MOUSE:FOXE3

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Foxe3
Protein Name(s)	Forkhead box protein E3
External Links
UniProt	Q9QY14
EMBL	AF142647
CCDS	CCDS18483.1
RefSeq	NP_056573.1
UniGene	Mm.377122
ProteinModelPortal	Q9QY14
SMR	Q9QY14
BioGrid	206001
STRING	10090.ENSMUSP00000050445
PhosphoSite	Q9QY14
PRIDE	Q9QY14
Ensembl	ENSMUST00000050940
GeneID	30923
KEGG	mmu:30923
UCSC	uc008uef.1
CTD	2301
MGI	MGI:1353569
eggNOG	COG5025
GeneTree	ENSGT00760000118904
HOGENOM	HOG000231286
HOVERGEN	HBG051642
InParanoid	Q9QY14
KO	K09398
OMA	PEPPCCA
OrthoDB	EOG7KWSK8
PhylomeDB	Q9QY14
TreeFam	TF316127
NextBio	307312
PRO	PR:Q9QY14
Proteomes	UP000000589
Bgee	Q9QY14
CleanEx	MM_FOXE3
Genevestigator	Q9QY14
GO	GO:0005634 GO:0005667 GO:0043565 GO:0003700 GO:0043010 GO:0048468 GO:0001654 GO:0050679 GO:0006366
Gene3D	1.10.10.10
InterPro	IPR001766 IPR018122 IPR011991
Pfam	PF00250
PRINTS	PR00053
SMART	SM00339
PROSITE	PS00657 PS00658 PS50039

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0061303	cornea development in camera-type eye	PMID:17064680^[1]	ECO:0000315			P		Fig 3d,h,l	complete
	GO:0061072	iris morphogenesis	PMID:17064680^[1]	ECO:0000315			P		Fig 2e,h,k	complete
	GO:0002088	lens development in camera-type eye	PMID:17064680^[1]	ECO:0000315			P		Fig 2e,h,k,l	complete
	GO:0061073	ciliary body morphogenesis	PMID:17064680^[1]	ECO:0000315			P		Fig 5c	complete
involved_in	GO:0002088	lens development in camera-type eye	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13461	P		Seeded From UniProt	complete
involved_in	GO:0042789	mRNA transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13461	P		Seeded From UniProt	complete
involved_in	GO:0001654	eye development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13461	P		Seeded From UniProt	complete
involved_in	GO:1902747	negative regulation of lens fiber cell differentiation	PMID:10652278^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902747	negative regulation of lens fiber cell differentiation	PMID:10890982^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:11980846^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17064680^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2001111	positive regulation of lens epithelial cell proliferation	PMID:10652278^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902747	negative regulation of lens fiber cell differentiation	PMID:16199865^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002088	lens development in camera-type eye	PMID:17064680^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061303	cornea development in camera-type eye	PMID:17064680^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002930	trabecular meshwork development	PMID:17064680^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061073	ciliary body morphogenesis	PMID:17064680^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061072	iris morphogenesis	PMID:17064680^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:25504734^[6]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13461	F		Seeded From UniProt	complete
involved_in	GO:2001111	positive regulation of lens epithelial cell proliferation	PMID:22527307^[7]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13461	P		Seeded From UniProt	complete
involved_in	GO:0071157	negative regulation of cell cycle arrest	PMID:22527307^[7]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13461	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:22527307^[7]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13461	P		Seeded From UniProt	complete
involved_in	GO:2001111	positive regulation of lens epithelial cell proliferation	PMID:16199865^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000930906 WB:WBGene00004013	P		Seeded From UniProt	complete
involved_in	GO:0009653	anatomical structure morphogenesis	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1347476 PANTHER:PTN000930906	P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000659 MGI:MGI:1347472 MGI:MGI:1347477 PANTHER:PTN000930906 UniProtKB:O00358 UniProtKB:Q9Y261 ZFIN:ZDB-GENE-000616-15	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000659 FB:FBgn0003430 FB:FBgn0004895 FB:FBgn0014143 MGI:MGI:1347466 MGI:MGI:1347472 MGI:MGI:1347476 MGI:MGI:1347477 MGI:MGI:1349428 MGI:MGI:1353569 MGI:MGI:1927549 MGI:MGI:95546 PANTHER:PTN000930906 PomBase:SPBC32H8.11 PomBase:SPBC4C3.12 RGD:2807 RGD:2808 RGD:2809 SGD:S000000661 SGD:S000001393 UniProtKB:O00358 UniProtKB:P55317 UniProtKB:P58012 UniProtKB:Q12948 UniProtKB:Q13461 UniProtKB:Q5AS72 UniProtKB:Q99958 UniProtKB:Q9Y261 WB:WBGene00001434 WB:WBGene00001441 WB:WBGene00002601 WB:WBGene00003017 WB:WBGene00004013 WB:WBGene00006853	C		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000659 PANTHER:PTN000930906 RGD:621723 UniProtKB:O00358 WB:WBGene00004013 ZFIN:ZDB-GENE-000616-15	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050679	positive regulation of epithelial cell proliferation	PMID:16199865^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3604211	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048468	cell development	PMID:16199865^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3604211	P	occurs_in:(EMAPA:17304) occurs_in:(CL:0000306)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043010	camera-type eye development	PMID:11309658^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2387330	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006366	transcription by RNA polymerase II	PMID:10652278^[2]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13461	P		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:10652278^[2]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13461	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:10652278^[2]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13461	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001654	eye development	PMID:10652278^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856851	P		Seeded From UniProt	complete
involved_in	GO:2001111	positive regulation of lens epithelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13461 ensembl:ENSP00000334472	P		Seeded From UniProt	complete
involved_in	GO:0071157	negative regulation of cell cycle arrest	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13461 ensembl:ENSP00000334472	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13461 ensembl:ENSP00000334472	P		Seeded From UniProt	complete
involved_in	GO:0042789	mRNA transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13461 ensembl:ENSP00000334472	P		Seeded From UniProt	complete
involved_in	GO:0006366	transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13461 ensembl:ENSP00000334472	P		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13461 ensembl:ENSP00000334472	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13461 ensembl:ENSP00000334472	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13461 ensembl:ENSP00000334472	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13461 ensembl:ENSP00000334472	F		Seeded From UniProt	complete
involved_in	GO:0002088	lens development in camera-type eye	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13461 ensembl:ENSP00000334472	P		Seeded From UniProt	complete
involved_in	GO:0001654	eye development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13461 ensembl:ENSP00000334472	P		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001766 InterPro:IPR018122 InterPro:IPR030456	F		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001766 InterPro:IPR018122 InterPro:IPR030456	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001766 InterPro:IPR018122 InterPro:IPR030456	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 ^1.9 Blixt, A et al. (2007) Foxe3 is required for morphogenesis and differentiation of the anterior segment of the eye and is sensitive to Pax6 gene dosage. Dev. Biol. 302 218-29 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Blixt, A et al. (2000) A forkhead gene, FoxE3, is essential for lens epithelial proliferation and closure of the lens vesicle. Genes Dev. 14 245-54 PubMed GONUTS page
↑ Brownell, I et al. (2000) Forkhead Foxe3 maps to the dysgenetic lens locus and is critical in lens development and differentiation. Genesis 27 81-93 PubMed GONUTS page
↑ Ormestad, M et al. (2002) Foxe3 haploinsufficiency in mice: a model for Peters' anomaly. Invest. Ophthalmol. Vis. Sci. 43 1350-7 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Medina-Martinez, O et al. (2005) Severe defects in proliferation and differentiation of lens cells in Foxe3 null mice. Mol. Cell. Biol. 25 8854-63 PubMed GONUTS page
↑ Islam, L et al. (2015) Functional analysis of FOXE3 mutations causing dominant and recessive ocular anterior segment disease. Hum. Mutat. 36 296-300 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Wang, Y et al. (2012) Growth inhibition of human lens epithelial cells by short hairpin RNA in transcription factor forkhead box E3 (FOXE3). Graefes Arch. Clin. Exp. Ophthalmol. 250 999-1007 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Maeda, YY et al. (2001) Two interactive genes responsible for a new inherited cataract (RCT) in the mouse. Mamm. Genome 12 278-83 PubMed GONUTS page

