MOUSE:FRDA

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Fxn (synonyms: Frda)
Protein Name(s)	Frataxin, mitochondrial Fxn Frataxin intermediate form Frataxin mature form
External Links
UniProt	O35943
EMBL	U95736
CCDS	CCDS29711.1
RefSeq	NP_032070.1
UniGene	Mm.7319
ProteinModelPortal	O35943
SMR	O35943
IntAct	O35943
MINT	MINT-1847605
PhosphoSite	O35943
MaxQB	O35943
PaxDb	O35943
PRIDE	O35943
Ensembl	ENSMUST00000081333
GeneID	14297
KEGG	mmu:14297
UCSC	uc008hao.1
CTD	2395
MGI	MGI:1096879
eggNOG	COG1965
HOGENOM	HOG000190729
HOVERGEN	HBG005745
InParanoid	O35943
OMA	KQSVCLM
OrthoDB	EOG7HHWVD
PhylomeDB	O35943
TreeFam	TF318958
Reactome	REACT_199053 REACT_199101
NextBio	285709
PRO	PR:O35943
Proteomes	UP000000589
Bgee	O35943
CleanEx	MM_FXN
ExpressionAtlas	O35943
Genevestigator	O35943
GO	GO:0005829 GO:0005739 GO:0051537 GO:0008199 GO:0008198 GO:0004322 GO:0034986 GO:0007628 GO:0009060 GO:0006879 GO:0070301 GO:0009792 GO:0006783 GO:0006811 GO:0018283 GO:0016226 GO:0007005 GO:0040015 GO:0046621 GO:0090201 GO:0006119 GO:0030307 GO:0008284 GO:0051349 GO:0048554 GO:0051353 GO:0051347 GO:0019230 GO:0016540 GO:0010722 GO:0010039
Gene3D	3.30.920.10
InterPro	IPR017789 IPR002908 IPR020895
PANTHER	PTHR16821
Pfam	PF01491
PRINTS	PR00904
SUPFAM	SSF55387
TIGRFAMs	TIGR03421 TIGR03422
PROSITE	PS01344 PS50810

