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MOUSE:GBRB3
Contents
Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
Gene Name(s) | Gabrb3 (synonyms: Gabrb-3) | |
Protein Name(s) | Gamma-aminobutyric acid receptor subunit beta-3
GABA(A) receptor subunit beta-3 | |
External Links | ||
UniProt | P63080 | |
EMBL | U14420 AK039070 AK147247 | |
CCDS | CCDS21324.1 | |
PIR | S53532 | |
RefSeq | NP_032097.1 | |
UniGene | Mm.8004 | |
ProteinModelPortal | P63080 | |
SMR | P63080 | |
BindingDB | P63080 | |
ChEMBL | CHEMBL2094133 | |
GuidetoPHARMACOLOGY | 412 | |
MaxQB | P63080 | |
PaxDb | P63080 | |
PRIDE | P63080 | |
DNASU | 14402 | |
Ensembl | ENSMUST00000039697 | |
GeneID | 14402 | |
KEGG | mmu:14402 | |
UCSC | uc009hee.1 | |
CTD | 2562 | |
MGI | MGI:95621 | |
eggNOG | NOG77438 | |
GeneTree | ENSGT00760000118821 | |
HOGENOM | HOG000231335 | |
HOVERGEN | HBG051707 | |
InParanoid | P63080 | |
KO | K05181 | |
Reactome | REACT_198558 REACT_198560 REACT_268398 | |
ChiTaRS | Gabrb3 | |
NextBio | 285953 | |
PRO | PR:P63080 | |
Proteomes | UP000000589 | |
Bgee | P63080 | |
ExpressionAtlas | P63080 | |
Genevestigator | P63080 | |
GO | GO:0030054 GO:0034707 GO:1902711 GO:0005887 GO:0005886 GO:0045211 GO:0005254 GO:0005230 GO:0004890 GO:0022851 GO:0071420 GO:1902476 GO:0090102 GO:0007214 GO:0060119 GO:0060384 GO:0043524 GO:1901215 GO:0048666 GO:0060021 GO:0043523 GO:0007605 | |
Gene3D | 2.70.170.10 | |
InterPro | IPR006028 IPR002289 IPR006202 IPR006201 IPR006029 IPR018000 | |
PANTHER | PTHR18945 | |
Pfam | PF02931 PF02932 | |
PRINTS | PR01160 PR00253 PR00252 | |
SUPFAM | SSF63712 SSF90112 | |
TIGRFAMs | TIGR00860 | |
PROSITE | PS00236 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
GO:0060080 |
regulation of inhibitory postsynaptic membrane potential |
ECO:0000315 |
P |
Figure 2 |
complete | |||||
involved_in |
GO:1904862 |
inhibitory synapse assembly |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
contributes_to |
GO:0022851 |
GABA-gated chloride ion channel activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060080 |
inhibitory postsynaptic potential |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:1902711 |
GABA-A receptor complex |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0022851 |
GABA-gated chloride ion channel activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004890 |
GABA-A receptor activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:1902476 |
chloride transmembrane transport |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0071420 |
cellular response to histamine |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:1902476 |
chloride transmembrane transport |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0022851 |
GABA-gated chloride ion channel activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:1902711 |
GABA-A receptor complex |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0004890 |
GABA-A receptor activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060021 |
roof of mouth development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007214 |
gamma-aminobutyric acid signaling pathway |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:1901215 |
negative regulation of neuron death |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0090102 |
cochlea development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060384 |
innervation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060119 |
inner ear receptor cell development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0048666 |
neuron development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0043524 |
negative regulation of neuron apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0043523 |
regulation of neuron apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007605 |
sensory perception of sound |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:1904315 |
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential |
ECO:0006013 |
patch-clamp recording evidence used in manual assertion |
F |
|
Seeded From UniProt |
complete | ||
enables |
GO:1904315 |
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential |
ECO:0001225 |
knockout evidence used in manual assertion |
F |
|
Seeded From UniProt |
complete | ||
part_of |
GO:0098982 |
GABA-ergic synapse |
ECO:0006013 |
patch-clamp recording evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
part_of |
GO:0098982 |
GABA-ergic synapse |
ECO:0001225 |
knockout evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
part_of |
GO:1902711 |
GABA-A receptor complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:95621 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0050877 |
nervous system process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:87888 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0045202 |
synapse |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:95747 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0043005 |
neuron projection |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:95747 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0042391 |
regulation of membrane potential |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:87885 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0034220 |
ion transmembrane transport |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:95613 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007268 |
chemical synaptic transmission |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0003011 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007165 |
signal transduction |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000434994 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1861899 |
C |
Seeded From UniProt |
complete | ||
contributes_to |
GO:0005230 |
extracellular ligand-gated ion channel activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000434994 |
F |
Seeded From UniProt |
complete | ||
contributes_to |
GO:0004890 |
GABA-A receptor activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:95621 |
F |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:1904862 |
inhibitory synapse assembly |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:1902711 |
GABA-A receptor complex |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:1902476 |
chloride transmembrane transport |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0099060 |
integral component of postsynaptic specialization membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2651 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0099055 |
integral component of postsynaptic membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2651 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0098982 |
GABA-ergic synapse |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2651 |
C |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0071420 |
