MOUSE:GBRG3

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Gabrg3
Protein Name(s)	Gamma-aminobutyric acid receptor subunit gamma-3 GABA(A) receptor subunit gamma-3
External Links
UniProt	P27681
EMBL	X59300 AC102098 AC102129 AC116146 AC134844 AC156610 AC158550 CH466599
CCDS	CCDS21320.1
PIR	S16915
RefSeq	NP_032100.2
UniGene	Mm.434343
ProteinModelPortal	P27681
SMR	P27681
STRING	10090.ENSMUSP00000067632
ChEMBL	CHEMBL2094133
GuidetoPHARMACOLOGY	415
PhosphoSite	P27681
PRIDE	P27681
Ensembl	ENSMUST00000068911
GeneID	14407
KEGG	mmu:14407
UCSC	uc009hdz.1
CTD	2567
MGI	MGI:95624
eggNOG	NOG300758
GeneTree	ENSGT00760000119010
HOGENOM	HOG000231337
HOVERGEN	HBG051707
InParanoid	P27681
KO	K05186
OMA	DACVYEC
OrthoDB	EOG7JX342
TreeFam	TF315453
Reactome	REACT_198558 REACT_198560 REACT_268398
ChiTaRS	Gabrg3
NextBio	285977
PRO	PR:P27681
Proteomes	UP000000589
ExpressionAtlas	P27681
Genevestigator	P27681
GO	GO:0030054 GO:0034707 GO:0045211 GO:0005254 GO:0005230 GO:0004890 GO:0007214 GO:0042493
Gene3D	2.70.170.10
InterPro	IPR006028 IPR005440 IPR005437 IPR006202 IPR006201 IPR006029 IPR018000
PANTHER	PTHR18945
Pfam	PF02931 PF02932
PRINTS	PR00253 PR01620 PR01623 PR00252
SUPFAM	SSF63712 SSF90112
TIGRFAMs	TIGR00860
PROSITE	PS00236