[PMID:17064680-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 ^1.9 Blixt, A et al. (2007) Foxe3 is required for morphogenesis and differentiation of the anterior segment of the eye and is sensitive to Pax6 gene dosage. Dev. Biol. 302 218-29 PubMed GONUTS page

[PMID:10652278-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Blixt, A et al. (2000) A forkhead gene, FoxE3, is essential for lens epithelial proliferation and closure of the lens vesicle. Genes Dev. 14 245-54 PubMed GONUTS page

[PMID:10890982-3] Brownell, I et al. (2000) Forkhead Foxe3 maps to the dysgenetic lens locus and is critical in lens development and differentiation. Genesis 27 81-93 PubMed GONUTS page

[PMID:11980846-4] Ormestad, M et al. (2002) Foxe3 haploinsufficiency in mice: a model for Peters' anomaly. Invest. Ophthalmol. Vis. Sci. 43 1350-7 PubMed GONUTS page

[PMID:16199865-5] 5.0 ^5.1 ^5.2 ^5.3 Medina-Martinez, O et al. (2005) Severe defects in proliferation and differentiation of lens cells in Foxe3 null mice. Mol. Cell. Biol. 25 8854-63 PubMed GONUTS page

[PMID:25504734-6] Islam, L et al. (2015) Functional analysis of FOXE3 mutations causing dominant and recessive ocular anterior segment disease. Hum. Mutat. 36 296-300 PubMed GONUTS page

[PMID:22527307-7] 7.0 ^7.1 ^7.2 Wang, Y et al. (2012) Growth inhibition of human lens epithelial cells by short hairpin RNA in transcription factor forkhead box E3 (FOXE3). Graefes Arch. Clin. Exp. Ophthalmol. 250 999-1007 PubMed GONUTS page

[PMID:21873635-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:11309658-9] Maeda, YY et al. (2001) Two interactive genes responsible for a new inherited cataract (RCT) in the mouse. Mamm. Genome 12 278-83 PubMed GONUTS page

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MOUSE:FOXE3

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