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MOUSE:GBRG2
Contents
Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
Gene Name(s) | Gabrg2 | |
Protein Name(s) | Gamma-aminobutyric acid receptor subunit gamma-2
GABA(A) receptor subunit gamma-2 | |
External Links | ||
UniProt | P22723 | |
EMBL | M86572 M62374 AF233775 AF233776 AF233777 AF233778 AF233779 AF233780 AF233781 AF233782 AF233783 AF233784 AF233785 AF233786 AF233787 AF233788 AF233789 AF233790 AF233791 AF233792 AF233793 AF233794 AF233795 AF233796 AF233797 AF233798 AF233799 AF233800 AF233801 AF233802 BC031762 | |
CCDS | CCDS24551.1 CCDS24552.2 | |
PIR | JH0316 JH0317 | |
RefSeq | NP_032099.1 NP_803127.3 | |
UniGene | Mm.5309 | |
ProteinModelPortal | P22723 | |
SMR | P22723 | |
BioGrid | 199808 | |
DIP | DIP-48995N | |
ChEMBL | CHEMBL2094133 | |
GuidetoPHARMACOLOGY | 414 | |
PhosphoSite | P22723 | |
MaxQB | P22723 | |
PaxDb | P22723 | |
PRIDE | P22723 | |
Ensembl | ENSMUST00000070725 ENSMUST00000070735 | |
GeneID | 14406 | |
KEGG | mmu:14406 | |
UCSC | uc007imb.1 | |
CTD | 2566 | |
MGI | MGI:95623 | |
eggNOG | NOG238757 | |
GeneTree | ENSGT00760000119010 | |
HOGENOM | HOG000231337 | |
HOVERGEN | HBG051707 | |
InParanoid | P22723 | |
KO | K05186 | |
OMA | PGFTSQK | |
OrthoDB | EOG7JX342 | |
PhylomeDB | P22723 | |
TreeFam | TF315453 | |
Reactome | REACT_198558 REACT_198560 REACT_268398 | |
NextBio | 285971 | |
PRO | PR:P22723 | |
Proteomes | UP000000589 | |
Bgee | P22723 | |
ExpressionAtlas | P22723 | |
Genevestigator | P22723 | |
GO | GO:0030424 GO:0030054 GO:0034707 GO:0005737 GO:0032590 GO:1902711 GO:0060077 GO:0005887 GO:0045211 GO:0005254 GO:0005230 GO:0004890 GO:0030534 GO:0071420 GO:1902476 GO:0007214 GO:0009791 GO:0007268 GO:0051932 | |
Gene3D | 2.70.170.10 | |
InterPro | IPR006028 IPR005439 IPR005437 IPR006202 IPR006201 IPR006029 IPR018000 | |
PANTHER | PTHR18945 | |
Pfam | PF02931 PF02932 | |
PRINTS | PR00253 PR01620 PR01622 PR00252 | |
SUPFAM | SSF63712 SSF90112 | |
TIGRFAMs | TIGR00860 | |
PROSITE | PS00236 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
involved_in |
GO:1904862 |
inhibitory synapse assembly |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
contributes_to |
GO:0022851 |
GABA-gated chloride ion channel activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:1902711 |
GABA-A receptor complex |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0005254 |
chloride channel activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004890 |
GABA-A receptor activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:1902476 |
chloride transmembrane transport |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0071420 |
cellular response to histamine |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:1904315 |
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential |
ECO:0006063 |
over expression analysis evidence used in manual assertion |
F |
|
Seeded From UniProt |
complete | ||
enables |
GO:1904315 |
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential |
ECO:0006013 |
patch-clamp recording evidence used in manual assertion |
F |
|
Seeded From UniProt |
complete | ||
enables |
GO:1904315 |
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential |
ECO:0001225 |
knockout evidence used in manual assertion |
F |
|
Seeded From UniProt |
complete | ||
part_of |
GO:0098982 |
GABA-ergic synapse |
ECO:0006063 |
over expression analysis evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
part_of |
GO:0098982 |
GABA-ergic synapse |
ECO:0006013 |
patch-clamp recording evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
part_of |
GO:0098982 |
GABA-ergic synapse |
ECO:0001225 |
knockout evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
enables |
GO:1904315 |
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:95613 |
F |
Seeded From UniProt |
complete | ||
part_of |
GO:1902711 |
GABA-A receptor complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:95623 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:1902476 |
chloride transmembrane transport |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:95623 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0098794 |
postsynapse |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:95614 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0060078 |
regulation of postsynaptic membrane potential |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:95613 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0051932 |
synaptic transmission, GABAergic |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000436343 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0050877 |
nervous system process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:87888 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0045202 |
synapse |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:95747 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0043005 |
neuron projection |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:95747 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0042391 |
regulation of membrane potential |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:87885 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0034220 |
ion transmembrane transport |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:95613 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0032590 |
dendrite membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000436343 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0022851 |
GABA-gated chloride ion channel activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000436343 |
F |
Seeded From UniProt |
complete | ||
contributes_to |
GO:0008503 |
benzodiazepine receptor activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001055383 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007268 |
chemical synaptic transmission |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0003011 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007214 |
gamma-aminobutyric acid signaling pathway |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:95623 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007165 |
signal transduction |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000434994 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1861899 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0005254 |
chloride channel activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:95623 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0005237 |
inhibitory extracellular ligand-gated ion channel activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001055383 |
F |
Seeded From UniProt |
complete | ||
contributes_to |
GO:0005230 |
extracellular ligand-gated ion channel activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000434994 |
F |
Seeded From UniProt |
complete | ||
contributes_to |