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:1904315	transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential	PMID:10536013^[1]	ECO:0006063	over expression analysis evidence used in manual assertion		F	occurs_in:(GO:0098982) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0000956)	Seeded From UniProt	complete
enables	GO:1904315	transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential	PMID:10536013^[1]	ECO:0006013	patch-clamp recording evidence used in manual assertion		F	occurs_in:(GO:0098982) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0000956)	Seeded From UniProt	complete
enables	GO:1904315	transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential	PMID:10536013^[1]	ECO:0005589	confocal microscopy evidence used in manual assertion		F	occurs_in:(GO:0098982) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0000956)	Seeded From UniProt	complete
part_of	GO:0099699	integral component of synaptic membrane	PMID:27681^[2]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(GO:0098982) part_of:(UBERON:0000061) part_of:(UBERON:0001897)	Seeded From UniProt	complete
part_of	GO:0098982	GABA-ergic synapse	PMID:10536013^[1]	ECO:0006063	over expression analysis evidence used in manual assertion		C	part_of:(UBERON:0000061) part_of:(UBERON:0000956)	Seeded From UniProt	complete
part_of	GO:0098982	GABA-ergic synapse	PMID:10536013^[1]	ECO:0006013	patch-clamp recording evidence used in manual assertion		C	part_of:(UBERON:0000061) part_of:(UBERON:0000956)	Seeded From UniProt	complete
part_of	GO:0098982	GABA-ergic synapse	PMID:27681^[2]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(UBERON:0001897)	Seeded From UniProt	complete
part_of	GO:0098982	GABA-ergic synapse	PMID:10536013^[1]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(UBERON:0000061) part_of:(UBERON:0000956)	Seeded From UniProt	complete
enables	GO:1904315	transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95613 PANTHER:PTN000436343	F		Seeded From UniProt	complete
part_of	GO:1902711	GABA-A receptor complex	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95623 PANTHER:PTN001055383 UniProtKB:P14867 UniProtKB:P47869 UniProtKB:P78334	C		Seeded From UniProt	complete
involved_in	GO:1902476	chloride transmembrane transport	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95623 PANTHER:PTN001055383 UniProtKB:P14867 UniProtKB:P47869	P		Seeded From UniProt	complete
part_of	GO:0098794	postsynapse	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95614 PANTHER:PTN000436343	C		Seeded From UniProt	complete
involved_in	GO:0060078	regulation of postsynaptic membrane potential	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95613 PANTHER:PTN000436343	P		Seeded From UniProt	complete
involved_in	GO:0051932	synaptic transmission, GABAergic	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000436343 RGD:61855 RGD:61861 RGD:61966	P		Seeded From UniProt	complete
involved_in	GO:0050877	nervous system process	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87888 PANTHER:PTN000434994 UniProtKB:P11230 UniProtKB:P17787 UniProtKB:P43681	P		Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95747 PANTHER:PTN000434994 UniProtKB:G5EDF1 UniProtKB:P11230 WB:WBGene00006765 WB:WBGene00006774	C		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95747 PANTHER:PTN000434994 RGD:2351 RGD:621544 WB:WBGene00000042 WB:WBGene00002974 WB:WBGene00006765 WB:WBGene00006774	C		Seeded From UniProt	complete
involved_in	GO:0042391	regulation of membrane potential	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87885 MGI:MGI:87887 MGI:MGI:87888 MGI:MGI:87890 MGI:MGI:87891 MGI:MGI:87892 MGI:MGI:87893 MGI:MGI:87894 MGI:MGI:87895 MGI:MGI:95747 MGI:MGI:95751 MGI:MGI:99779 PANTHER:PTN000434994 RGD:2348 UniProtKB:P02708 UniProtKB:P23415	P		Seeded From UniProt	complete
involved_in	GO:0034220	ion transmembrane transport	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95613 PANTHER:PTN000434994 UniProtKB:P23416 UniProtKB:P36544 UniProtKB:Q401N2 WB:WBGene00000055 WB:WBGene00002974 WB:WBGene00006797	P		Seeded From UniProt	complete
part_of	GO:0032590	dendrite membrane	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000436343 RGD:61856 RGD:61966	C		Seeded From UniProt	complete
enables	GO:0022851	GABA-gated chloride ion channel activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000436343 RGD:61861 UniProtKB:P14867 UniProtKB:P47869 UniProtKB:P78334	F		Seeded From UniProt	complete
contributes_to	GO:0008503	benzodiazepine receptor activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001055383 RGD:61861 UniProtKB:P47869	F		Seeded From UniProt	complete
involved_in	GO:0007268	chemical synaptic transmission	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003011 FB:FBgn0086778 MGI:MGI:103156 MGI:MGI:95613 MGI:MGI:95623 MGI:MGI:95747 PANTHER:PTN000434994 RGD:2648 RGD:61859 RGD:61901 UniProtKB:P48167 WB:WBGene00000050 WB:WBGene00000054	P		Seeded From UniProt	complete
