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MOUSE:GA45A
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Gadd45a (synonyms: Ddit1, Gadd45) | |
| Protein Name(s) | Growth arrest and DNA damage-inducible protein GADD45 alpha
DNA damage-inducible transcript 1 protein DDIT-1 | |
| External Links | ||
| UniProt | P48316 | |
| EMBL | L28177 U00937 BC011141 | |
| CCDS | CCDS20217.1 | |
| PIR | B56535 | |
| RefSeq | NP_031862.1 | |
| UniGene | Mm.72235 | |
| ProteinModelPortal | P48316 | |
| SMR | P48316 | |
| BioGrid | 199077 | |
| IntAct | P48316 | |
| STRING | 10090.ENSMUSP00000044034 | |
| PhosphoSite | P48316 | |
| PaxDb | P48316 | |
| PRIDE | P48316 | |
| Ensembl | ENSMUST00000043098 | |
| GeneID | 13197 | |
| KEGG | mmu:13197 | |
| UCSC | uc009cfc.1 | |
| CTD | 1647 | |
| MGI | MGI:107799 | |
| eggNOG | ENOG410IFHI ENOG4111M8M | |
| HOGENOM | HOG000013221 | |
| HOVERGEN | HBG051684 | |
| InParanoid | P48316 | |
| KO | K04402 | |
| OMA | NPHASQW | |
| OrthoDB | EOG7J1819 | |
| PhylomeDB | P48316 | |
| TreeFam | TF300196 | |
| Reactome | [www.reactome.org/content/detail/R-MMU-6804114 R-MMU-6804114] | |
| PRO | PR:P48316 | |
| Proteomes | UP000000589 | |
| Bgee | P48316 | |
| CleanEx | MM_GADD45A | |
| ExpressionAtlas | P48316 | |
| Genevisible | P48316 | |
| GO | GO:0005737 GO:0005654 GO:0005634 GO:0001047 GO:0000185 GO:0071479 GO:0071260 GO:0007098 GO:0000086 GO:0071850 GO:0006469 GO:0043065 GO:0046330 GO:1900745 GO:2000379 GO:0051726 GO:0042770 | |
| InterPro | IPR024824 IPR029064 IPR004038 | |
| PANTHER | PTHR10411 | |
| Pfam | PF01248 | |
| SUPFAM | SSF55315 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0016525 |
negative regulation of angiogenesis |
ECO:0000315 |
P |
Figure 1 shows that Gadd45a deletion promotes angiogenesis and hence tumor growth. |
complete | |||||
| GO:0043537 |
negative regulation of blood vessel endothelial cell migration |
ECO:0000315 |
P |
Figure 2 (e and f) (in vivo) shows that knockdown of Gadd54a results in blood vessel endothelial cell migration. Therefore, the presence of Gadd54a inhibits this process; it negatively regulates endothelial cell migration |
complete | |||||
| GO:1903262 |
negative regulation of serine phosphorylation of STAT3 protein |
ECO:0000315 |
P |
Figure 6a and d show that Gadd45a knockdown in mouse cells (MEFs) results in enhanced transcriptional activity of STAT3 by increasing the STAT3 phosphorylation site on a serine residue. |
complete | |||||
|
involved_in |
GO:0051726 |
regulation of cell cycle |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:107776 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000823659 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0033153 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0000185 |
activation of MAPKKK activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000823659 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:2000379 |
positive regulation of reactive oxygen species metabolic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:1900745 |
positive regulation of p38MAPK cascade |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0071850 |
mitotic cell cycle arrest |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0071479 |
cellular response to ionizing radiation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0051726 |
regulation of cell cycle |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0047485 |
protein N-terminus binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046982 |
protein heterodimerization activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0046330 |
positive regulation of JNK cascade |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0043065 |
positive regulation of apoptotic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042803 |
protein homodimerization activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0042770 |
signal transduction in response to DNA damage |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0019900 |
kinase binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016607 |
nuclear speck |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0007098 |
centrosome cycle |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:104537 |
P |
occurs_in:(CL:0000057) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0006469 |
negative regulation of protein kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000979 |
RNA polymerase II core promoter sequence-specific DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0000185 |
activation of MAPKKK activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:2000379 |
positive regulation of reactive oxygen species metabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P24522 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1900745 |
positive regulation of p38MAPK cascade |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P24522 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0071850 |
mitotic cell cycle arrest |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P24522 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0071479 |
cellular response to ionizing radiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P24522 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0071260 |
cellular response to mechanical stimulus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P24522 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0047485 |
protein N-terminus binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P24522 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0046982 |
protein heterodimerization activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P24522 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0046330 |
positive regulation of JNK cascade |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P24522 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043065 |
positive regulation of apoptotic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P24522 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0042803 |
protein homodimerization activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P24522 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042770 |
signal transduction in response to DNA damage |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P24522 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0019900 |
kinase binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P24522 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0016607 |
nuclear speck |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P24522 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P24522 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P24522 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0000185 |
activation of MAPKKK activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P24522 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051726 |
regulation of cell cycle |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006974 |
cellular response to DNA damage stimulus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007049 |
cell cycle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007050 |
cell cycle arrest |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Yang, F et al. (2013) Gadd45a suppresses tumor angiogenesis via inhibition of the mTOR/STAT3 protein pathway. J. Biol. Chem. 288 6552-60 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Vairapandi, M et al. (2002) GADD45b and GADD45g are cdc2/cyclinB1 kinase inhibitors with a role in S and G2/M cell cycle checkpoints induced by genotoxic stress. J. Cell. Physiol. 192 327-38 PubMed GONUTS page
- ↑ Wang, X et al. (2004) Genetic interactions between Brca1 and Gadd45a in centrosome duplication, genetic stability, and neural tube closure. J. Biol. Chem. 279 29606-14 PubMed GONUTS page
- ↑ Nishiyama, A et al. (2009) Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell 5 420-33 PubMed GONUTS page
- ↑ Kamileri, I et al. (2012) Defective transcription initiation causes postnatal growth failure in a mouse model of nucleotide excision repair (NER) progeria. Proc. Natl. Acad. Sci. U.S.A. 109 2995-3000 PubMed GONUTS page
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- GO:0016525 ! negative regulation of angiogenesis
- GO:0043537 ! negative regulation of blood vessel endothelial cell migration
- GO:0006469 ! negative regulation of protein kinase activity
- GO:1903262 ! negative regulation of serine phosphorylation of STAT3 protein
- GO:0016607 ! nuclear speck
- GO:0005634 ! nucleus
o
p
- GO:0046330 ! positive regulation of JNK cascade
- GO:1900745 ! positive regulation of p38MAPK cascade
- GO:2000379 ! positive regulation of reactive oxygen species metabolic process
- GO:0043065 ! positive regulation of apoptotic process
- GO:0046982 ! protein heterodimerization activity
- GO:0042803 ! protein homodimerization activity
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