GO:0004890 |
GABA-A receptor activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:95623 |
F |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:1904862 |
inhibitory synapse assembly |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:1902710 |
GABA receptor complex |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:61966 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0099060 |
integral component of postsynaptic specialization membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:61966 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0098982 |
GABA-ergic synapse |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:61966 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0098978 |
glutamatergic synapse |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:61966 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0060077 |
inhibitory synapse |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0051932 |
synaptic transmission, GABAergic |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:61966 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0032590 |
dendrite membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:61966 |
C |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0030534 |
adult behavior |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3579440 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0030424 |
axon |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
contributes_to |
GO:0022851 |
GABA-gated chloride ion channel activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
contributes_to |
GO:0016917 |
GABA receptor activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:61966 |
F |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0009791 |
post-embryonic development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3582967 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0007268 |
chemical synaptic transmission |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0007214 |
gamma-aminobutyric acid signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:61966 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0005254 |
chloride channel activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:61966 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0004890 |
GABA-A receptor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004890 |
GABA-A receptor activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:61966 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:1904862 |
inhibitory synapse assembly |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P18507 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0022851 |
GABA-gated chloride ion channel activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P18507 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0004888 |
transmembrane signaling receptor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004890 |
GABA-A receptor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0005216 |
ion channel activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0005230 |
extracellular ligand-gated ion channel activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006811 |
ion transport |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR006029 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006821 |
chloride transport |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007214 |
gamma-aminobutyric acid signaling pathway |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR005437 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0034220 |
ion transmembrane transport |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006821 |
chloride transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0045211 |
postsynaptic membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006811 |
ion transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0042995 |
cell projection |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0034707 |
chloride channel complex |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0030054 |
cell junction |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0005254 |
chloride channel activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0031410 |
cytoplasmic vesicle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0045202 |
synapse |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0030659 |
cytoplasmic vesicle membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0030425 |
dendrite |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Brown, LE et al. (2016) γ-Aminobutyric Acid Type A (GABAA) Receptor Subunits Play a Direct Structural Role in Synaptic Contact Formation via Their N-terminal Extracellular Domains. J. Biol. Chem. 291 13926-42 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Saras, A et al. (2008) Histamine action on vertebrate GABAA receptors: direct channel gating and potentiation of GABA responses. J. Biol. Chem. 283 10470-5 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 Alldred, MJ et al. (2005) Distinct gamma2 subunit domains mediate clustering and synaptic function of postsynaptic GABAA receptors and gephyrin. J. Neurosci. 25 594-603 PubMed GONUTS page
- ↑ 4.00 4.01 4.02 4.03 4.04 4.05 4.06 4.07 4.08 4.09 4.10 4.11 4.12 4.13 4.14 4.15 4.16 4.17 4.18 4.19 4.20 4.21 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 5.0 5.1 Chandra, D et al. (2005) GABAA receptor gamma 2 subunit knockdown mice have enhanced anxiety-like behavior but unaltered hypnotic response to benzodiazepines. BMC Neurosci 6 30 PubMed GONUTS page
- ↑ Fritschy, JM et al. (1998) Independent assembly and subcellular targeting of GABA(A)-receptor subtypes demonstrated in mouse hippocampal and olfactory neurons in vivo. Neurosci. Lett. 249 99-102 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 Wang, J et al. (2003) Interaction of calcineurin and type-A GABA receptor gamma 2 subunits produces long-term depression at CA1 inhibitory synapses. J. Neurosci. 23 826-36 PubMed GONUTS page
c
- GO:0071420 ! cellular response to histamine
- GO:0030054 ! cell junction
- GO:0042995 ! cell projection
- GO:0007268 ! chemical synaptic transmission
- GO:0005254 ! chloride channel activity
- GO:0034707 ! chloride channel complex
- GO:0006821 ! chloride transport
- GO:1902476 ! chloride transmembrane transport
- Chordata
- Craniata
- GO:0005737 ! cytoplasm
- GO:0030659 ! cytoplasmic vesicle membrane
- GO:0031410 ! cytoplasmic vesicle
e
g
- GO:0004890 ! GABA-A receptor activity
- GO:1902711 ! GABA-A receptor complex
- GO:0098982 ! GABA-ergic synapse
- GO:0022851 ! GABA-gated chloride ion channel activity
- GO:1902710 ! GABA receptor complex
- GO:0016917 ! GABA receptor activity
- GO:0007214 ! gamma-aminobutyric acid signaling pathway
- Glires
- GO:0098978 ! glutamatergic synapse
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