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0051537	2 iron, 2 sulfur cluster binding	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000423706 UniProtKB:Q16595	F		Seeded From UniProt	complete
enables	GO:0034986	iron chaperone activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0030092 PANTHER:PTN000423706 SGD:S000002278 UniProtKB:Q16595	F		Seeded From UniProt	complete
involved_in	GO:0018283	iron incorporation into metallo-sulfur cluster	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000423706 UniProtKB:Q16595	P		Seeded From UniProt	complete
enables	GO:0008199	ferric iron binding	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000423706 UniProtKB:Q16595	F		Seeded From UniProt	complete
enables	GO:0008198	ferrous iron binding	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000423706 SGD:S000002278 UniProtKB:Q16595	F		Seeded From UniProt	complete
involved_in	GO:0007005	mitochondrion organization	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1096879 PANTHER:PTN000423706	P		Seeded From UniProt	complete
involved_in	GO:0006879	cellular iron ion homeostasis	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1096879 PANTHER:PTN000423706 SGD:S000002278 UniProtKB:Q16595	P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0030092 MGI:MGI:1096879 PANTHER:PTN000423706 PomBase:SPCC1183.03c RGD:1565754 SGD:S000002278 TAIR:locus:2125477 UniProtKB:Q16595 WB:WBGene00001486	C		Seeded From UniProt	complete
enables	GO:0004322	ferroxidase activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000423706 SGD:S000002278 UniProtKB:Q16595	F		Seeded From UniProt	complete
part_of	GO:1990221	L-cysteine desulfurase complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16595	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904234	positive regulation of aconitate hydratase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16595	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904231	positive regulation of succinate dehydrogenase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16595	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090201	negative regulation of release of cytochrome c from mitochondria	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16595	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070301	cellular response to hydrogen peroxide	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16595	P		Seeded From UniProt	complete
enables	GO:0051537	2 iron, 2 sulfur cluster binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16595	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051349	positive regulation of lyase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16595	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046621	negative regulation of organ growth	PMID:9405681^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2177175,MGI:MGI:2177176	P	regulates_o_occurs_in:(EMAPA:16105)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045773	positive regulation of axon extension	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1565754	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043085	positive regulation of catalytic activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16595	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16595	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0040015	negative regulation of multicellular organism growth	PMID:17404227^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2177176,MGI:MGI:2182103	P		Seeded From UniProt	complete
enables	GO:0034986	iron chaperone activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16595	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030307	positive regulation of cell growth	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16595	P		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1565754	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019230	proprioception	PMID:14985441^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2177177	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019230	proprioception	PMID:11175786^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2177175,MGI:MGI:2177176	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018283	iron incorporation into metallo-sulfur cluster	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16595	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016540	protein autoprocessing	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16595	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016226	iron-sulfur cluster assembly	PMID:17597094^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176228,MGI:MGI:2177176	P	occurs_in:(EMAPA:16846)\|occurs_in:(EMAPA:16105)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016226	iron-sulfur cluster assembly	PMID:16278235^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176228,MGI:MGI:2177176	P	occurs_in:(EMAPA:16846) occurs_in:(CL:0000182)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016226	iron-sulfur cluster assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16595	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010722	regulation of ferrochelatase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16595	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010039	response to iron ion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16595	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009792	embryo development ending in birth or egg hatching	PMID:10767347^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2177162	P	results_in_development_of:(EMAPA:16039)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009060	aerobic respiration	PMID:9405681^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2177175,MGI:MGI:2177176	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009060	aerobic respiration	PMID:16278235^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176228,MGI:MGI:2177176	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16595	P		Seeded From UniProt	complete
enables	GO:0008199	ferric iron binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16595	F		Seeded From UniProt	complete
enables	GO:0008198	ferrous iron binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16595	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007628	adult walking behavior	PMID:9405681^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2177175,MGI:MGI:2177176	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007628	adult walking behavior	PMID:14985441^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2177177	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007005	mitochondrion organization	PMID:9405681^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2177175,MGI:MGI:2177176	P	occurs_in:(EMAPA:32688) occurs_in:(CL:0000746)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007005	mitochondrion organization	PMID:14985441^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2177177	P	occurs_in:(EMAPA:16668) occurs_in:(CL:0000117)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006879	cellular iron ion homeostasis	PMID:9405681^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2177175,MGI:MGI:2177176	P	occurs_in:(EMAPA:32688) occurs_in:(CL:0000746)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006879	cellular iron ion homeostasis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16595	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006119	oxidative phosphorylation	PMID:17404227^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2177176,MGI:MGI:2182103	P	occurs_in:(EMAPA:35112)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006119	oxidative phosphorylation	PMID:16278235^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176228,MGI:MGI:2177176	P	occurs_in:(EMAPA:16846) occurs_in:(CL:0000182)	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16595	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:18614015^[9]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:14651853^[10]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(EMAPA:16846)\|part_of:(EMAPA:16894)\|part_of:(EMAPA:17373)\|part_of:(EMAPA:16105)	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:17597094^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16595	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1565754	C		Seeded From UniProt	complete
enables	GO:0004322	ferroxidase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16595	F		Seeded From UniProt	complete
part_of	GO:1990221	L-cysteine desulfurase complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16595 ensembl:ENSP00000496143	C		Seeded From UniProt	complete
involved_in	GO:1904234	positive regulation of aconitate hydratase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16595 ensembl:ENSP00000496143	P		Seeded From UniProt	complete
involved_in	GO:1904231	positive regulation of succinate dehydrogenase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16595 ensembl:ENSP00000496143	P		Seeded From UniProt	complete
involved_in	GO:0090201	negative regulation of release of cytochrome c from mitochondria	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16595 ensembl:ENSP00000496143	P		Seeded From UniProt	complete
involved_in	GO:0070301	cellular response to hydrogen peroxide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16595 ensembl:ENSP00000496143	P		Seeded From UniProt	complete
enables	GO:0051537	2 iron, 2 sulfur cluster binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16595 ensembl:ENSP00000496143	F		Seeded From UniProt	complete
involved_in	GO:0051349	positive regulation of lyase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16595 ensembl:ENSP00000496143	P		Seeded From UniProt	complete
involved_in	GO:0043085	positive regulation of catalytic activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16595 ensembl:ENSP00000496143	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16595 ensembl:ENSP00000496143	P		Seeded From UniProt	complete
enables	GO:0034986	iron chaperone activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16595 ensembl:ENSP00000496143	F		Seeded From UniProt	complete
involved_in	GO:0030307	positive regulation of cell growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16595 ensembl:ENSP00000496143	P		Seeded From UniProt	complete
involved_in	GO:0018283	iron incorporation into metallo-sulfur cluster	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16595 ensembl:ENSP00000496143	P		Seeded From UniProt	complete
involved_in	GO:0016540	protein autoprocessing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16595 ensembl:ENSP00000496143	P		Seeded From UniProt	complete
involved_in	GO:0016226	iron-sulfur cluster assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16595 ensembl:ENSP00000496143	P		Seeded From UniProt	complete
involved_in	GO:0010722	regulation of ferrochelatase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16595 ensembl:ENSP00000496143	P		Seeded From UniProt	complete
involved_in	GO:0010039	response to iron ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16595 ensembl:ENSP00000496143	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16595 ensembl:ENSP00000496143	P		Seeded From UniProt	complete
enables	GO:0008199	ferric iron binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16595 ensembl:ENSP00000496143	F		Seeded From UniProt	complete
enables	GO:0008198	ferrous iron binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16595 ensembl:ENSP00000496143	F		Seeded From UniProt	complete
involved_in	GO:0006879	cellular iron ion homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16595 ensembl:ENSP00000496143	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16595 ensembl:ENSP00000496143	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16595 ensembl:ENSP00000496143	C		Seeded From UniProt	complete
enables	GO:0004322	ferroxidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16595 ensembl:ENSP00000496143	F		Seeded From UniProt	complete
enables	GO:0004322	ferroxidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017789	F		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017789	C		Seeded From UniProt	complete
enables	GO:0008199	ferric iron binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002908 InterPro:IPR036524	F		Seeded From UniProt	complete
involved_in	GO:0016226	iron-sulfur cluster assembly	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002908 InterPro:IPR036524	P		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017789	P		Seeded From UniProt	complete
enables	GO:0004322	ferroxidase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.16.3.1	F		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0406	P		Seeded From UniProt	complete
involved_in	GO:0006783	heme biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0350	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
involved_in	GO:0006879	cellular iron ion homeostasis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0409	P		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496 UniProtKB-SubCell:SL-0173	C		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
involved_in	GO:0055072	iron ion homeostasis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0410	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0091	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Oliver, PM et al. (1997) Hypertension, cardiac hypertrophy, and sudden death in mice lacking natriuretic peptide receptor A. Proc. Natl. Acad. Sci. U.S.A. 94 14730-5 PubMed GONUTS page
↑ ^3.0 ^3.1 Pomplun, D et al. (2007) Reduced expression of mitochondrial frataxin in mice exacerbates diet-induced obesity. Proc. Natl. Acad. Sci. U.S.A. 104 6377-81 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Simon, D et al. (2004) Friedreich ataxia mouse models with progressive cerebellar and sensory ataxia reveal autophagic neurodegeneration in dorsal root ganglia. J. Neurosci. 24 1987-95 PubMed GONUTS page
↑ Puccio, H et al. (2001) Mouse models for Friedreich ataxia exhibit cardiomyopathy, sensory nerve defect and Fe-S enzyme deficiency followed by intramitochondrial iron deposits. Nat. Genet. 27 181-6 PubMed GONUTS page
↑ ^6.0 ^6.1 Martelli, A et al. (2007) Frataxin is essential for extramitochondrial Fe-S cluster proteins in mammalian tissues. Hum. Mol. Genet. 16 2651-8 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Thierbach, R et al. (2005) Targeted disruption of hepatic frataxin expression causes impaired mitochondrial function, decreased life span and tumor growth in mice. Hum. Mol. Genet. 14 3857-64 PubMed GONUTS page
↑ Cossée, M et al. (2000) Inactivation of the Friedreich ataxia mouse gene leads to early embryonic lethality without iron accumulation. Hum. Mol. Genet. 9 1219-26 PubMed GONUTS page
↑ Pagliarini, DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134 112-23 PubMed GONUTS page
↑ Mootha, VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell 115 629-40 PubMed GONUTS page