involved_in	GO:0007214	gamma-aminobutyric acid signaling pathway	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95623 PANTHER:PTN001055383 RGD:68320 UniProtKB:P47869	P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000434994 UniProtKB:P11230 UniProtKB:P17787 UniProtKB:P30926 UniProtKB:P32297 UniProtKB:P36544 UniProtKB:P43681 UniProtKB:Q15822	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1861899 MGI:MGI:95623 MGI:MGI:95750 PANTHER:PTN000434994 RGD:2649 RGD:2650 RGD:61855 RGD:61861 RGD:621229 UniProtKB:O75311 UniProtKB:P23415 UniProtKB:P23416 UniProtKB:P28472 UniProtKB:P48167 UniProtKB:Q9UGM1 WB:WBGene00000955 WB:WBGene00001133 WB:WBGene00001591 WB:WBGene00001592	C		Seeded From UniProt	complete
enables	GO:0005254	chloride channel activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95623 PANTHER:PTN001055383 RGD:61966 RGD:621735	F		Seeded From UniProt	complete
enables	GO:0005237	inhibitory extracellular ligand-gated ion channel activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001055383 RGD:61861	F		Seeded From UniProt	complete
contributes_to	GO:0005230	extracellular ligand-gated ion channel activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000434994 WB:WBGene00000043 WB:WBGene00001512 WB:WBGene00003386 WB:WBGene00006774 WB:WBGene00012857 WB:WBGene00017375	F		Seeded From UniProt	complete
contributes_to	GO:0004890	GABA-A receptor activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95623 PANTHER:PTN001055383 RGD:2648 RGD:61859 RGD:61861 RGD:61966 RGD:621732 RGD:621735 RGD:68320	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042493	response to drug	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621735	P		Seeded From UniProt	complete
enables	GO:0005254	chloride channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621735	F		Seeded From UniProt	complete
enables	GO:0004890	GABA-A receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621735	F		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28473 ensembl:ENSRNOP00000076184	P		Seeded From UniProt	complete
enables	GO:0005254	chloride channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28473 ensembl:ENSRNOP00000076184	F		Seeded From UniProt	complete
enables	GO:0004890	GABA-A receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28473 ensembl:ENSRNOP00000076184	F		Seeded From UniProt	complete
enables	GO:0004888	transmembrane signaling receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006028 InterPro:IPR006201	F		Seeded From UniProt	complete
enables	GO:0004890	GABA-A receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005437 InterPro:IPR005440	F		Seeded From UniProt	complete
enables	GO:0005216	ion channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006028 InterPro:IPR006201	F		Seeded From UniProt	complete
enables	GO:0005230	extracellular ligand-gated ion channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006202 InterPro:IPR036734	F		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006029 InterPro:IPR006202 InterPro:IPR036719 InterPro:IPR036734	P		Seeded From UniProt	complete
involved_in	GO:0006821	chloride transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005437 InterPro:IPR005440	P		Seeded From UniProt	complete
involved_in	GO:0007214	gamma-aminobutyric acid signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005437 InterPro:IPR005440	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005437 InterPro:IPR005440 InterPro:IPR006028 InterPro:IPR006029 InterPro:IPR006201 InterPro:IPR006202 InterPro:IPR036719 InterPro:IPR036734	C		Seeded From UniProt	complete
involved_in	GO:0034220	ion transmembrane transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006028 InterPro:IPR006201	P		Seeded From UniProt	complete
part_of	GO:0034707	chloride channel complex	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0869	C		Seeded From UniProt	complete
enables	GO:0005254	chloride channel activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0869	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
involved_in	GO:0006821	chloride transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0869	P		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0628 UniProtKB-SubCell:SL-0219	C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0406	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Baer, K et al. (1999) Postsynaptic clustering of gamma-aminobutyric acid type A receptors by the gamma3 subunit in vivo. Proc. Natl. Acad. Sci. U.S.A. 96 12860-5 PubMed GONUTS page
↑ ^2.0 ^2.1 Sulpizio, A et al. (1978) Antagonism of fenfluramine-induced hyperthermia: a measure of central serotonin inhibition. Life Sci. 22 1439-46 PubMed GONUTS page
↑ ^3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 ^3.11 ^3.12 ^3.13 ^3.14 ^3.15 ^3.16 ^3.17 ^3.18 ^3.19 ^3.20 ^3.21 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:10536013-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Baer, K et al. (1999) Postsynaptic clustering of gamma-aminobutyric acid type A receptors by the gamma3 subunit in vivo. Proc. Natl. Acad. Sci. U.S.A. 96 12860-5 PubMed GONUTS page

[PMID:27681-2] 2.0 ^2.1 Sulpizio, A et al. (1978) Antagonism of fenfluramine-induced hyperthermia: a measure of central serotonin inhibition. Life Sci. 22 1439-46 PubMed GONUTS page

[PMID:21873635-3] 3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 ^3.11 ^3.12 ^3.13 ^3.14 ^3.15 ^3.16 ^3.17 ^3.18 ^3.19 ^3.20 ^3.21 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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MOUSE:GBRG3

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Notes

References

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