_occurs_in:(CL:0000117)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010625

positive regulation of Schwann cell proliferation

PMID:16988027[12]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857176

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0009611

response to wounding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2679

P

Seeded From UniProt

complete

part_of

GO:0005882

intermediate filament

PMID:9364068[14]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000127)

Seeded From UniProt

complete

part_of

GO:0005882

intermediate filament

PMID:15656993[15]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005882

intermediate filament

PMID:12878680[16]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005882

intermediate filament

PMID:12533615[17]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005882

intermediate filament

PMID:11487638[6]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:17577)
  • part_of:(CL:0000127)

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

PMID:29350434[18]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:24582971[19]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:18076286[20]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:15965470[21]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:12074840[22]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000127)

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:11834298[23]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(EMAPA:16894)

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:11064363[24]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:16894)
  • part_of:(CL:0000540)

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:12355421[25]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P14136

C

Seeded From UniProt

complete

enables

GO:0005200

structural constituent of cytoskeleton

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2679

F

Seeded From UniProt

complete

enables

GO:0005198

structural molecule activity

PMID:12177195[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2384719

F

Seeded From UniProt

complete

enables

GO:0005178

integrin binding

GO_REF:0000008

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P47819

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1904714

regulation of chaperone-mediated autophagy

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2679

P

Seeded From UniProt

complete

part_of

GO:0098574

cytoplasmic side of lysosomal membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2679

C

Seeded From UniProt

complete

part_of

GO:0097450

astrocyte end-foot

PMID:21212183[26]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0097449

astrocyte projection

PMID:24035762[9]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0097449

astrocyte projection

PMID:23861879[27]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0097449

astrocyte projection

PMID:23447615[28]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0097449

astrocyte projection

PMID:20826656[29]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0097449

astrocyte projection

PMID:19646951[30]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0097449

astrocyte projection

PMID:12368262[31]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P47819

C

Seeded From UniProt

complete

part_of

GO:0097386

glial cell projection

PMID:20531390[32]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:1904714

regulation of chaperone-mediated autophagy

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P47819
ensembl:ENSRNOP00000032389

P

Seeded From UniProt

complete

part_of

GO:0098574

cytoplasmic side of lysosomal membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P47819
ensembl:ENSRNOP00000032389

C

Seeded From UniProt

complete

part_of

GO:0097449

astrocyte projection

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P47819
ensembl:ENSRNOP00000032389

C

Seeded From UniProt

complete

involved_in

GO:0060252

positive regulation of glial cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P47819
ensembl:ENSRNOP00000032389

P

Seeded From UniProt

complete

enables

GO:0019900

kinase binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P47819
ensembl:ENSRNOP00000032389

F

Seeded From UniProt

complete

involved_in

GO:0009611

response to wounding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P47819
ensembl:ENSRNOP00000032389

P

Seeded From UniProt

complete

enables

GO:0005200

structural constituent of cytoskeleton

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P47819
ensembl:ENSRNOP00000032389

F

Seeded From UniProt

complete

enables

GO:0005178

integrin binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P47819
ensembl:ENSRNOP00000032389

F

Seeded From UniProt

complete

enables

GO:0005198

structural molecule activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001664

F

Seeded From UniProt

complete

part_of

GO:0005882

intermediate filament

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001664
InterPro:IPR006821
InterPro:IPR027701