[PMID:21873635-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:9405681-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Oliver, PM et al. (1997) Hypertension, cardiac hypertrophy, and sudden death in mice lacking natriuretic peptide receptor A. Proc. Natl. Acad. Sci. U.S.A. 94 14730-5 PubMed GONUTS page

[PMID:17404227-3] 3.0 ^3.1 Pomplun, D et al. (2007) Reduced expression of mitochondrial frataxin in mice exacerbates diet-induced obesity. Proc. Natl. Acad. Sci. U.S.A. 104 6377-81 PubMed GONUTS page

[PMID:14985441-4] 4.0 ^4.1 ^4.2 Simon, D et al. (2004) Friedreich ataxia mouse models with progressive cerebellar and sensory ataxia reveal autophagic neurodegeneration in dorsal root ganglia. J. Neurosci. 24 1987-95 PubMed GONUTS page

[PMID:11175786-5] Puccio, H et al. (2001) Mouse models for Friedreich ataxia exhibit cardiomyopathy, sensory nerve defect and Fe-S enzyme deficiency followed by intramitochondrial iron deposits. Nat. Genet. 27 181-6 PubMed GONUTS page

[PMID:17597094-6] 6.0 ^6.1 Martelli, A et al. (2007) Frataxin is essential for extramitochondrial Fe-S cluster proteins in mammalian tissues. Hum. Mol. Genet. 16 2651-8 PubMed GONUTS page

[PMID:16278235-7] 7.0 ^7.1 ^7.2 Thierbach, R et al. (2005) Targeted disruption of hepatic frataxin expression causes impaired mitochondrial function, decreased life span and tumor growth in mice. Hum. Mol. Genet. 14 3857-64 PubMed GONUTS page

[PMID:10767347-8] Cossée, M et al. (2000) Inactivation of the Friedreich ataxia mouse gene leads to early embryonic lethality without iron accumulation. Hum. Mol. Genet. 9 1219-26 PubMed GONUTS page

[PMID:18614015-9] Pagliarini, DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134 112-23 PubMed GONUTS page

[PMID:14651853-10] Mootha, VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell 115 629-40 PubMed GONUTS page

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MOUSE:FRDA

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