cellular response to histamine |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0060077 |
inhibitory synapse |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0051932 |
synaptic transmission, GABAergic |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2651 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0043195 |
terminal bouton |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2651 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0042802 |
identical protein binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0035612 |
AP-2 adaptor complex binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2651 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0022851 |
GABA-gated chloride ion channel activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0007214 |
gamma-aminobutyric acid signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RefSeq:NM_017065 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0007214 |
gamma-aminobutyric acid signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(CL:0002609) |
Seeded From UniProt |
complete | ||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2651 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0005254 |
chloride channel activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2651 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0004890 |
GABA-A receptor activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RefSeq:NM_017065 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0004890 |
GABA-A receptor activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004890 |
GABA-A receptor activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2651 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:1904862 |
inhibitory synapse assembly |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P28472 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:1902711 |
GABA-A receptor complex |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P28472 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:1902476 |
chloride transmembrane transport |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P28472 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0071420 |
cellular response to histamine |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P28472 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0042802 |
identical protein binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P28472 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0022851 |
GABA-gated chloride ion channel activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P28472 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007214 |
gamma-aminobutyric acid signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P28472 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P28472 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P28472 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0004890 |
GABA-A receptor activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P28472 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0004888 |
transmembrane signaling receptor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004890 |
GABA-A receptor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0005216 |
ion channel activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0005230 |
extracellular ligand-gated ion channel activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006811 |
ion transport |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR002289 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0016020 |
membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR006028 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0034220 |
ion transmembrane transport |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0005254 |
chloride channel activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0034707 |
chloride channel complex |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0045202 |
synapse |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006821 |
chloride transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0045211 |
postsynaptic membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0031410 |
cytoplasmic vesicle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0030054 |
cell junction |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006811 |
ion transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0030659 |
cytoplasmic vesicle membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Hentschke, H et al. (2009) Altered GABAA,slow inhibition and network oscillations in mice lacking the GABAA receptor beta3 subunit. J. Neurophysiol. 102 3643-55 PubMed GONUTS page
- ↑ 2.0 2.1 Brown, LE et al. (2016) γ-Aminobutyric Acid Type A (GABAA) Receptor Subunits Play a Direct Structural Role in Synaptic Contact Formation via Their N-terminal Extracellular Domains. J. Biol. Chem. 291 13926-42 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 Homanics, GE et al. (1997) Mice devoid of gamma-aminobutyrate type A receptor beta3 subunit have epilepsy, cleft palate, and hypersensitive behavior. Proc. Natl. Acad. Sci. U.S.A. 94 4143-8 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 4.7 Maison, SF et al. (2006) Functional role of GABAergic innervation of the cochlea: phenotypic analysis of mice lacking GABA(A) receptor subunits alpha 1, alpha 2, alpha 5, alpha 6, beta 2, beta 3, or delta. J. Neurosci. 26 10315-26 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 Ramadan, E et al. (2003) GABA(A) receptor beta3 subunit deletion decreases alpha2/3 subunits and IPSC duration. J. Neurophysiol. 89 128-34 PubMed GONUTS page
- ↑ 6.00 6.01 6.02 6.03 6.04 6.05 6.06 6.07 6.08 6.09 6.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 7.0 7.1 Kamatchi, GL et al. (1995) GABAA receptor beta 1, beta 2, and beta 3 subunits: comparisons in DBA/2J and C57BL/6J mice. Biochim. Biophys. Acta 1261 134-42 PubMed GONUTS page
- ↑ Yamanaka, M et al. (2006) Protective effect of brain-derived neurotrophic factor on pancreatic islets in obese diabetic mice. Metab. Clin. Exp. 55 1286-92 PubMed GONUTS page
c
- GO:0071420 ! cellular response to histamine
- GO:0030054 ! cell junction
- GO:0007268 ! chemical synaptic transmission
- GO:0034707 ! chloride channel complex
- GO:0005254 ! chloride channel activity
- GO:0006821 ! chloride transport
- GO:1902476 ! chloride transmembrane transport
- Chordata
- GO:0090102 ! cochlea development
- Craniata
- GO:0030659 ! cytoplasmic vesicle membrane
- GO:0031410 ! cytoplasmic vesicle
e
g
i
- GO:0042802 ! identical protein binding
- GO:0060080 ! inhibitory postsynaptic potential
- GO:1904862 ! inhibitory synapse assembly
- GO:0060077 ! inhibitory synapse
- GO:0060384 ! innervation
- GO:0060119 ! inner ear receptor cell development
- GO:0005887 ! integral component of plasma membrane
- GO:0016021 ! integral component of membrane
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