C

Seeded From UniProt

complete

part_of

GO:0005882

intermediate filament

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0403

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Bandyopadhyay, U et al. (2010) Identification of regulators of chaperone-mediated autophagy. Mol. Cell 39 535-47 PubMed GONUTS page
  2. ↑ Werner, HB et al. (2007) Proteolipid protein is required for transport of sirtuin 2 into CNS myelin. J. Neurosci. 27 7717-30 PubMed GONUTS page
  3. ↑ 3.0 3.1 McCall, MA et al. (1996) Targeted deletion in astrocyte intermediate filament (Gfap) alters neuronal physiology. Proc. Natl. Acad. Sci. U.S.A. 93 6361-6 PubMed GONUTS page
  4. ↑ Giménez Y Ribotta, M et al. (2000) Comparative anatomy of the cerebellar cortex in mice lacking vimentin, GFAP, and both vimentin and GFAP. Glia 31 69-83 PubMed GONUTS page
  5. ↑ Hughes, EG et al. (2004) Loss of glial fibrillary acidic protein results in decreased glutamate transport and inhibition of PKA-induced EAAT2 cell surface trafficking. Brain Res. Mol. Brain Res. 124 114-23 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 6.4 6.5 Menet, V et al. (2001) Inactivation of the glial fibrillary acidic protein gene, but not that of vimentin, improves neuronal survival and neurite growth by modifying adhesion molecule expression. J. Neurosci. 21 6147-58 PubMed GONUTS page
  7. ↑ 7.0 7.1 Takemura, M et al. (2002) Protective role of phosphorylation in turnover of glial fibrillary acidic protein in mice. J. Neurosci. 22 6972-9 PubMed GONUTS page
  8. ↑ Molthagen, M et al. (1996) Apoptotic cell death of photoreceptor cells in mice deficient for the adhesion molecule on glia (AMOG, the beta 2- subunit of the Na, K-ATPase). J. Neurocytol. 25 243-55 PubMed GONUTS page
  9. ↑ 9.0 9.1 Ouyang, Q et al. (2013) Christianson syndrome protein NHE6 modulates TrkB endosomal signaling required for neuronal circuit development. Neuron 80 97-112 PubMed GONUTS page
  10. ↑ Parenti, R et al. (2010) Dynamic expression of Cx47 in mouse brain development and in the cuprizone model of myelin plasticity. Glia 58 1594-609 PubMed GONUTS page
  11. ↑ Ha, BK & King, JS (2000) Localization of gp130 in the developing and adult mouse cerebellum. J. Chem. Neuroanat. 19 129-41 PubMed GONUTS page
  12. ↑ 12.0 12.1 Triolo, D et al. (2006) Loss of glial fibrillary acidic protein (GFAP) impairs Schwann cell proliferation and delays nerve regeneration after damage. J. Cell. Sci. 119 3981-93 PubMed GONUTS page
  13. ↑ Kleene, R et al. (2001) The neural recognition molecule L1 is a sialic acid-binding lectin for CD24, which induces promotion and inhibition of neurite outgrowth. J. Biol. Chem. 276 21656-63 PubMed GONUTS page
  14. ↑ Shibata, T et al. (1997) Glutamate transporter GLAST is expressed in the radial glia-astrocyte lineage of developing mouse spinal cord. J. Neurosci. 17 9212-9 PubMed GONUTS page
  15. ↑ Gingras, H et al. (2005) Biochemical characterization of the mammalian Cux2 protein. Gene 344 273-85 PubMed GONUTS page
  16. ↑ Reuss, B et al. (2003) Functions of fibroblast growth factor (FGF)-2 and FGF-5 in astroglial differentiation and blood-brain barrier permeability: evidence from mouse mutants. J. Neurosci. 23 6404-12 PubMed GONUTS page
  17. ↑ Sakai, K et al. (2003) Neutral amino acid transporter ASCT1 is preferentially expressed in L-Ser-synthetic/storing glial cells in the mouse brain with transient expression in developing capillaries. J. Neurosci. 23 550-60 PubMed GONUTS page
  18. ↑ Ottestad-Hansen, S et al. (2018) The cystine-glutamate exchanger (xCT, Slc7a11) is expressed in significant concentrations in a subpopulation of astrocytes in the mouse brain. Glia 66 951-970 PubMed GONUTS page
  19. ↑ Murthy, M et al. (2014) Transcription factor Runx1 inhibits proliferation and promotes developmental maturation in a selected population of inner olfactory nerve layer olfactory ensheathing cells. Gene 540 191-200 PubMed GONUTS page
  20. ↑ Kittappa, R et al. (2007) The foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old age. PLoS Biol. 5 e325 PubMed GONUTS page
  21. ↑ Eiraku, M et al. (2005) DNER acts as a neuron-specific Notch ligand during Bergmann glial development. Nat. Neurosci. 8 873-80 PubMed GONUTS page
  22. ↑ Fukami, S et al. (2002) Abeta-degrading endopeptidase, neprilysin, in mouse brain: synaptic and axonal localization inversely correlating with Abeta pathology. Neurosci. Res. 43 39-56 PubMed GONUTS page
  23. ↑ Kuramochi, Y et al. (2002) Characterization of mouse homolog of brain acyl-CoA hydrolase: molecular cloning and neuronal localization. Brain Res. Mol. Brain Res. 98 81-92 PubMed GONUTS page
  24. ↑ Kinoshita, A et al. (2000) Differential localization of septins in the mouse brain. J. Comp. Neurol. 428 223-39 PubMed GONUTS page
  25. ↑ Ju, WK & Neufeld, AH (2002) Cellular localization of cyclooxygenase-1 and cyclooxygenase-2 in the normal mouse, rat, and human retina. J. Comp. Neurol. 452 392-9 PubMed GONUTS page
  26. ↑ Zou, J et al. (2011) Whirlin replacement restores the formation of the USH2 protein complex in whirlin knockout photoreceptors. Invest. Ophthalmol. Vis. Sci. 52 2343-51 PubMed GONUTS page
  27. ↑ Stegeman, S et al. (2013) Loss of Usp9x disrupts cortical architecture, hippocampal development and TGFβ-mediated axonogenesis. PLoS ONE 8 e68287 PubMed GONUTS page
  28. ↑ Shimozaki, K et al. (2013) Paired related homeobox protein 1 is a regulator of stemness in adult neural stem/progenitor cells. J. Neurosci. 33 4066-75 PubMed GONUTS page
  29. ↑ Hideyama, T et al. (2010) Induced loss of ADAR2 engenders slow death of motor neurons from Q/R site-unedited GluR2. J. Neurosci. 30 11917-25 PubMed GONUTS page
  30. ↑ Smorodchenko, A et al. (2009) Comparative analysis of uncoupling protein 4 distribution in various tissues under physiological conditions and during development. Biochim. Biophys. Acta 1788 2309-19 PubMed GONUTS page
  31. ↑ Olave, I et al. (2002) Identification of a polymorphic, neuron-specific chromatin remodeling complex. Genes Dev. 16 2509-17 PubMed GONUTS page
  32. ↑ Shiwaku, H et al. (2010) Suppression of the novel ER protein Maxer by mutant ataxin-1 in Bergman glia contributes to non-cell-autonomous toxicity. EMBO J. 29 2446-60 PubMed GONUTS page
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